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Reliability-Based Optimum Design of a Simple Offshore Platform Based on Genetic Algorithms

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China Ocean Engineering 1998年第1期13卷 43-52页

作者： zhang, ly Hu, YC Li, XJ Tianjin Univ Dept Ocean Engn & Naval Architecture Tianjin 300072 Peoples R China

In this paper, the problem of reliability-based optimal design of simple offshore platform is studied, and a nonlinear fatigue damage model based on damage mechanics and genetic algorithms are used in the fatigue reliability optimum design of the structure under stochastic wave load. The fatigue damage model and the yield failure reliability analyzing model are used in the paper. The reliability of the models and the effectiveness of genetic algorithm are shown by the results of optimum design.

关键词： damage mechanics genetic algorithms reliability-based optimum design fatigue reliability

Nondestructive Evaluation of Ferroelectric Multilayer Capacitors Using Electromechanical Resonances

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Journal of Materials Science & Technology 1995年第2期11卷 114-118页

作者： SUN, HT WANG, HF zhang, ly YAO, X Xi'an Jiaotong Univ Xi'an China

Under the mechanically free and clamped boundary conditions, electromechanical resonances-of ceramic multilayer capacitors are calculated using vibration and piezoelectric equations. Multilayer capacitors made of ferroelectric BaTiO3 and Pb(Mp(1/3)Nb(2/3))O-3 ceramics have been used to examine the theoretical calculation. Frequency spectra of impedance and phase angle, capacitance and loss tangent of the capacitors under de bias fields are carefully measured. A sudden change around the resonant frequency is observed in these spectra. A damped resonance indicates a defective capacitor while an undamped resonance is corresponding to defect free. Experimental results suggest that it is possible to use the spectra as a real time nondestructive evaluation method.

关键词： Capacitors

Interface effect on the giant magnetoresistance for different magnetic multilayers systems

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Chinese Science Bulletin 1997年第9期42卷 729-733页

作者： zhang, ly Sun, H Li, BZ Pu, FK Institute of Physics Chinese Academy of Sciences Beijing China State Key Laboratory of Molecular Reaction Dynamics Institute of Chemistry Chinese Academy of Sciences Beijing China

THE giant magnetoresistance(GMR)effect in magnetic multilayer has been the subject of in-tense investigation since its *** theories,including semiclassical theoryand quantum theory,have been developed to deal with the... 详细信息

关键词： magnetic multilayer interface effect giant magnetoresistance Anderson model.

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2型糖尿病的运动疗法及新进展

中国组织工程研究与临床康复 2007年第45期11卷 9201-9203页

作者：张凌云殷长春肇庆医学高等专科学校护理教研室广东省肇庆市526020 肇庆医学高等专科学校附属医院内科广东省肇庆市526020

目的:总结近年来2型糖尿病运动疗法的研究进展。资料来源:应用计算机检索American Diabetes Association(http://***/***)2005/2007的相关文章,检索词"Type2diabetes,Exercise therapy",限定文章语言为English。并应用计算机检索中国期刊全文数据库2001-01/2006-12期间的相关文章,检索词"糖尿病的运动疗法",限定文章语言为中文。并手工检索1995-01/2006-12相关专著。资料选择:对资料进行初审,选取与2型糖尿病运动疗法有关的文献。纳入标准:①随机对照研究。②试验包含平行对照组,即饮食控制+药物治疗组。③治疗组为在饮食控制+药物治疗基础上实施运动疗法组。排除综述及重复性研究。资料提炼:共检索到130篇文献,符合纳入标准的30篇,排除5篇重复性研究,2篇meta分析研究。资料综合:①中等强度的有氧耐力运动能够调节糖代谢,降低血糖,增强胰岛素敏感性,延缓糖尿病并发症的发生发展,控制肥胖,降低血脂,提高机体适应性。②运动疗法适用于糖耐量低减、血糖控制良好且无严重并发症的糖尿病患者;运动前应进行必要的检查,以明确能否进行运动疗法。③运动项目因病情不同而异,病情轻者可进行较高强度的运动,病情重者进行较低强度的运动,合适的运动时间为餐后60～90min,运动前后应做好准备活动和整理活动,运动应遵循循序渐进的原则。结论:运动疗法是2型糖尿病的一种行之有效的治疗方法,并能预防、控制2型糖尿病的发生发展,在临床工作中应该得到足够的重视和普及。

关键词： 2型糖尿病运动疗法生理作用适应证禁忌证

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阿德福韦在乙型肝炎中的应用现状

世界华人消化杂志 2005年第1期13卷 61-63页

作者：党晓燕成军邓红张黎颖中国人民解放军第302医院传染病研究所基因治疗研究中心北京市100039 西安交通大学第二医院传染科陕西省西安市710004

0引言乙型肝炎病毒(HBV)不仅可形成急、慢性病毒性肝炎,而且与肝纤维化、肝细胞癌的发生、发展密切相关.目前对慢性乙型肝炎有两种基本的治疗方法,一种是免疫激活治疗如干扰素,另一种是抑制病毒复制如核苷类似物.阿德福韦作为一种新的抗... 详细信息

0引言乙型肝炎病毒(HBV)不仅可形成急、慢性病毒性肝炎,而且与肝纤维化、肝细胞癌的发生、发展密切相关.目前对慢性乙型肝炎有两种基本的治疗方法,一种是免疫激活治疗如干扰素,另一种是抑制病毒复制如核苷类似物.阿德福韦作为一种新的抗HBV感染的核苷酸类似物已经于2002-09经FDA批准在美国上市,目前在我国正在进行3期临床实验.本文就阿德福韦的研究现状及临床观察作一综述.

关键词：阿德福韦慢性乙型肝炎治疗 FDA批准核苷酸类似物抗HBV 乙型肝炎病毒引言中国美国

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温热治疗肿瘤的基础研究进展

世界华人消化杂志 2006年第17期14卷 1726-1730页

作者：张安平刘宝华张连阳第三军医大学大坪医院野战外科研究所普通外科重庆市400042

在肿瘤治疗学中,温热治疗是指运用不同方法对恶性肿瘤进行热治疗,他常与放疗、化疗联用,肿瘤的温度常在40-43℃．现综述温热治疗的细胞死亡、体内温热治疗的特征以及温热治疗的效应器等方面的研究进展．

关键词：温热治疗温热敏感性效应器

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乙型肝炎核心启动子的研究进展

世界华人消化杂志 2005年第8期13卷 933-936页

作者：高学松成军甄真郭江张黎颖北京地坛医院传染病研究所北京市100011 河北医科大学第三医院感染科河北省石家庄市050051

乙型肝炎病毒(HBV)核心启动子(CP)与病毒复制、转录及疾病的关系密切,近年来国内外对核心启动子的结构、功能进行了广泛的研究,但目前研究的热点集中在核心启动子变异后的生物学活性改变以及与治疗的关系等方面,本文就其研究进展作一综述.

关键词：乙型肝炎核心启动子研究进展乙型肝炎病毒

Glucocorticoid receptor signaling in the brain and its involvement in cognitive function

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Neural Regeneration Research 2025年第9期20卷 2520-2537页

作者： Chonglin Su Taiqi Huang Meiyu zhang Yanyu zhang Yan Zeng Xingxing Chen Brain Science and Advanced Technology Institute Hubei Province Key Laboratory of Occupational Hazard Identification and ControlSchool of MedicineWuhan University of Science and TechnologyWuhanHubei ProvinceChina

The hypothalamic-pituitary-adrenal axis regulates the secretion of glucoco rticoids in response to environmental *** the brain,a nuclear receptor transcription fa ctor,the glucocorticoid recepto r,is an important component of the hypothalamicpituitary-a d renal axis's negative feedback loop and plays a key role in regulating cognitive equilibrium and *** glucoco rticoid receptor influences cognitive processes,including glutamate neurotransmission,calcium signaling,and the activation of brain-derived neurotrophic factor-mediated pathways,through a combination of genomic and non-genomic *** interactions within the central nervous system can alter the expression and activity of the glucocorticoid receptor,there by affecting the hypothalamic-pituitary-a d renal axis and stress-related cognitive *** appropriate level of glucocorticoid receptor expression can improve cognitive function,while excessive glucocorticoid receptors or long-term exposure to glucoco rticoids may lead to cognitive *** with cognitive impairment-associated diseases,such as Alzheimer's disease,aging,depression,Parkinson's disease,Huntington's disease,stroke,and addiction,often present with dysregulation of the hypothalamic-pituitary-adrenal axis and glucocorticoid receptor *** review provides a comprehensive overview of the functions of the glucoco rticoid receptor in the hypothalamic-pituitary-a d renal axis and cognitive *** emphasizes that appropriate glucocorticoid receptor signaling fa cilitates learning and memory,while its dysregulation can lead to cognitive *** provides clues about how glucocorticoid receptor signaling can be targeted to ove rcome cognitive disability-related disorders.

关键词： brain-derived neurotrophic factor calcium signaling glucocorticoid receptor glucocorticoid glutamate transmission hypothalamic-pituitary-adrenal axis long-term potentiation neurocognitive disorders neuroplasticity stress

Lipid levels and insulin resistance markers in patients with colorectal cancer:Propensity score matching analysis

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 130-142页

作者： Ren-Hao Hu Dong-Yi Yan Ke-Hui zhang Di zhang Xi-Mao Cui Xiao-Hua Jiang Shun zhang Department of Gastrointestinal Surgery Shanghai East HospitalSchool of MedicineTongji UniversityShanghai 200120China School of Medicine Tongji UniversityShanghai 200092China Department of Emergency Medicine Shanghai East HospitalSchool of MedicineTongji UniversityShanghai 200120China

BACKGROUND Colorectal cancer(CRC)is a prevalent malignant neoplasm characterized by subtle early *** To investigate the correlation among serum lipid profiles,the triglyceride-glucose(TyG)index,and the atherosclerotic index(AI)in patients with ***,it explored the clinical diagnostic utility of combining serum lipids with cancer antigens in the context of *** A retrospective analysis encompassed 277 patients with CRC and 1034 healthy *** Following propensity score matching,patients with CRC exhibited significantly reduced levels of serum triglyceride(TG),total cholesterol(TC),high-density lipoprotein cholesterol,and low-density lipoprotein cholesterol(LDL-C),as well as a diminished TyG ***,they displayed elevated AI levels compared to their healthy *** in advanced stages exhibited lower serum levels of TG,TC,and LDL-C compared to those in early *** with positive lymph node metastasis demonstrated reduced levels of TG,LDL-C,and the TyG *** operating characteristic analysis revealed that the combination of the TyG index,carcinoembryonic antigen,and carbohydrate antigen 19-9 yielded the highest positive prediction rate for CRC at 75.3%.CONCLUSION Preoperative serum lipid profiles exhibit a robust association with patients with *** concurrent assessment of multiple serum lipids and cancer antigens effectively enhances the diagnostic accuracy for CRC.

关键词： Colorectal cancer Serum lipids Triglyceride-glucose index Atherosclerotic index Diagnostic marker