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An Analysis and Simulation of Failure in Dower Connectors

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The Journal of China Universities of Posts and Telecommunications 2002年第3期9卷 79-80页

作者： LUO Guo ping directed by zhang ji gao

Power connector, as one kind of fittings, is used to connect power equipmentto conductor, conductor to wire or wire to wire in power lines. Owing to its simple structure, easyinstallation and low cost, bolt-type power connector-parallel groove clamp is widely used inoverhead power transmission and distribution line. However, owing to high current load and harshenvironment in China, there are still some problems in application of this kind of connector. So,some failure connectors replaced from domestic overhead power lines are collected. The main reasonsthe failure are given out through investigation into residual contact force, connection resistance,substrate quality, makeup, condition of contact interface and installation, manufacture techniqueetc. Then, the current test on parallel groove clamps is carried out and finite element method isused to simulate its failure process.

关键词： power connector analysis of failure parallel groove clump finite element simulation

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战斗机气动布局划分

空气动力学学报 2009年第5期27卷 616-622页

作者：张继高北京航空航天大学航空科学与工程学院北京100191

战斗机气动布局的类别,没有统一标准,分类众多。本文在归纳战斗机气动布局划分的基础上,提出目前可将战斗机气动布局划分成5种形式。

关键词：气动布局常规布局鸭式布局三翼面布局飞翼布局

Mechanism of thalidomide to enhance cytotoxicity of temozolomide in U251-MG glioma cells in vitro

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Chinese Medical Journal 2009年第11期122卷 1260-1266页

作者： gao Song YANG Xue-jun zhang Wen-gao ji Yan-wei PAN Qiang Department of Neurosurgery Tianjin Medical University General Hospital Tianjin 300052 China

Background Glioma is the most common primary brain tumor with poor prognosis. Temozolomide has been used with thalidomide to treat gliomas. We investigated the synergistic mechanism of these two drugs in vitro. Methods Human malignant glioma cells U251-MG were cultured and assigned to four groups with different treatments for 3 days： temozolomide group （100 μmol/L）, thalidomide group （100 μg/L）, temozolomide （100 μmol/L） plus thalidomide group （100 μg/L） and control group. MTT assay was applied to evaluate the cell viability. Cell cycle was analyzed by flow cytometry. The ultra-structural features of autophagosomes were observed with electron microscope. Acridine orange and monodansylcadaverine were adopted to label autophagosomes and flow cytometry was applied for quantification of autophagosomes. The expression of autophagy-associated protein was detected by Western blotting. Results Proliferation of tumor cell was obviously suppressed by temozolomide with thalidomide treatment than by either drug used alone （P=0.000 for each day）. The combination treatment induced cell cycle arrest at G0/G1 phase. Typical autophagic ultra-structural character was found after the combined treatment. Thalidomide promoted the autophagy induced by temozolomide. The autophagy-associated proteins - microtubule associated protein 1 light chain 3 （MAP1LC3） and Beclinl were more significantly up-regulated by the combined treatment than temozolomide used alone （MAP1LC3, P=0.000; Beclinl, P=0.004）. The expression level of phosphatase and tensin homolog deleted on chromosome ten （PTEN）, which promoted autophagy by suppressing PI3K/Akt/mTOR signaling pathway, was elevated by thalidomide （thalidomide group： P=0.000; combined group： P=0.002）. Conclusions Thalidomide enhances the cytotoxicity of temozolomide by promoting the autophagy induced by temozolomide. Contributing to the up-regulation of PTEN by thalidomide, the expression of autophagy associated protein-MAP1LC3 and Beclinl was enhanced,

关键词： glioma thalidomide temozolomide autophagy

Nanomaterials-mediated lysosomal regulation:a robust protein-clearance approach for the treatment of Alzheimer’s disease

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Neural Regeneration Research 2025年第2期20卷 424-439页

作者： Mengqi Hao jianjian Chu Tinglin zhang Tong Yin Yuankai Gu Wendanqi Liang Wenbo ji jianhua Zhuang Yan Liu jie gao You Yin Department of Neurology Second Affiliated Hospital of Naval Medical University(Shanghai Changzheng Hospital)ShanghaiChina School of Health Science and Engineering University of Shanghai for Science and TechnologyShanghaiChina Changhai Clinical Research Unit Shanghai Changhai HospitalNaval Medical UniversityShanghaiChina Department of Clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Neurology Shanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina

Alzheimer’s disease is a debilitating,progressive neurodegenerative disorder characterized by the progressive accumulation of abnormal proteins,including amyloid plaques and intracellular tau tangles,primarily within the ***,crucial intracellular organelles responsible for protein degradation,play a key role in maintaining cellular *** studies have suggested a link between the dysregulation of the lysosomal system and pathogenesis of neurodegenerative diseases,including Alzheimer’s *** the normal physiological function of lysosomes hold the potential to reduce the pathological burden and improve the symptoms of Alzheimer’s ***,the efficacy of drugs in treating Alzheimer’s disease is limited,with major challenges in drug delivery efficiency and ***,nanomaterials have gained widespread use in Alzheimer’s disease drug research owing to their favorable physical and chemical *** review aims to provide a comprehensive overview of recent advances in using nanomaterials(polymeric nanomaterials,nanoemulsions,and carbon-based nanomaterials)to enhance lysosomal function in treating Alzheimer’s *** review also explores new concepts and potential therapeutic strategies for Alzheimer’s disease through the integration of nanomaterials and modulation of lysosomal *** conclusion,this review emphasizes the potential of nanomaterials in modulating lysosomal function to improve the pathological features of Alzheimer’s *** application of nanotechnology to the development of Alzheimer’s disease drugs brings new ideas and approaches for future treatment of this disease.

关键词： Alzheimer’s disease autophagy dysfunction lysosomal acidification lysosomal system nanomaterials neurodegenerative diseases

Structural and microwave absorption properties of CoFe_(2)O_(4)/residual carbon composites

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 221-232页

作者： Yuanchun zhang Shengtao gao Xingzhao zhang Dacheng Ma Chuanlei Zhu Jun He Joint National-Local Engineering Research Centre for Safe and Precise Coal Mining Anhui University of Science and TechnologyHuainan 232001China School of Chemical and Blasting Engineering Anhui University of Science and TechnologyHuainan 232001China

Electromagnetic interference,which necessitates the rapid advancement of substances with exceptional capabilities for bsorbing electromagnetic waves,is of urgent concern in contemporary *** this work,CoFe_(2)O_(4)/residual carbon from coal gasification fine slag(CFO/RC)composites were created using a novel hydrothermal *** mechanisms for microwave absorption,including conductive loss,natural resonance,interfacial dipole polarization,and magnetic flux loss,are involved in these ***,compared with pure residual carbon materials,this composite offers superior capabilities in microwave *** 7.76GHz,the CFO/RC-2 composite achieves an impressive minimum reflection loss(RL_(min))of-43.99 dB with a thickness of 2.44 ***,CFO/RC-3 demonstrates an effective absorption bandwidth(EAB)of up to 4.16 GHz,accompanied by a thickness of *** study revealed the remarkable capability of the composite to diminish electromagnetic waves,providing a new generation method for microwave absorbing materials of superior quality.

关键词： coal gasification slag residual carbon hydrothermal method microwave absorption CoFe_(2)O_(4)

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走向高抽巷抽放瓦斯技术研究

中国矿业 2012年第1期21卷 122-124页

作者：刘如铁张继高北京科技大学金属矿山高效开采与安全教育部重点实验室北京100083 河北工程大学河北邯郸056038

结合邯郸某矿的实际状况,对走向高抽巷瓦斯抽放技术进行了研究:①采用FLUENT软件对采用走向高抽巷抽放瓦斯的系统进行了数值模拟分析,确定了走向高抽巷的垂高和倾斜方向位置。②对巷道抽放瓦斯密封系统进行了改进。论文的研究为其他矿... 详细信息

结合邯郸某矿的实际状况,对走向高抽巷瓦斯抽放技术进行了研究:①采用FLUENT软件对采用走向高抽巷抽放瓦斯的系统进行了数值模拟分析,确定了走向高抽巷的垂高和倾斜方向位置。②对巷道抽放瓦斯密封系统进行了改进。论文的研究为其他矿井采用高抽巷对煤矿瓦斯进行抽放有一定参考意义。

关键词：高抽巷竖向位置倾向位置数值模拟水封式密封系统

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开采覆岩运动特征及动力响应的数值模拟研究

中国矿业 2012年第8期21卷 101-103,115页

作者：赵亚军张继高河北工程大学河北邯郸056038

以地质单元勘查研究报告为背景,应用计算机对某煤矿厚岩浆岩下煤层开采时覆岩移动规律及其动力响应进行了数值模拟分析,得到:①由于岩浆岩这种特殊岩层的存在,使采空区上覆岩层的运动规律发生变异;②岩浆岩存在时,岩体内的应力、变形及... 详细信息

以地质单元勘查研究报告为背景,应用计算机对某煤矿厚岩浆岩下煤层开采时覆岩移动规律及其动力响应进行了数值模拟分析,得到:①由于岩浆岩这种特殊岩层的存在,使采空区上覆岩层的运动规律发生变异;②岩浆岩存在时,岩体内的应力、变形及位移的变化趋势,揭示了工作面开拓过程中岩体内应力的重新分布过程、工作面支承压力和支架阻力的变异性。

关键词：厚岩浆岩数值模拟支承压力离散单元法覆岩移动

Magneto‑Dielectric Synergy and Multiscale Hierarchical Structure Design Enable Flexible Multipurpose Microwave Absorption and Infrared Stealth Compatibility

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Nano-Micro Letters 2025年第2期17卷 401-416页

作者： Chen Li Leilei Liang Baoshan zhang Yi Yang Guangbin ji School of Electronic Science and Engineering Nanjing UniversityNanjing 210093People’s Republic of China College of Materials Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 210016People’s Republic of China

Developing advanced stealth devices to cope with radar-infrared(IR)fusion detection and diverse application scenarios is increasingly demanded,which faces significant challenges due to conflicting microwave and IR cloaking mechanisms and functional integration ***,we propose a multiscale hierarchical structure design,integrating wrinkled MXene IR shielding layer and flexible Fe_(3)O_(4)@C/PDMS microwave absorption *** top wrinkled MXene layer induces the intensive diffuse reflection effect,shielding IR radiation signals while allowing microwave to pass ***,the permeable microwaves are assimilated into the bottom Fe_(3)O_(4)@C/PDMS layer via strong magneto-electric *** theoretical and experimental optimization,the assembled stealth devices realize a near-perfect stealth capability in both X-band(8–12 GHz)and long-wave infrared(8–14μm)wavelength ***,it delivers a radar cross-section reduction of−20 dB m^(2),a large apparent temperature modulation range(ΔT=70℃),and a low average IR emissivity of ***,the optimal device demonstrates exceptional curved surface conformability,self-cleaning capability(contact angle≈129°),and abrasion resistance(recovery time≈5 s).This design strategy promotes the development of multispectral stealth technology and reinforces its applicability and durability in complex and hostile environments.

关键词： Microwave absorption Radar-infrared compatible stealth Wrinkled MXene Magneto-dielectric synergy Multifunction

岑巩页岩气区块牛蹄塘组黑色页岩稀土元素地球化学特征及沉积环境分析

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矿物岩石 2016年第4期36卷 66-73页

作者：毛瑞勇张杰冷济高李鹏王沙贵州大学矿业学院贵州贵阳550025 贵州省非金属矿产资源综合利用重点实验室贵州贵阳550025 铜仁中能天然气有限公司贵州铜仁554300

岑巩页岩气区块发育牛蹄塘组黑色页岩是一套优质烃源岩,是我国页岩气勘探开发亟待突破的重点层系之一。对该套黑色页岩采用电感耦合等离子体质谱仪(ICPMS)进行稀土元素(REE)测试分析,以揭示黑色页岩沉积环境。结果表明:总体上稀土元素... 详细信息

岑巩页岩气区块发育牛蹄塘组黑色页岩是一套优质烃源岩,是我国页岩气勘探开发亟待突破的重点层系之一。对该套黑色页岩采用电感耦合等离子体质谱仪(ICPMS)进行稀土元素(REE)测试分析,以揭示黑色页岩沉积环境。结果表明:总体上稀土元素总量较低(ΣREE为72.64×10^(-6)~156.98×10^(-6)),LREE相对富集(LREE/HREE为5.22~11.8),铕负异常较显著(δEu为0.40~0.58),铈呈弱负异常(δCe为0.74~0.98)。研究区黑色页岩母岩为先期沉积岩,形成于被动大陆边缘的相对较深的浅海斜坡环境;在早寒武世曾发生过一次明显的海侵-海退过程;沉积时水体为弱还原缺氧环境,沉积过程中有一个短暂的充氧期;沉积过程受到较强的热水作用的影响,上部和下部沉积速率低于中部;黑色页岩有机碳含量(TOC)与ΣREE存在较为明显的负相关性。对岑巩页岩气区块牛蹄塘组黑色页岩稀土元素地球化学分析,可为该区块进一步开展页岩气勘探开发工作提供参考。

关键词：牛蹄塘组黑色页岩稀土元素地球化学沉积环境