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Identification of differentially expressed mRNAs as novel predictive biomarkers for gastric cancer diagnosis and prognosis

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1947-1964页

作者： jian-Wei Zhou yi-Bing zhang Zhi-Yang Huang Yu-Ping Yuan Jie Jin Department of Gastroenterology Wenzhou Central HospitalDingli Clinical College of Wenzhou Medical UniversityThe Second Affiliated Hospital of Shanghai UniversityWenzhou 325000Zhejiang ProvinceChina

BACKGROUND Gastric cancer(GC)has a high mortality rate *** significant progress in GC diagnosis and treatment,the prognosis for affected patients still remains *** To identify important candidate genes related to the development of GC and iden-tify potential pathogenic mechanisms through comprehensive bioinformatics *** The Gene Expression Omnibus database was used to obtain the GSE183136 dataset,which includes a total of 135 GC *** limma package in R software was employed to identify differentially expressed genes(DEGs).Thereafter,enrichment analyses of Gene Ontology(GO)terms and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathways were performed for the gene modules using the clusterProfile package in R *** protein-protein interaction(PPI)networks of target genes were constructed using STRING and visualized by Cytoscape *** common hub genes that emerged in the cohort of DEGs that was retrieved from the GEPIA database were then screened using a Venn *** expression levels of these overlapping genes in stomach adenocarcinoma samples and non-tumor samples and their association with prognosis in GC patients were also obtained from the GEPIA database and Kaplan-Meier ***,real-time quantitative polymerase chain reaction(RT-qPCR)and western blotting were performed to determine the mRNA and protein levels of glutamic-pyruvic transaminase(GPT)in GC and normal immortalized cell *** addition,cell viability,cell cycle distribution,migration and invasion were evaluated by cell counting kit-8,flow cytometry and transwell ***,we also conducted a retrospective analysis on 70 GC patients diagnosed and surgically treated in Wenzhou Central Hospital,Dingli Clinical College of Wenzhou Medical University,The Second Affiliated Hospital of Shanghai University between January 2017 to December *** tumor and adjacent normal samples were collected from the patients to determine the

关键词： Gastric cancer Differentially expressed genes Bioinformatics Hub genes Prognosis

Recent progress in carbene-catalyzed fluoroalkylation

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Science China Chemistry 2024年第8期67卷 2448-2460页

作者： Bei zhang Xuan zhang jian Wang jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control Collaborative Innovation Center of Atmospheric Environment and Equipment TechnologySchool of Environmental Science and EngineeringNanjing University of Information Science and TechnologyNanjing 210044China School of Pharmaceutical Sciences Tsinghua UniversityBeijing 100084China

The fluoroalkyl fragment plays a vital role in various fields such as pharmaceuticals and materials science, and has a significant impact on human life not only on the present but also in the future. The insertion of fluoroalkyl groups into the chemical skeletons can cause considerable alternations in the chemical, physical and biological properties of molecules, which has attracted numerous scientists from different fields. This review focuses on N-heterocyclic carbene(NHC)-catalyzed fluoroalkylation reactions, providing a detailed analysis and summary of the achievements in the past two decades. Many successful examples clearly indicate that NHCs can catalyze the tranformation of fluoroalkylation reagents with various electronic characteristics, whether electrophilic, nucleophilic, or radical precursors. Herein, the fluoroalkylation reactions are classified based on different catalytic modes of NHCs: Lewis base catalysis, Umploung catalysis, radical catalysis and others. Meanwhile, by refining and systematically studying the contribution of NHC catalysis in fluoroalkylation reactions, this review is expected to provide valuable insights and enlightenment for related fields.

关键词： N-heterocyclic carbene fluoroalkylation radical catalysis

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Influence of the Acoustic Liner in Large Eddy Simulation of Longitudinal Thermoacoustic Instability in a Model Annular Combustor

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Journal of Thermal Science 2024年第2期33卷 710-724页

作者： MENG Sheng zhang Man GAO yi AECC Commercial Aircraft Engine Co. Ltd.Shanghai200241China School of Aeronautics and Astronautics Shanghai Jiao Tong UniversityShanghai200240China

Although extensive efforts have been made to dampen the thermoacoustic instability,successfully controlling the pressure oscillations in modern gas turbines or aeroengines remains *** influence of the acoustic liner on the longitudinal thermoacoustic mode in a model annular combustor is investigated by Large Eddy Simulation(LES) in this *** result of the self-excited longitudinal thermoacoustic instability without the liner agrees well with the frequency and acoustic analysis of the pressure mode based on experimental *** different bias flow velocities of the liner located downstream of the combustor are then *** results reveal that the existence of the liner influences not only the acoustic field but also the flow *** the bias velocity is large,it leads to intense turbulence-induced fluctuations,and the pressure oscillation is modulated *** shows that the weak coupling between flow and pressure oscillations plays a significant role in the onset of the intermittency of a thermoacoustic *** on the dynamic analysis of the thermoacoustic system with the acoustic liner,this intermittency is caused by the influence of the flow field on the flame-acoustic ***,a low-order modeling method based on Van der Pol(VdP) oscillator with additive stochastic forcing is conducted to reproduce the evolving dynamics of the thermoacoustic *** the numerical cases demonstrated in this work are relatively simpler than those in a practical combustion system,the results are helpful for us to understand the effect of the acoustic liner and show the attractive potential to apply this device to suppress thermoacoustic instability.

关键词： thermoacoustic instability acoustic liner Large Eddy Simulation low-order modeling

Accurate Distinction of Weak and Strong AC Grids for Emerging Hierarchical-Infeed LCC-UHVDC Systems

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CSEE Journal of Power and Energy Systems 2024年第2期10卷 772-777页

作者： Hao Xiao Xianzhong Duan yi zhang Department of Electrical and Computer Engineering University of ManitobaWinnipeg R3T 2N2ManitobaCanada State Key Laboratory of Advanced Electromagnetic Engineering and Technology Hubei Electric Power Security and High Efficiency Key LaboratorySchool of Electrical and Electronic EngineeringHuazhong University of Science and TechnologyWuhan 430074HubeiChina RTDS Technologies Inc. Winnipeg R3T 2E1ManitobaCanada

Distinction of weak and strong AC grids for emerging hierarchical-infeed LCC-UHVDC systems is important for planning and operation departments. However, accuracy of earlier distinction methods is limited as they were developed by empirical reasoning without rigorous theoretical analysis. Hence in this letter, hierarchical-infeed interactive effective short-circuit ratio (HIESCR) index is first used for strength evaluation of HIDC systems with complex inter-inverter interactions considered. Boundary HIESCR (BHIESCR) is also introduced in the proposed distinction method of weak and strong AC grids. That is, weak (or strong) AC grids are, respectively, identified when HIESCR is less (or greater) than BHIESCR. Second, it is shown BHIESCR remains almost unchanged as 3.0 versus various system parameters and rated operation variables based on rigorous theoretical analysis. This salient feature makes the proposed method more accurate than earlier methods. Finally, the proposed method is validated by simulations based on the PSCAD/EMTDC program.

关键词： Hierarchical-Infeedinteractive effective short-circuit ratio hierarchical-infeed LCC-UHVDC systems inter-inverter interactions strong AC grids weak AC grids

Is appendoscope a new option for the treatment of acute appendicitis?

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World Journal of Gastroenterology 2024年第28期30卷 3386-3392页

作者： Shu-Jiong Feng yi-Feng Zhou jian-Feng Yang Hong-zhang Shen Guang-Xing Cui Xiao-Feng zhang Department of Gastroenterology Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhou 310000Zhejiang ProvinceChina Department of Gastroenterology Key Laboratory of Integrated Traditional Chinese and Western Medicine for Biliary and Pancreatic Diseases of Zhejiang ProvinceHangzhou 310000Zhejiang ProvinceChina Department of Gastroenterology Hangzhou Institute of Digestive DiseasesHangzhou 310000Zhejiang ProvinceChina

Acute appendicitis is a common surgical *** is commonly caused by obstruction of the appendiceal lumen due to fecaliths,tumors,or lymphoid *** over a century,appendectomy has been the primary treatment for acute *** Groves performed the first open appendectomy in *** 1983,Kurt Semm completed the first laparoscopic appendectomy,heralding a new era in ***,appendectomy is associated with certain complications and a rate of negative *** have suggested controversy over the impact of appendectomy on the development of inflammatory bowel disease and Parkinson’s disease,but an increasing number of studies indicate a possible positive correlation between appendectomy and colorectal cancer,gallstones,and cardiovascular *** the recognition that the appendix is not a vestigial organ and the advancement of endoscopic technology,Liu proposed the endoscopic retrograde appendicitis *** is an effective minimally invasive alternative for treating uncomplicated acute *** team has developed an appendoscope with a disposable digital imaging system operated through the biopsy channel of a colonoscope and successfully applied it in the treatment of *** article provides an overview of the progress in endoscopic treatment for acute appendicitis and offers a new perspective on the future direction of appendiceal disease treatment.

关键词： Acute appendicitis Endoscopic technology Endoscopic retrograde appendicitis therapy Appendoscope Appendiceal disease treatment

A Novel Anti-Collision Algorithm for Large Scale of UHF RFID Tags Access Systems

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Computers, Materials & Continua 2024年第7期80卷 897-912页

作者： Xu zhang yi He Haiwen yi Yulu zhang Yuan Li Shuai Ma Gui Li Zhiyuan Zhao Yue Liu Junyang Liu Guangjun Wen jian Li School of Information and Communication Engineering/yibin Institute University of Electronic Science and Technology of ChinaChengdu611731China Department of IoT Technology Research China Mobile Research InstituteBeijing100053China The 10th Research Institute of China Electronics Technology Group Corporation Chengdu611731China College of Information and Communication National University of Defense TechnologyWuhan430019China

When the radio frequency identification(RFID)system inventories multiple tags,the recognition rate will be seriously affected due to *** on the existing dynamic frame slotted Aloha(DFSA)algorithm,a sub-frame observation and cyclic redundancy check(CRC)grouping combined dynamic framed slotted Aloha(SUBF-CGDFSA)algorithm is *** algorithm combines the precise estimation method of the quantity of large-scale tags,the large-scale tags grouping mechanism based on CRC pseudo-randomcharacteristics,and the Aloha anti-collision optimization mechanism based on sub-frame *** grouping tags and sequentially identifying themwithin subframes,it accurately estimates the number of remaining tags and optimizes frame length accordingly to improve efficiency in large-scale RFID *** outcomes demonstrate that this proposed algorithmcan effectively break through the system throughput bottleneck of 36.8%,which is up to 30%higher than the existing DFSA standard scheme,and has more significant advantages,which is suitable for application in largescale RFID tags scenarios.

关键词： Radio frequency identification anti-collision tags grouping dynamic framed slotted Aloha

The stable Auslander-Reiten components of certain monomorphism categories

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Science China Mathematics 2024年第3期67卷 505-526页

作者： Rasool Hafezi yi zhang School of Mathematics and Statistics Nanjing University of Information Science and TechnologyNanjing 210044China

Let Λ be an Artin algebra and let Gprj-Λ denote the class of all the finitely generated Gorenstein projective Λ-modules. In this paper, we study the components of the stable Auslander-Reiten quiver of a certain subcategory of the monomorphism category S(Gprj-Λ) containing boundary vertices. We describe the shape of such components. It is shown that certain components are linked to the orbits of an auto-equivalence on the stable category Gprj. In particular, for the finite components, we show that under certain mild conditions,their cardinalities are divisible by 3. We see that this three-periodicity phenomenon reoccurs several times in the paper.

关键词： monomorphism category almost split sequence Auslander-Reiten quiver Gorenstein projective module

Individualized Traditional Chinese Medicine treatment vs antibiotics for recurrent urinary tract infections: a multicenter, randomized controlled study

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Journal of Traditional Chinese Medicine 2024年第3期44卷 524-529页

作者： GU Xiangchen QIU Meisi XIE Lin CHEN Min DENG Yueyi zhang Changming jian Guihua WANG Chen WANG yi Department of Nephrology Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine Department of Nephrology Rizhao Hospital of Traditional Chinese Medicine Department of Nephrology Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine Department of Nephrology Shanghai Municipal Traditional Chinese Medicine Hospital Affiliated to Shanghai University of Traditional Chinese Medicine Department of Nephrology the Sixth People's Hospital Affiliated Shanghai Jiaotong University Department of Nephrology Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine

OBJECTIVE: To systematically assess the effects of individualized Chinese medicines on recurrent urinary tract infections(rUTIs).METHODS: This study recruited 230 adult female patients in the remission phase of rUTIs from five hospitals in China. The patients were randomly allocated to two groups: an individualized Chinese medicine group(n = 114) and a control group(n = 116). Patients in the Chinese medicine group received individualized Chinese herbs, which were evaluated for syndrome *** in the control group received antibiotic treatment combined with a Chinese medicine placebo. The duration of treatment was three courses of four weeks each, with a three-month subsequent follow-up. UTI recurrence rate,Traditional Chinese Medicine(TCM) syndrome scores,36-item Short Form Survey(SF-36) score, and urine secretory immunoglobulin A(SIgA) were measured and analyzed before and after treatment in each group. RESULTS: Patients from the Chinese medicine group exhibited significant decreases in both short-and longterm UTI recurrence rates compared with the control group(P < 0.05). The changes in TCM syndrome scores between the Chinese medicine and control groups were significant(P < 0.05). The changes in the average SF-36 quality-of-life scores in the Chinese medicine group were also significantly higher than those in the control group after treatment(P < 0.05). The Chinese medicine group also demonstrated a significant increase in urine SIg A expression. CONCLUSION: Taken together, compared to the oftenused long-term antimicrobial prophylaxis during the remission stage of r UTIs, treating patients with an individualized Chinese medicine decoction by syndrome differentiation could effectively reduce the recurrence rate, improve the patients' TCM syndrome scores and quality of life, and enhance immunity, which in turn helps to prevent antibiotic resistance.

关键词： immunoglobulin A, secretory medicine, Chinese traditional quality of life randomized controlled trial syndrome differentiation urinary tract infections

Biomimetic soft robotic wrist with 3-DOF motion and stiffness tunability based on ring-reinforced pneumatic actuators and a particle jamming joint

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Science China(Technological Sciences) 2024年第3期67卷 774-790页

作者： HU TeTe LU Xinjiang yi jian WANG YuHui XU Du State Key Laboratory of Precision Manufacturing for Extreme Service Performance School of Mechanical and Electrical EngineeringCentral South UniversityChangsha 410083China

The human wrist, a complex articulation of skeletal muscles and two-carpal rows, substantially contributes to improvements in maneuverability by agilely performing three-degree-of-freedom(3-DOF) orienting tasks and regulating stiffness according to variations in interaction forces. However, few soft robotic wrists simultaneously demonstrate dexterous 3-DOF motion and variable stiffness;in addition, they do not fully consider a soft-rigid hybrid structure of integrated muscles and two carpal *** this study, we developed a soft-rigid hybrid structure to design a biomimetic soft robotic wrist(BSRW) that is capable of rotating in the x and y directions, twisting around the z-axis, and possessing stiffness-tunable capacity. To actuate the BSRW, a lightweight soft-ring-reinforced bellows-type pneumatic actuator(SRBPA) with large axial, linear deformation(η_(lcmax)=70.6%,η_(lemax)=54.3%) and small radial expansion(η_(demax)=3.7%) is designed to mimic the motion of skeletal muscles. To represent the function of two-carpal rows, a compact particle-jamming joint(PJJ) that combines particles with a membrane-covered ballsocket mechanism is developed to achieve various 3-DOF motions and high axial load-carrying capacity(>60 N). By varying the jamming pressure, the stiffness of the PJJ can be adjusted. Finally, a centrally positioned PJJ and six independently actuated SRBPAs, which are in an inclined and antagonistic arrangement, are sandwiched between two rigid plates to form a flexible,stable, and compact BSRW. Such a structure enables the BSRW to have a dexterous 3-DOF motion, high load-carrying ability,and stiffness tunability. Experimental analysis verify 3-DOF motion of BSRW, producing force of 29.6 N and 36 N and torque of2.2 Nm in corresponding rotations. Moreover, the range of rotational angle and stiffness-tuning properties of BSRW are studied by applying jamming pressure to the PJJ. Finally, a system combining a BSRW and a soft enclosing gripper is proposed to demo

关键词： pneumatic soft actuators particle jamming robotic wrist soft robotics stiffness-tunable

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