Hetero-bimetallic transition metal-substituted Krebs-type polyoxometalate with N-chelating ligand as anticancer agents

作     者：Han-Zhi Zhang Hong-Xia Zhao Wen-Hui Chang Xin-Yuan Liu Peng Chen Ai-Qin Yu Aadil Nabi Chishti Yu-Zhen Zhang Lu-Bin Ni Xi-Qing Wang Yong-Ge Wei 

作者机构：School of Chemistry and Chemical EngineeringYangzhou UniversityYangzhou 225002China College of Bioscience and BiotechnologyYangzhou UniversityYangzhou 225009China School of Chemistry and Chemical EngineeringGuangxi Minzu UniversityNo.158Daxue West RoadNanning 530006China Key Lab of Organic Optoelectronics and Molecular Engineering of Ministry of EducationDepartment of ChemistryTsinghua UniversityBeijing 100084China 

出 版 物：《钨科技(英文)》 (Tungsten)

年 卷 期：2023年第5卷第2期

页      面：225-234页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：This work was supported by the National Natural Science Foundation of China(No.21971221,21401162) the Yangzhou University Interdisciplinary Research Foundation for Chemistry Discipline(yzuxk202010) Qing Lan Project in Colleges and Universities of Jiangsu Province Innovation and entrepreneurship training programs for college students in Jiangsu(202211117066Z) Y.Zhang acknowledges supports from Guangxi Natural Science Foundation(AD20238043,2018GXNSFDA281002) 

主　　题：Polyoxometalate Inorganic-organic hybrid material-In vitro cytotoxicity Anticancer agent 

摘      要：A novel hetero-bimetallic transition metal(Sb^(Ⅴ)/Mn^(Ⅱ))-substituted Krebs-type polyoxometalate(POM)with N-chelating ligand H_(4)Na_(4)[Mn_(4)(H_(2)O)_(4)(trz)_(2)(SbO_(2))_(2)(SbW_(9)O_(33))_(2)]-20H_(2)O(Sb_(2)Mn_(2))(1)(trz=1,2,4-triazole)built from trilacunary Keggin POM unitα-B-[SbW_(9)O_(33)]^(9-){SbW_(9)]has been synthesized and characterized by single-crystal/powder X-ray diffraction and a wide range of analytical methods,including powder X-ray diffraction,Fourier transform infrared spectroscopy,Raman,ultraviolet-visible spectroscopy,electrospray ionization-mass spectroscopy,and thermogravimetric *** further investigate the antitumor activity of the(Sb_(2)Mn_(2))(1)in human gastric cancer Human Gastric Adenocarcinoma Cells and Human Gastric Cancer Cell lines,in vitro cytotoxicity assay and flow cytometry analysis was *** results indicated that the IC_(50) values of(Sb_(2)Mn_(2))(1)on Human Gastric Adenocarcinoma(AGS)and Human Gastric Cancer(BGC-823)Cell Lines were 1.86±0.05μmol·L^(-1) and 14.61±0.55μmol·L^(-1),respectively.(Sb_(2)Mn_(2))(1)also exhibited high cytotoxicity on Human Gastric Cancer Cells and could induce cell apoptosis by inhibiting S and G_(2)/M cell ***,the result not only shows that this new POM-based inorganic-organic hybrid compound has high selectivity and low toxicity,but also provides an effective method for the development of potential transition metal-substituted POMs based antitumor drugs.