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Journal of Pharmaceutical Analysis 2023年第4期13卷 340-354页

作者： Duanping sun Ying Ma Maoqiang Wu Zuanguang Chen Luyong zhang Jing Lu Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances Center for Drug Research and DevelopmentGuangdong Pharmaceutical UniversityGuangzhou510006China Key Specialty of Clinical Pharmacy The First Affiliated Hospital of Guangdong Pharmaceutical UniversityGuangzhou510699China National and Local United Engineering Lab of Druggability and New Drugs Evaluation School of Pharmaceutical SciencesSun Yat-Sen UniversityGuangzhou510006China

Liquid biopsy is a technology that exhibits potential to detect cancer early,monitor therapies,and predict cancer prognosis due to its unique characteristics,including noninvasive sampling and real-time *** tumor cells(CTCs)and extracellular vesicles(EVs)are two important components of circulating targets,carrying substantial disease-related molecular information and playing a key role in liquid *** are single-stranded oligonucleotides with superior affinity and specificity,and they can bind to targets by folding into unique tertiary ***-based microfluidic platforms offer new ways to enhance the purity and capture efficiency of CTCs and EVs by combining the advantages of microfluidic chips as isolation platforms and aptamers as recognition *** this review,we first briefly introduce some new strategies for aptamer discovery based on traditional and aptamer-based microfluidic ***,we subsequently summarize the progress of aptamer-based microfluidics for CTC and EV ***,we offer an outlook on the future directional challenges of aptamer-based microfluidics for circulating targets in clinical applications.

关键词： Aptamer Microfluidic Circulating tumor cells Extracellular vesicles Bioanalysis

Limited Spatial Transferability of the Relationships Between Kriging Variance and Soil Sampling Spacing in Some Grasslands of Ireland:Implications for Sampling Design

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Pedosphere 2019年第5期29卷 577-589页

作者： sun Xiaolin WANG Huili Dermot FORRISTAL FU Weijun Hubert TUNNEY Chaosheng zhang Guangdong Provincial Key Laboratory for Urbanization and Geo-simulation School of Geography and PlanningSun Yat-sen UniversityGuangzhou 510275 (China) State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of SciencesNanjing 210008 (China) International Network for Environment and Health School of Geography and ArchaeologyNational University of IrelandGalway H91 TK33 (Ireland) Guangxi Forestry Research Institute Nanning 530002 (China) Crop science Department TeagascOak ParkCarlow (Ireland) school of Environmental and Resource sciences Zhejiang 4&F UniversityLirVan 311300 (China) Teagasc Johnstown Castle Research CentreWexford (Ireland)

Sampling plays an important role in acquiring precise soil information required in modern agricultural production worldwide, which determines both the cost and quality of final soil mapping products. For sampling design, it has been proposed possibile to transfer the relationships between kriging variance and sampling grid spacing from an area with existing information to other areas with similar soil-forming environments. However, this approach is challenged in practice because of two problems: i) different population vaxiograms among similar areas and ii) sampling errors in estimated variograms. This study evaluated the effects of these two problems on the transferability of the relationships between kriging variance and sampling grid spacing, by using spatial data simulated with three variograms and soil samples collected from four grasslands in Ireland with similar soil-forming environments. Results showed that the variograms suggested by different samples collected with the same grid spacing in the same or similar areas were different, leading to a range of mean kriging variance (MKV) for each grid spacing. With increasing grid spacing, the variation of MKV for a specific grid spacing increased and deviated more from the MKV generated using the population variograms. As a result, the spatial transferability of the relationships between kriging variance and grid spacing for sampling design was limited.

关键词： Key Words. geostatistics, population variogram, sampling error, sampling grid spacing soil-forming environment soil information soil mapping spatial variability

Four-dimensional direct detection receiver enabling Jones-space field recovery with phase and polarization diversity

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Photonics Research 2024年第3期12卷 399-410页

作者： QI WU YIXIAO ZHU XUEYANG LI HEXUN JIANG CHEN CHENG MENGFAN FU YIKUN zhang QUNBI ZHUGE ZHAOHUI LI WEISHENG HU Peng Cheng Laboratory Shenzhen 518055China State Key Laboratory of Advanced Communication Systems and Networks Department of Electronic EngineeringShanghai Jiao Tong UniversityShanghai 200240China school of Electronics and information technology and Guangdong Provincial Key Laboratory of Optoelectronic information Processing Chips and Systems Sun Yat-sen UniversityGuangzhou 510006China

Data centers,the engines of the global Internet,rely on powerful high-speed optical *** optical fiber communication,classic direct detection captures only the intensity of the optical field,while the coherent detection counterpart utilizes both phase and polarization diversities at the expense of requiring a narrow-linewidth and high-stability local oscillator(LO).Herein,we propose and demonstrate a four-dimensional Jones-space optical field recovery(4-D JSFR)scheme without an *** polarization-diverse full-field receiver structure captures information encoded in the intensity and phase of both polarizations,which can be subsequently extracted *** our knowledge,our proposed receiver achieves the highest electrical spectral efficiency among existing direct detection systems and potentially provides similar electrical spectral efficiency as standard intradyne coherent detection *** fully recovered optical field extends the transmission distance beyond the limitations imposed by fiber chromatic ***,the LO-free advantage makes 4-D JSFR suitable for photonic integration,offering a spectrally efficient and cost-effective solution for massively parallel data center *** results may contribute to the ongoing developments in the theory of optical field recovery and the potential design considerations for future high-speed optical transceivers.

关键词： polarization receiver phase

10 Gb/s classical secure key distribution based on temporal steganography and private chaotic phase scrambling

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Photonics Research 2024年第2期12卷 321-330页

作者： ZHENsen GAO ZHITAO DENG LIHONG zhang XULIN GAO YUEHUA AN ANBANG WANG SONGNIAN FU ZHAOHUI LI YUNCAI WANG YUWEN QIN school of information Engineering Guangdong University of TechnologyGuangzhou 510006China Pengcheng Laboratory Shenzhen 518062China Key Laboratory of Photonic technology for Integrated Communication and sensing Ministry of EducationGuangzhou 510006China school of Optoelectronic Engineering Guangdong Polytechnic Normal UniversityGuangzhou 510665China school of Electrical and information technology Sun Yat-sen UniversityGuangzhou 510006China

Secure distribution of high-speed digital encryption/decryption keys over a classical fiber channel is strongly pursued for realizing perfect secrecy communication ***,it is still challenging to achieve a secret key rate in the order of tens of gigabits per second to be comparable with the bit rate of commercial fiber-optic *** this paper,we propose and experimentally demonstrate a novel solution for high-speed secure key distribution based on temporal steganography and private chaotic phase scrambling in the classical physical *** encryption key is temporally concealed into the background noise in the time domain and randomly phase scrambled bit-by-bit by a private chaotic signal,which provides two layers of enhanced security to guarantee the privacy of key distribution while providing a high secret key *** experimentally achieved a record classical secret key rate of 10 Gb/s with a bit error rate lower than the hard-decision forward error correction(HD-FEC)over a 40 km standard single mode *** proposed solution holds great promise for achieving high-speed key distribution in the classical fiber channel by combining steganographic transmission and chaotic scrambling.

关键词： chaotic distribution phase

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后量子的智能电表隐私保护方案

计算机研究与发展 2019年第10期56卷 2229-2242页

作者：田杨童张煌谢少浩张方国中山大学数据科学与计算机学院广州510006 广东省信息安全技术重点实验室(中山大学) 广州510006

智能电网作为下一代的电力系统,允许电力供应商对用户数据进行高频率地数据采集以支持能耗监管、智能配电与能源管理.然而,细粒度的用户能耗相关数据也带来了安全与隐私方面的挑战,如何保护智能电网的用户隐私已经成为智能电网研究中的... 详细信息

智能电网作为下一代的电力系统,允许电力供应商对用户数据进行高频率地数据采集以支持能耗监管、智能配电与能源管理.然而,细粒度的用户能耗相关数据也带来了安全与隐私方面的挑战,如何保护智能电网的用户隐私已经成为智能电网研究中的关键问题.当今量子计算科学正在快速发展,在抗量子计算领域基于格的密码学是相当有效的.关注智能电网的三层模型中用户电表与小区集中器的实时数据上传阶段的隐私保护问题,可利用基于格的可链接环签名来构造抗量子计算的保护用户隐私的智能电表数据采集方案.选择一个较为先进的基于格的在one-out-of-many证明之上构造的次线性大小的环签名方案,并为其增添可链接性以期为抗量子计算的隐私保护系统提供异常用户监测和追踪功能.利用后量子签名方案,该系统可以支持动态的用户加入和撤销,拥有更好的灵活性与实用性.对该系统进行安全性证明与性能分析,以表明其有效性.

关键词：智能电表隐私性可链接环签名格密码后量子

Gut microbiota-mediated metabolism of Panax notoginseng saponins and its role in pharmacokinetics and pharmacodynamics

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Traditional Medicine Research 2024年第12期9卷 41-50页

作者： Yu-Ying Zheng Wei-Wei Su Yu-Ling Liu Wei-Jian zhang Xuan Zeng Experimental Center the First Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510405China Guangdong Engineering&technology Research Center for Quality and Efficacy Reevaluation of Post-Market Traditional Chinese Medicine Guangdong Provincial Key Laboratory of Plant ResourcesSchool of Life SciencesSun Yat-sen UniversityGuangzhou 510275China Department of Neurosurgery First People’s Hospital of FoshanFoshan 528010China Guangdong Hybribio Biotech Co. Ltd.Chaozhou 521011China

Panax notoginseng saponins(PNS)are a class of effective ingredients in Notoginseng Radix et Rhizoma,a well-known herbal medicine called San-Qi in *** oral administration,PNS inevitably interacts with gut microbiota,and thus affect the pharmacokinetic profiles and pharmacological *** date,studies concering gut microbiota-mediated metabolism of PNS have not been reviewed ***,we outline the metabolic profiles of Panax notoginseng saponins mediated by gut microbiota,as well as its role in the pharmacokinetics and pharmacodynamics on the basis of reported *** metabolic pathways of primary saponins are proposed,and step-by-step deglycosylation is found to be the primary degradation pathways of PNS mediated by gut *** microorganisms and enzymes involved in the metabolic processes were *** microbiota is deeply involved in the metabolism of PNS,affects the pharmacokinetic profiles,and produces a series of active *** metabolites were documented to play an essential role in the efficacy of the parent *** studies should focus on strengthening the real-world evidence,defining the interaction between gut microbiota and PNS,and developing the strategy for modulating gut microbiota to enhance the bioavailability and efficacy of *** information would be useful for further research and clinical application of PNS.

关键词： Panax notoginseng saponins gut microbiota metabolism pharmacokinetics pharmacodynamics

Screening of Brown Planthopper Resistant miRNAs in Rice and Their Roles in Regulation of Brown Planthopper Fecundity

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Rice science 2022年第6期29卷 559-568,I0031-I0033页

作者： LÜJun LIU Jinhui CHEN Lin sun Jiawei SU Qin LI Shihui YANG Jianhua zhang Wenqing State Key Laboratory of Biocontrol School of Life SciencesSun Yat-sen UniversityGuangzhou 510275China

MicroRNAs(miRNAs)can participate in plant-insect interactions,which regulate plant defense *** this study,we analyzed the miRNA expression profiles of six rice varieties before and after brown planthopper(BPH)-*** identified 45 differentially expressed miRNAs between BPH-susceptible and BPH-resistant rice varieties and 144 miRNAs that responded to ***,miRNAs may be involved in multiple pathways regulating rice defense response against *** addition,we found that the genetic history of rice varieties determined the regulation mode of the miRNA and affected the amounts,types,changing trends and response periods of miRNAs in response to *** conclude,we scanned seven potential cross-kingdom miRNAs,of which miR5795 may target the vitellogenin gene in BPH,causing a 16.07%reduction in BPH *** results provide new miRNA information of rice-BPH interactions and BPH-resistant rice variety breeding.

关键词： Nilaparvata lugens insect-resistant rice miR5795 fecundity

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利用门罗币实现隐蔽通信

西安电子科技大学学报 2020年第5期47卷 19-27页

作者：蓝怡琴张方国田海博中山大学数据科学与计算机学院广东广州510006 广东省信息安全技术重点实验室广东广州510006

流量分析技术的不断发展,使以往基于TCP/IP架构的隐蔽通信方式面临许多威胁。阈下信道是以数字签名、认证等密码体制作为载体的一种能够实现隐蔽通信的信道,在数字签名过程中,通信双方能够传输秘密信息,除通信双方以外的任何人不知道秘... 详细信息

流量分析技术的不断发展,使以往基于TCP/IP架构的隐蔽通信方式面临许多威胁。阈下信道是以数字签名、认证等密码体制作为载体的一种能够实现隐蔽通信的信道,在数字签名过程中,通信双方能够传输秘密信息,除通信双方以外的任何人不知道秘密信息的存在。区块链作为新一代技术,采用分布式结构,其公开性、数据不可篡改和安全性使之有效成为构造阈下信道的载体。论述了采用区块链技术的门罗币这种新型数字货币,并在门罗币中构建了两种阈下信道:第一种是基于签名者和验证者之间共享密钥的阈下信道;第二种则是不共享密钥的阈下信道。通过这两种阈下信道可实现隐蔽通信。

关键词：门罗币区块链隐蔽通信阈下信道

Incidence and prognosis of olfactory and gustatory dysfunctions related to SARS-CoV-2 Omicron strain infection in china:A national multicenter survey of 35,566 individuals

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第2期10卷 113-120页

作者： Meng-Fan Liu Rui-Xia Ma Xian-Bao Cao Hua zhang Shui-Hong Zhou Wei-Hong Jiang Yan Jiang Jing-Wu sun Qin-Tai Yang Xue-Zhong Li Ya-Nan sun Li Shi Min Wang Xi-Cheng Song Fu-Quan Chen Xiao-Shu zhang Hong-Quan Wei Shao-Qing Yu Dong-Dong Zhu Luo Ba Zhi-Wei Cao Xu-Ping Xiao Xin Wei Zhi-Hong Lin Feng-Hong Chen Chun-Guang Shan Guang-Ke Wang Jing Ye Shen-Hong Qu Chang-Qing Zhao Zhen-Lin Wang Hua-Bin Li Feng Liu Xiao-Bo Cui Sheng-Nan Ye Zheng Liu Yu Xu Xiao Cai Wei Huang Ru-Xin zhang Yu-Lin Zhao Guo-Dong Yu Guang-Gang Shi Mei-Ping Lu Yang Shen Yu-Tong Zhao Jia-Hong Pei Shao-Bing Xie Long-Gang Yu Ye-Hai Liu Shao-Wei Gu Yu-Cheng Yang Lei Cheng Jian-Feng liu Graduate school of Beijing university of Chinese Medicine BeijingChina Department of Otorhinolaryngology Head and Neck Surgery China-Japan Friendship HospitalBeijingChina Department of Otorhinolaryngology Head and Neck Surgery The First People's Hospital of YinchuanYinchuanChina Department of Otorhinolaryngology The First People's Hospital of Yunnan ProvinceKunmingChina Department of Otorhinolaryngology The First Affiliated Hospital of Xinjiang Medical UniversityUrumqiChina Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of Zhejiang University School of MedicineHangzhouChina Department of Otorhinolaryngology Head and Neck Surgery Xiangya Hospital Central South UniversityChangshaChina Department of Otorhinolaryngology Head and Neck Surgery The Affiliated Hospital of Qingdao UniversityQingdaoChina Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of USTCHefeiChina Department of Otorhinolaryngology Head and Neck Surgery The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina Department of Otorhinolaryngology Head and Neck Surgery Qilu Hospital of Shandong UniversityJinanChina Department of Otorhinolaryngology Head and Neck Surgery The Second Affiliated Hospital of Harbin Medical UniversityHarbinChina Department of Otolaryngology The Second Hospital of Shandong UniversityShandong UniversityJinanChina Department of Otorhinolaryngology Head and Neck Surgery Peking University People's HospitalBeijingChina Department of Otorhinolaryngology Head and Neck Surgery Yantai Yuhuangding HospitalQingdao UniversityYantaiChina Department of Otorhinolaryngology Head and Neck Surgery Xijing HospitalThe Fourth Military Medical UniversityXi'anChina Gansu Provincial Center for Disease Control and Prevention LanzhouChina Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of China Medical UniversityShenyangChina Department of Otorhinolaryngology Head and Neck Surgery Tongji Hospit

Objective:This cross-sectional study aimed to determine the epidemiology of olfactory and gustatory dysfunctions related to COVID-19 in ***:This study was conducted by 45 tertiary Grade-A hospitals in *** and offline questionnaire data were obtained from patients infected with COVID-19 between December 28,2022,and February 21,*** collected information included basic demographics,medical history,smoking and drinking history,vaccination history,changes in olfactory and gustatory functions before and after infection,and other postinfection symptoms,as well as the duration and improvement status of olfactory and gustatory ***:Complete questionnaires were obtained from 35,566 *** overall incidence of olfactory and taste dysfunction was 67.75%.Being female or being a cigarette smoker increased the likelihood of developing olfactory and taste *** received four doses of the vaccine or having good oral health or being a alcohol drinker decreased the risk of such *** infection,the average olfactory and taste VAS scores were 8.41 and 8.51,respectively;after infection,they decreased to 3.69 and 4.29 and recovered to 5.83 and 6.55 by the time of the *** median duration of dysosmia and dysgeusia was 15 and 12 days,respectively,with 0.5%of patients having symptoms lasting for more than 28 *** overall self-reported improvement rate was 59.16%.Recovery was higher in males,never smokers,those who received two or three vaccine doses,and those that had never experienced dental health issues,or chronic accompanying ***:The incidence of dysosmia and dysgeusia following infection with the SARS-CoV-2 virus is high in *** and prognosis are influenced by several factors,including sex,SARS-CoV-2 vaccination,history of head-facial trauma,nasal and oral health status,smoking and drinking history,and the persistence of accompanying symptoms.

关键词： epidemiologic studies incidence olfactory disorders prognosis SARS-CoV-2 taste disorders

光谱—频域属性模式融合的高光谱遥感图像变化检测

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遥感学报 2024年第1期28卷 105-120页

作者：周承乐石茜李军张新长中山大学地理科学与规划学院广州510275 广东省城镇化与地理模拟重点实验室广州510275 中国地质大学(武汉)计算机学院武汉430074 广州大学地理科学与遥感学院广州510006

高光谱作为“图谱合一”的遥感技术,具有精细光谱和空间影像的地面覆盖观测与识别优势。然而,高光谱遥感数据的光谱信息表征以及空间信息的利用给双时相高光谱遥感图像变化检测任务带来了巨大的挑战。为此,本文探讨了一种光谱—频域属... 详细信息

高光谱作为“图谱合一”的遥感技术,具有精细光谱和空间影像的地面覆盖观测与识别优势。然而,高光谱遥感数据的光谱信息表征以及空间信息的利用给双时相高光谱遥感图像变化检测任务带来了巨大的挑战。为此,本文探讨了一种光谱—频域属性模式融合的高光谱遥感图像变化检测方法 SFDAPF(Spectral-Frequency Domain Attribute Pattern Fusion)。首先,设计一种基于梯度相关性的光谱绝对距离,使双时相高光谱遥感图像像元对的属性模式从光谱信息表征方面得到了逐级量化;其次,基于傅里叶变换理论提出一种变化像元属性模式显著性增强策略,从全局空间信息利用方面改善了变化与非变化属性像元对的可分性;再次,将全图属性模式显著性水平与梯度相关性的光谱绝对距离进行融合,得到变化检测的综合界定值;最后,依据虚警阈值确定双时相高光谱遥感图像变化检测的二值化结果。将本文提出的SFDAPF方法在开源的双时相高光谱遥感图像河流和农场数据集上进行了变化检测性能验证,结果表明SFDAPF方法能够优于传统的和最新的变化检测方法,变化检测的总体精度在河流和农场数据集上分别达到了0.96508和0.97287 (最高精度为1.00000)。证实了本文SFDAPF方法的有效性。

关键词：高光谱图像变化检测图像融合特征提取显著性分析傅里叶变换