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A Flow-Based Authentication Handover Mechanism for Multi-Domain SDN Mobility Environment

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China Communications 2017年第9期14卷 127-143页

作者： Ke Ding Xiulei Wang guomin zhang Zhen Wang Ming Chen PLA University of Science & Technology

The long authentication handover delay is the greatest challenge in multi-domain SDN environment. In order to solve this problem, an authentication handover mechanism under multi-SDN domain(AHMMD) is proposed in this paper. In AHMMD, firstly, when the mobility entity accesses the network for the first time, its identity and service attributes are authenticated by the flow authentication protocol, which is designed based on the asymmetric encryption key; secondly, when the mobility entity moves to the neighbor domain, the authentication information will be delivered from the current controller to the neighborhood controller through a security communication channel. In order to promote the efficiency, a handover time prediction algorithm is adopted in AHMMD. Experimental results based on our AHMMD prototype have shown that the handover delay decreases by 50% while the handover cost decreases by 60%.

关键词： SDN authentication protocol prediction mobility

Estrogen intervention in microvascular morphology and choline acetyltransferase expression in rat hippocampal neurons in chronic cerebral ischemia

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Neural Regeneration Research 2011年第17期6卷 1285-1290页

作者： Zhenjun Yang Hongwei Yan guomin zhang Zhihong Chen Jingfeng xue Department of Anatomy Chengde Medical College Chengde 067000 Hebei Province China Affiliated Hospital.of Chengde Medical College Chengde 067000 Hebei Province China

We observed dynamic changes in microvessels and a protective effect of estrogen on chronic cerebral ischemia ovariectomized rat models established through permanent occlusion of bilateral carotid arteries at 7, 14 and 21 days. The results revealed that estrogen improved microvasculature in the hippocampus of chronic cerebral ischemic rats, upregulated Bcl-2 protein expression, downregulated Bax protein expression, increased choline acetyltransferase expression in hippocampal cholinergic neurons, and suppressed hippocampal neuronal apoptosis. These findings indicate that estrogen can protect hippocampal neurons in rats with chronic cerebral ischemia.

关键词： estrogen chronic cerebral ischemia hippocampus microvasculature Bcl-2 Bax choline acetyltransferase neural regeneration

Influence of fault geometry and fault interaction on strain partitioning within western Sichuan and its adjacent region

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Science China Earth Sciences 2010年第7期53卷 1056-1070页

作者： WANG Hui LIU Jie SHEN XuHui LIU Mian LI QingSong SHI YaoLin zhang guomin Institute of Earthquake Science China Earthquake AdministrationBeijing 100036China Department of Geological Sciences University of MissouriColumbiaMO 65211USA China Earthquake Network Center China Earthquake AdministrationBeijing 100045China Lunar and Planetary Institute HoustonTX 77058USA Laboratory of Computational Geodynamics Graduate University of Chinese Academy of SciencesBeijing 100049China

There are several major active fault zones in the western Sichuan and its vicinity. Slip rates and seismicity vary on different fault zones. For example, slip rates on the Xianshuihe fault zone are higher than 10 mm/a. Its seismicity is also intense. Slip rates on the Longmenshan fault zone are low. However, Wenchuan Ms8.0 earthquake occurred on this fault zone in 2008. Here we study the impact of fault geometry on strain partitioning in the western Sichuan region using a three-dimensional viscoe- lastoplastic model. We conclude that the slip partitioning on the Xianshuihe-Xiaojiang fault presents as segmented, and it is related to fault geometry and fault structure. Slip rate is high on fault segment with simple geometry and structure, and vice versa. Strain rate outside the fault is localized around the fault segment with complex geometry and fault structure. Strain partitioning on the central section of the Xianshuihe-Xiaojiang fault zone is influenced by the interaction between the Anninghe-Zemuhe fault and the Daliangshan fault zone. Striking of the Longmenshan fault zone is nearly orthogonal to the direction of eastward extrusion in the Tibetan Plateau. It leads to low slip rate on the fault zone.

关键词： Xianshuihe-Xiaojiang fault zone Longmenshan fault zone fault geometry strain partitioning 3D viscoelastoplastic model

Acute Hepatitis B--China,2005−2019

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China CDC weekly 2020年第30期2卷 559-563页

作者： Ning Miao Hui Zheng Xiaojin Sun Fuzhen Wang guomin zhang Zundong Yin National Immunization Program Chinese Center for Disease Control and PreventionBeijingChina

Introduction:Hepatitis B is a major public health threat in *** subtyping of acute hepatitis B(AHB)has been reported to China’s National Notifiable Disease Reporting System(NNDRS)since *** divided the years since NNDRS reporting started into three stages:a“primary stage”(2005−2008),a“catch-up stage”(2009−2012),and an“AHB surveillance pilot stage”(2013−2019).We evaluated characteristics of AHB and progress towards AHB control in these three ***:We obtained data on cases reported to NNDRS between January 1,2005 and December 31,2019 and compared the annual incidence of reported AHB in each of the three stages by region,age,and ***:The incidence of reported AHB declined from 7.52 per 100,000 in 2005 to 3.21 per 100,000 in 2019—a decrease of 57.31%.The annual incidences of AHB in the primary stage,the catch-up stage,and the AHB surveillance pilot stage were 7.45 per 100,000,5.78 per 100,000,and 4.26 per 100,000,respectively;7 provincial-level administrative divisions(PLADs)had an annual incidence of more than 10 per 100,000 in the primary stage,5 PLADs in the catch-up stage,and 1 in the AHB surveillance pilot *** group aged 20−29 years old had the highest annual rate of reported AHB in the primary stage(14.35 per 100,000)and in the catch-up stage(10.42 per 100,000),and the group aged 30−39 years old had the highest annual rate in the surveillance pilot stage(5.89 per 100,000).AHB affected males and females in all age *** and Implications for Public Health Practice:The incidence of AHB had decreased significantly since the start of the NNDRS reporting in 2005,but additional action is needed to eliminate AHB in *** B vaccine(HepB)coverage in adults should be increased to reduce new AHB cases among people over 20 years old,epidemiological investigations of AHB cases should be conducted to identify risk factors for infection,and prevention of mother-to-child transmission needs to be strengthened.

关键词： prevention mother eliminate

A Scoping Review of Real-World Study in Vaccine Evaluation

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China CDC weekly 2024年第16期6卷 357-362页

作者： Lei Wang Hong Yang Lanfang Xia Quanwei Song Na Liu guomin zhang Fuzhen Wang Huaqing Wang National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases(NITFID) BeijingChina National Immunization Program Chinese Center for Disease Control and PreventionBeijingChina

Real-world study(RWS)gained prominence starting with a significant investigation on ramipril’s impact on hypertension in 1993(1).A key advancement for the Food and Drug Administration(FDA)occurred with the enactment of the 21st Century Cures Act in 2016,emphasizing RWS(2).The FDA’s Real-world Evidence Program establishes real-world data(RWD)as“data relating to patient health status and/or the delivery of health care routinely collected from a variety of sources”,while real-world evidence(RWE)is“clinical evidence about the usage and potential benefits or risks of a medical product derived from analysis of RWD”(3).The proliferation of big data,electronic medical records(EMR),electronic health records(EHR),and medical claims data offers vast information resources facilitating *** access to RWD allows for worldwide monitoring of the impacts of various public health initiatives like vaccination *** randomized clinical trials(RCTs)traditionally gauge vaccine efficacy and shortterm safety,RWS can assess vaccine performance and safety across larger,more diverse populations and are adept at identifying rare events not easily discernible in RCTs due to their infrequency.

关键词： routine gained traditionally

Progress Towards Hepatitis A Control and Prevention Through 2019:the National Immunization Program of China

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China CDC weekly 2020年第31期2卷 591-595页

作者： Xiaojin Sun Fuzhen Wang guomin zhang Hui Zheng Ning Miao Zundong Yin Zhijie An National Immunization Program Chinese Center for Disease Control and PreventionBeijingChina

Hepatitis A is an infectious liver disease caused by hepatitis A virus(HAV)that results in mild to severe *** is spread to immunologically naïve persons who ingest food or water contaminated with feces from HAV-infected individuals(1).Hepatitis A is often seen in sporadic cases,but is also seen in large outbreaks,such as the 1988 outbreak in Shanghai that caused over 300,000 cases and huge economic losses(2).

关键词： cases infected illness

Active tectonic blocks and strong earthquakes in the continent of China

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Science China Earth Sciences 2003年第Z2期46卷 13-24页

作者： zhang Peizhen (张培震) DENG Qidong (邓起东) zhang guomin (张国民) MA Jin (马瑾) GAN Weijun (甘卫军) MIN Wei (闵伟) MAO Fengying (毛凤英) WANG Qi (王琪) Institute of Geology China Seismological Bureau Beijing 100029China Laboratory of Tectonophysics China Seismological Bureau Beijing 100029 China Institute of Geology China Seismological Bureau Beijing 100029China Center for Earthquake Analysis and Prediction China Seismological Bureau Beijing100036China Institute of Geology China Seismological Bureau Beijing 100029China Laboratory of Tectonophysics China Seismological Bureau Beijing 100029 China Institute of Geology China Seismological Bureau Beijing 100029China Laboratory of Tectonophysics China Seismological Bureau Beijing 100029 China Institute of Geology China Seismological Bureau Beijing 100029China Institute of Geology China Seismological Bureau Beijing 100029China Institute of Seismology China Seismological Bureau Wuhan 430071China

The primary pattern of the late Cenozoic to the present tectonic deformation of China is characterized by relative movements and interactions of tectonic blocks. Active tectonic blocks are geological units that have been separated from each other by active tectonic zones. Boundaries between blocks are the highest gradient of differential movement. Most of tectonic activity occurs on boundaries of the blocks. Earthquakes are results of abrupt releases of accumulated strain energy that reaches the threshold of strength of the earth's crust. Boundaries of tectonic blocks are the locations of most discontinuous deformation and highest gradient of stress accumulation, thus are the most likely places for strain energy accumulation and releases, and in turn, devastating earthquakes. Almost all earthquakes of magnitude greater than 8 and 80%-90% of earthquakes of magnitude over 7 occur along boundaries of active tectonic blocks. This fact indicates that differential movements and interactions of active tectonic blocks are the primary mechanism for the occurrences of devastating earthquakes.

关键词： active tectonic block, interactions of blocks, differential movement, strong earthquake activity.

Simulation of Discharge Plasma in Mid-frequency Pulsed DC Magnetron

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高电压技术 2013年第10期39卷 2526-2531页

作者： QIU Qingquan QU Fei GU Hongwei zhang guomin DAI Shaotao Institute of Electrical Engineering Chinese Academy of Sciences Key Laboratory of Applied Superconductivity Beijing 100190 China

Pulsed magnetron sputtering in the mid-frequency range (5-350 kHz) has recently become a promising industrial technique for the deposition of high-quality films. In order to study the plasma properties in a pulsed DC magnetron, a two-dimensional self-consistent particle model is developed, and the temporal and spacial evolution of electrons and ions in discharge space are simulated. In these simulations, the magnetic field is calculated by finite element method, and the plasma is modeled by PIC/MCC (Particle-In-Cell, Monte Carlo Collision) method. The plasma density and the electric potential in the pulse-on and the pulse-off phases are preassigned, and then the temporal evolution of plasma close to the cathode and the substrate is analyzed. It is found that electrons accumulate close to the cathode in the pulse-off phase more than in the pulse-on phase, and hence the positive particles at the target are neutralized and the electric arc is suppressed. Moreover, more energetic ions accumulate close to the substrate. They bombard the film, and this enhances the film's quality.

关键词：放电等离子体脉冲磁控溅射脉冲直流模拟系统中频等离子体性能粒子模型等离子体密度

Review of the Clinical Applications of Metagenomic Next-Generation Sequencing in Bloodstream Infection

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Advances in Infectious Diseases 2022年第1期12卷 137-146页

作者： Jiajun zhang guomin zhang Shiman Jin Department of Infectious Diseases Affiliated Hospital of Chengde Medical College Chengde China

Bloodstream infection (BSI) is an important cause of morbidity and mortality worldwide. If we can make early diagnosis and start effective antibiotic treatment in time, the hospitalization time of patients with bloodstream infection can be significantly shortened. However, the current diagnosis of bloodstream infection cannot achieve the ideal therapeutic effect to a large extent because of the matrix effect of blood and the long turnaround time of blood culture. Therefore, a new detection method with a short turnaround time and high sensitivity is needed for the early diagnosis and timely treatment to improve the prognosis of patients. Metagenomic next-generation sequencing (mNGS) is a recently developed method for the comprehensive analysis of all microorganisms and genetic materials in clinical samples and is expected to be the main method for the early diagnosis of bloodstream infections. This review discusses the clinical application of mNGS in bloodstream infections. We also discuss technical challenges that need to be addressed to improve the diagnostic applicability of mNGS.

关键词： Metagenomic Next-Generation Sequencing (mNGS) Bloodstream Infection (BSI) Bacteremia Sepsis Diagnosis