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动态力学加载下MC3T3-E1细胞在3D打印三维仿生复合支架上的成骨效应研究

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中国修复重建外科杂志 2018年第4期32卷 448-456页

作者：宋秀钢李晖李瑞欣袁清献刘迎节程威张西正天津医科大学总医院骨科天津300052 天津医科大学研究生院临床医学系天津300070 中国人民解放军军事医学科学院卫生装备研究所天津300161 天津市口腔医院中心实验室天津理工大学机械学院生物力学系天津300384

目的观察动态力学加载对低温3D打印联合冷冻干燥法制备的三维仿生复合支架材料内MC3T3-E1细胞增殖、分化、成骨特异性基因表达的影响。方法将丝素蛋白、Ⅰ型胶原、羟基磷灰石按质量比3∶9∶2.合后,采用低温3D打印联合冷冻干燥技术制备... 详细信息

目的观察动态力学加载对低温3D打印联合冷冻干燥法制备的三维仿生复合支架材料内MC3T3-E1细胞增殖、分化、成骨特异性基因表达的影响。方法将丝素蛋白、Ⅰ型胶原、羟基磷灰石按质量比3∶9∶2.合后,采用低温3D打印联合冷冻干燥技术制备三维仿生复合支架;大体观察支架外形,Micro-CT观察支架孔径及孔隙率,测定吸水膨胀率以及应力、应变、弹性模量。取MC3T3-E1细胞接种至三维仿生复合支架,随机分成两组:实验组培养期间行动态力学加载,每天1次、每次15 min、频率1 Hz、应变3 500με;对照组不作力学加载。培养7、14 d,分别对细胞-支架复合物行HE染色及扫描电镜观察细胞在支架上生长情况;Western blot以及实时荧光定量PCR检测Ⅰ型胶原、BMP-2.骨钙素(osteocalcin,OCN)蛋白及m RNA表达。结果制备的三维仿生复合支架为白色立方体网格,Micro-CT检测见支架材料内部呈孔隙网状结构,孔隙连通性良好;大孔径直径为(506.37±18.63)μm,微孔径直径为(62.14±17.35)μm,孔隙率为97.70%±1.37%,吸水膨胀率为1 341.97%±64.41%。力学测试示,支架压缩至10%时,支架压缩位移为(0.376±0.004)mm、压缩应力为(0.016±0.002.MPa、弹性模量为(162.418±18.754)k Pa。复合培养7、14 d,两组HE染色及扫描电镜均见细胞在支架内部生长,主要分布在支架孔壁周围,其中实验组细胞较对照组增多,且细胞由梭形变为扁平状。除2.0倍镜下14 d时两组细胞计数差异无统计学意义(t=–2.02.,P=0.080)外,其余不同放大倍数(40、100、400倍)下各时间点实验组细胞数均显著高于对照组(P14 d时Ⅰ型胶原、OCN m RNA相对表达量显著高于对照组(P2.m RNA相对表达量与对照组比较差异无统计学意义(P>0.05)。Western blot检测示,实验组培养7、14 d时Ⅰ型胶原、BMP-2.OCN蛋白相对表达量均显著高于对照组(P1细胞BMP-2.Ⅰ型胶原、OCN表达明显上调,表明适当力学载荷有利于MC3T3-E1细胞向成骨细胞分化。

关键词：丝素蛋白胶原羟基磷灰石 MC3T3-E1细胞力学加载

Flow and thermal modeling of liquid metal in expanded microchannel heat sink

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Frontiers in Energy 2023年第6期17卷 796-810页

作者： Mingkuan zhang Xudong zhang Luna GUO Xuan li {2. RAO Tianjin Key Laboratory for Advanced Mechatronic System Design and Intelligent Control School of Mechanical EngineeringTianjin University of TechnologyTianjin 300384China National Demonstration Center for Experimental Mechanical and Electrical Engineering Education Tianjin University of TechnologyTianjin 300384China Key Laboratory for Thermal Science and Power Engineering of the Ministry of Education Department of Engineering MechanicsTsinghua UniversityBeijing 100084China School of Mechanical Engineering Tianjin University of CommerceTianjin 300134China institute of Refrigeration and Cryogenics Shanghai Jiao Tong UniversityShanghai 200240China Beijing Key Laboratory of CryoBiomedical Engineering and Key Laboratory of Cryogenics Beijing 100190China

liquid metal-based microchannel heat sinks (MCHSs) suffer from the low heat capacity of coolant, resulting in an excessive temperature rise of coolant and heat sink when dealing with high-power heat dissipation. In this paper, it was found that expanded space at the top of fins could distribute the heat inside microchannels, reducing the temperature rise of coolant and heat sink. The orthogonal experiments revealed that expanding the top space of channels yielded similar temperature reductions to changing the channel width. The flow and thermal modeling of expanded microchannel heat sink (E-MCHS) were analyzed by both using the 3-dimensional (3D) numerical simulation and the 1-dimensional (1D) thermal resistance model. The fin efficiency of E-MCHS was derived to improve the accuracy of the 1D thermal resistance model. The heat conduction of liquid metal in Z direction and the heat convection between the top surface of fins and the liquid metal could reduce the total thermal resistance (Rt). The above process was effective for microchannels with low channel aspect ratio, low mean velocity (Um) or long heat sink length. The maximum thermal resistance reduction in the example of this paper reached 36.0%. The expanded space endowed the heat sink with lower pressure, which might further reduce the pumping power (P). This rule was feasible both when fins were truncated (h_(2. 2. is the height of expanded channel for E-MCHS) and when over plate was raised (h_(2. > 0).

关键词： liquid metal cooling heat sink expanded microchannel flow and thermal modeling

基于中阶梯光栅光谱仪的激光诱导等离子体分析系统研究

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光谱学与光谱分析 2018年第5期38卷 1605-1609页

作者：张锐朱继伟刘建利崔继承李晓天巴音贺希格中国科学院长春光学精密机械与物理研究所吉林长春130033 中国科学院大学北京100049

为了满足激光诱导等离子体分析系统(liPS)对分光系统的分辨率,光谱范围,体积等多方面要求。本文研制了一台中阶梯光栅光谱仪,该光谱仪能同时获得所有谱段范围内的光谱信息,令liPS系统可实现快速在线实时分析。并且,该光谱仪采用可调节... 详细信息

为了满足激光诱导等离子体分析系统(liPS)对分光系统的分辨率,光谱范围,体积等多方面要求。本文研制了一台中阶梯光栅光谱仪,该光谱仪能同时获得所有谱段范围内的光谱信息,令liPS系统可实现快速在线实时分析。并且,该光谱仪采用可调节延迟时间的ICCD作为后端探测器,令整个系统可根据实际实验情况选择最优延迟时间接收光谱,提高了整个系统的信噪比。最后,搭建了一套激光诱导等离子体分析系统,对研制的中阶梯光栅光谱仪在系统中的可用性进行验证。通过对合金样品测试,整个系统的分辨率达0.02.m,光谱范围覆盖190~600nm。并且研制的liPS系统光谱重复性较好,特征元素波长提取误差不超过0.01nm,可较准确的对样品成分进行分析。

关键词：分辨率中阶梯光栅中阶梯光栅光谱仪激光诱导等离子体谱

High-frequency enhanced response based on Sb_(2.Te_(3)topological insulators

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Photonics Research 2022年第10期10卷 2302-2308页

作者： SHI zhang CHAOFAN SHI weiwei TANG liBO zhang li HAN CHENGSEN YANG ZHENGYANG zhang JIAN WANG MIAO CAI GUANHAI li CHANGLONG liu liN WANG XIAOSHUANG CHEN wei LU College of Physics and Optoelectronic Engineering Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China State Key Laboratory of Infrared Physics Shanghai Institute of Technical PhysicsChinese Academy of SciencesShanghai 200083China Shanghai institute of Optics and Fine mechanics Chinese Academy of SciencesShanghai 201800China Department of Optoelectronic Science and Engineering Donghua UniversityShanghai 201620China Terahertz Technology Innovation Research institute Shanghai Key Laboratory of Modern Optical SystemUniversity of Shanghai for Science and TechnologyShanghai 200093China

Topological insulators represent a new quantum phase of matter with spin-polarized surface states that are protected from backscattering, exhibiting electronic responses to light, such as topological quantum phase transitions. However, the effects of high-frequency driving topological intrinsic systems have remained largely unexplored challenges experimentally for high-sensitivity terahertz detection. In this study, by integrating Sb2.e3 topological insulators with subwavelength metal antennas through micro-nano processing, a high-frequency terahertz detector with high sensitivity is proposed. The enhanced response originates from the asymmetric scattering of the surface electrons in the Sb_(2.Te_(3) flakes induced by the terahertz wave. The device displays room-temperature photodetection with a responsivity of 192.mA/W and equivalent noise power of less than 0.35 nW/Hz^(1/2. in the frequency range from 0.02.to 0.3 THz. These results pave the way for the exploitation of topological insulators for high-frequency operation in real-time imaging within long-wavelength optoelectronics.

关键词： scattering insulator quantum

Composition analysis of colored dissolved organic matter in Taihu Lake based on three dimension excitation-emission fuorescence matrix and PARAFAC model, and the potential application in water quality monitoring

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Journal of Environmental Sciences 2007年第7期19卷 787-791页

作者： WANG Zhi-gang liu Wen-qing ZHAO Nan-jing li Hong-bin zhang Yu-jun SI-MA {2.-cang liu Jian-guo School of Earth and Space Science University of Science and Technology of China Hefei 230026 China. Key Laboratory of Environmental Optics and Technology Anhui Institute of Optics and Fine Mechanics Chinese Academy of Sciences Hefei 230031 China

Taihu Lake is one of the five biggest lakes in china. Surface water samples from 2. sampling sites of Taihu Lake were collected. Furthermore wet chemical analysis （CODCr and BOD5） and measurement of three dimensional excitation-emission matrix （3DEEM） spectra in the laboratory have been conducted. Using parallel factor analysis （PARAFAC） model, three components of colored dissolved organic matter （CDOM） have been identified successfully, based on the analysis of 3DEEM data. The characteristics of the three components also have been described by comparing them to some components of CDOM, identified in earlier researches. Meanwhile, spatial variations of concentration for the three components in Taihu Lake have been analyzed, and the result indicates that the concentration of component 1 depends more on the situation of wastewater pollution and can be used as the indicator of wastewater pollution. The relationship between the concentrations of the three components and results of the wet chemical analysis show that none of the three components can be used as indicators of gross organic matter in water. However, the concentrations of all the three components have obvious linear relationships with the BOD5 value, especially for component 1 （r = 0.72.78）. Finally, the potential applications of the composition analysis based on 3DEEM and PARAFAC model in water quality monitoring have been illuminated.

关键词： 3DEEM Taihu Lake monitoring of water quality CDOM PARAFAC

The Low Energy X-ray telescope (LE) onboard the Insight-HXMT astronomy satellite

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Science china(Physics,mechanics & Astronomy) 2020年第4期63卷 49-61页

作者： Yong Chen weiwei Cui wei li Juan Wang YuPeng Xu FangJun Lul YuSa Wang TianXiang Chen Dawei Han wei Hu Yi zhang Jia Huo YanJi Yang MaoShun li Bo Lu Ziliang zhang TiPei li ShuangNan zhang Shaolin Xiong Shu zhang RongFeng Xue XiaoFan Zhao Yue Zhu YuXuan Zhu Hongwei liu YiJung Yang Fan zhang Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China Department of Physics Tsinghua UniversityBeijing 100084China Department of Education Lu Liang UniversityLuliang 033000China Qian Xuesen Laboratory of Space Technology China Academy of Space TechnologyBeijing 100094China College of Physics Jilin UniversityChangchun 130023China

The Low Energy X-ray telescope(LE) is one of the three main instruments of the Insight-Hard X-ray Modulation Telescope(Insight-HXMT). It is equipped with Swept Charge Device(SCD) sensor arrays with a total geometrical area of 384 cm^2.and an energy band from 0.7 to 13 ke V. In order to evaluate the particle induced X-ray background and the cosmic X-ray background simultaneously, LE adopts collimators to define four types of Field Of Views(FOVs), i.e., 1.6°×6°, 4°×6°, 50°-60°×2.-6 oand the blocked ones which block the X-ray by an aluminum cover. LE is constituted of three detector boxes(LEDs) and an electric control box(LEB) and achieves a good energy resolution of 140 e V@5.9 ke V, an excellent time resolution of 0.98 ms, as well as an extremely low pileup(libration on the ground have been performed,including energy-channel relation, energy response, detection efficiency and time response.

关键词： LE X-ray telescope SCD collimators

Switching Optimally Balanced Fe-N Interaction Enables Extremely Stable Energy Storage

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Energy & Environmental Materials 2023年第2期6卷 275-283页

作者： Zhenzhen Zhao wei zhang Miao {2. Dong Wang Xiyang Wang lirong Zheng Xu Zou Zizhun Wang Dabing li Keke Huang weitao Zheng Key Laboratory of Mobile Materials MOE and School of Materials Science&Engineeringand Electron Microscopy Centerand International Center of Future ScienceJilin UniversityChangchun 130012China State Key Laboratory of Chem/Bio-Sensing and Chemometrics Provincial Hunan Key Laboratory for Graphene Materials and DevicesCollege of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082China Department of Mechanical and Mechatronics Engineering University of WaterlooWaterloo Canada Beijing Synchrotron Radiation Facility Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China State Key Laboratory of Luminescence and Applications Changchun Institute of OpticsFine Mechanics and PhysicsChinese Academy of SciencesChangchun 130033China State Key Laboratory of Inorganic Synthesis and Preparative Chemistry College of ChemistryJilin UniversityChangchun 130012China

The interaction between electrode materials and charge carriers is one of the central issues dominating underlying energy storage *** address the notoriously significant volume changes accompanying intercalation or formation of alloy/compounds,we aim to introduce and utilize a weak,reversible Fe-N interaction during the(de)intercalation of ammonium ions(NH_(4)^(+))within iron(Ⅲ)hexacyanoferrate(FeHCF),inspired by manipulating the electrostatic adsorption between N and Fe in the early stages of ammonia synthesis(Bosch-Harber Process,Chemical Engineering)and steel nitriding processes(Metal Industry).Such strategy of switching well-balanced Fe-N interaction is confirmed in between the nitrogen of ammonium ions and highspin Fe in FeHCF,as observed by using X-ray absorption *** resulting material provided an extremely stable energy storage(58 mAh g^(-1) after 10000 cycles at current density of 1 A g^(-1))as well as high-rate performance(2..6 mAh g^(-1) at current density of 10 A g^(-1)).

关键词： ammonium ion battery Iron(Ⅲ)hexacyanoferrate reversible Fe-N interaction stability

搜寻第二个地球——系外地球(ET)巡天计划

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空间科学学报 2024年第3期44卷 400-424页

作者：葛健陈雯陈永和宋宗玺王坚张辉李岩臧伟呈周丹张永帅陈琨阳应权毛淑德黄煦药新雨李兴隆姜海娇于涌唐正宏董峰高伟张鸿飞申超王峰涛魏传新杨宝玉李豫东文林张朋军张聪聪谢基伟马波邓洪平刘慧根段旭亮王昊宇黄江江高扬王伊菲王磊秦根健刘欣宇高婕中国科学院上海天文台上海200030 中国科学院微小卫星创新研究院上海201304 中国科学院上海技术物理研究所上海200083 中国科学院西安光学精密机械研究所西安710119 中国科学技术大学合肥230026 清华大学天文系北京100190 南昆士兰大学天体物理中心图文巴QLD4350 中国航天科技集团公司第八研究院803研究所上海201109 中国科学院新疆理化技术研究所乌鲁木齐830011 南京大学天文系南京210023 中山大学物理与天文学院珠海519082

系外地球科学卫星(ET)将通过采用空间大视场超高精度测光这一关键技术在国际上率先突破生命起源中的系外地球存在及其演化这一重大前沿科学问题. ET卫星将在日地拉格朗日L2.晕(Halo)轨道部署由6台广角凌星望远镜和1台微引力透镜望远镜... 详细信息

系外地球科学卫星(ET)将通过采用空间大视场超高精度测光这一关键技术在国际上率先突破生命起源中的系外地球存在及其演化这一重大前沿科学问题. ET卫星将在日地拉格朗日L2.晕(Halo)轨道部署由6台广角凌星望远镜和1台微引力透镜望远镜构成的空间天文台,结合凌星法和微引力透镜法,利用空间超大视场和超高精度的光学测光观测,首次发现富有重要意义、被广泛关注的系外地球,并确定其发生率,对目前了解甚少的类地行星和流浪行星进行国际上第一次大规模的种群普查,首次发现流浪地球,并确定其发生率,揭示类地行星和流浪行星起源,为地外生命探寻提供候选者和新方向. ET卫星的观测结果、统计研究以及和对理论的检验将回答系外地球在宇宙中有多普遍,类地行星是如何形成和演化的,流浪行星又是如何起源的这些亟待解决的前沿科学问题.对ET卫星发现的系外地球样本的后随观测,将精确测量其质量、密度和大气成分,有助于深入分析宜居性特征.此外,对ET新发现的大量各种系外行星样本的研究,以及对理论的检验将推动这些种类的行星形成和演化规律的更深入认识, ET的大量高精度、高频次和长基线测光数据将推动星震学、银河系考古学、时域天文学、双星和双星黑洞等领域的研究.

关键词：系外行星类地行星宜居带凌星微引力透镜测光

Overview to the Hard X-ray Modulation Telescope (Insight-HXMT) Satellite

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Science china(Physics,mechanics & Astronomy) 2020年第4期63卷 2-19页

作者： Shuang-Nan zhang TiPei li FangJun Lu liMing Song YuPeng X u CongZhan liu Yong Chen Xue{2. Cao QingCui Bu Zhi Chang Gang Chen li Chen TianXiang Chen YiBao Chen YuPeng Chen wei Cui weiwei Cui JingKang Deng Yongwei Dong Yuan Yuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan Can Gungor ChengCheng Guo Dawei Han wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang weiChun Jiang Jing Jin YongJie Jin Bing li ChengKui li Gang li MaoShun li wei li Xian li XiaoBo li XuFang li YanGuo li ZiJian li Zhengwei li XiaoHua liang JinYuan liao GuoQing liu Hongwei liu ShaoZhen liu XiaoJing liu Yuan liu YiNong liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge Ou JinLu Qu Na Sai RenCheng Shang GuoHong Shen liang Sun Ying Tan lian Tao Youli Tuo Chen Wang ChunQin Wang GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BaiYang Wu BoBing Wu Mei Wu GuangCheng Xiao Shaolin Xiong linli Yan Jiawei Yang Sheng Yang YanJi Yang QiBin Yi Bin Yuan AiMei zhang Chun{2. zhang ChengMo zhang Fan zhang HongMei zhang Juan zhang Qiang zhang ShenYi zhangs Shu zhang Tong zhang WanChang zhang wei zhang WenZhao zhang Yi zhang YiFei zhang YongJie zhang Yue zhang Zhao zhang Zhi zhang Ziliang zhang HaiSheng Zhao XiaoFan Zhao ShiJie Zheng JianFeng Zhou YuXuan Zhu Yue Zhu Renlin Zhuang Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China Department of Astronomy Tsinghua UniversityBeijing 100084China Department of Physics Tsinghua UniversityBeijing 100084China Department of Astronomy Beijing Normal UniversityBeijing 100088China Department of Engineering Physics Tsinghua UniversityBeijing 100084China National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China National Space Science Center Chinese Academy of SciencesBeijing 100190China

As china’s first X-ray astronomical satellite, the Hard X-ray Modulation Telescope (HXMT), which was dubbed as Insight-HXMT after the launch on June 15, 2.17, is a wide-band(1-2.0 ke V) slat-collimator-based X-ray astronomy satellite with the capability of all-sky monitoring in 0.2.3 Me V. It was designed to perform pointing, scanning and gamma-ray burst(GRB)observations and, based on the Direct Demodulation Method (DDM), the image of the scanned sky region can be *** we give an overview of the mission and its progresses, including payload, core sciences, ground calibration/facility, ground segment, data archive, software, in-orbit performance, calibration, background model, observations and some preliminary results.

关键词： X-and γ-ray telescopes and instrumentation neutron stars black holes X-ray binaries γ-ray bursts