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Protection Effect of Qiwei Jingganling on Carbon Tetrachloride-induced Acute Liver Injury in Mice

Medicinal Plant 2018年第3期9卷 44-46,50页

作者： Boting XI Houkang CAO Simao HUANG yuman GUAN Kefeng zhang Guilin Medical University

[Objectives] The aim was to study the protection effect of Qiwei Jingganling on carbon tetrachloride-induced acute liver injury in mice and its mechanism of action. [Methods]Total 60 mice were randomly and evenly divided into 6 groups,normal group,model group,silymarin group( 150 mg/kg),high-dose Qiwei Jingganling group( 8 g/kg,crude drug),middle-dose Qiwei Jingganling group( 4 g/kg,crude drug) and low-dose Qiwei Jingganling group( 2 g/kg,crude drug). The mice were administered orally once a day according to the amount of10 m L/kg,and 10-day continuous administration was carried out. After 2 h of the last administration,0. 12% CCl4 peanut oil solution( 10 m L/kg) was injected intraperitoneally to all the mice except those in the normal group to establish acute liver injury model. After 16 h,the blood of the mice was collected from the eyeballs,and their liver tissues were collected. The levels of alanine aminotransferase( ALT),aspartate aminotransferase( AST),superoxide dismutase( SOD),malondialdehyde( MDA) and glutathione peroxidase( GSH-Px) in the sera were determined by biochemical methods,and the contents of tumor necrosis factor-α( TNF-α),interleukin-1β( IL-1β) and interleukin-6( IL-6) in the liver tissues were determined with enzyme-linked immunosorbent assays( ELISA). [Results]Qiwei Jingganling significantly reduced the activities or content of ALT,AST and MDA in serum of mice with liver injury( P < 0. 05,P < 0. 01),increased the activities of SPD and GSH-Px( P < 0. 05,P < 0. 01) and down-regulated the expression levels of IL-1β,IL-6 and TNF-α in liver tissue( P < 0. 05,P < 0. 01).[Conclusions]Qiwei Jingganling has a good protection effect on CCl4-induced acute liver injury in mice,which may be related to the inhibition of oxidative stress and inhibition of inflammatory responses.

关键词： Qiwei Jingganling Acute liver injury Carbon tetrachloride Oxidative stress Inflammatory response

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Based on network pharmacology to explore the mechanism of nephrotoxicity of Xanthii Fructus

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Asian Toxicology Research 2022年第1期4卷 24-31页

作者： Tao Chen Tengda Li Wenna zhang Yulin Song yuman Tang Rui Gong Hua Jin Nankai University Hospital Tianjin300071China Tianjin University of Traditional Chinese Medicine Tianjin301617China Chinese Medicine College Tianjin University of Traditional Chinese MedicineTianjin301617China

Objective:To explore the potential mechanism of nephrotoxicity induced by Xanthii Fructus(XF)through network ***:The active ingredients and targets of XF were screened through Traditional Chinese Medicine Systems Pharmacology Database,PubChem Database and Swiss Target Prediction Database,and the related pathogenic genes of nephrotoxicity were downloaded from Genecards,pharmGKB and OMIM *** potential target is the intersection of XF and the pathogenic gene of *** software was used to construct a network of“XF-Potential active ingredient-Target-Nephrotoxicity network”.Protein protein interaction(PPI)network was constructed by String database,and the data was analyzed and sorted out to obtain the key active components and core target proteins of *** functional enrichment analysis and KEGG pathway enrichment analysis of key target proteins were performed by R ***:11 active components,167 targets,6839 nephrotoxicity related pathogenic genes and 139 intersection target genes were screened from *** constructing the network of“XF-Potential active ingredient-target-nephrotoxicity network”and PPI network,the key active ingredients of XF were identified as Moupinamide,Beta-sitosterol and Stigmasterol,and the core target proteins were CASP3,HSP90AA1 and *** were 2072 GO entries(P<0.05),including 1876 Biological Process(BP),64 Cellular Component(CC)and 132 Molecular Function(MF).KEGG enrichment analysis revealed 138 pathways(P<0.05),mainly involving p53 signaling pathway,IL-17 signaling pathway,PI3K-Akt signaling pathway were strongly correlated with the nephrotoxicity of ***:The core target protein of XF HSP90AA1,CASP3 and TP53 participate in p53 signaling Pathway,PI3K-Akt signaling Pathway,IL-17 signaling Pathway and other pathways to regulate apoptosis and induce inflammatory responses,resulting in kidney damage.

关键词： Network pharmacology Nephrotoxicity Inflammatory responses Apoptosis

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Congenital Left Atrial Appendage Aneurysm:Diagnosis and Management

Congenital Left Atrial Appendage Aneurysm:Diagnosis and Mana...

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中国超声医学工程学会第十四届全国超声心动图学术会议

作者： Bin Wang He Li Li zhang yuman Li Lin He MingXing Xie Department of Ultrasound Union HospitalTongji Medical CollegeHuazhong University of Science and Technology

Objective:Aneurysm of the left atrial appendage is *** sought to review the published literature on left atrial appendage aneurysm(LAAA) to address its epidemiology,pathology,clinical symptoms,diagnosis and management Methods:We reviewed PubMed from 1962 to 2016 to find relevant LAAA cases using medical subject heading(MESH) terms "atrial appendage" and "aneurysm" as search *** analysis was done using Minitab 17.0 Results:One hundred and one cases of LAAA were *** symptoms do not arise until the second to the fourth decades of ***,dyspnea and chest pain were common clinical *** is considered to be the primary method of *** imaging modalities such as cardiac computed tomography(CT) and magnetic resonance imaging(MRI) are useful for ruling out the differential *** treatment is often recommended even in asymptomatic patients for prevention the thromboembolic ***-four patients(73.2%)reported in the literatures were treated by surgical *** prognosis is favorable,for freedom from recurrent symptoms and arrhythmia has been reported from 10 days to 8 years ***:Echocardiography is considered the initial diagnostic tool for *** associated high risk of life-threatening complications and the relative ease of surgical removal suggest that prompt evaluation should be considered in patients with lesions adjacent to the left heart border.

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Deep learning models for automatic classification ofechocardiographic views

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中国医学影像技术 2024年第8期40卷 1124-1129页

作者： CHEN Wenwen ZHU Ye zhang Yiwei WU Chun LI yuman zhang Ziming SUN Zhenxing XIE Mingxing zhang Li Department of Ultrasound Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Clinical Research Center for Medical Imaging in Hubei Province Wuhan 430022China Hubei Province Key Laboratory of Molecular Imaging Wuhan 430022China

Objective To observe the value of deep learning (DL) models for automatic classification of echocardiographic views. Methods Totally 100 patients after heart transplantation were retrospectively enrolled and divided into training set, validation set and test set at a ratio of 7 ∶ 2 ∶ 1. ResNet18, ResNet34, Swin Transformer and Swin Transformer V2 models were established based on 2D apical two chamber view, 2D apical three chamber view, 2D apical four chamber view, 2D subcostal view, parasternal long-axis view of left ventricle, short-axis view of great arteries, short-axis view of apex of left ventricle, short-axis view of papillary muscle of left ventricle, short-axis view of mitral valve of left ventricle, also 3D and CDFI views of echocardiography. The accuracy, precision, recall, F1 score and confusion matrix were used to evaluate the performance of each model for automatically classifying echocardiographic views. The interactive interface was designed based on Qt Designer software and deployed on the desktop. Results The performance of models for automatically classifying echocardiographic views in test set were all good, with relatively poor performance for 2D short-axis view of left ventricle and superior performance for 3D and CDFI views. Swin Transformer V2 was the optimal model for automatically classifying echocardiographic views, with high accuracy, precision, recall and F1 score was 92.56%, 89.01%, 89.97% and 89.31%, respectively, which also had the highest diagonal value in confusion matrix and showed the best classification effect on various views in t-SNE figure. Conclusion DL model had good performance for automatically classifying echocardiographic views, especially Swin Transformer V2 model had the best performance. Using interactive classification interface could improve the interpretability of prediction results to some extent.

关键词： heart transplantation echocardiography deep learning

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考虑后退行波的长初级双边直线感应电机电磁性能计算

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电工技术学报 2020年第7期35卷 1398-1409页

作者：张千刘慧娟马杰芳李雨蔓北京交通大学电气工程学院北京100044 中国科学院空间应用工程与技术中心北京100094

根据一维电磁场理论建立以次级板为运动参考坐标系的长初级双边直线感应电机(DLIM)解析模型。首先推导气隙磁通密度在实数域的表达式,分析端部效应引起的前进和后退行波磁场的时空分布特点及其对基波气隙磁场的影响;然后推导考虑前进和... 详细信息

根据一维电磁场理论建立以次级板为运动参考坐标系的长初级双边直线感应电机(DLIM)解析模型。首先推导气隙磁通密度在实数域的表达式,分析端部效应引起的前进和后退行波磁场的时空分布特点及其对基波气隙磁场的影响;然后推导考虑前进和后退行波磁场的电机推力密度和稳态推力表达式,分析推力密度在次级板纵向的分布特点、各电磁推力分量随速度的分布特征以及端部效应对总电磁推力的影响;最后建立电机的有限元模型,对电机的气隙磁场分布和不同频率下推力特性进行计算,并与解析计算的结果对比,证实解析计算方法的准确性,为长初级DLIM的初始设计和后续优化提供理论依据和方法。

关键词：双边直线感应电机后退行波解析法电磁性能端部效应

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基于WLCS-ALA模型的建设项目投资估算研究

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铁道学报 2016年第7期38卷 117-123页

作者：段晓晨吕倩张小平王玉满石家庄铁道大学经济管理学院河北石家庄050043 河北地质大学河北石家庄050031

当前建设项目投资迅速增长,为我国国民经济发展提供了良好环境,但投资控制情况不甚理想。主要原因是现行的造价估算方法多采用线性方法,准确性较低,并不能反映出造价和影响因素之间的不确定性和非线性关系。人工生命进化算法具有较高的... 详细信息

当前建设项目投资迅速增长,为我国国民经济发展提供了良好环境,但投资控制情况不甚理想。主要原因是现行的造价估算方法多采用线性方法,准确性较低,并不能反映出造价和影响因素之间的不确定性和非线性关系。人工生命进化算法具有较高的全范围搜寻能力,通过迭代可以获得较精确的全局优化值,其具有的不确定性、非线性、自组织、自学习、自进化等特征能够有效拟合投资估算复杂系统。结合全生命显著性造价理论和人工生命进化算法理论,建立WLCS-ALA模型,尝试将人工生命算法应用于造价投资预测问题,运用全生命显著性造价模型(WLCS)简化数据处理量,通过计算与拟建项目类似的已完工程的显著性造价历史数据,建立显著性成本项目(CSIs)和显著性因子数据序列,采用人工生命算法(ALA)进行数据优化,寻求优化造价。通过案例实证分析,采用WLCS-ALA模型估算的单位造价精确度远高于传统方法,说明在投资决策领域应用人工生命进化方法会使投资预测更加精确,从而验证了本模型的有效性和准确性。

关键词：投资估算显著性项目 WLCS 显著性因子人工生命算法

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Multi-objective optimization of three mechanical properties of Mg alloys through machine learning

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Materials Genome Engineering Advances 2024年第3期2卷 83-95页

作者： Wei Gou zhang-Zhi Shi yuman Zhu Xin-Fu Gu Fu-Zhi Dai Xing-Yu Gao Lu-Ning Wang State Key Laboratory for Advance Metals and Materials Beijing Advanced Innovation Center for Materials Genome EngineeringSchool of Materials Science and EngineeringUniversity of Science and Technology BeijingBeijingChina Institute of Materials Intelligent Technology Liaoning Academy of MaterialsShenyangChina Department of Materials Science and Engineering Monash UniversityClaytonVictoriaAustralia Institute of Microelectronics Chinese Academy of SciencesBeijingChina

Conventional trial-and-error method is usually time-consuming and expensive for multi-objective optimization of Mg *** machine learning exhibits great potential to accelerate related research studies,machine learning prediction of properties of Mg alloys is often a prediction of a single target at a *** address this,this paper integrates non-dominated sorting genetic algorithm III multiobjective optimization algorithm with light gradient boosting machine algorithm to simultaneously optimize yield strength,ultimate tensile strength,and elongation of Mg *** is the first time that simultaneous machine learning optimization of these three objectives has been achieved for Mg alloys.

关键词： alloy design machine learning Mg alloys multi-objective optimization

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双边型长初级直线感应电机电磁推力特性研究

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中国电机工程学报 2019年第S1期39卷 268-277页

作者：刘慧娟马杰芳张千李雨蔓北京交通大学电气工程学院北京市海淀区100044 中国科学院空间应用工程与技术中心北京市海淀区100094

针对电磁弹射及空间实验系统用双边型长初级直线感应电机(double sided long primary linear induction motor,DSLPLIM)的电磁推力特性,首先根据电磁场理论,通过对初级行波电流层和次级电流的微分运算,推导出计及端部效应的直线感应电... 详细信息

针对电磁弹射及空间实验系统用双边型长初级直线感应电机(double sided long primary linear induction motor,DSLPLIM)的电磁推力特性,首先根据电磁场理论,通过对初级行波电流层和次级电流的微分运算,推导出计及端部效应的直线感应电机气隙磁密的解析表达式,同时,依据洛伦兹力公式,推导出直线感应电机平均电磁推力的解析计算表达式;其次,为削弱端部效应引起的推力波动,采用发卡式全填充绕组以改善直线感应电机气隙磁密分布的正弦性(减小推力波动),同时为提升电机的电磁推力,改进现有次级板开槽结构,实现涡流路径的优化;最后,针对发卡式绕组和次级板开槽2种改进,利用推导的解析计算公式和3D有限元仿真软件,分别计算双边型直线感应电机的气隙磁密分布和电磁推力特性曲线。对比分析表明:发卡式全填充绕组的使用不仅能削弱直线感应电机的推力波动,还能有效提升电磁推力的大小,提高直线感应电机的运行性能;改进次级开槽结构可有效提升电机的电磁推力,增大推力密度。

关键词：双边型长初级直线感应电机端部效应气隙磁密电磁推力推力波动

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蛇纹石物相X射线衍射定量分析精密度评估方法的探讨

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岩矿测试 2023年第3期42卷 513-522页

作者：张梅蔡玉曼肖灵王禄彬江苏省地质调查研究院江苏南京210018

蛇纹石是一种重要的矿物材料和化工原料,广泛应用于化工、农业、建材、冶金及环保等领域,中国由于对蛇纹石矿开采品位要求较高,形成了较多的弃尾矿,造成了大量的浪费和环境污染。根据弃尾矿中蛇纹石的不同含量,进而生产不同的工业产品,... 详细信息

蛇纹石是一种重要的矿物材料和化工原料,广泛应用于化工、农业、建材、冶金及环保等领域,中国由于对蛇纹石矿开采品位要求较高,形成了较多的弃尾矿,造成了大量的浪费和环境污染。根据弃尾矿中蛇纹石的不同含量,进而生产不同的工业产品,可改善生态环境,为蛇纹石企业寻求到新的发展出路。这些工作的基础是能够对蛇纹石进行快速和精确的测定。目前蛇纹石矿石的测定方法采用行业标准《蛇纹石矿石分析方法》(HG/T 3575—2006)进行,其分析步骤繁琐,分析时间过长,现有的检测方法已不能满足市场和企业的急需,而长期以来利用X射线衍射进行的蛇纹石定量分析,其分析方法的精密度一直没有得到规范的量化控制,实验室之间的精密度比对也缺乏相应的依据。为进一步提高X射线衍射法检测蛇纹石矿物含量的水平,本文根据GB/T 6379.2—2004标准中的要求,首先通过挑选加配制共10个不同含量的样品,进行均匀性检验,当检测结果F_(实测值)均小于F_(临界值),表明试验样品是均匀的,然后选择8家实验室使用检验后合格的样品进行精密度协作试验,对得到的测试结果进行格拉布斯检验和柯克伦检验,通过检验的数据才能参与精密度参数的计算,最终获得X射线衍射标准曲线法和K值法的精密度与含量之间的数学函数关系。实验结果表明:本次协作试验的数据,全部通过格拉布斯检验和柯克伦检验,均可参与精密度参数的计算,结果也侧面证明了不同实验室不同仪器测试的结果一致性较高。精密度参数的计算结果显示:在X射线衍射标准曲线法和K值法重复性限和再现性限数据中,含量最低的样品,其重复性限和再现性限也最小,验证了X射线衍射对物相定量分析的误差主要源自于样品的均匀性误差这一特征。证实了在所有影响X射线衍射定量分析结果的因素中,样品的均匀性是最关键的因素,而其他因素产生的影响可用改变测试条件等相应方法来克服。只要样品足够均匀,就能将定量分析的误差限定在可控范围内。本文针对蛇纹石物相定量分析方法精密度的研究,可为蛇纹石物相定量分析标准方法的建立和分析方法的评价及分析质量的监控等提供依据。

关键词：蛇纹石 X射线衍射法物相定量分析精密度协作实验重复性限再现性限

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基于改进的岩石物理模型表征页岩天然裂缝特征

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天然气工业 2021年第2期41卷 56-64页

作者：管全中董大忠张华玲张素荣吕修祥王玉满成都理工大学能源学院中国石油勘探开发研究院 University of Houston 中国石油大学(北京)

为了给四川盆地下志留统龙马溪组页岩气勘探开发提供技术支撑,以长宁、涪陵2个页岩气田的龙马溪组为研究对象,利用氦气法、X射线衍射、真密度测试等方法,借助改进的岩石物理模型,定量表征了龙马溪组页岩中天然裂缝的发育特征,并探讨了... 详细信息

为了给四川盆地下志留统龙马溪组页岩气勘探开发提供技术支撑,以长宁、涪陵2个页岩气田的龙马溪组为研究对象,利用氦气法、X射线衍射、真密度测试等方法,借助改进的岩石物理模型,定量表征了龙马溪组页岩中天然裂缝的发育特征,并探讨了天然裂缝的发育类型、成因机制以及对页岩气开发的影响。研究结果表明:①运用改进的岩石物理模型可以精确刻画长宁页岩气田页岩孔隙系统,拟合度达0.74;②页岩中天然裂缝的发育具有区域控制因素的差异性,其中长宁页岩气田裂缝局部限制发育,钙质充填,裂缝孔隙平均值为0.15%,由基底逆冲断层、滑脱层和内部褶皱作用控制,而涪陵页岩气田裂缝则普遍较发育,硅质未充填或半充填,裂缝孔隙平均值为1.30%,主要受控于逆断层和滑脱作用;③地层条件下,天然裂缝的开启性存在着差异,长宁页岩气田基本处于封闭状态、渗流能力弱,而涪陵页岩气田则处于相对开启状态、渗流能力强;④天然裂缝影响页岩气的赋存方式,内部以游离气为主体,页岩气井的初始产气量相对较高。结论认为:①引进回归系数计算现今实际的总有机质含量,使得改进的岩石物理模型能够更加精确地刻画基质孔隙和裂缝孔隙;②四川盆地页岩产层段中天然裂缝发育对页岩气富集与开采相对有利,但原始地层条件下会削弱天然裂缝的渗流能力。

关键词：四川盆地长宁页岩气田涪陵页岩气田下志留统龙马溪组岩石物理模型回归系数天然裂缝游离气含量

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