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基于MaxEnt模型的兴隆山保护区野生马麝秋季生境适宜性评价

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生态学杂志 2024年第1期43卷 299-304页

作者：林宏东郑启泽申立泉王功刘瑞张学炎祁军张爱萍孟秀祥甘肃兴隆山国家级自然保护区管护中心兰州730117 西藏大学理学院生态学系拉萨850000 中国人民大学环境学院北京100872 西昌学院动物科学学院四川西昌615000

生境适宜性评价对野生动物保护及自然保护区管理均具有重要意义。甘肃兴隆山国家级自然保护区是我国野生马麝(Moschus chrysogaster)的重要分布区,为了解该保护区野生马麝的生境状况,本研究利用红外相机于2021年秋季在兴隆山保护区采集... 详细信息

生境适宜性评价对野生动物保护及自然保护区管理均具有重要意义。甘肃兴隆山国家级自然保护区是我国野生马麝(Moschus chrysogaster)的重要分布区,为了解该保护区野生马麝的生境状况,本研究利用红外相机于2021年秋季在兴隆山保护区采集野生马麝分布数据,结合地形、归一化植被指数(NDVI)、距离河流距离和距离道路距离等环境因子变量,通过MaxEnt模型对野生马麝的秋季生境进行了适宜性评价。结果表明:NDVI、道路距离、河流距离和海拔是影响兴隆山保护区野生马麝秋季生境适宜性的主要因子,其贡献率分别为33.20%、22.70%、16.70%和14.60%;兴隆山保护区野生马麝的秋季潜在适宜区面积为75.22 km^(2),占保护区面积的26.13%;其中,高适宜区主要分布在保护区西北部和东南部区域,占保护区面积3.26%。本研究确定了兴隆山保护区野生马麝秋季适宜生境的分布状况及关键环境影响因子,可为优化野生马麝保护和生境管理提供重要参考。

关键词：马麝(Moschus chrysogaster) 兴隆山国家级自然保护区最大熵模型生境适宜性秋季

地龙蛋白对糖尿病性勃起功能障碍大鼠阴茎海绵体平滑肌细胞表型转化及其勃起功能的影响

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中药新药与临床药理 2024年第3期35卷 325-333页

作者：冀小卫张爱平刘黎明杨佳树邢喜平甘肃中医药大学甘肃兰州730000 甘肃中医药大学附属医院甘肃兰州730000

目的探讨地龙蛋白对糖尿病性勃起功能障碍(DMED)大鼠阴茎海绵体平滑肌细胞(CCSMC)表型转化及其勃起功能的影响。方法将60只勃起功能正常的雄性SD大鼠随机分为空白组、模型组、西地拉非组(5 mg·kg^(-1))及地龙蛋白低、中、高剂量组(45... 详细信息

目的探讨地龙蛋白对糖尿病性勃起功能障碍(DMED)大鼠阴茎海绵体平滑肌细胞(CCSMC)表型转化及其勃起功能的影响。方法将60只勃起功能正常的雄性SD大鼠随机分为空白组、模型组、西地拉非组(5 mg·kg^(-1))及地龙蛋白低、中、高剂量组(45、90、180 mg·kg^(-1)),每组10只。采用腹腔注射链脲佐菌素(STZ,50 mg·kg^(-1))结合高脂饲料喂养建立糖尿病大鼠模型;8周后,颈部注射阿朴吗啡(APO,100μg·kg^(-1)),制备DMED大鼠模型。造模成功后,按剂量灌胃给药,每日1次,连续4周。测定各组大鼠造模前、造模第3天、给药4周后的血糖水平及体质量。采用多导生理记录仪测定大鼠阴茎海绵体内压(ICP)、颈动脉内压(MAP),计算ICP/MAP比值;免疫组织化学法检测阴茎海绵体中收缩型标志物α-平滑肌肌动蛋白(α-SMA)、平滑肌肌球蛋白重链(SMMHC)和合成型标志物Ⅰ型胶原蛋白(CollagenⅠ)、骨桥蛋白(OPN)表达情况;RT-PCR法检测阴茎海绵体中α-SMA、SMMHC、CollagenⅠm RNA表达水平;Western Blot法检测阴茎海绵体中α-SMA、肌间线蛋白(Desmin)、CollagenⅠ、OPN蛋白表达水平。结果与空白组比较,模型组大鼠在造模第3天和给药4周后的血糖值均显著升高(P0.05);ICP及ICP/MAP比值均显著升高(P<0.01);阴茎海绵体中α-SMA、SMMHC、Desmin蛋白表达水平显著升高(P<0.01),CollagenⅠ、OPN蛋白表达水平显著降低(P<0.01);阴茎海绵体中α-SMA、SMMHC m RNA表达水平显著升高(P<0.01),CollagenⅠmRNA表达水平显著降低(P<0.01)。结论地龙蛋白能够改善DMED大鼠勃起功能,其机制可能与通过抑制CCSMC由“收缩型”向“合成型(增殖型)”转化有关。

关键词：地龙蛋白糖尿病性勃起功能障碍阴茎海绵体平滑肌细胞表型转化大鼠

Sensitive electrochemiluminescence resonance energy transfer(ECL-RET) between Ru(bpy)3^2＋ and Au nanorod for hydrogen peroxide detection

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Science China Chemistry 2017年第3期60卷 410-414页

作者： Meisheng Wu Zhiqin Chen Hengyu Xu aiping zhang Department of Chemistry College of Science Nanjing Agricultural University Nanjing 210095 China

Here,we developed a novel electrochemiluminescence resonance energy transfer(ECL-RET) approach between Ru(bpy)_3^(2+) and Au nanorods(NRs) for sensitive determination of H_2O_*** NRs were synthesized through silver ion-assisted seed-mediated method which exhibited an obvious absorption peak at about 627 *** were modified at glassy carbon electrode(GCE) surface which showed a significant ECL quenching efficiency about 56.5%due to the ECL-RET *** Au NRs modified electrode was then utilized to measure the concentration of H_2O_2 on the basis of the significant quenching effect of H_2O_2 on Ru(bpy)_3^(2+) *** demonstrated that the decrement of ECL intensity at Au NRs modified electrode had ~ 6.6-fold enhancement as compared with that at bare electrode.

关键词： electrochemiluminescence resonance energy transfer Au NRs

An unusual case of severe pneumonia caused by Tropheryma whipplei combined with Legionella pneumophila

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World Journal of Emergency Medicine 2023年第6期14卷 492-494页

作者： Zhenfeng Lu aiping zhang Jingsheng Guo Haibin Ni Department of Emergency Medicine Affiliated Hospital of Integrated Traditional Chinese and Western MedicineNanjing University of Chinese MedicineNanjing 210046China

Community-acquired pneumonia is a common disease caused by a variety of *** whipplei (***) is a rare pathogenic bacterium,few cases have been *** Hoyt Whipple described Whipple’s disease as a chronic infectious disea... 详细信息

关键词： pneumonia Whipple

Variation and driving factors of nitrous oxide emissions from irrigated paddy field in the arid and semiarid region

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International Soil and Water Conservation Research 2018年第3期6卷 245-252页

作者： Qingwen zhang Hui zhang Xingren Liu aiping zhang Meijia Xiao Zhengli Yang Agricultural Clean Watershed Research Group Institute of Environment and Sustainable Development in AgricultureCAASBeijing100081China Ningxia Vocational and Technical College Yinchuan750002China

Agricultural pollution source as Nitrous oxide (N2O) emission from irrigated paddy field as affected by overuse of chemical fertilizer application and flooding irrigation is the primary anthropogenic source of nitrogen (N) losses in the Ningxia irrigation district. The emissions variation and driving factors of N2O emission in the large irrigation districts needs much more investigation. A static chamber-gas chromatograph method was conducted to quantify N losses from a paddy field in Lingwu Farm during 2009– 2010. Three nitrogen (N) treatments were conducted, including the conventional N application rate of 300 kg ha-1 (N300), the reducing N application rate of 240 kg ha-1 (N240) and control plot (N0). The N2O emissions due to combined effects of the fertilizer application and flood irrigation after winter dry follow was 2.86–3.27 kg ha-1 in N300. The flood irrigation at the beginning of the rice transplanting promotes N2O emissions due to nitrification–denitrification of a richer N source provided by the N fertilizer accumulation of soil NH4 + and NO3 -. During the rice growth stage when the paddy field was submerged, N2O emission was very low while intermittent irrigation before tillering and the maturation stages, frequent alteration of dry and wet soil condition enhance N2O emission. The reducing N fertilizer application improved the recovery rate in rice and resulted in a less N2O emission from irrigated paddy field in the arid and semiarid region while keeping the rice yield.

关键词： N2O emission Irrigated paddy field Flood irrigation Anthropogenic-alluvial alkaline soil

Effectiveness of Xielikang capsules in treating HIV-related diarrhea by increasing the plasma concentration of interleukin-17

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Journal of Traditional Chinese Medicine 2017年第5期37卷 616-620页

作者： zhang Xiaowei Guo Huijun Li Zhen Xu Liran zhang aiping Ji Aiying Department of Clinical Research Center of Acquired Immune Deficiency Syndrome Acquired Immune Deficiency Syndrome The First Affiliated Hospital of Henan University of Traditional Chinese Medicine Zhengzhou 450000 China Department of Obstetrics and Gynecology Zhengzhou Hospital of Traditional Chinese Medicine Zhengzhou 450000 China Department of Digestion The First Affiliated Hospital of Henan University of Traditional Chinese MedicineZhengzhou 450000 China

OBJECTIVE: To evaluate the efficacy of Xielikang capsules(XLKC) in the treatment of HIV-related diarrhea(HRD) and its effect on the plasma concentration of interleukin-17(IL-17).METHODS: This was a randomized, open-label, pos-itively-controlled clinical trial. Sixty-seven HRD patients were randomly assigned to two groups: one group was treated with XLKC(n = 35), the other with diosmectite(Smecta~?, n = 32). All patients were treated for 4 weeks. The HRD symptom scores were evaluated in each patient based on the frequency of diarrhea, and the quality and shape of the stool according to the Chinese Medicine Clinical Treatment of AIDS Program. The plasma concentration of IL-17 before and after treatment was measured with ***: Compared with the Smecta~? group, the XLKC group had a significantly reduced frequency of diarrhea and HRD symptom score regarding the quality and shape of stools(P < 0.05). The IL-17 concentration in the peripheral blood of the XLKC group was significantly increased after treatment,while the IL-17 concentration in the Smecta~? group significantly decreased after ***: XLKC improves the symptoms of patients with HRD, and increases the plasma concentration of IL-17.

关键词： HIV Acquired immunodeficiency syndrome Diarrhea Interleukin-17 Xielikang capsules

基于特征筛选的综合能源系统多元负荷日前-日内预测

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综合智慧能源 2024年第3期46卷 45-53页

作者：徐聪胡永锋张爱平由长福中国华电科工集团有限公司北京100160 清华大学能源与动力工程系北京100084

负荷预测是指导综合能源系统调度与运行的前提。为更加经济高效地实施系统日前计划、日内优化,提出一种基于特征筛选的多元负荷日前-日内预测方法。首先,结合特征工程中3类特征筛选方法筛选预测模型输入特征,简化模型的同时能够保存下... 详细信息

负荷预测是指导综合能源系统调度与运行的前提。为更加经济高效地实施系统日前计划、日内优化,提出一种基于特征筛选的多元负荷日前-日内预测方法。首先,结合特征工程中3类特征筛选方法筛选预测模型输入特征,简化模型的同时能够保存下最重要的特征,针对日前-日内预测策略分别确立输入特征集;然后通过多任务学习硬共享机制,采用长短期记忆神经网络建立预测模型,实现不同子任务信息共享,并通过随机搜索方法优化网络参数以提高预测精度;最后以北京某产业园区供暖季电、热负荷为案例进行分析,日前、日内预测综合精度分别达到91.3%和95.2%。分析结果表明,该预测方法能够为系统日前调度和日内运行优化提供良好支撑,且预测结果优于未经特征筛选预测和单独负荷预测,证明了该预测方法具有更高的预测精度。

关键词：综合能源系统多元负荷特征筛选日前-日内预测多任务学习长短期记忆神经网络

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挤压镁-镓-锌合金微观组织与力学性能

内蒙古工业大学学报（自然科学版） 2024年第5期43卷 417-424页

作者：朱亚慧潘晨韵未欣悦张爱平张宇重庆大学材料科学与工程学院重庆400044

镁-镓(Mg-Ga)合金是一种新型的可时效硬化型合金。在Mg-Ga合金的基础上添加少量锌(Zn),通过熔炼和热挤压,综合采用扫描电子显微镜、电子背散射衍射、透射电子显微镜、室温拉伸等表征测试手段,研究了挤压Mg-Ga-Zn合金的微观组织及力学性... 详细信息

镁-镓(Mg-Ga)合金是一种新型的可时效硬化型合金。在Mg-Ga合金的基础上添加少量锌(Zn),通过熔炼和热挤压,综合采用扫描电子显微镜、电子背散射衍射、透射电子显微镜、室温拉伸等表征测试手段,研究了挤压Mg-Ga-Zn合金的微观组织及力学性能。研究发现,挤压后Mg-7.6Ga wt.%和Mg-7.6Ga-1.7Zn wt.%合金具有完全再结晶组织,晶粒大小分别为51μm和38μm,表明添加Zn元素可以显著细化晶粒。通过电子背散射衍射表征,挤压态Mg-7.6Ga和Mg-7.6Ga-1.7Zn合金具有强基面织构,即[0001]α垂直于挤压方向。时效后,两种合金的硬度都明显上升。通过扫描透射电子显微分析表征,在两种合金的基体中可观察到棒状析出相,并且添加Zn可明显地增加析出相数密度。室温拉伸测试表明,挤压态Mg-7.6Ga合金的屈服强度、抗拉强度和断裂延伸率分别为118 MPa,225 MPa和25%;添加Zn后,Mg-7.6Ga-1.7Zn合金的力学性能明显提升,屈服强度、抗拉强度和断裂延伸率分别为131 MPa、250 MPa和22%。

关键词：镁-镓-锌合金挤压成型微观组织力学性能

DNA-mediated coordinative assembly of upconversion hetero-nanostructures for targeted dual-modality imaging of cancer cells

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Chinese Chemical Letters 2019年第4期30卷 899-902页

作者： Wenting Xue Zhenghan Di Ya Zhao aiping zhang Lele Li College of Pharmacy Shanxi Medical University CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology University of Chinese Academy of Sciences

superstructures has enormous potential in material sciences and engineering. Despite the potential,controlled assembly of different kinds of NPs into spatially addressable hybrid configurations still remains a formidable challenge. Herein, we report a simple and universal strategy for DNA-mediated assembly of CdTe quantum dots(QDs) and lanthanide-doped upconversion nanoparticles(UCNPs). Such DNA-QD/UCNPs heterostructures not only maintains both fluorescent properties of QDs and upconversion luminescence behaviors of UCNPs, but also offers a polyvalent DNA surface, allowing for targeted dual-modality imaging of cancer cells using an aptamer. The hetero-assembly mediated by the DNA à inorganic interfacial interaction may provide a scalable way to fabricate hybrid superstructures of both theoretical and practical interests.

关键词： Bioimaging Upconversion nanoparticles Self-assembly Quantum dots Cancer targeting