检索结果-南通市图书馆

Hydroxysafflor Yellow A Inhibits Pyroptosis and Protecting HUVECs from OGD/R via NLRP3/Caspase-1.GSDMD Pathway

Chinese Journal of Integrative Medicine 2024年第11期30卷 1027-1034页

作者： GUO Fan HAN Xiao YOU Yue XU Shu-juan zhang Ye-hao CHEN Yuan-yuan {1. Gao-jie liU Zi-{1. REN Jun-guo cao Ce li ling-mei FU Jian-hua Institute of Basic Medical Sciences of Xiyuan Hospital China Academy of Chinese Medical Sciences beijing Key Laboratory of Chinese Materia Pharmacology Department of Central Laboratory Kunshan Hospital of Chinese Medicine

Objective: To observe the protective effect and mechanism of hydroxyl safflower yellow A(HSYA)from myocardial ischemia-reperfusion injury on human umbilical vein endothelial cells(HUVECs). Methods:HUVECs were treated with oxygen-glucose deprivation reperfusion(OGD/R) to simulate the ischemia reperfusion model, and cell counting kit-8 was used to detect the protective effect of different concentrations(1.25–1.0 μmol/L)of HSYA on HUVECs after OGD/R. HSYA 80 μmol/L was used for follow-up experiments. The contents of inflammatory cytokines interleukin(IL)-1., IL-1., monocyte chemotactic protein 1.MCP-1., tumor necrosis factor α(TNF-α) and IL-6 before and after administration were measured by enzyme-linked immunosorbent assay. The protein expressions of toll-like receptor, NOD-like receptor containing pyrin domain 3(NLRP3), gasdermin D(GSDMD) and GSDMD-N-terminal domain(GSDMD-N) before and after administration were detected by Western blot. NLRP3 inflammasome inhibitor cytokine release inhibitory drug 3 sodium salt(CRID3 sodium salt, also known as MCC950) and agonist were added, and the changes of NLRP3, cysteine-aspartic acid protease 1.Caspase-1., GSDMD and GSDMD-N protein expressions were detected by Western blot. Results: HSYA inhibited OGD/R-induced inflammation and significantly decreased the contents of inflammatory cytokines IL-1.,IL-1., MCP-1. TNF-α and IL-6(P1.or P1.GSDMD pathway, HSYA can reduce the occurrence of pyroptosis after OGD/R and reduce the expression of NLRP3,Caspase-1. GSDMD and GSDMD-N proteins(P1.. Conclusions: The protective effect of HSYA on HUVECs after OGD/R is related to down-regulating the expression of NLRP3 inflammasome and inhibiting pyroptosis.

关键词： Chinese medicine NLRP3 inflammasome human umbilical vein endothelial cells hydroxysafflor yellow A myocardial reperfusion injury oxygen-glucose deprivation reperfusion pyroptosis

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Understanding Simulated Causes of Damaging Surface Winds in a Derecho-Producing Mesoscale Convective System near the East china Coast Based on Convection-Permitting Simulations

引用

Advances in Atmospheric Sciences 2024年第11期41卷 2112-2130页

作者： liping LUO Ming XUE xin XU lijuan li Qiang {1. Ziqi FAN College of Civil Aviation Nanjing University of Aeronautics and AstronauticsNanjing 211106China State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Key Laboratory of Mesoscale Severe Weather/Ministry of Education and school of Atmospheric Sciences Nanjing UniversityNanjing 210023China center for Analysis and Prediction of Storms and {1. of Meteorology University of OklahomaNormanOklahoma 73072USA Civil Aviation North china Air Traffic Management Bureau Meteorological {1. Beijing 100621China

A mesoscale convective system(MCS) occurred over the East china coastal provinces and the East china Sea on 30April 2021. producing damaging surface winds near the coastal city Nantong with observed speeds reaching 45 m s^(–1.. A simulation using the Weather Research and Forecasting model with a 1.5-km grid spacing generally reproduces the development and subsequent organization of this convective system into an MCS, with an eastward protruding bow segment over the sea. In the simulation, an east-west-oriented high wind swath is generated behind the gust front of the MCS. Descending dry rear-to-front inflows behind the bow and trailing gust front are found to feed the downdrafts in the main precipitation regions. The inflows help to establish spreading cold outflows and enhance the downdrafts through evaporative cooling. Meanwhile, front-to-rear inflows from the south are present, associated with severely rearward-tilted updrafts initially forming over the gust front. Such inflows descend behind(north of) the gust front, significantly enhancing downdrafts and near-surface winds within the cold pool. Consistently, calculated trajectories show that these parcels that contribute to the derecho originate primarily from the region ahead(south) of the east-west-oriented gust front, and dry southwesterly flows in the low-to-middle levels contribute to strong downdrafts within the MCS. Moreover, momentum budget analyses reveal that a large westward-directed horizontal pressure gradient force within the simulated cold pool produced rapid flow acceleration towards Nantong. The analyses enrich the understanding of damaging wind characteristics over coastal East china and will prove helpful to operational forecasters.

关键词： damaging surface winds convection-permitting simulations mesoscale convective system gust front cold pool

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Simultaneous acceleration of sulfur reduction and oxidation on bifunctional electrocatalytic electrodes for quasi-solid-state Zn–S batteries

引用

Science china Chemistry 2024年第5期67卷 1531-1538页

作者： Mingli wang {1. zhang Tianhang Ding Fangjun Wu lin Fu Bin Song Pengfei cao Ke Lu Institutes of Physical Science and Information Technology School of Materials Science and EngineeringKey Laboratory of Structure and Functional Regulation of Hybrid Materials of Ministry of EducationAnhui UniversityHefei 230601China Hefei National Laboratory for Physical Sciences at the Microscale University of Science and Technology of ChinaHefei 230026China school of Chemistry and Chemical Engineering Harbin Institute of TechnologyHarbin 150001China school of Chemistry and Chemical Engineering Guizhou UniversityGuiyang 550025China Institute of Functional Nano&Soft Materials(FUNSOM) Soochow UniversitySuzhou 215123China State Key Lab of Organic-Inorganic Composites Beijing University of Chemical TechnologyBeijing 100029China

The incomplete sulfur reduction and high ZnS re-oxidation energy barrier along with severe side reactions during the battery cycling compromise the practical application of Zn–S electrochemistry. Herein, a bifunctional electrocatalytic sulfur matrix that simultaneously accelerates the sulfur reduction and ZnS oxidation is proposed to realize a highly-efficient Zn–S cell. It is revealed that the N-heteroatom hotspots are more favorable for facilitating the conversion of S to ZnS while the CoO nanocrystal substantially lowers the ZnS activation energy barrier thereby suppressing the formation of disproportionation species(e.g.,SO_(4)^(2-)) and accumulation of inactive ZnS. Accordingly, the Co O anchored on the N-doped carbon-supported sulfur cathode delivers a high Zn^(2+)storage capacity of 1.1.2 m Ahg^(-1.and outstanding cycling stability with a capacity retention of 71.6% after500 cycles with a high average Coulombic efficiency of 97.8%. Simultaneously, the stable cycling of solid-state Zn–S pouch cells with an energy density of 585 Whkg^(-1.sulfuris also demonstrated. Moreover, the postmortem analysis reveals that the degradation of Zn–S cells is mainly attributed to the limited reversibility of Zn anodes rather than the ZnS decomposition and/or accumulation. The approach to the bidirectional catalysis manipulated the sulfur redox provides a new perspective to realize the theoretical potentials of Zn–S cells.

关键词： Zn–S battery bifunctional catalysts solid-state battery sulfur redox degradation mechanism

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Global, regional, and national burden of early-onset gastric cancer

引用

Cancer Biology & Medicine 2024年第8期21卷 667-678页

作者： Nuopei Tan hongliang Wu Maomao {1. Fan Yang xinxin Yan Siyi He Mengdi {1. Shaoli zhang Yi Teng Qianru li Jiachen wang Changfa Xia Wanqing Chen Department of Cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Anesthesiology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

Objective: The burden of gastric cancer(GC) across different age groups needs updating. We determined the GC global, regional, and national burden profiles and changes in incidence for 3 sequential 5-year intervals from 2003 to ***: The latest incidence and mortality estimates of GC from 1.5 countries and regions were extracted from the GLOBOCAN 2022 database. The 5-year interval age-standardised incidence rates(ASIRs) were evaluated using cancer registry data from volumes X±XII of the Cancer Incidence in Five Continents(CI5). Correlation analysis was used to evaluate the relationship between ASIR or the age-standardised mortality rate(ASMR) and the Human Development Index(HDI).Results: There was an estimated global 968,000 new GC cases and 660,000 deaths in 2022, with male predominance. GC ASIRs and ASMRs were 9.2 and 6.1.per 1.0,000 persons, respectively. East Asia had the highest burden, with 53.8% of cases and 48.2% of deaths among all geographic regions. There was a significant correlation between ASIR and HDI. Over three 5-year intervals from 2003 to 201., the incidence of GC notably decreased in most countries but peaked at 2008±201. in New Zealand, Turkey, and South Africa. Several countries in Europe, Oceania, and America suggest an increasingly concerning trend among younger individuals, especially ***: GC is a significant health issue, especially among males and in geographic regions with an HDI, such as eastern Asia. While the incidence of GC is decreasing in many countries due to prevention efforts and improved treatments, a rising trend persists among younger individuals. Comprehensive prevention strategies tailored to different age patterns are clearly needed.

关键词： Gastric cancer cancer burden GLOBOCAN incidence mortality

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Superwetting Ag/α-Fe_(2)O_(3) anchored mesh with enhanced photocatalytic and antibacterial activities for efficient water purification

引用

Green Energy & Environment 2024年第1期9卷 89-103页

作者： Jiakai li Changpeng Lv Jiajia Song Xiaoling zhang Xizhen Huang Yingzhuo Ma Haijie {1. Na liu Department of Chemistry Tsinghua UniversityBeijing100084China Anhui Provincial Engineering Laboratory of Silicon-based Materials Engineering Technology Research Center of Silicon-based Materials(Anhui)School of Material and Chemical EngineeringBengbu UniversityBengbu233030China Institute of Materials for Energy and Environment College of Materials Science and EngineeringQingdao UniversityQingdao266071China

Superwetting materials have drawn unprecedented attention in the treatment of oily wastewater due to their preferable anti-fouling property and selective oil/water ***,it is still a challenge to fabricate multifunctional and environmentally friendly materials,which can be stably applied to purify the actual complicated ***,a Ag/Ag/α-Fe_(2)O_(3) heterostructure anchored copper mesh was intentionally synthesized using a facile two-step hydrothermal *** resultant mesh with superhydrophilicity and underwater superoleophobicity was capable of separating various oil/water mixtures with superior separation efﬁciency and high permeationﬂux driven by ***ﬁting from the joint effects of the smaller band gap of Ag/α-Fe_(2)O_(3) heterojunction,inherent antibacterial capacity of Ag/α-Fe_(2)O_(3) and Ag nanoparticles,favorable conductive substrate,as well as the hierarchical structure with superwettability,such mesh presented remarkably enhanced degradation capability toward organic dyes under visible light irradiation and antibacterial activity against both Escherichia coli(***)and Staphylococcus aureus(***)compared with the pure Ag/α-Fe_(2)O_(3) coated ***,the mesh exhibited bifunctional water puriﬁcation performance,in which organic dyes were eliminated simultaneously from water during oil/water separation in oneﬁltration *** importantly,this mesh behaved exceptional chemical resistance,mechanical stability and long-term ***,this material with multifunctional integration may hold promising potential for steady water puriﬁcation in practice.

关键词： Superwetting Ag/α-Fe_(2)O_(3)heterostructure Enhanced photocatalytic and antibacterial activities Water purification Long-term reusability

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Physiological,transcriptome and gene functional analysis provide novel sights into cadmium accumulation and tolerance mechanisms in kenaf

引用

Journal of Environmental Sciences 2024年第3期137卷 500-514页

作者： Shan cao Meng {1. Jiao Pan Dengjie Luo Samavia Mubeen Caijin {1. Jiao Yue Xia Wu Qijing Wu Hui zhang Canni Chen Muzammal Rehman Sichen Xie Ru li Peng Chen Guangxi Key Laboratory of Agro-environment and Agric-products safety Key Laboratory of Plant Genetics and BreedingCollege of AgricultureGuangxi UniversityNanning 530004China State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources College of Life Science and TechnologyGuangxi UniversityNanning 530004China

Kenaf is considered to have great potential for remediation of heavy metals in ***,studies on molecular mechanisms of root Cd accumulation and tolerance are still *** this study,two differently tolerant kenaf cultivars were selected as materials and the physiological and transcriptomic effects were evaluated under Cd *** study showed that 200μmol/L CdCl_(2) treatment triggered the reactive oxygen species(ROS)explosion and membrane lipid *** with the Cd-sensitive cultivar‘Z',the Cd-tolerant cultivar‘F'was able to resist oxidative stress in cells by producing higher antioxidant enzyme activities and increasing the contents of ascorbic acid(AsA)and glutathione(GSH).The root cell wall of‘F'exhibited higher polysaccharide contents under Cd treatment,providing more Cd-binding *** were 3,439 differentially expressed genes(DEGs)that were co-regulated by Cd treatment in two *** biosynthesis and plant hormone signal transduction pathways were significantly enriched by functional annotation *** associated with pectin,cellulose,and hemi-cellulose metabolism were involved in Cd chelation of root cell wall;V-ATPases,ABCC3 and Narmp3 could participated in vacuolar compartmentalization of Cd;PDR1.was responsible for Cd effux;the organic acid transporters contributed to the absorption of Cd in *** genes might have played key roles in kenaf Cd tolerance and Cd ***,HcZIP2 was identified to be involved in Cd uptake and transport in *** findings provide a deeper understanding of the molecular pathways underlying Cd accumulation and detoxification mechanisms in kenaf.

关键词： Kenaf Cd stress Physiological Transcriptome HcZIP2

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Dynamic response mechanism and precursor characteristics of gneiss rockburst under different initial burial depths

引用

Journal of Mountain Science 2024年第3期21卷 1004-1018页

作者： liU Dongqiao SUN Jie MENG Wen HE Manchao zhang C{1.yuan li Ran cao Binghao State Key Laboratory for Tunnel Engineering China University of Mining and TechnologyBeijing 100083China Key Laboratory of Active Tectonics and Geological Safety Ministry of Natural ResourcesInstitute of GeomechanicsChinese Academy of Geological SciencesBeijing 100081China school of Mechanics and Civil Engineering China University of Mining and TechnologyBeijing 100083China

To investigate the influence mechanism of geostress on rockburst characteristics,three groups of gneiss rockburst experiments were conducted under different initial geostress conditions.A high-speed photography system and acoustic emission(AE)monitoring system were used to monitor the entire rockburst process in real *** experimental results show that when the initial burial depth increases from 928 m to 1.20 m,the proportion of large fracture scale in rockburst increases by 1.4.54%,and the AE energy increases by 565.63%,reflecting that the degree and severity of rockburst increase with the increase of burial *** then,two mechanisms are proposed to explain this effect,including(i)the increase of initial geostress improves the energy storage capacity of gneiss,and then,the excess energy which can be converted into kinetic energy of debris ejection increases,consequently,a more pronounced violent ejection phenomenon is observed at rockburst;(ii)the increase of initial geostress causes more sufficient plate cracks of gneiss after unloading ofσh,which provides a basis for more severe ejection of ***’s more,a precursor with clear physical meaning for rockburst is proposed under the framework of dynamic response process of crack ***,potential value in long term rockburst warning of the precursor obtained in this study is shown via the comparison of conventional precursor.

关键词： Traffic Engineering Gneiss Rockburst Crack propagation Excess energy Precursor characteristic

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Progress in research on metal-based materials in stabilized Zn anodes

引用

Rare Metals 2024年第1期43卷 20-40页

作者： Le li Shao-Feng Jia Ming-Hui cao Yong-Qiang Ji Heng-Wei Qiu Dan {1. Shaanxi Key Laboratory of Industrial Automation School of Mechanical EngineeringShaanxi University of TechnologyHanzhong 723001China school of Electronic and Information Engineering Qingdao UniversityQingdao 266071China State Key Laboratory for Artifcial Microstructure and Mesoscopic Physics School of PhysicsPeking UniversityBeijing 100871China Department of Chemistry Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical BiologyTsinghua UniversityBeijing 100084China Shaanxi Key Laboratory of Catalysis School of Chemistry and Environment ScienceShaanxi University of TechnologyHanzhong 723001China

Aqueous zinc-ion batteries(ZIBs) combine the benefits of metallic Zn anodes with those of aqueous electrolytes and are well suited for large-scale energy storage because of their inherent high safety, cost-effectiveness, and eco-friendliness. Currently, the practical application of such batteries is hindered by the poor cycling performance of Zn anodes due to uncontrolled dendrite formation and severe side reactions, although recent reports suggest that these problems can be mitigated through the modification of Zn anodes with metal-based *** that the mechanisms of improving Zn deposition and the structural evolution of metal-based materials have not been systematically reviewed, we herein systematically overview the metal-based materials used to stabilize Zn anodes, starting with a brief summary of the anode working mechanism and the challenges faced by stabilized Zn anodes. Subsequently, the design principles of Zn anodes stabilized by metal-based materials and the related recent progress are reviewed, and the key challenges and perspectives for the future development of such Zn anodes are proposed.

关键词： Zinc-ion batteries(ZIBs) Zn anode Metalbased materials Alloying metal Stabilized Zn anodes

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Experimental study on the effect of unloading rate on gneiss rockburst

引用

Journal of Rock Mechanics and Geotechnical Engineering 2024年第6期16卷 2064-2076页

作者： Dongqiao liu Jie Sun Ran li Manchao He Binghao cao C{1.yuan zhang Wen Meng State Key Laboratory for Tunnel Engineering China University of Mining and TechnologyBeijing100083China Key Laboratory of Active Tectonics and Geological Safety Ministry of Natural ResourcesInstitute of GeomechanicsChinese Academy of Geological SciencesBeijing100081China school of Mechanics and Civil Engineering China University of Mining and TechnologyBeijing100083China

Rockburst are often encountered in tunnel construction due to the complex geological *** study the influence of unloading rate on rockburst,gneiss rockburst experiments were conducted under three groups of unloading rates.A high-speed photography system and acoustic emission(AE)system were used to monitor the entire process of rockburst process in *** results show that the intensity of gneiss rockburst decreases with decrease of unloading rate,which is manifested as the reduction of AE energy and fragments ejection *** mechanisms are proposed to explain this effect:(i)The reduction of unloading rate changes the crack propagation mechanism in the process of *** makes the rockbursts change from the tensile failure mechanism at high unloading rate to the tension-shear mixed failure mechanism at low unloading rate,and more energy released in the form of shear crack ***,less strain energy is converted into kinetic energy of fragments ejection.(ii)Less plate cracking degree of gneiss has taken shape due to decrease of unloading rate,resulting in the destruction of rockburst incubation *** enlightenments of reducing the unloading rate for the project are also described *** rockburst magnitude is reduced from the medium magnitude at the unloading rate of 0.1.MPa/s to the slight magnitude at the unloading rate of 0.025 MPa/s,which was judged by the ejection velocity.

关键词： Rockburst Unloading rate Crack propagation Influence mechanisms

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A three-dimensional co-continuous network structure polymer electrolyte with efficient ion transport channels enabling ultralong-life all solid-state lithium metal batteries

引用

Journal of Energy Chemistry 2024年第7期94卷 635-645页

作者： Meng wang Hu {1. Yewen li Ruiping liu Huai Yang school of Chemical&Environmental Engineering China University of Mining and Technology(Beijing)Beijing 100083China beijing Advanced Innovation {1. for Materials Genome Engineering&school of Materials Science and Engineering Peking UniversityBeijing 100871China

Solid polymer electrolytes(SPEs)have emerged as one of the most promising candidates for the construction of solid-state lithium batteries due to their excellent flexibility,scalability,and interface compatibility with ***,a novel all-solid polymer electrolyte(PPLCE)was fabricated by the copolymer network of liquid crystalline monomers and poly(ethylene glycol)dimethacrylate(PEGDMA)acts as a structural frame,combined with poly(ethylene glycol)diglycidyl ether short chain interspersed serving as mobile ion transport *** preparaed PPLCEs exhibit excellent mechanical property and out-standing electrochemical performances,which is attributed to their unique three-dimensional cocontinuous structure,characterized by a cross-linked semi-interpenetrating network and an ionic liquid phase,resulting in a distinctive nanostructure with short-range order and long-range ***,the addition of PEGDMA is proved to be critical to the comprehensive performance of the PPLCEs,which effectively modulates the microscopic morphology of polymer networks and improves the mechanical properties as well as cycling stability of the solid *** used in a lithiumion symmetrical battery configuration,the 6 wt%-PPLCE exhibites super stability,sustaining operation for over 2000 h at 30 C,with minimal and consistent overpotential of 50 *** resulting li|PPLCE|LFP solid-state battery demonstrates high discharge specific capacities of 1.0.9 and 1.0.1.mA h g^(-1.at current densities of 0.2 and 1.C,*** after more than 300 cycles at a current density of 0.2 C,it retaines an impressive 73.5%***,it displayes stable cycling for over 1.0 cycles at a high current density of *** super cycle stability may promote the application for ultralong-life all solid-state lithium metal batteries.

关键词： Solid-state electrolyte lithium-metal batteries liquid crystalline polymer Copolymer 3D co-continuous structure Long cycle stability

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：