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Influence of pH, heat and Enzymatic Treatments on the Activity of Antibacterial Substance in MRS and Milk Media Produced by Lactobacillus fermentum F6

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Agricultural Sciences in China 2010年第6期9卷 911-920页

作者： zhang Yong LIU Yong BAO Yan zhang he-ping Key Laboratory of Dairy Biotechnology and Engineering Ministry of Education/Department of Food Science and Engineering InnerMongolia Agricultural University Hohhot 010018 P.R. China

This study aimed to investigate the influence of pH,heat and enzymatic treatments on the activity of antibacterial substance in MRS,skim soy milk and bovine milk media fermented by a potential probiotic Lactobacillus fermentum *** antibacterial activity of the culture supernatant of *** F6 was tested against a wide range of Gram-positive and Gram-negative pathogenic bacteria including Staphylococcus aureus,Escherichia coli,Listeria monocytogenes,Salmonella typhimurium,and Shigella *** antibacterial activities were detected in MRS and milk but not in soy *** presumed that three kinds of probable components including organic acids,heat-stable and heat-labile proteinaceous compounds were involved in antibacterial activity of fermented MRS and *** influence of acids on antibacterial activity was pH-dependent and this effect multiplied with thermal treatments seemed *** analyses showed various significant differences of antibacterial activity among five pathogens were observed in pH and heat *** untreated fermented milk showed higher inhibitory activity to Gram-positive pathogenic bacteria than Gram-negative bacteria （P 〈 0.05）,indicating antibacterial substances of fermented milk are greatly different from fermented *** accurate stimulated gastrointestinal transit showed antibacterial substances would have no influence on intestinal *** range of antibacterial substances from pH 2.0 to 6.0 can be potentially used as food biopreservatives and alternative therapeutics.

关键词： Lactobacillusfermentum F6 antibacterial activity pH thermal treatments enzymatic effect

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Unicyclic graphs with extremal Lanzhou index

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Applied Mathematics(A Journal of Chinese Universities) 2022年第3期37卷 350-365页

作者： LIU Qian-qian LI Qiu-li zhang he-ping School of Mathematics and Statistics Lanzhou UniversityLanzhou 730000China

Very recently *** et al.[8]introduced a new topological index for a molecular graph G named Lanzhou index as∑_(u∈V(G))d_(u)d^(2)_(u),where d_(u)and d_(u)denote the degree of vertex u in G and in its complement *** index Lz(G)can be expressed as(n-1)M_(1)(G)-F(G),where M_(1)(G)and F(G)denote the first Zagreb index and the forgotten index of G respectively,and n is the number of vertices in *** turns out that Lanzhou index outperforms M_(1)(G)and F(G)in predicting the logarithm of the octanol-water partition coefficient for octane and nonane *** was shown that stars and balanced double stars are the minimal and maximal trees for Lanzhou index *** this paper,we determine the unicyclic graphs and the unicyclic chemical graphs with the minimum and maximum Lanzhou indices separately.

关键词： Lanzhou index unicyclic graph extremal graph Zagreb index forgotten index

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Data Do Not Support Effectiveness of Acupuncture for Improving Live Birth Rate in Women with Polycystic Ovary Syndrome

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Chinese Journal of Integrative Medicine 2018年第5期24卷 399-400页

作者： KUANG Hong-ying1 LI Yan1 zhang he-ping2 Richard S.Legro3 Elisabet Stener-Victorin4 Department of Obstetrics and Gynecology the First Affiliated Hospital of Heilongjiang University of Chinese Medicine Department of Biostatistics Yale School of Public Health Department of Obstetrics and Gynecology Penn State University College of Medicine Department of Physiology and Pharmacology Karolinska Institutet

Recently, the arguments raised by Gang and Jing have been published in Chinese Journal of Integrative Medicine, concerning the randomized controlled trial （RCT） of our team published in JAMA. The conclusions of Gang and Jingo） result not only from misunderstanding of the aims of our study,） but also a lack of basic knowledge for the design of RCT and the limitations on the content, and hence the length, of the primary outcome article in high-impact journals （i.e. 2,500 words and a total of 5 figures/tables in JAMA）. We will address their main critiques point by point below.

关键词： Polycystic Ovary Syndrome

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Cross-talk between calcium and reactive oxygen species signaling

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Acta Pharmacologica Sinica 2006年第7期27卷 821-826页

作者： Yuan YAN Chao-liang WEI Wan-rui zhang he-ping CheNG Jie LIU~1 Laboratory of Calcium Signaling,Institute of Molecular Medicine,Peking University,Beijing 100871,China Laboratory of Calcium Signaling Institute of Molecular Medicine Peking University Beijing China

Calcium(Ca2+)and reactive oxygen species(ROS)constitute the most importantintracellular signaling molecules participating in the regulation and integration ofdiverse cellular *** we briefly review cross-talk between the two promi-nent signaling systems that finely tune the homeostasis and integrate functional-ity of Ca2+and ROS in different types of ***2+modulates ROS homeostasisby regulating ROS generation and annihilation mechanisms in both the mitochon-dria and the *** redox regulation of Ca2+homeostasis occurs indifferent physiological and pathological processes,by modulating componentsof the Ca2+signaling toolkit and altering characteristics of local and global Ca2+***,interactions between Ca2+and ROS signaling systems canbe both stimulatory and inhibitory,depending on the type of target proteins,theROS species,the dose,duration of exposure,and the cell *** extensiveand complex cross-talk might enhance signaling coordination and integration,whereas abnormalities in either system might propagate into the other system andundermine the stability of both systems.

关键词： calcium reactive oxygen species signal transduction receptor cross talk

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饲喂益生菌Lactobacillus casei zhang对高脂日粮大鼠肝脏脂质代谢的作用

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中国农业科学 2012年第5期45卷 943-950页

作者：张勇杜瑞亭何秋雯礼贺张和平内蒙古农业大学食品科学与工程学院/国家奶牛产业技术体系乳制品研究室/乳品生物技术与工程教育部重点实验室江南大学食品科学与技术学院

【目的】研究不同剂量益生菌*** zhang(2.0×1010CFU/d、2.0×109CFU/d和2.0×108CFU/d)及其发酵乳饮料(2.0×108CFU/mL/d)对高胆固醇血症大鼠肝脏脂质的治疗作用。【方法】采用高脂饲料诱导高脂血症,采用相应试剂盒测定肝脏总胆固醇水... 详细信息

【目的】研究不同剂量益生菌*** zhang(2.0×1010CFU/d、2.0×109CFU/d和2.0×108CFU/d)及其发酵乳饮料(2.0×108CFU/mL/d)对高胆固醇血症大鼠肝脏脂质的治疗作用。【方法】采用高脂饲料诱导高脂血症,采用相应试剂盒测定肝脏总胆固醇水平(TC)和甘油三酯(TG)水平、粪便总胆汁酸水平与胆固醇水平以及血清载脂蛋白ApoAⅠ与ApoB水平。【结果】益生菌各剂量组和发酵饮料组与高脂模型组相比,肝脏总胆固醇水平(TC)和甘油三酯(TG)水平均显著降低(P0.05)。【结论】益生菌*** zhang主要通过增加总胆汁酸的排出和调节载脂蛋白水平来改善高血脂大鼠肝脏脂质水平。

关键词： Lactobacillus casei zhang 肝脏脂质高血脂大鼠总胆汁酸载脂蛋白粪便胆固醇

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Lactobacillus casei zhang和Bifidobacterium lactis V9在益生菌酸乳中的应用

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中国乳品工业 2012年第10期40卷 4-7页

作者：刘彪张和平内蒙古伊利集团伊利母婴营养研究中心呼和浩特010110 内蒙古农业大学乳品生物技术与工程教育部重点实验室呼和浩特010018

益生菌在酸乳中的应用已非常普遍,将Lactobacillus casei zhang单独(样品A)以及与Bifidobacterium lactis V9复合(样品B),同酸乳发酵剂(G027)共同发酵益生菌酸乳,于4℃贮藏21 d。结果表明,整个贮藏期间2组样品间的黏度和持水性差异不显... 详细信息

益生菌在酸乳中的应用已非常普遍,将Lactobacillus casei zhang单独(样品A)以及与Bifidobacterium lactis V9复合(样品B),同酸乳发酵剂(G027)共同发酵益生菌酸乳,于4℃贮藏21 d。结果表明,整个贮藏期间2组样品间的黏度和持水性差异不显著;贮藏期间2组样品间*** zhang的活菌数没有差异,且*** zhang和*** V9的活菌数不随贮藏时间而降低;*** zhang和*** V9复合益生菌酸奶感官评价优于单独添加*** zhang酸乳。*** zhang和*** V9复合添加,更适合于益生菌酸乳的生产。

关键词： Lactobacillus casei zhang Bifidobacterium lactis V9 益生菌酸乳

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新型高效对撞流液-液萃取实验装置的设计

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现代化工 2005年第Z1期25卷 265-267页

作者：张和平刘洁淮海工学院机械工程系江苏连云港222005

设计了一种新型高效对撞流液-液萃取实验装置,并与其他萃取装置进行了比较,得出该萃取器在提高液-液萃取速率方面具有优良的特性。借助ANSYS有限元程序对该装置进行了流场数值模拟,为进一步研究提供理论依据。

关键词：对撞流萃取有限元分析

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Recent progress in constructing fluorinated solid-electrolyte interphases for stable lithium metal anodes

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 270-291页

作者： Di zhang Pengfei Lv Wei Qin Xin he Yuanhua he Civil Aircraft Fire Science and Safety Engineering Key Laboratory of Sichuan Province College of Civil Aviation Safety EngineeringCivil Aviation Flight University of ChinaGuanghan 618307China School of Chemical Engineering Sichuan UniversityChengdu 610065China

Lithium metal batteries(LMBs)are emerging as a promising energy storage solution owing to their high energy density and specific ***,the non-uniform plating of lithium and the potential rupture of the solid-electrolyte interphase(SEI)during extended cycling use may result in dendrite growth,which can penetrate the separator and pose significant short-circuit *** a stable SEI is essential for the long-term operation of the ***-rich SEI has garnered significant attention for its ability to effectively passivate electrodes,regulate lithium deposition,and inhibit electrolyte *** the structural components and preparation methods of existing fluorinated SEI is crucial for optimizing lithium metal anode *** paper reviews the research on optimizing LiF passivation interfaces to protect lithium metal *** focuses on four types of compositions in fluorinated SEI that work synergistically to enhance SEI *** instance,combining compounds with LiF can further enhance the mechanical strength and ionic conductivity of the *** metals with LiF significantly improves electrochemical performance at the SEI/anode interface,with a necessary focus on reducing electron tunneling ***,incorporating polymers with LiF offers balanced improvements in interfacial toughness and ionic conductivity,though maintaining structural stability over long cycles remains a critical area for future *** alloys combined with LiF increase surface energy and lithium affinity,challenges such as dendrite growth and volume expansion *** summary,this paper emphasizes the crucial role of interfacial structures in LMBs and offers comprehensive guidance for future design and development efforts in battery technology.

关键词： LiF lithium metal anodes solid-electrolyte interphase interface cycling stability

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干酪乳杆菌zhang对小鼠肠道免疫功能的影响

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营养学报 2009年第4期31卷 396-399页

作者：杜瑞亭托娅张和平乳品生物技术与工程教育部重点实验室内蒙古农业大学呼和浩特010018 内蒙古医学院附属医院临床检验中心呼和浩特010059

目的研究干酪乳杆菌zhang(Lactobacillus casei zhang,Lczhang)活菌制剂对小鼠肠粘膜免疫功能的影响。方法将分离自酸马奶的干酪乳杆菌zhang,以活菌制剂的形式分三个剂量灌服小鼠11d,观察小鼠肠道局部免疫组织一派伊尔氏结(Payer’s Pat... 详细信息

目的研究干酪乳杆菌zhang(Lactobacillus casei zhang,Lczhang)活菌制剂对小鼠肠粘膜免疫功能的影响。方法将分离自酸马奶的干酪乳杆菌zhang,以活菌制剂的形式分三个剂量灌服小鼠11d,观察小鼠肠道局部免疫组织一派伊尔氏结(Payer’s Patches,PP)的数量及小肠粘膜CD3+、IgA+细胞数量及其阳性信号平均光密度值。结果干酪乳杆菌zhang可使小鼠肠道粘膜相关淋巴组织中派伊尔氏结计数、计分值显著提高,并可显著提高肠粘膜内CD3+、IgA+细胞数量及表达强度。结论干酪乳杆菌zhang对小鼠肠道粘膜免疫具有明显的促进作用。

关键词：干酪乳杆菌zhang 小鼠肠道粘膜免疫

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益生菌Lactobacillus casei zhang在常规培养条件下连续传代1000代过程中稳定性研究

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中国乳品工业 2013年第11期41卷 16-18页

作者：张文羿白梅张和平内蒙古农业大学乳品生物技术与工程教育部重点实验室呼和浩特010018

以益生菌Lactobacillus casei zhang为研究对象,通过观察该菌株在普通MRS培养基中连续传代1 000代期间细胞形态、菌落形态、活菌数、浊度和菌株活力的变化对其稳定性进行了初步评价。结果表明,*** zhang在1000代期间细胞形态与菌落形态... 详细信息

以益生菌Lactobacillus casei zhang为研究对象,通过观察该菌株在普通MRS培养基中连续传代1 000代期间细胞形态、菌落形态、活菌数、浊度和菌株活力的变化对其稳定性进行了初步评价。结果表明,*** zhang在1000代期间细胞形态与菌落形态没有发生变化;活菌数、浊度均和菌株活力随培养代数的增加呈现波动性变化,但波动幅度较小,总数基本维持不变。上述研究结果初步表明*** zhang具有良好的稳定性,暗示其可用于产业化生产。

关键词：益生菌 Lactobacillus casei zhang 连续传代稳定性

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