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Improved prescription of taohechengqi-tang alleviates D-galactosamine acute liver failure in rats

World Journal of Gastroenterology 2016年第8期22卷 2558-2565页

作者： yang {1. Jian-Xing Luo Xiao-Yu Hu Fang yang Sen Zhong Wu Lin department of Infectious Diseases Affiliated Hospital of Chengdu University of Traditional Chinese Medicine department of Neurology Affiliated Hospital of Chengdu University of Traditional Chinese Medicine department of Clinical Medicine Chengdu University of Traditional Chinese Medicine

AIM: To investigate the hepatoprotective effect of improved prescription of Taohechengqi-tang (IPTT) against acute liver failure (ALF) in ***: Seventy specific pathogen free male Wistar rats were randomly divided into four groups: control group (normal rats, n = 1.), ALF group (ALF model, n = 20), Stronger Neo-Minophagen C (SNMC) group (ALF model + SNMC, n = 20), and IPTT group (ALF model + IPTT, n = 20). The ALF model group was administered an intraperitoneal injection of D-galactosamine (1.4 g/kg), and the control group received normal saline intraperitoneally. The SNMC and IPTT groups were treated with SMMC (1..6 mg/kg) or IPTT (28.6 g/kg) by gavage at 24 h intervals, and the ALF and control groups were treated with normal saline. At 36 h after injection, serum alanine aminotransferase, aspartate aminotransferase, total bilirubin, albumin, and cholinesterase and prothrombin time were determined, and liver histopathological scores were observed by microscopy after hematoxylin and eosin staining. mRNA expression of high mobility group box (HMGB) 1. toll-like receptor (TLR) 4, nuclear factor kappa B (NF-κB) and caspase-3 were analyzed via fluorescence quantitative reverse transcriptase polymerase chain reaction. Proliferating cell nuclear antigen (PCNA) immunohistochemistry in liver tissue was also ***: D-galactosamine notably decreased the biochemical and coagulation profiles in serum. IPTT not only improved liver function and histopathology but also normalized the gene expression levels in liver tissue. Compared with the model group, in the IPTT and SNMC groups, HMGB1.mRNA/β-actin (0.06 ±. 0.03, 0.1. ±. 0.04 vs 0.25 ±. 0.04, P 2;-actin (0.07 ±. 0.02, 0.22 ±. 0.08 vs 0.41.±. 0.22, P 2;-actin (0.74 ±. 0.41. 1.78 ±. 0.64 vs 2.68 ±. 1.35, P 2;-actin

关键词： Acute liver failure Traditional Chinese medicine Taohechengqi-tang High mobility group box 1 Inflammation

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Calcium overload and reactive oxygen species accumulation induced by selenium deficiency promote autophagy in swine small intestine

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Animal Nutrition 2021年第4期7卷 997-1008页

作者： Yingying Zheng Haoyue Guan Jie yang Jingzeng Cai Qi Liu Ziwei {1. College of Veterinary Medicine Northeast Agricultural UniversityHarbinChina College of Animal Science and Veterinary Medicine Southwest Minzu UniversityChengduSichuanChina Key Laboratory of the Provincial Education Department of Heilongjiang for Common Animal Disease Prevention and TreatmentCollege of Veterinary MedicineNortheast Agricultural UniversityHarbinChina

Selenium(Se)deficiency can seriously affect the small intestine of swine,and cause diarrhea in ***,the specific mechanism of Se deficiency-induced swine diarrhea has rarely been ***,to explore the damage of Se deficiency on the calcium homeostasis and autophagy mechanism of swine,in vivo and in vitro models of swine intestinal Se deficiency were ***-four pure line castrated male Yorkshire pigs(45 d old,1..50±1.32 kg,1. full-sibling pairs)were divided into 2 equal groups and fed Se-deficient diet(0.007 mg Se/kg)as the Se-deficiency group,or fed Se-adequate diet(0.3 mg Se/kg)as the control group for 1. *** intestinal porcine enterocyte cell line(IPEC-J2)was divided into 2 groups,and cultured by Se-deficient medium as the Se-deficient group,or cultured by normal medium as the control *** observations showed that compared with the control group,intestinal cells in the Se-deficiency group were significantly damaged,and autophagosomes *** staining and cytoplasmic calcium staining results showed that in the Sedeficiency group,autophagy increased and calcium homeostasis was *** to the reactive oxygen species(ROS)staining results,the percentage of ROS in the Se-deficiency group was higher than that in the control group in the in vitro *** with the control group,the protein and mRNA expressions of autophagy-calcium-related genes including Beclin 1.microtubule-associated proteins 1.A(LC3-1.,microtubule-associated proteins 1.B(LC3-2),autophagy-related protein 5(ATG5),autophagy-related protein 1.(ATG1.),autophagy-related protein 1.(ATG1.),mammalian target of rapamycin(mTOR),calmodulin-dependent protein kinase kinaseβ(CAMKK-β),adenosine 5’-monophosphate-activated protein kinase(AMPK),sarco(endo)plasmic reticulum Ca2+-ATPase(SERCA),and calpain in the Se-deficiency group were significantly increased which was consistent in vivo and in vitro(P<0.05).Altogether,our results indicated th

关键词： Se deficiency swine Small intestine Intestinal porcine enterocyte cell line Autophagy Ca overload

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Size matters:Steric hindrance of precursor molecules controlling the evolution of CdSe magic-size clusters and quantum dots

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Nano Research 2022年第9期15卷 8564-8572页

作者： Juan Shen Chaoran Luan Nelson Rowell yang Li Meng {1. Xiaoqin Chen Kui Yu Institute of Atomic and Molecular Physics Sichuan UniversityChengdu 610065China Laboratory of Ethnopharmacology Tissue-orientated Property of Chinese Medicine Key Laboratory of Sichuan ProvinceWest China School of MedicineWest China HospitalSichuan UniversityChengdu 610065China Metrology Research Centre National Research Council CanadaOttawaOntario K1A 0R6Canada Engineering Research Center in Biomaterials Sichuan UniversityChengdu 610065China

Little is known about how to precisely promote the selective production of either colloidal semiconductor metal chalcogenide(ME),magic-size clusters(MSCs),or quantum dots(QDs).Recently,a two-pathway model has been proposed to comprehend their evolution;here,we reveal for the first time that the size of precursors plays a decisive role in the selected evolution pathway of MSCs and *** the reaction of cadmium myristate(Cd(MA)2)and tri-n-octylphosphine selenide(SeTOP)in 1.octadecene(ODE)as a model system,the size of Cd precursors was manipulated by the steric hindrance of carboxylic acid(RCOOH)*** RCOOH,the reaction produced both CdSe MSCs and QDs(from 1.0 to 240℃).With RCOOH,the reaction produced MSCs or QDs when R was small(such as CH3−)or large(such as C6H5−),*** to the twopathway model,the selective evolution is attributed to the promotion and suppression of the self-assembly of Cd and Se precursors,*** propose that the addition of carboxylic acid may occur ligand exchange with Cd(MA)2,causing the different sizes of Cd *** results suggest that the size of Cd precursors regulates the self-assemble behavior of the precursors,which dictates the directed evolution of either MSCs or *** present findings bring insights into the two-pathway model,as the size of M and E precursors determine the evolution pathways of MSCs or QDs,the understanding of which is of great fundamental significance toward mechanism-enabled design and predictive synthesis of functional nanomaterials.

关键词： cadmium selenide(CdSe) magic-size clusters(MSCs) quantum dots(QDs) self-assembly steric hindrance

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重症监护病房患者多重耐药菌感染的危险因素分析和列线图模型评价

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中国医药 2024年第3期19卷 426-430页

作者：黎琪杨柔周小诗张昌吉李果霖杨勇四川省医学科学院·四川省人民医院药学部电子科技大学医学院个体化药物治疗四川省重点实验室成都610000 电子科技大学医学院个体化药物治疗四川省重点实验室成都610000

目的分析重症监护病房(ICU)患者多重耐药菌(MDRO)感染的危险因素,构建列线图模型并评价模型预测拟合效果。方法收集2020年1.至2022年1.月四川省人民医院905例ICU患者的临床资料进行回顾性分析。依据患者是否发生MDRO感染,将患者分为MDR... 详细信息

目的分析重症监护病房(ICU)患者多重耐药菌(MDRO)感染的危险因素,构建列线图模型并评价模型预测拟合效果。方法收集2020年1.至2022年1.月四川省人民医院905例ICU患者的临床资料进行回顾性分析。依据患者是否发生MDRO感染,将患者分为MDRO感染组(303例)和非MDRO感染组(602例)。对收集的患者相关资料进行单因素及多因素Logistic回归分析。利用R4.3.1.件构建MDRO感染风险的列线图模型,并通过受试者工作特征曲线和校准曲线评价模型的预测拟合效果。结果多因素Logistic回归分析结果显示,男性、急性生理学与慢性健康状况评分系统Ⅱ(APACHEⅡ)评分、混合感染、呼吸衰竭、慢性呼吸系统疾病、神经系统疾病、有创机械通气时间、胃管插管、使用碳青霉烯类抗菌药物、使用第三代头孢菌素、使用四环素类抗菌药物是ICU患者MDRO感染的独立危险因素(均P23~0.874,Hosmer-Lemeshow检验显示χ^(2)=1.9.69,P=0.332,且校准曲线预测发生率与实测发生率之间偏差小,模型校准度好、预测拟合效果好。结论男性、APACHEⅡ评分、一些合并症、胃管插管、使用某些抗菌药物等因素是ICU患者MDRO感染的独立危险因素。基于危险因素构建的列线图风险预测模型具有良好的预测能力,可以为及时采取预防性感染控制措施提供参考。

关键词：多重耐药菌感染重症监护病房危险因素列线图

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201.—2021.巴中市平昌县梅毒流行病学分析

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职业与健康 2024年第10期40卷 1356-1360页

作者：张翠华丁彩华杨小红罗俊杰杨帆成都中医药大学公共卫生学院四川成都611137 成都中医药大学教务处四川成都611137 苏州大学公共卫生学院江苏苏州215137 巴中市平昌县疾病预防控制中心卫生科四川巴中636420 巴中市平昌县自然资源和规划局四川巴中636499

目的了解201.—2021.巴中市平昌县梅毒的分布情况及疫情特征,为制定合适有效的防治方针提供依据。方法从“中国疾病预防控制信息系统”中导出数据,采用描述流行病学的方法,对201.—2021.巴中市平昌县梅毒疫情进行分析。结果 201.—2... 详细信息

目的了解201.—2021.巴中市平昌县梅毒的分布情况及疫情特征,为制定合适有效的防治方针提供依据。方法从“中国疾病预防控制信息系统”中导出数据,采用描述流行病学的方法,对201.—2021.巴中市平昌县梅毒疫情进行分析。结果 201.—2021.巴中市平昌县共报告梅毒病例1.763例,年均发病率为36.29/1.万;报告发病率由201.年的22.59/1.万增长到2021.的39.93/1.万(χ^(2)_(趋势)=55.1.2,P1.,年平均增长率为1..07%;各年发病率比较,差异有统计学意义(χ^(2)=95.375,P1.;发病类型主要是隐性梅毒(89.05%);发病数位于前1.的地区分别是江口镇、笔山镇、土兴镇、镇龙镇、驷马镇、白衣镇、云台镇、邱家镇、青云镇和元山镇,共占比50.20%,年均增长幅度最大的是镇龙镇(67.03%);男女梅毒发病率均呈增长趋势(χ^(2)_(趋势)=1..576、43.492,均P1.,但女性发病率的年均增长率高于男性;≥60岁年龄组的梅毒报告发病数在总病例数中的构成比最高(60.58%);职业以农民、家务待业和离休人员为主。结论 201.—2021.巴中市平昌县的梅毒防控形势仍然不容乐观,防治任务艰巨,应加大对重点地区和重点人群的干预力度和宣传教育工作,以有效控制梅毒流行传播。

关键词：梅毒报告发病率流行病学特征

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肩袖修补联合肱二头肌长头肌腱转位治疗伴或不伴肩胛下肌损伤的巨大肩袖撕裂

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中华骨科杂志 2024年第14期44卷 956-962页

作者：杨金松韩志惠向明李一平张清代飞邓明月四川省骨科医院上肢科成都610041

目的比较肩袖修补联合肱二头肌长头肌腱转位治疗伴或不伴肩胛下肌损伤的巨大肩袖撕裂的临床疗效。方法回顾性分析201.年1.至2022年9月于四川省骨科医院上肢科接受关节镜下肩袖修补联合肱二头肌长头肌腱转位治疗的巨大肩袖撕裂患者73例,... 详细信息

目的比较肩袖修补联合肱二头肌长头肌腱转位治疗伴或不伴肩胛下肌损伤的巨大肩袖撕裂的临床疗效。方法回顾性分析201.年1.至2022年9月于四川省骨科医院上肢科接受关节镜下肩袖修补联合肱二头肌长头肌腱转位治疗的巨大肩袖撕裂患者73例,男35例、女38例,年龄(58.8±7.6)岁(范围46~73岁)。左侧1.例、右侧62例。致伤原因:车祸伤6例、摔伤1.例、无明显诱因54例。根据是否合并肩胛下肌损伤分为肩胛下肌损伤组(37例)和无肩胛下肌损伤组(36例)。采用疼痛视觉模拟评分(visual analogue scale,VAS)、Constant-Murley评分、美国加州大学洛杉矶分校(university of California Los Angeles,UCLA)肩关节评分和肩关节活动度评价肩关节疼痛及功能改善情况。末次随访摄肩关节MRI,采用Sugaya分级评估肩袖是否存在再撕裂。结果所有患者均顺利完成手术。无肩胛下肌损伤组术后1.VAS评分为(0.58±0.87)分,小于肩胛下肌损伤组的(1.1.±1.1.)分,差异有统计学意义(t=-2.426,P=0.01.)。无肩胛下肌损伤组术后1.Constant-Murley评分和UCLA评分分别为(94.03±6.1.)分和(32.94±2.59)分,均大于肩胛下肌损伤组的(86.51.1..96)分和(30.38±3.33)分,差异有统计学意义(P1.无肩胛下肌损伤组前屈和体侧外旋分别为1.7.22°±26.79°和54.72°±1..20°,大于肩胛下肌损伤组的1.1.08°±22.83°和38.65°±1..1.°,差异有统计学意义(P0.05)。无肩胛下肌损伤组术后1.肩峰下间距为(9.4±1.3)mm,肩胛下肌损伤组为(9.0±1.5)mm,差异无统计学意义(t=1.31.,P=0.1.2)。无肩胛下肌损伤组术后1.肩袖再撕裂2例,肩胛下肌损伤组5例。结论关节镜下肩袖修补联合肱二头肌长头肌腱转位治疗伴或不伴肩胛下肌损伤的巨大肩袖撕裂临床疗效满意,对无肩胛下肌损伤的患者疼痛及功能改善更明显。

关键词：回旋套损伤关节镜检查修复外科手术治疗结果

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Colorectal cancer-derived extracellular vesicles induce liver premetastatic immunosuppressive niche formation to promote tumor early liver metastasis

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Signal Transduction and Targeted Therapy 2023年第4期8卷 1357-1360页

作者： Xuyang yang Yaguang zhang yang zhang Huifang Li Li Li yangping Wu Xiangzheng Chen Lei Qiu Junhong Han Ziqiang Wang Colorectal Cancer Center Department of General SurgeryState Key Laboratory of Biotherapy and Cancer Centerand Frontiers Science Center for Disease-related Molecular NetworkWest China HospitalSichuan UniversityChengdu 610041 Sichuan ProvinceChina State Key Laboratory of Biotherapy and Cancer Center and Frontiers Science Center for Disease-related Molecular NetworkWest China HospitalSichuan UniversityChengdu 610041 Sichuan ProvinceChina Core Facility Institute of Clinical PathologyDepartment of Respiratory and Critical Care Medicineand Department of Liver Surgery&Liver TransplantationState Key Laboratory of Biotherapy and Cancer CenterWest China HospitalSichuan University and Collaborative Innovation Center of BiotherapyChengdu 610041China

Dear Editor,To date,the effect of colorectal cancer(CRC)-derived extracellular vesicles(EVs)on liver pre-metastatic niche(PMN)remain incompletely understood.1.To investigate the role of CRC-derived EVs in the remodeling of the liver PMN,we isolated EVs from CT26 cell culture *** characteristics of EVs(the morphology,size,and markers)were identified by transmission electron microscopy(TEM),Nanoparticle Tracking Analysis(NTA),and western blotting(Supplementary Fig.S1.–e).Then,BALB/c mice with an intact liver immune status were pretreated with CRCderived EVs and phosphate-buffered saline(PBS)for one month,and a liver metastasis model was established via spleen injection of tumor cells to determine whether EVs influence liver metastasis(Fig.1.).Two hours after the operation,in vivo imaging indicated that the animal model was successfully established,and the tumor fluorescence intensity in the liver was consistent between the two groups(Supplementary Fig.S2a,b).Amazingly,the liver tumor fluorescence intensity in the EVs group was significantly stronger than that in the PBS group after 24 h(Fig.1.;Supplementary Fig.S2c,d).The number of liver tumor nodules in the EVs group was also significantly higher than that in the PBS group on day 4(Fig.1.;Supplementary Fig.S2e,f).

关键词： metastasis metastatic cancer

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肌肉能量技术联合常规康复治疗对慢性非特异性颈痛患者的影响

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康复学报 2024年第4期34卷 396-401页

作者：郑坤杨浩伦贾程森张黎明四川大学华西医院四川成都610044 四川大学华西天府医院四川成都610021

目的观察肌肉能量技术(MET)联合常规康复治疗方法对慢性非特异性颈痛(CNSNP)患者的影响。方法选取2022年5月—2023年3月在四川大学华西医院康复医学中心门诊诊治的CNSNP患者54例,采用随机数字软件分为对照组和观察组,每组27例。治疗过... 详细信息

目的观察肌肉能量技术(MET)联合常规康复治疗方法对慢性非特异性颈痛(CNSNP)患者的影响。方法选取2022年5月—2023年3月在四川大学华西医院康复医学中心门诊诊治的CNSNP患者54例,采用随机数字软件分为对照组和观察组,每组27例。治疗过程中共有3例患者因依从性不强而退出研究,其中对照组脱落2例,观察组脱落1.,最终对照组、观察组分别纳入25例、26例。对照组接受常规康复治疗(物理因子治疗和运动训练)联合拉伸训练,物理因子治疗主要包括磁热理疗和中频脉冲电理疗,每项20 min/次,1./d,连续治疗,3次/周,共治疗1.;运动训练包括等长收缩训练和颈部深层屈肌群训练,3次/d,连续治疗,3次/周,共治疗1.;拉伸训练,1./d,连续治疗,3次/周,共治疗1.。观察组在对照组常规康复治疗基础上接受MET治疗,治疗师将目标肌肉牵伸至引发疼痛或能够感觉到软组织阻力点的位置,双手分别固定肌肉起止点处并施加中等的阻力,让患者的目标肌肉进行等长收缩(强度为最大力的20%)并持续1. s后放松,然后继续拉伸该目标肌肉并到达下一个阻力点的位置,以该阻力点作为开始位置,重复3~5次,1./d,连续治疗,3次/周,共治疗1.。分别于治疗前、治疗后采用视觉模拟疼痛评分法(VAS)评估患者疼痛程度;采用颈椎功能障碍指数调查问卷(NDI)评估患者颈椎功能障碍情况;采用田中靖久颈椎病症状量表20分法(CSR20)评估患者颈椎功能;采用《非特异性颈痛的物理治疗指南》评价临床疗效;观察治疗过程中出现的不良反应(颈部疼痛加重、恶心、呕吐、头晕、心率加快等)。结果与治疗前比较,2组治疗后VAS评分、NDI指数均明显降低(P20评分明显升高,差异均具有统计学意义(P20评分明显更高,差异均具有统计学意义(P2.31.)高于对照组(28.00%),差异具有统计学意义(P2组均未发生不良反应。结论MET联合常规康复治疗可有效改善CNSNP患者疼痛、颈椎功能,值得临床推广应用。

关键词：慢性非特异性颈痛肌肉能量技术拉伸训练等长收缩训练颈椎功能

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Clinical observation on effect of scalp electroacupuncture for mild cognitive impairment

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Journal of Traditional Chinese Medicine 2013年第1期33卷 46-50页

作者： Hong zhang Ling Zhao Sha {1. Zhigang Chen Yingkun Li Xiaohong Peng Yulong {1. Manjia Zhu department of Acupuncture and Tuina the Chengdu University of Tranditional Chinese Medicine department of Acupuncture the Teaching Hospital of Chengdu University of Tranditional Chinese Medicine department of Tranditional Chinese Medicine the Chengdu Hospital of Integrated Chinese and Western Medicine department of Tranditional Chinese Medicine the Sichuan Provincial People's Hospital

OBJECTIVE: To evaluate the therapeutic effect of scalp electroacupuncture for mild cognitive impairment (MCI) in the early stage. METHODS: Two hundred and thirty three MCI patients were randomly divided into three groups: the drug group, the scalp electroacupuncture group, and the syndrome differentiation group. For the scalp electroacupuncture group, the points of Baihui (DU 20), Sishecong (EX-HN1., Fengchi (GB 20), and Shenting (DU 24) were selected. For the syndrome differentiation group, specific acupoints were added on the basis of syndrome differentiation and according to the scale for the differentiation of syndromes in vascular dementia (SDSVD) beside the acupoints used in the scalp electroacupuncture group. For the drug group, nimodipine was orally administered. Each patient was treated for two courses, eight weeks. The score differences in minimental state examination (MMSE), picture recognition, and clock drawing test were observed before and after the treatment. RESULTS: After treatment, the score differences in MMSE and clock drawing test were of obvious statistical significance among three groups (P1. P1., while the difference was not found in the drug group (P>0.05). There were statistical significant differences in therapeutic effects between the scalp electroacupuncture group and the drug group, and between the syndrome differentiation group and the drug group (P0.05). CONCLUSION: All the three therapies may improve the cognitive function of MCI patients. The therapeutic effects in the scalp electroacupuncture and syndrome differentiation groups were basically the same, but superior to nimodipine.

关键词： Memory disorders Electroacupunc-ture Nimodipine Picture recognition Clock draw-ing test

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EPAS1.and VEGFA gene variants are related to the symptoms of acute mountain sickness in Chinese Han population: a cross-sectional study

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Military Medical Research 2021年第1期8卷 25-36页

作者： Ji-Hang zhang {1. Shen Chuan Liu Jie {1. Yuan-Qi {1. Chen zhang Shi-Zhu Bian Jie Yu Xu-Bin Gao Lai-Ping zhang Jing-Bin Ke Fang-Zheng-Yuan Yuan Wen-Xu Pan Zhi-Nian Guo Lan Huang Institute of Cardiovascular Diseases Department of CardiologyXinqiao HospitalArmy Medical UniversityChongqing 400037China

Background: More people ascend to high altitude(HA) for various activities, and some individuals are susceptible to HA illness after rapidly ascending from plains. Acute mountain sickness(AMS) is a general complaint that affects activities of daily living at HA. Although genomic association analyses suggest that single nucleotide polymorphisms(SNPs) are involved in the genesis of AMS, no major gene variants associated with AMS-related symptoms have been ***: In this cross-sectional study, 604 young, healthy Chinese Han men were recruited in June and July of 201. in chengdu, and rapidly taken to above 3700 m by plane. Basic demographic parameters were collected at sea level, and heart rate, pulse oxygen saturation(Sp O2), systolic and diastolic blood pressure and AMS-related symptoms were determined within 1.–24 h after arriving in Lhasa. AMS patients were identified according to the latest Lake Louise scoring system(LLSS). Potential associations between variant genotypes and AMS/AMS-related symptoms were identified by logistic regression after adjusting for potential confounders(age, body mass index and smoking status).Results: In total, 320 subjects(53.0%) were diagnosed with AMS, with no cases of high-altitude pulmonary edema or high-altitude cerebral edema. Sp O2 was significantly lower in the AMS group than that in the non-AMS group(P=0.003). Four SNPs in hypoxia-inducible factor-related genes were found to be associated with AMS before multiple hypothesis testing correction. The rs6756667(EPAS1. was associated with mild gastrointestinal symptoms(P=0.01.), while rs3025039(VEGFA) was related to mild headache(P=0.0007). The combination of rs6756667 GG and rs3025039 CT/TT further increased the risk of developing AMS(OR=2.70, P1..Conclusions: Under the latest LLSS, we find that EPAS1.and VEGFA gene variants are related to AMS susceptibility through different AMS-related symptoms in the Chinese Han population;this tool might be useful for screenin

关键词： Acute mountain sickness Hypoxia Single nucleotide polymorphism Endothelial PAS domain protein 1 Vascular endothelial growth factor

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