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Chinese Medical Journal 2013年第23期126卷 4575-4582页

作者： zhang lan-fang xia chang-qing Department of Hematology Xuanwu Hospital Capital Medical University Beijing 100053 China

Objective To review the characteristics of regulatory T cells （Tregs） and ex vivo expansion of Tregs for treatment of graftversus-host disease （GVHD）.Data sources The data used in this review were retrieved from PubMed （1970-2013）.The terms ＂ex vivo expansion＂,＂regulatory T cell＂,and ＂graft-versus-host disease＂ were used for literature *** selection The publications about the characteristics of Tregs,ex vivo expansion of Tregs and clinical applications of Tregs against GVHD were identified,retrieved and *** Tregs can be classified as natural Tregs （nTregs） and induced Tregs （iTregs）.Both subsets share most Treg *** their immunosuppressive property,Tregs have been tested for their capability of preventing *** bottleneck of Treg therapy is the limited numbers of naturally existing *** solve this problem,ex vivo expansion of nTregs or iTregs has been *** initial data indicate Treg therapy is effective in reducing GVHD without compromising graft-versus-leukemia （GVL）.Conclusion Ex vivo expansion of Tregs is a reliable way to prepare sufficient number of Tregs for management of GVHD.

关键词： ex vivo expansion regulatory T cells adoptive therapy graft-versus-host disease allogeneic hematopoietic stem cell transplantation

Astragaloside Ⅳ Improves Angiogenesis and Promotes Wound Healing in Diabetic Rats via the Activation of the SUMOylation Pathway

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Biomedical and Environmental Sciences 2021年第2期34卷 124-129页

作者： WANG Bao Shen MA xiao fang zhang Chun Yan LI Yan xia LIU xiao Zhi HU chang qing Department of Cardiovascular Surgery The No.1 Central Hospital of Baoding CityBaoding 071000HebeiChina Central Laboratory The Fifth Central Hospital of TianjinTianjin 300450China Tianjin Key Laboratory of Epigenetics for Organ Development in Preterm Infants The Fifth Central Hospital of TianjinTianjin 300450China Department of Pharmacy Tianjin Binhai New Area Hospital of Traditional Chinese MedicineTianjin 300450China The Fifth Orthopaedics Department The No.1 Central Hospital of Baoding CityBaoding 071000HebeiChina

Radix astragali is the dried root of the legume Mongolian Astragalus or Astragalus membranaceus~([1]). Modern research has found that the main active ingredients in astragalus are astragalus polysaccharides, astragaloside, and astragalus isoflavones. Astragaloside IV(AS-IV) has been used internationally as a standard for evaluating the quality of astragalus medicinal materials.

关键词： Radix Wound dried

Synthesis,spectroscopic and electrochemical property of an unsymmetrical porphyrin and its Zn compound

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Chinese Chemical Letters 2010年第7期21卷 769-773页

作者： chang Fu Zhuang Yu Jing zhang Ai qing xia Wen Hui Lian Yun fang Wang Ping zhang Tong Shun Shi College of Chemistry Jilin UniversityChangchun 130023China

In this article,a new 5-（p-maleicaminophenyl）-10,15,20-triphenylporphyrin（H_2P） and relative zinc compound（ZnP） were synthesized and characterized by means of elemental analyses,UV-vis,IR,MS and 1H NMR ***,we have investigated the fluorescence spectroscopy of these *** oxidation and reduction properties of the compounds were studied by the cyclic voltarnmetry,the oxidation-reduction potentials were obtained.

关键词： Synthesis Porphyrin Cyclic voltammetry Fluorescence

Study on crab-cavity-based longitudinal injection scheme and prototype realization of C-band crab cavity for electron storage rings

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Nuclear Science and Techniques 2023年第7期34卷 137-147页

作者： Guan-Hua Wang Bo-Cheng Jiang Jian-Hao Tan qing-Lei zhang Wen-Cheng fang chang-Liang Li Kun Wang xiao-xia Huang Sheng-Li Pu University of Shanghai for Science and Technology Shanghai 200093China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China Laboratory for Ultrafast Transient Facility Chongqing UniversityChongqing 401331China Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201204China

A diffraction-limited storage ring with a multi-bend achromat lattice suffers from a small dynamic aperture for conventional off-axis ***,a longitudinal on-axis injection scheme based on a new type of crab cavity is proposed in this *** tracking simulations were performed to study the disturbance of the stored beam and the motion of the injected beam during the injection *** possibility of multi-bunch injections was *** addition,the effect of the long-range wake field induced by the stored beam was analyzed.A C-band standing-wave crab cavity was designed and produced as requested,and its field distribution was *** corresponding results are consistent with the simulation results.

关键词： On-axis injection Crab cavity Bump orbit Wakefield

Efficacy and safety of transcutaneous auricular vagus nerve stimulation combined with conventional rehabilitation training in acute stroke patients: a randomized controlled trial conducted for 1 year involving 60 patients

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Neural Regeneration Research 2022年第8期17卷 1809-1813页

作者： Jia-Ni Li Chen-Chen Xie chang-qing Li Gui-fang zhang Hao Tang Chuan-Na Jin Jing-Xi Ma lan Wen Ke-Ming zhang Ling-Chuan Niu Department of Neurology The Second Affiliated Hospital of Chongqing Medical UniversityChongqingChina Department of Neurology Chongqing General HospitalUniversity of Chinese Academy of SciencesChongqingChina Chongqing Key Laboratory of Neurodegenerative Diseases ChongqingChina Department of Neurology West China Hospital of Sichuan UniversityChengduSichuan ProvinceChina Clinical College Chongqing Medical and Pharmaceutical CollegeChongqingChina

Transcutaneous auricular vagus nerve stimulation(ta-VNS)is a novel noninvasive treat-ment for stroke that directly stimulates the peripheral auricular branch of the vagus *** have been recent reports that ta-VNS combined with conventional rehabilitation training promotes the recovery of neurological function of patients with acute ***,these were small-sample-sized studies on the recovery of neurological function in patients after percutaneous vagus nerve stimulation in the subacute and chronic phases after *** double-blinded randomized controlled trial involved 60 acute ischemic or hemorrhagic stroke patients aged 18-80 years who received treatment in the Second Affiliated Hospital of Chongqing Medical *** subjects were randomly assigned to receive ta-VNS or sham ta-VNS combined with conventional rehabilitation *** follow-up results over 1 year revealed that ta-VNS combined with conventional rehabilitation training greatly improved the recovery of motor and sensory functions and emotional responses compared with sham ta-VNS combined with conventional rehabilitation *** were no obvious side *** findings suggest that ta-VNS combined with conventional rehabilitation training for the treatment of acute ischemic or hemorrhagic stroke patients is safe and effective.

关键词： activity of daily living early stage treatment emotional disorder limb dysfunction neural regeneration randomized controlled clinical trial rehabilitation safety of treatment stroke transcutaneous auricular-vagus nerve stimulation

Identification and QTL mapping of Z550, a rice backcrossed inbred line with increased grains per panicle

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Journal of Integrative Agriculture 2019年第3期18卷 526-531页

作者： WANG Shi-ming CUI Guo-qing WANG Hui MA Fu-ying xia Sai-sai LI Yun-feng YANG Zheng-lin LING Ying-hua zhang chang-wei HE Guang-hua ZHAO fang-ming Rice Research Institute Academy of Agricultural SciencesSouthwest UniversityChongqing 400715P.R.China

An elite backcrossed inbred line Z550 with increased grains per panicle was identified from advanced backcrosses between Nipponbare and Xihui 18 by simple sequence repeat(SSR) marker-assisted selection(MAS). Z550 carries 13 substitution segments distributed on chromosomes 1, 6, 7, 8, 9, 10, and 12, with an average substitution length of 1.68 Mb. Compared with the Nipponbare parental line, plant height, panicle length, spikelets per panicle, grains per panicle, and grain weight for Z550 were significantly increased. While the grain width of Z550 was significantly narrower, and the seed setting ratio(81.43%) was significantly lower than that of Nipponbare, it is still sufficient for breeding purposes. Quantitative trait loci(QTLs) mapping for important agronomic traits was conducted with the F_2 population derived from Nipponbare crossed with Z550 using the restricted maximum likelihood(REML) method. A total of 16, including 12 previously unreported QTLs were detected, with contribution rates ranging from 1.46 to 10.49%. Grains per panicle was controlled by 8 QTLs, 5 of which increased number of grains whereas 3 decreased it. qGPP-1, with the largest contribution(10.49%), was estimated to increase grains per panicle by 30.67, while q GPP-9, with the minimum contribution rate(2.47%), had an effect of increasing grains per panicle by 15.79. These results will be useful for further development of single segment substitution lines with major QTLs, and for research of their molecular functions via QTL cloning.

关键词： rice backcrossed inbred line yield QTL mapping

EPHA2 mediates PDGFA activity and functions together with PDGFRA as prognostic marker and therapeutic target in glioblastoma

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Signal Transduction and Targeted Therapy 2022年第3期7卷 746-757页

作者： Qu-Jing Gai Zhen Fu Jiang He Min Mao xiao-Xue Yao Yan Qin Xi lan Lin zhang Jing-Ya Miao Yan-xia Wang Jiang Zhu Fei-Cheng Yang Hui-Min Lu Ze-Xuan Yan fang-Lin Chen Yu Shi Yi-fang Ping You-Hong Cui xia zhang Xindong Liu xiao-Hong Yao Sheng-qing Lv Xiu-Wu Bian Yan Wang Institute of Pathology and Southwest Cancer Center Southwest HospitalArmy Medical University(Third Military Medical University)ChongqingChina Biobank of Institute of Pathology Southwest HospitalArmy Medical University(Third Military Medical University)ChongqingChina Institute of Cancer Xinqiao HospitalArmy Medical University(Third Military Medical University)ChongqingChina Department of Neurosurgery Xinqiao HospitalArmy Medical University(Third Military Medical University)ChongqingChina

Platelet-derived growth subunit A(PDGFA)plays critical roles in development of glioblastoma(GBM)with substantial evidence from TCGA database analyses and in vivo mouse *** far,only platelet-derived growth receptor a(PDGFRA)has been identified as receptor for ***,PDGFA and PDGFRA are categorized into different molecular subtypes of GBM in TCGA_GBM database.

关键词： PDGFRA Platelet glioblastoma

Hetero-bimetallic transition metal-substituted Krebs-type polyoxometalate with N-chelating ligand as anticancer agents

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Tungsten 2023年第2期5卷 225-234页

作者： Han-Zhi zhang Hong-xia Zhao Wen-Hui chang Xin-Yuan Liu Peng Chen Ai-Qin Yu Aadil Nabi Chishti Yu-Zhen zhang Lu-Bin Ni Xi-qing Wang Yong-Ge Wei School of Chemistry and Chemical Engineering Yangzhou UniversityYangzhou 225002China College of Bioscience and Biotechnology Yangzhou UniversityYangzhou 225009China School of Chemistry and Chemical Engineering Guangxi Minzu UniversityNo.158Daxue West RoadNanning 530006China Key Lab of Organic Optoelectronics and Molecular Engineering of Ministry of Education Department of ChemistryTsinghua UniversityBeijing 100084China

A novel hetero-bimetallic transition metal(Sb^(Ⅴ)/Mn^(Ⅱ))-substituted Krebs-type polyoxometalate(POM)with N-chelating ligand H_(4)Na_(4)[Mn_(4)(H_(2)O)_(4)(trz)_(2)(SbO_(2))_(2)(SbW_(9)O_(33))_(2)]-20H_(2)O(Sb_(2)Mn_(2))(1)(trz=1,2,4-triazole)built from trilacunary Keggin POM unitα-B-[SbW_(9)O_(33)]^(9-){SbW_(9)]has been synthesized and characterized by single-crystal/powder X-ray diffraction and a wide range of analytical methods,including powder X-ray diffraction,Fourier transform infrared spectroscopy,Raman,ultraviolet-visible spectroscopy,electrospray ionization-mass spectroscopy,and thermogravimetric *** further investigate the antitumor activity of the(Sb_(2)Mn_(2))(1)in human gastric cancer Human Gastric Adenocarcinoma Cells and Human Gastric Cancer Cell lines,in vitro cytotoxicity assay and flow cytometry analysis was *** results indicated that the IC_(50) values of(Sb_(2)Mn_(2))(1)on Human Gastric Adenocarcinoma(AGS)and Human Gastric Cancer(BGC-823)Cell Lines were 1.86±0.05μmol·L^(-1) and 14.61±0.55μmol·L^(-1),respectively.(Sb_(2)Mn_(2))(1)also exhibited high cytotoxicity on Human Gastric Cancer Cells and could induce cell apoptosis by inhibiting S and G_(2)/M cell ***,the result not only shows that this new POM-based inorganic-organic hybrid compound has high selectivity and low toxicity,but also provides an effective method for the development of potential transition metal-substituted POMs based antitumor drugs.

关键词： Polyoxometalate Inorganic-organic hybrid material-In vitro cytotoxicity Anticancer agent

Clinical effect and antiviral mechanism of T-705 in treating severe fever with thrombocytopenia syndrome

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Signal Transduction and Targeted Therapy 2021年第5期6卷 1546-1558页

作者： Hao Li xia-Ming Jiang Ning Cui Chun Yuan Shao-Fei zhang qing-Bin Lu Zhen-Dong Yang Qin-Lin Xin Ya-Bin Song xiao-Ai zhang Hai-Zhou Liu Juan Du Xue-Juan Fan lan Yuan Yi-Mei Yuan Zhen Wang Juan Wang lan zhang Dong-Na zhang Zhi-Bo Wang Ke Dai Jie-Ying Bai Zhao-Nian Hao Hang Fan Li-Qun fang Gengfu xiao Yang Yang Ke Peng Hong-Quan Wang Jian-Xiong Li Lei-Ke zhang Wei Liu Beijing Institute of Microbiology and Epidemiology State Key Laboratory of Pathogen and BiosecurityBeijingP.R.China State Key Laboratory of Virology Wuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of SciencesWuhanHubeiP.R.China The 154 Hospital Peopled Liberation ArmyXinyangHenanP.R.China School of Public Health Peking UniversityBeijingP.R.China lnstitute of Molecular Medicine Peking UniversityBeijingP.R.China Rongji Medical College Huazhong University of Science and TechnologyWuhanP.R.China Department of Biostatistics and Emerging Pathogens Institute University of FloridaGainesvilleFLUSA Department of Cancer People's Liberation Army General HospitalBeijingP.R.China Beijing Key Laboratory of Vector Borne and Natural Focus Infectious Diseases BeijingP.R.China

Severe fever with thrombocytopenia syndrome(SFTS)virus(SFTSV)is an emerging tick-borne virus with high fatality and an expanding ***,effective anti-SFTSV intervention remains ***(T-705)was recently reported to show in vitro and in animal model antiviral efficacy against ***,we conducted a single-blind,randomized controlled trial to assess the efficacy and safety of T-705 in treating SFTS(Chinese Clinical Trial Registry website,number ChiCTR1900023350).From May to August 2018,laboratory-confirmed SFTS patients were recruited from a designated hospital and randomly assigned to receive oral T-705 in combination with supportive care or supportive care *** outcome occurred in 9.5%(7/74)of T-705 treated patients and 18.3%(13/71)of controls(odds ratio,0.466,95%Cl,0.174-1.247).Cox regression showed a significant reduction in case fatality rate(CFR)with an adjusted hazard ratio of 0.366(95%Cl,0.142-0.944).Among the low-viral load subgroup(RT-PCR cycle threshold>26),T-705 treatment significantly reduced CFR from 11.5 to 1.6%(P=0.029),while no between-arm difference was observed in the high-viral load subgroup(RT-PCR cycle threshold<26).The T-705-treated group showed shorter viral clearance,lower incidence of hemorrhagic signs,and faster recovery of laboratory abnormities compared with the *** in vitro and animal experiments demonstrated that the antiviral efficacies of T-705 were proportionally induced by SFTSV mutation rates,particularly from two transition mutation *** mutation analyses on T-705-treated serum samples disclosed a partially consistent mutagenesis pattern as those of the in vitro or animal experiments in reducing the SFTSV viral loads,further supporting the anti-SFTSV effect of T-705,especially for the low-viral loads.

关键词： effect faster supporting

Chinese Guideline on the Management of Polypoidal Choroidal Vasculopathy (2022)

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Chinese Medical Sciences Journal 2023年第2期38卷 77-93页

作者： You-Xin Chen Yu-qing zhang chang-Zheng Chen Hong Dai Su-Yan xiang Ma xiao-Dong Sun Shi-Bo Tang Yu-Sheng Wang Wen-Bin Wei Feng Wen Ge-Zhi Xu Wei-Hong Yu Mei-xia zhang Ming-Wei Zhao Yang zhang fang Qi Xun Xu xiao-Xin Li Department of Ophthalmology Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing China Key Laboratory of Ocular Fundus Diseases Chinese Academy of Medical Sciences&Peking Union Medical College Department of Health Research Methods Evidenceand ImpactMc Master University Ningbo Nottingham GRADE center University of Nottingham Institute of Acupuncture and Moxibustion China Academy of Chinese Medical Sciences CEBIM(Center for Evidence Based Integrative Medicine)-Clarity Collaboration Guang'anmen HospitalChina Academy of Chinese Medical Sciences Department of Ophthalmology Renmin Hospital of Wuhan University Department of Ophthalmology Beijing Hospital Department of Ophthalmology Xuzhou Municipal Hospital Affiliated to Xuzhou medical University Department of Ophthalmology the First Affiliated Hospital of Dalian Medical University Department of Oph thalmology Shanghai General HospitalShanghai Jiao Tong University School of Medicine Aire Eye Hospital Department of Ophthalmology Xijing HospitalFouth Military Medical University Department of Ophthalmology Beijing Tongren Hospital State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen University Ophthalmology the Affiliated Eye and ENT HospitalShanghai Medical SchoolFudan University Department of Ophthalmology West China School of MedicineWest China HospitalSichuan University Department of Ophthalmology Peking University People’s Hospital Systematic Review Solutions Ltd Department of Ophthalmology Shanghai General Hospital Eye Center of xiamen University People Eye Center of People’s Hospital Peking University

Background In China's Mainland,patients with neovascular age-related macular degeneration(nAMD)have approximately an 40%prevalence of polypoidal choroidal vasculopathy(PCV).This disease leads to recurrent retinal pigment epithelium detachment(PED),extensive subretinal or vitreous hemorrhages,and severe vision *** has introduced various treatment modalities in the past years and gained comprehensive experience in treating *** A total of 14 retinal specialists nationwide with expertise in PCV were empaneled to prioritize six questions and address their corresponding outcomes,regarding opinions on inactive PCV,choices of anti-vascular endothelial growth factor(anti-VEGF)monotherapy,photodynamic therapy(PDT)monotherapy or combined therapy,patients with persistent subretinal fluid(SRF)or intraretinal fluid(IRF)after loading dose anti-VEGF,and patients with massive subretinal *** evidence synthesis team conducted systematic reviews,which informed the recommendations that address these *** guideline used the GRADE(Grading of Recommendations,Assessment,Development,and Evaluation)approach to assess the certainty of evidence and grade the strengths of *** The panel proposed the following six conditional recommendations regarding treatment choices.(1)For patients with inactive PCV,we suggest observation over treatment.(2)For treatment-na?ve PCV patients,we suggest either anti-VEGF monotherapy or combined anti-VEGF and PDT rather than PDT monotherapy.(3)For patients with PCV who plan to initiate combined anti-VEGF and PDT treatment,we suggest later/rescue PDT over initiate PDT.(4)For PCV patients who plan to initiate anti-VEGF monotherapy,we suggest the treat and extend(TE)regimen rather than the pro re nata(PRN)regimen following three monthly loading doses.(5)For patients with persistent SRF or IRF on optical coherence tomography(OCT)after three monthly anti-VEGF treatments,we suggest proceeding with anti-VEGF treatment r

关键词： polypoidal choroidal vasculopathy anti-vascular endothelial growth factor photodynamic therapy surgery