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血清淀粉样蛋白A、白介素6、肿瘤坏死因子α及微小RNA在脓毒症并发急性肾损伤患儿中的表达及预后评估价值研究

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中国全科医学 2025年第3期28卷 293-298页

作者：王林娜张靖辉河南省平顶山市第一人民医院新生儿重症监护病区 467000

背景急性肾损伤(AKI)是脓毒症常见并发症,机体免疫-炎症指标是预测脓毒症并发AKI患儿预后的常用指标,目前从微小RNA(miR)方面评估的研究较少,有待临床探究。目的探究血清淀粉样蛋白A(SAA)、白介素6(IL-6)、肿瘤坏死因子α(TNF-α)及mi... 详细信息

背景急性肾损伤(AKI)是脓毒症常见并发症,机体免疫-炎症指标是预测脓毒症并发AKI患儿预后的常用指标,目前从微小RNA(miR)方面评估的研究较少,有待临床探究。目的探究血清淀粉样蛋白A(SAA)、白介素6(IL-6)、肿瘤坏死因子α(TNF-α)及miR在脓毒症并发AKI患儿中的表达,并分析其对预后的评估价值。方法选取2020年3月—2023年3月平顶山市第一人民医院收治的100例脓毒症并发AKI患儿为观察组,另选取同期80例单纯脓毒症患儿为对照组。收集患者一般资料,酶联免疫吸附试验(ELISA)检测血清SAA、IL-6、TNF-α水平,采用实时荧光定量PCR法检测miR-21-3p、miR-182-5p、miR-128-3p相对表达量。比较两组序贯性器官功能衰竭(SOFA)评分、急性生理与慢性健康(APACHEⅡ)评分。采用Pearson相关性检验分析血清SAA、IL-6、TNF-α及miR水平与SOFA、APACHEⅡ评分的相关性。绘制受试者工作特征(ROC)曲线探究血清SAA、IL-6、TNF-α及miR水平对脓毒症并发AKI患儿死亡的预测价值并计算ROC曲线下面积(AUC)。结果观察组SOFA评分、APACHEⅡ评分、血清SAA、IL-6、TNF-α、miR-21-3p、miR-182-5p、miR-128-3p水平均高于对照组(P<0.05)。住院28 d后观察组74例患儿生存,26例患儿死亡。生存患儿血清SAA、IL-6、TNF-α、miR-21-3p、miR-182-5p、miR-128-3p均低于死亡患儿(P<0.05)。血清SAA、IL-6、TNF-α、miR-21-3p、miR-182-5p、miR-128-3p与SOFA、APACHEⅡ评分均呈正相关(P<0.05)。ROC曲线结果显示联合预测的AUC为0.926(95%CI=0.856~0.969,P<0.05)。结论脓毒症并发AKI患儿血清SAA、IL-6、TNF-α、miR-21-3p、miR-182-5p、miR-128-3p异常高表达,临床检测各项指标水平对患儿预后评估有较高价值及预警作用。

关键词：脓毒症急性肾损伤血清淀粉样蛋白A 白介素6 肿瘤坏死因子α

封严流量对轴流涡轮轮缘径向封严非定常流动结构的影响

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兵器装备工程学报 2025年第1期46卷 144-150,196页

作者：张晶辉田杨涛陶佳欣西安航空学院西安710077 庆安集团有限公司西安710077

为了确定最小封严流量,非定常数值研究了封严流量对轴流涡轮径向封严结构封严效果的影响。结果表明:随着封严流量的增大,盘腔内涡结构数量增加,封严间隙内旋转的入侵及出流结构的强度减弱;内侧轴向封严间隙内的非定常波动增大,直到内侧... 详细信息

为了确定最小封严流量,非定常数值研究了封严流量对轴流涡轮径向封严结构封严效果的影响。结果表明:随着封严流量的增大,盘腔内涡结构数量增加,封严间隙内旋转的入侵及出流结构的强度减弱;内侧轴向封严间隙内的非定常波动增大,直到内侧实现完全封严,继续增加封严流量,非定常波动减小。封严间隙内达到最大波动时的封严流量可以认为是实现完全封严的最小封严流量,这为试验条件下判断最小封严流量提供了一种参考准则。设计封严结构时优化封严结构的尺寸、在间隙内引入叠加封严流、封严齿上设计蜂窝结构等,都可以产生较大的非定常波动,以减小最小封严流量,提高封严效率。

关键词：最小封严流量径向封严轮缘封严机理非定常数值模拟涡轮盘腔

Experimental Study of Effects of One Kind of Tangentially Non-uniform Tip Clearance on the Flow Field at an Exit of a Compressor Cascade Passage

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Journal of Thermal Science 2010年第1期19卷 7-13页

作者： Hongwei MA jinghui zhang Jun zhang School of Jet Propulsion Beihang University Beijing 100191 China National Key Laboratory of Science and Technology on Aero-Engines Beijing 100191 China

This paper presents an experimental investigation of effects of one kind of tangentially non-uniform tip clearance on the flow field at an exit of a compressor cascade *** tests were performed in a low-speed large-scale cascade with the uniform tip clearance and the non-uniform *** three-dimensional flow field was measured at the exit at three incidence angles of 0°,5°,and 8° using a mini five-hole pressure *** measurement results show that the non-uniform tip clearance can moderate the leakage flow and blow down more low-energy fluids at the tip corner and decrease the accumulation of low-energy fluids which cause the flow blockage in the blade *** the meantime,the non-uniform clearance can weaken the tangential migration of the low-energy fluids in the endwall boundary layer and reduce the secondary loss and the flow blockage in the tip region.

关键词： compressor cascade clearance leakage flow secondary flow vortex

Mapping genetic variations in the first assembled human genome

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Quantitative Biology 2021年第4期9卷 361-365页

作者： jinghui zhang Department of Computational Biology St.Jude Children's Research HospitalMemphisTN 38105-3678USA

On June 26,2000,President Bill Clinton held aceremony at the White House announcing the completion of the human genome ***,the leaders of the two competing groups,*** Collins from the National Institute of Health,and *** Venter from Celera Genomics,shook their *** a scientist who had been actively involved in both the public and private sides of human genome sequencing,I can still feel the excitement of being a contributor of this landmark scientific project even after 20 ***,I can also attest the significance of this achievement as the reference human genome sequence is being used every day by my research team to find cures for pediatric *** this feature I would like to present a foot soldier’s account on assembling and analyzing the sequence of the human genome.

关键词： Mapping Clinton pediatric

Insulin-like growth factor 1 modulates the phosphorylation, expression, and activity of organic anion transporter 3 through protein kinase A signaling pathway

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Acta Pharmaceutica Sinica B 2020年第1期10卷 186-194页

作者： jinghui zhang Zhou Yu Guofeng You Department of Pharmaceutics RutgersThe State University of New JerseyPiscatawayNJ 08854USA

Organic anion transporter 3(OAT3)plays a vital role in removing a broad variety of anionic drugs from kidney,thus avoiding their possible toxicity in the *** the current study,we investigated the role of insulin-like growth factor 1(IGF-1)in the regulation of *** showed that IGF-1 induced a dose-and time-dependent increase in OAT3 transport activity,which correlated well with an increase in OAT3 *** IGF-1-induced increase in OAT3 expression was blocked by protein kinase A(PKA)inhibitor ***,IGF-1 induced an increase in OAT3 phosphorylation,which was also blocked by *** data suggest that the IGF-1 modulation of OAT3 occurred through PKA signaling *** further confirm the involvement of PKA,we treated OAT3-expressing cells with PKA activator Bt’2-cAMP,followed by examining OAT activity and *** showed that OAT3 activity and phosphorylation were much enhanced in Bt2-cAMP-treated cells as compared to that in control ***,linsitinib,an anticancer drug that blocks the IGF-1 receptor,abrogated IGF-1-stimulated OAT3 transport *** conclusion,our study demonstrated that IGF-1 regulates OAT3 expression and transport activity through PKA signaling pathway,possibly by phosphorylating the transporter.

关键词： Organic anion transporter Drug transport Regulation IGF-1 PKA Phosphorylation

Effects of a Kind of Surface Groove on Flow Loss in Both Rectangular and Circular Ducts at Different Reynolds Numbers

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Journal of Thermal Science 2016年第5期25卷 389-393页

作者： MA Rong MA Hongwei zhang Zhenyang zhang jinghui National Key Laboratory of Science and Technology on Aero-Engines Collaborative Innovation Center of Advanced Aero-EngineSchool of Energy & Power EngineeringBeihang University

Pipes are widely used to transport gas,oil and water in *** reduction in pipes is an increasingly concerned problem to save *** researches have indicated that the non-smooth surface with special structures can reduce flow *** this paper,an experimental investigation has been performed on the effects of a kind of surface groove on the drag in both rectangular and circular duct at different Reynolds *** the experiment of the rectangular duct,total pressure at both inlet and outlet were *** pressure on the wall was measured on the surface with smooth and grooved film *** the circular duct,a boundary layer pressure probe was used to measure the total pressure distribution at both inlet and *** taps at inlet and outlet were used to measure static *** loss coefficient is used to evaluate the effects of the surface groove on drag *** experiment was conducted with the Reynolds number range from 1.28×10~4 to 2.57×10~*** result shows a maximum drag loss reduction of approximately 2.4% in rectangular duct at Reynolds number of 2.4×10~4.A 10%reduction of pipe pressure loss by grooved surface is measured in circular duct at a Reynolds number of 3.0×10~5.

关键词： drag reduction surface groove rectangular duct circular duct

Efficient Location-Aware Data Placement for Data-Intensive Applications in Geo-distributed Scientific Data Centers

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Tsinghua Science and Technology 2016年第5期21卷 471-481页

作者： jinghui zhang Jian Chen Junzhou Luo Aibo Song School of Computer Science and Engineering Southeast University Nanjing 211189 China

Recent developments in cloud computing and big data have spurred the emergence of data-intensive applications for which massive scientific datasets are stored in globally distributed scientific data centers that have a high frequency of data access by scientists worldwide. Multiple associated data items distributed in different scientific data centers may be requested for one data processing task, and data placement decisions must respect the storage capacity limits of the scientific data centers. Therefore, the optimization of data access cost in the placement of data items in globally distributed scientific data centers has become an increasingly important *** data placement approaches for geo-distributed data items are insufficient because they either cannot cope with the cost incurred by the associated data access, or they overlook storage capacity limitations, which are a very practical constraint of scientific data centers. In this paper, inspired by applications in the field of high energy physics, we propose an integer-programming-based data placement model that addresses the above challenges as a Non-deterministic Polynomial-time（NP）-hard problem. In addition we use a Lagrangian relaxation based heuristics algorithm to obtain ideal data placement solutions. Our simulation results demonstrate that our algorithm is effective and significantly reduces overall data access cost.

关键词： data placement geo-distributed data center Lagrangian relaxation

A Dynamic and Deadline-Oriented Road Pricing Mechanism for Urban Traffic Management

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Tsinghua Science and Technology 2022年第1期27卷 91-102页

作者： Jiahui Jin Xiaoxuan Zhu Biwei Wu jinghui zhang Yuxiang Wang the School of Computer Science and Engineering Southeast UniversityNanjing 211189China the Department of Computer Science and Engineering Hangzhou Dianzi UniversityHangzhou 310018China

Road pricing is an urban traffic management mechanism to reduce traffic ***,most of the road pricing systems based on predefined charging tolls fail to consider the dynamics of urban traffic flows and travelers’demands on the arrival *** this paper,we propose a method to dynamically adjust online road toll based on traffic conditions and travelers’demands to resolve the above-mentioned *** method,based on deep reinforcement learning,automatically allocates the optimal toll for each road during peak hours and guides vehicles to roads with lower toll ***,it further considers travelers’demands to ensure that more vehicles arrive at their destinations before their estimated arrival *** method can increase the traffic volume effectively,as compared to the existing static mechanisms.

关键词： road pricing traffic congestion al eviation deep reinforcement learning

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混合键合剪切强度的影响因素

电子工艺技术 2025年第1期46卷 22-26页

作者：贺京峰张京辉贵州振华风光半导体股份有限公司贵阳550018 中国运载火箭技术研究院北京100076

对混合键合产品中可靠性评价之一的剪切强度影响因素进行了阐述,重点从混合键合界面材料和键合工艺条件两个方面介绍了材料与工艺因素对混合键合产品剪切强度的影响,并对国内外研究中混合键合界面材料的铜晶粒结构、介电层种类和混合键... 详细信息

对混合键合产品中可靠性评价之一的剪切强度影响因素进行了阐述,重点从混合键合界面材料和键合工艺条件两个方面介绍了材料与工艺因素对混合键合产品剪切强度的影响,并对国内外研究中混合键合界面材料的铜晶粒结构、介电层种类和混合键合工艺条件的界面活化、界面钝化层保护、退火处理对混合键合强度的影响进行了评述,总结了近年来混合键合界面材料与键合工艺对键合剪切强度的影响研究进展。最后,对特定晶粒取向的铜与聚合物介电层在混合键合工艺中表现出的剪切强度优势进行了分析总结,并对混合键合未来发展方向进行了展望。

关键词：混合键合剪切强度界面材料界面活化热处理