DNA-mediated coordinative assembly of upconversion hetero-nanostructures for targeted dual-modality imaging of cancer cells

作     者：Wenting Xue Zhenghan Di Ya Zhao Aiping Zhang Lele Li 

作者机构：College of Pharmacy Shanxi Medical University CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology University of Chinese Academy of Sciences 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2019年第30卷第4期

页      面：899-902页

核心收录：

学科分类：07[理学] 0703[理学-化学] 

基　　金：supported financially by the National Natural Science Foundation of China (Nos. 21822401, 21771044) the Young Thousand Talented Program 

主　　题：Bioimaging Upconversion nanoparticles Self-assembly Quantum dots Cancer targeting 

摘      要：superstructures has enormous potential in material sciences and engineering. Despite the potential,controlled assembly of different kinds of NPs into spatially addressable hybrid configurations still remains a formidable challenge. Herein, we report a simple and universal strategy for DNA-mediated assembly of CdTe quantum dots(QDs) and lanthanide-doped upconversion nanoparticles(UCNPs). Such DNA-QD/UCNPs heterostructures not only maintains both fluorescent properties of QDs and upconversion luminescence behaviors of UCNPs, but also offers a polyvalent DNA surface, allowing for targeted dual-modality imaging of cancer cells using an aptamer. The hetero-assembly mediated by the DNA à inorganic interfacial interaction may provide a scalable way to fabricate hybrid superstructures of both theoretical and practical interests.