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马流产沙门氏菌研究进展

动物医学进展 2024年第4期45卷 102-106页

作者：齐佳欣邵明杰崔平张玉良张鹤平肖跃强河北工程大学生命科学与食品工程学院河北邯郸056021 山东省滨州畜牧兽医研究院山东滨州256600 滨州市畜牧兽医管理服务中心山东滨州256600 无棣县畜牧兽医管理服务中心山东无棣251900

马流产沙门氏菌(Salmonella abortus equi)是以引起母马流产、种马睾丸炎和小马驹败血症及多发性关节炎为主要症状的病原菌。近年来,由于马属动物集约化养殖,该病在我国山东、新疆、内蒙等马属动物养殖地区陆续发生,造成了严重的经济损... 详细信息

马流产沙门氏菌(Salmonella abortus equi)是以引起母马流产、种马睾丸炎和小马驹败血症及多发性关节炎为主要症状的病原菌。近年来,由于马属动物集约化养殖,该病在我国山东、新疆、内蒙等马属动物养殖地区陆续发生,造成了严重的经济损失。论文通过对马流产沙门氏菌引起的临床症状、致病机制、疫苗研制等方面的研究进展进行论述或回顾,并对其研究趋势进行展望,旨在为更好地开展该菌引起的疾病的预防、控制和净化等提供参考。

关键词：马流产沙门氏菌临床症状致病机制疫苗

Influence of pH, heat and Enzymatic Treatments on the Activity of Antibacterial Substance in MRS and Milk Media Produced by Lactobacillus fermentum F6

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Agricultural Sciences in China 2010年第6期9卷 911-920页

作者： zhang Yong LIU Yong BAO Yan zhang he-ping Key Laboratory of Dairy Biotechnology and Engineering Ministry of Education/Department of Food Science and Engineering InnerMongolia Agricultural University Hohhot 010018 P.R. China

This study aimed to investigate the influence of pH,heat and enzymatic treatments on the activity of antibacterial substance in MRS,skim soy milk and bovine milk media fermented by a potential probiotic Lactobacillus fermentum *** antibacterial activity of the culture supernatant of *** F6 was tested against a wide range of Gram-positive and Gram-negative pathogenic bacteria including Staphylococcus aureus,Escherichia coli,Listeria monocytogenes,Salmonella typhimurium,and Shigella *** antibacterial activities were detected in MRS and milk but not in soy *** presumed that three kinds of probable components including organic acids,heat-stable and heat-labile proteinaceous compounds were involved in antibacterial activity of fermented MRS and *** influence of acids on antibacterial activity was pH-dependent and this effect multiplied with thermal treatments seemed *** analyses showed various significant differences of antibacterial activity among five pathogens were observed in pH and heat *** untreated fermented milk showed higher inhibitory activity to Gram-positive pathogenic bacteria than Gram-negative bacteria （P 〈 0.05）,indicating antibacterial substances of fermented milk are greatly different from fermented *** accurate stimulated gastrointestinal transit showed antibacterial substances would have no influence on intestinal *** range of antibacterial substances from pH 2.0 to 6.0 can be potentially used as food biopreservatives and alternative therapeutics.

关键词： Lactobacillusfermentum F6 antibacterial activity pH thermal treatments enzymatic effect

Unicyclic graphs with extremal Lanzhou index

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Applied Mathematics(A Journal of Chinese Universities) 2022年第3期37卷 350-365页

作者： LIU Qian-qian LI Qiu-li zhang he-ping School of Mathematics and Statistics Lanzhou UniversityLanzhou 730000China

Very recently *** et al.[8]introduced a new topological index for a molecular graph G named Lanzhou index as∑_(u∈V(G))d_(u)d^(2)_(u),where d_(u)and d_(u)denote the degree of vertex u in G and in its complement *** index Lz(G)can be expressed as(n-1)M_(1)(G)-F(G),where M_(1)(G)and F(G)denote the first Zagreb index and the forgotten index of G respectively,and n is the number of vertices in *** turns out that Lanzhou index outperforms M_(1)(G)and F(G)in predicting the logarithm of the octanol-water partition coefficient for octane and nonane *** was shown that stars and balanced double stars are the minimal and maximal trees for Lanzhou index *** this paper,we determine the unicyclic graphs and the unicyclic chemical graphs with the minimum and maximum Lanzhou indices separately.

关键词： Lanzhou index unicyclic graph extremal graph Zagreb index forgotten index

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宫颈腺癌分类的新进展

诊断病理学杂志 2024年第7期31卷 674-677页

作者：张和平许宏亮安徽省妇女儿童医学中心/合肥市妇幼保健院病理科合肥230001

宫颈腺癌是一组异质性较高的肿瘤,具有不同的病因学、形态学特征及分子特征。人乳头瘤病毒(HPV)感染在宫颈癌的发生中起着重要作用,特别是鳞状细胞癌,但是HPV感染并非所有宫颈腺癌的致病因素。越来越多的证据显示仅根据细胞形态的分类... 详细信息

宫颈腺癌是一组异质性较高的肿瘤,具有不同的病因学、形态学特征及分子特征。人乳头瘤病毒(HPV)感染在宫颈癌的发生中起着重要作用,特别是鳞状细胞癌,但是HPV感染并非所有宫颈腺癌的致病因素。越来越多的证据显示仅根据细胞形态的分类在临床诊疗过程中存在局限性。新的国际宫颈腺癌标准和分类(IECC)将宫颈腺癌按照病因学分为HPV相关腺癌及非HPV相关腺癌,这不仅是对传统形态学分类系统的突破,更突出其病因学的本质及与临床的联系。同时根据非HPV相关腺癌的形态学和分子遗传特征又分为胃型、透明细胞型、中肾型和子宫内膜样腺癌。此外,基于是否有损毁性间质浸润的Silva分型系统将HPV相关宫颈腺癌分为三类:Pattern A、Pattern B和Pattern C,以改善该类患者的风险分层系统。本文将对宫颈腺癌的最新进展,包括宫颈腺癌IECC分类、Silva浸润模式和相关分子特征做一综述。

关键词：宫颈腺癌 HPV IECC分类 Silva分型分子特征

虎杖苷调节Sirt1-FoxO1信号通路对高糖诱导的心肌细胞焦亡的影响

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心脏杂志 2024年第1期36卷 7-12页

作者：户小均黄丹苏维张和平张泉绵阳市中心医院检验科四川绵阳621000 绵阳市中心医院门诊科四川绵阳621000 川北医学院附属医院门诊科四川南充637000 绵阳市人民医院心血管内科四川绵阳621000

目的基于沉默信息调节因子1(silence information regulator1,Sirt1)-叉头状转录因子O1(forkhead transcription factor O1,FoxO1)信号通路研究虎杖苷(polydatin,PD)抑制高糖诱导的心肌细胞焦亡的作用机制。方法以心肌细胞H9c2为研究对象,使用不同浓度PD处理筛选PD浓度。将细胞分为模型组、PD低、中、高剂量组(PD-L、M、H,20、40、80μmol/L)、空白对照(control)组、Sirt1抑制剂[PD-H+sirtinol (10μmol/L)]组。细胞计数试剂盒(cell counting Kit-8,CCK8)法检测细胞活性;酶联免疫吸附试验(enzyme-linked immunosorbent assay,Elisa)法检测细胞内乳酸脱氢酶(lactate dehydrogenase,LDH)释放量、白细胞介素1β(Interleukin-1β,IL-1β)水平;二氯荧光素双醋酸盐(dichlorodihydrofluorescein diacetate,DCFH-DA)荧光探针检测细胞活性氧(reactive oxygen species,ROS)水平;流式细胞术检测细胞焦亡情况;实时荧光定量PCR检测细胞中Nod样受体蛋白3(Nod-like receptor protein 3,NLRP3) mRNA、消皮素D(gasdermin D,GSDMD) mRNA表达水平;Western blot检测蛋白表达。结果与control组比较,模型组细胞活性下降(P<0.01),经过PD不同浓度处理后,细胞活性逐渐上升(P<0.01);与control组比较,模型组LDH释放量、IL-1β水平、ROS水平、细胞焦亡率、NLRP3 mRNA、GSDMD mRNA表达、焦亡蛋白NLRP3、裂解的半胱氨酸天冬氨酸酶(cleaved-caspase-1,c-caspase-1)、GSDMD、GSDMDN表达均上升,Sirt1-Foxo1信号通路蛋白表达下降(P<0.01);与模型组比较,PD各组及PD-H+sirtinol组LDH释放量、IL-1β水平、ROS水平、细胞焦亡率、NLRP3 mRNA、GSDMD mRNA表达、焦亡蛋白NLRP3、c-caspase-1、GSDMD、GSDMD-N表达均下降,Sirt1-FoxO1信号通路蛋白表达上升(P<0.05)。sirtinol可以逆转PD对于高糖诱导的心肌细胞焦亡的保护作用。结论 PD可以通过上调Sirt1-FoxO1信号通路蛋白表达,改善细胞炎症损伤,抑制高糖诱导的心肌细胞焦亡。

关键词：虎杖苷心肌细胞焦亡炎症 Sirt1-FoxO1信号通路

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制造业数字化转型会影响会计稳健性吗?

湖南财政经济学院学报 2024年第3期40卷 36-47页

作者：杨芳张和平孙晴晴刘禹轩云南民族大学经济与管理学院云南昆明650504

选取2011—2021年沪深A股上市制造业企业作为研究样本,实证检验制造业数字化转型对会计稳健性的影响及其作用机制。研究发现,制造业数字化转型对会计稳健性具有正向促进作用。机制层面,制造业数字化转型主要通过两个渠道来增强会计稳健... 详细信息

选取2011—2021年沪深A股上市制造业企业作为研究样本,实证检验制造业数字化转型对会计稳健性的影响及其作用机制。研究发现,制造业数字化转型对会计稳健性具有正向促进作用。机制层面,制造业数字化转型主要通过两个渠道来增强会计稳健性:一是从管理层面提高企业内部控制质量;二是从生产层面提高企业全要素生产率。异质性结果表明,制造业数字化转型对企业会计稳健性的正向影响效应在国有企业更为显著,而高科技企业属性则会削弱制造业数字化转型对会计稳健性的作用效果。研究结论对制造业数字化转型与会计稳健性的相关研究起到了增量作用,对推动制造业数字化转型和构建智能经济新形态具有重要参考价值与启示意义。

关键词：数字化转型会计稳健性内部控制全要素生产率高质量发展

维普期刊数据库博看期刊

Improving Federated Learning through Abnormal Client Detection and Incentive

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Computer Modeling in Engineering & Sciences 2024年第4期139卷 383-403页

作者： Hongle Guo Yingchi Mao Xiaoming he Benteng zhang Tianfu Pang ping ping College of Computer and Information Hohai UniversityNanjing211100China Key Laboratory ofWater Big Data Technology of Ministry ofWater Resources Hohai UniversityNanjing211100China

Data sharing and privacy protection are made possible by federated learning,which allows for continuous model parameter sharing between several clients and a central *** reliable and high-quality clients must participate in practical applications for the federated learning global model to be accurate,but because the clients are independent,the central server cannot fully control their *** central server has no way of knowing the correctness of the model parameters provided by each client in this round,so clients may purposefully or unwittingly submit anomalous data,leading to abnormal behavior,such as becoming malicious attackers or defective *** reduce their negative consequences,it is crucial to quickly detect these abnormalities and incentivize *** this paper,we propose a Federated Learning framework for Detecting and Incentivizing Abnormal Clients(FL-DIAC)to accomplish efficient and security federated *** build a detector that introduces an auto-encoder for anomaly detection and use it to perform anomaly identification and prevent the involvement of abnormal clients,in particular for the anomaly client detection *** them,before the model parameters are input to the detector,we propose a Fourier transform-based anomaly data detectionmethod for dimensionality reduction in order to reduce the computational ***,we create a credit scorebased incentive structure to encourage clients to participate in training in order tomake clients actively *** training models(CNN,MLP,and ResNet-18)and three datasets(MNIST,Fashion MNIST,and CIFAR-10)have been used in *** to theoretical analysis and experimental findings,the FL-DIAC is superior to other federated learning schemes of the same type in terms of effectiveness.

关键词： Federated learning abnormal clients incentive credit score abnormal score detection

Recent advances in bioinspired vision systems with curved imaging structures

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Rare Metals 2024年第4期43卷 1407-1434页

作者： Ze-ping he Xun Han Wen-Qiang Wu zhang-Sheng Xu Cao-Feng Pan CAS Center for Excellence in Nanoscience Beijing Key Laboratory of Micro-Nano Energy and SensorBeijing Institute of Nanoenergy and NanosystemsChinese Academy of SciencesBeijing100083China School of Nanoscience and Technology University of Chinese Academy of SciencesBeijing100049China ZJU-Hangzhou Global Scientific and Technological Innovation Center School of Micro-Nano ElectronicsZhejiang UniversityHangzhou311200China Institute of Microscale Optoelectronics Shenzhen UniversityShenzhen518060China

Limited by the planar imaging structure,the commercial camera needs to introduce additional optical elements to compensate for the curved focal plane to match the planar image *** results in a complex and bulky *** contrast,biological eyes possess a simple and compact structure due to their curved imaging structure that can directly match with the curved focal *** by the structures and functions of biological eyes,curved vision systems not only improve the image quality,but also offer a variety of advanced ***,we review the recent advances in bioinspired vision systems with curved imaging ***,we focus on their applications in implementing different functions of biological eyes,as well as the emerging curved neuromorphic imaging systems that incorporate bioinspired optical and neuromorphic processing *** addition,the challenges and opportunities of bioinspired curved imaging systems are also discussed.

关键词： Bioinspired Curved vision system Compound eye Chambered eye Neuromorphic

Viscosity and structure of CaO-BaO-SiO_(2)-Al_(2)O_(3)-based mold slags for continuous casting of high titanium steel with different Tio2 absorption

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Journal of Iron and Steel Research International 2024年第8期31卷 1936-1946页

作者： Ya-tao Cui Xue-you Wang Xu-bin zhang Qiang-qiang Wang Sheng-ping he College of Materials Science and Engineering Chongqing UniversityChongqing 400044China

The effect of TiO_(2) absorption into two different CaO-BaO-SiO_(2)-Al_(2)O_(3)-based mold slags from the steel plant on the viscosity,melting performance and microstructure of slags was investigated through the measurement of the viscosity-temperature relationship,melting temperature and Raman *** parameter of the number of non-bridging oxygen per tetrahedrally-coordinated atom(NBO/T)was also calculated to explain the microstructure variation of molten slags with different TiO_(2) *** variation of the actual slag consumption and the depth of the liquid slag in mold was explained through the comparison of the viscosity and the melting temperature of two different *** viscosity of mold slags(basicity=0.6)decreased from 1.1 to 0.68 Pa s with the increase in the Ti0_(2) absorption from 0 to 10%,while that of slags(basicity=0.7)decreased from 0.76 to 0.56 Pa s with the Ti0_(2) absorption from 0 to 6%.The activation energy of both two groups of slags had the tendency to decrease with the increasing TiO_(2) *** network structure of both two groups of slags measured by the Raman spectra showed that the fraction of complex structure units(Q^(1),Q^(2),Q^(3) and A1-O-Al)decreased and simple structure units(Al-O-and Q^(0))increased with the increase in TiO_(2) ***/T also increased with the increase in the TiO2 absorption,indicating that the absorption of TiO_(2) into slags resulted in the destruction of silicate/aluminate ***,the absorption of TiO_(2) into the current CaO-BaO-SiO_(2)-Al_(2)O_(3) mold slags decreased the degree of polymerization of these slags and then led to the decrease of viscosity.

关键词： Mold slag Viscosity Melting temperature Slag consumption Liquid slag depth Structure