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Science china Earth Sciences 2010年第5期53卷 657-664页

作者： zhai qingguo1 wang jun1, li {2. {3. {2. institute of Geology, Chinese Academy of Geological Sciences, Beijing 100037, china 2.College of Earth Sciences, Jilin University, Changchun 13.061, china 3.The Geological Laboratory Center and State Key Laboratory of Geological Processes and Mineral Resources, china University of Geo- sciences, Beijing 100083. china institute of Geology Chinese Academy of Geological Sciences Beijing China College of Earth Sciences Jilin University Changchun China The Geological Laboratory Center and State Key Laboratory of Geological Processes and Mineral Resources China University of Geosciences Beijing China

Metabasites consisting of metamorphic ultra-mafic rocks, cumulate gabbro, gabbro (diabase), basalt, and plagiogranite are exposed at the Taoxinghu area in central Qiangtang, northern Tibetan Plateau. Zircon SHRIMP U-Pb dating for the cumulate gabbro yields a weighted mean age of 467±4 Ma, which is the oldest and most reliable magmatic age in this area. Zircon 176Hf/177Hf ratios range from 0.2.2.15 to 0.2.2.57, with εHf(t) values of 5.02.0.2., indicating that the cumulate gabbro was mainly derived from the depleted mantle. In addition, geochemical data of metabasites suggest that they have similar characteristics to those in the mid-ocean ridge basalts (MORB). The Taoxinghu metabasites may represent the fragment of Early Paleozoic ophiolite in the "Central Uplift" of the Qiangtang, northern Tibetan Plateau.

关键词： Qiangtang cumulate gabbro SHRIMP dating Hf isotope

The activity and immune dynamics of PD-1 inhibition on high-risk pulmonary ground glass opacity lesions:insights from a single-arm,phase II trial

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2202-2214页

作者： Bo Cheng caichen li Jianfu li Longlong Gong Peng liang Ying Chen Shuting Zhan Shan Xiong Ran Zhong Hengrui liang Yi Feng Runchen wang Haixuan wang Hongbo Zheng jun liu Chengzhi Zhou Wenlong Shao Yuan Qiu Jiancong sun Zhanhong Xie Zhu liang Chenglin Yang Xiuyu cai Chunxia su Wei wang Jianxing He Wenhua liang Department of Thoracic surgery and Oncology the First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou Institute of Respiratory HealthState Key Laboratory of Respiratory DiseaseNational Clinical Research Center for Respiratory DiseaseGuangzhouChina Medical Department Genecast Biotechnology Co.LtdWuxiChina Department of Radiation Oncology the First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouChina Department of Respiratory Medicine the First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou Institute of Respiratory HealthState Key Laboratory of Respiratory DiseaseNational Clinical Research Center for Respiratory DiseaseGuangzhouChina Department of Cardiothoracic surgery Affiliated Hospital of Guangdong Medical UniversityZhanjiangChina Department of Thoracic surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital&Shenzhen HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeShenzhenChina Department of VIP Inpatient Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaSun Yat-sen UniversityGuangzhouChina Department of Medical Oncology Shanghai Pulmonary HospitalSchool of MedicineTongji UniversityShanghaiChina

Immune checkpoint inhibitors targeting the programmed cell death-1(PD-1)protein significantly improve survival in patients with advanced non-small-cell lung cancer(NSCLC),but its impact on early-stage ground-glass opacity(GGO)lesions remains *** is a single-arm,phase II trial(NCT0402.841)using Simon’s optimal two-stage design,of which 4 doses of sintilimab(2.0 mg per 3.weeks)were administrated in 3. enrolled multiple primary lung cancer(MPLC)patients with persistent high-risk(Lung-RADS category 4 or had progressed within 6 months)*** primary endpoint was objective response rate(ORR).T/B/NK-cell subpopulations,TCR-seq,cytokines,exosomal RNA,and multiplexed immunohistochemistry(mIHC)were monitored and compared between responders and ***,two intent-to-treat(ITT)lesions(pure-GGO or GGO-predominant)showed responses(ORR:5.6%,2.3.),and no patients had progressive disease(PD).No grade 3.5 TRAEs *** total response rate considering two ITT lesions and three non-intent-to-treat(NITT)lesions(pure-solid or solid-predominant)was 13.9%(5/3.).The proportion of CD8^(+)T cells,the ratio of CD8^(+)/CD4^(+),and the TCR clonality value were significantly higher in the peripheral blood of responders before treatment and decreased over ***,the mIHC analysis showed more CD8^(+)T cells infiltrated in ***,responders’cytokine concentrations of EGF and CTLA-4 increased during *** exosomal expression of fatty acid metabolism and oxidative phosphorylation gene signatures were down-regulated among ***,PD-1 inhibitor showed certain activity on high-risk pulmonary GGO lesions without safety *** effects were associated with specific T-cell re-distribution,EGF/CTLA-4 cytokine compensation,and regulation of metabolism pathways.

关键词： lesions metabolism doses

Malignant glaucoma treated by low-dose laser cycloplasty: a 1-year multicenter prospective noncomparative study

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International Journal of Ophthalmology(English edition) 2024年第7期17卷 1248-1254页

作者： Hai-Shuang lin Xiao-Ping Xu Xuan-li Zheng Ji-Bing {2. {3.-Jie Fan Zuo-HongWu {3.-Mian Cheng li-jun Zhao Qin-Hua cai Shao-Dan Zhang Shan-Shan liu Ai-Guo Lyu Ying Zhang Hong Chen Dan-Ni Jiang Wu-liang li Nathan Congdon Clement C Tham Ming-Guang He Yuan-Bo liang the Malignant Glaucoma TreatmentTrial Study(MGTT)Group Wenzhou Medical University Wenzhou 325027Zhejiang ProvinceChina Ningbo Eye Hospital Ningbo 315100Zhejiang ProvinceChina Weifang Eye Hospital Weifang 261000Shandong ProvinceChina Handan Eye Hospital Handan 056000Hebei ProvinceChina Aier Eye Hospital(Wuhan) Wuhan 430061Hubei ProvinceChina Hebei Eye Hospital Xingtai 054001Hebei ProvinceChina The Third People’s Hospital of Dalian Dalian 116033Liaoning ProvinceChina First Affiliated Hospital of suzhou University Suzhou 215031Jiangsu ProvinceChina National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina Glaucoma Research institute Wenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina Centre for Public Health Queen’s University BelfastBelfast BT71NNUK Orbis International New YorkUSA Department of Ophthalmology and Visual Sciences the Chinese University of Hong KongHong Kong SAR 999077China Centre for Eye Research Australia University of MelbourneRoyal Victorian Eye and Ear HospitalEast Melbourne 3000VICAustralia 不详

AIM:To report a one-year clinical outcomes of low-dose laser cycloplasty(LCP)among malignant glaucoma ***:In this prospective,multicenter,noncomparative clinical study,participants with malignant glaucoma were recruited and underwent LCP at eight ophthalmic centers in *** were followed up at 1wk,1,3.6,and *** pressure(IOP),number of glaucoma medications,anterior chamber depth(ACD),and complications were *** success was defined as the reformation of the anterior chamber based on slit-lamp *** was defined by the presence of a shallow orﬂat anterior chamber after initial recovery from ***:A total of 3. eyes received *** IOP and medications decreased from 3..1±11.5 mm Hg with 3.3.1.5 glaucoma medications pre-treatment to 2..9±9.8 mm Hg(P2.9±1.6 medications(P=0.046)at 1d,and 17.4±6.7 mm Hg(P3.1.7 medications(Pline to 1.7±1.0 mm and to 2.0±0.5 mm at 1d and 12.o,respectively.A total of 3.9}94.1%)eyes achieved initial anatomical *** follow-up,2.5.9%)eyes failed and 8(2..5%)eyes relapsed,yielding a 12.month anatomical success rate of 64.3..Complications including anterior synechia(8.82.),choroidal/ciliary detachment(5.88%)and hypopyon(2.94%)were observed within ***:LCP is simple,safe,and effective in reforming the anterior chamber in malignant glaucoma.

关键词： anterior chamber reformation intraocular pressure low-dose laser cycloplasty malignant glaucoma anatomical success

Distinguished biological adaptation architecture aggravated population differentiation of Tibeto-Burman-speaking people

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Journal of Genetics and Genomics 2024年第5期51卷 517-530页

作者： Yuntao sun Mengge wang Qiuxia sun Yan {3.u Shuhan Duan Zhiyong wang Yunyu Zhou jun Zhong Yuguo Huang Xinyu Huang Qingxin Yang Xiangping {3. Haoran su Yan cai Xiucheng Jiang Jing Chen Jiangwei Yan Shengjie Nie {3.ping Hu junbao Yang Renkuan Tang Chuan-Chao wang Chao {3.u Xiaohui Deng {3.bing Yun Guang{3.n He West china School of Basic Science&Forensic Medicine Sichuan UniversityChengduSichuan 610041China institute of Rare Diseases West China Hospital of Sichuan UniversitySichuan UniversityChengduSichuan 610000China Center for Archaeological Science Sichuan UniversityChengduSichuan 610000China Faculty of Forensic Medicine Zhongshan School of MedicineSun Yat-sen UniversityGuangzhouGuangdong 510275China Guangzhou Forensic Science institute GuangzhouGuangdong 510055China Department of Forensic Medicine College of Basic MedicineChongqing Medical UniversityChongqing 400331China School of Clinical Medical Sciences North Sichuan Medical CollegeNanchongSichuan 637100China School of Basic Medical Sciences North Sichuan Medical CollegeNanchongSichuan 637100China School of Forensic Medicine Kunming Medical UniversityKunmingYunnan 650500China School of Stomatology North Sichuan Medical CollegeNanchongSichuan 637100China Department of Medical Laboratory North Sichuan Medical CollegeNanchongSichuan 637007China School of life Sciences Xiamen UniversityXiamenFujian 361005China Anti-Drug Technology Center of Guangdong Province GuangzhouGuangdong 510230China School of Forensic Medicine Shanxi Medical UniversityJinzhongShanxi030600China

Tibeto-Burman(TB)people have endeavored to adapt to the hypoxic,cold,and high-UV high-altitude environments in the Tibetan Plateau and complex disease exposures in lowland rainforests since the late Paleolithic ***,the full landscape of genetic history and biological adaptation of geographically diverse TB-speaking people,as well as their interaction mechanism,remain ***,we generate a whole-genome meta-database of 500 individuals from 3. TB-speaking populations and present a comprehensive landscape of genetic diversity,admixture history,and differentiated adaptative features of geographically different TB-speaking *** identify genetic differentiation related to geography and language among TB-speaking people,consistent with their differentiated admixture process with incoming or indigenous ancestral source populations.A robust genetic connection between the Tibetan-Yi corridor and the ancient Yellow River people supports their Northern{3. origin *** finally report substructure-related differentiated biological adaptative signatures between highland Tibetans and Loloish *** signatures associated with the physical pigmentation(EDAR and SLC2.A5)and metabolism(ALDH9A1)are identified in Loloish people,which differed from the high-altitude adaptative genetic architecture in ***-related genomic resources provide new insights into the genetic basis of biological adaptation and better reference for the anthropologically informed sampling design in biomedical and genomic cohort research.

关键词： Tibeto-Burman people Genetic profile Natural selection Genetic diversity Biological adaptation

Study on the Tectonic Setting for the Ophiolites in Xigaze, Tibet

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Acta Geologica Sinica(English Edition) 2013年第2期87卷 395-425页

作者： BAO Peisheng su li {2. {3. zhai {2. institute of Geology Chinese Academy of Geological Sciences institute of Earth Sciences China University of Geosciences

The Xigaze ophiolite is located in the middle section of the Yarlung Zangbo River ophiolite belt and includes a well-preserved sequence section of seven ophiolite blocks. The relatively complete ophiolitic sequence sections are represented by Jiding, Dejixiang, Baigang, and Dazhuqu ophiolites and consist of three-four units. The complete ophiolite sequence in order from the bottom to top consists of mantle peridotite, cumulates, sheeted sill dike swarms, and basic lavas±radiolarian chert. These cumulates are absent in the remaining blocks of Dejixiang and Luqu. The age of radiolaria in the radiolarian chert is Late Jurassic-Cretaceous. The basalt and ultramafic rock of the ophiolite also are overlaid by Tertiary liuqu conglomerate, which contains numerous pebble components of ophiolite, indicating that the Tethys Ocean began to close at the end of Cretaceous Period. The isotopic data of gabbro, diabase, and albite granite in the Xigaze ophiolite are approximately 12.-13. Ma, which indicates that the ophiolite formed in the Early Cretaceous. The K-Ar age of amphibole in garnet amphibolite in the ophiolite melange is 81 Ma, indicating that tectonic ophiolite emplacement occurred at the end of Late Cretaceous. Research in petrology, petrological chemistry, mineralogy, and geochemistry of volcanic rocks and dikes of the Xigaze ophiolite indicate the following characteristics：（1） They are mainly composed of basalt, basaltic andesite, dolerite, and diabase and are characterized by high TiO2.（0.7-1.47%）, low MgO （mostly less than 8%）, and low SiO2.（mostly less than 53.）. （2. The volcanic rocks and dikes of the Xigaze ophiolite show light rare earth element （LREE）-depleted rare earth element （REE） patterns. （3. The spider diagrams of the volcanic rocks and dikes of the Xigaze ophiolite exhibit liLE depletion relative to high-field-strength element （HFSE） patterns with left oblique features. （4） No protogenetic olivine and clinoenstatite was detected. （5） Some dikes show lo

关键词： MORB boninite series rocks forearc extention subduction initiation Xigaze ophiolite

Origin of the Zedang and Luobusa Ophiolites, Tibet

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Acta Geologica Sinica(English Edition) 2014年第2期88卷 669-698页

作者： BAO Peisheng su li {2. {3. zhai {2. institute of Geology Chinese Academy of Geological Sciences institute of Earth Sciences China University of Geosciences

The Zedang and Luobusa ophiolites are located in the eastern section of the Yalung Zangbo ophiolite belt,and they share similar geological tectonic setting and ***,an understanding of their origins is very important for discussion of the evolution of the Eastern Tethys *** is no complete ophiolite assemblage in the Zedang *** Zedang ophiolite is mainly composed of mantle peridotite and a suite of volcanic rocks as well as siliceous rocks,with some blocks of *** mantle peridotite mainly consists of Cpx-harzburgite,harzburgite,some lherzolite,and some dunite.A suite of volcanic rocks is mainly composed of caic-aikaline pyroclastic rocks and secondly of tholeiitic pillow lavas,basaltic andesites,and some boninitic rocks with a lower TiO2.content （TiO2.＜ 0.6％）.The pyroclastic rocks have a LREE-enriched REE pattern and a liLE-enriched （compared to HFSE） spider diagram,demonstrating an island-arc *** tholeiitic volcanic rock has a LREE-depleted REE pattern and a liLE-depleted （compared to HFSE） spider diagram,indicative of an origin from *** boninitic rock was generated from fore-arc *** Luobusa ophiolite consists of mantle peridotite and mafic-ultramaflc cumulate units,without dike swarms and volcanic *** mantle peridotite mainly consists of dunite,harzburgite with low-Opx （Opx ＜ 2.％）,and harzburgite （Opx ＞ 2.％）,which can be divided into two facies *** upper is a dunite-harzburgite （Opx ＜ 2.％） belt,containing many dunite lenses and a large-scale chromite deposit with high Cr2.3. the lower is a harzburgite （Opx ＞2.％） belt with small amounts of dunite and *** Luobusa mantle peridotite exhibits a distinctive vertical zonation of partial melting with high melting in the upper unit and low melting in the *** mantle peridotites are highly depleted,with a characteristic U-shaped REE pattern peculiar to fore-arc *** Luobusa cumulates are composed of wehrlite and olivine-pyroxe

关键词： Zedang ophiolite Luobusa ophiolite MORB island arc fore-arc extension subduction initiation

10B-doped MCP detector developed for neutron resonance imaging at Back-n white neutron source

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Nuclear Science and Techniques 2024年第8期35卷 58-68页

作者： Qiang li li‑Jiao {2. Jing‑Yu Tang Xiang‑Biao Qiu Zhen Chen Mao‑Yuan Zhao Chang‑{3. Ning Kai Pan Wei Xu Tao li su‑Peng Lu Han Yi Rui‑Rui Fan Chang‑Qing Feng Rong Zhang Xiao‑Yang sun Qi An Hao‑Fan Bai Jiang‑Bo Bai Jie Bao Ping Cao Qi‑Ping Chen Yong‑Hao Chen Zeng‑Qi Cui An‑Chuan Fan Fan‑Zhen Feng Min‑Hao Gu Chang‑cai Han Zi‑Jie Han Guo‑Zhu He Yong‑Cheng He Yang Hong Yi‑Wei Hu Han‑Xiong Huang Wei Jiang Zhi‑Jie Jiang Zheng‑Yao Jin ling Kang Bo li Gong li Xiao li Yang li Jie liu Rong liu Shu‑Bin liu Yi‑Na liu Guang‑Yuan Luan Jie Ren Zhi‑Zhou Ren Xi‑Chao Ruan Zhao‑Hui Song Kang sun Zhi‑Xin Tan Sheng‑Da Tang Jin‑Cheng {2. Peng‑Cheng {2. Zhao‑Hui {2. Zhong‑Wei Wen Xiao‑Guang Wu Xuan Wu Cong Xia Yong‑Ji Yu Guo‑Hui Zhang Hang‑Chang Zhang lin‑Hao Zhang Qi‑Wei Zhang Xian‑Peng Zhang Yu‑liang Zhang Yue Zhang Zhi‑Yong Zhang Zhi‑Hao Zhou Ke‑{3. Zhu Chong Zou institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China State Key Laboratory of Particle Detection and Electronics Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Dongguan Songshan Lake Future School Dongguan 523808China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230027China State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China North Night Vision Science and Technology(Nanjing)Research institute Co.Ltd Nanjing 211106China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China institute of Modern Physics Fudan UniversityShanghai 200433China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China china Academy of Engineering Physics Institute of Nuclear Physics and ChemistryMianyang 621900China USTC archaeometry lab University of Science and Technology of ChinaHefei 230026China Northwest institute of Nuclear Technology Xi’an 710024China University of Chinese Academy of Sciences Beijing 100049China china Shipbuilding Trading Co. LtdBeijing 100044China

Neutron resonance imaging(NRI)has recently emerged as an appealing technique for neutron *** complexity surpasses that of conventional transmission imaging,as it requires a high demand for both a neutron source and ***,the progression of NRI technology has been sluggish since its inception in the 1980s,particularly considering the limited studies analyzing the neutron energy range above *** white neutron source(Back-n)at the{3. Spallation Neutron Source(CSNS)provides favorable beam conditions for the development of the NRI technique over a wide neutron energy range from eV to ***-sensitive microchannel plates(MCP)have emerged as a cutting-edge tool in the field of neutron detection owing to their high temporal and spatial resolutions,high detection efficiency,and low *** this study,we report the development of a 10B-doped MCP detector,along with its associated electronics,data processing system,and NRI experiments at the *** heavy elements such as gold,silver,tungsten,and indium can be easily identified in the transmission images by their characteristic resonance peaks in the 1–100 eV energy range;the more difficult medium-weight elements such as iron,copper,and aluminum with resonance peaks in the 1–100 keV energy range can also be *** particular,results in the neutron energy range of dozens of keV(Aluminum)are reported here for the first time.

关键词： Neutron resonance imaging 10B doped MCP detector White neutron source Sample nuclide identification

国家重点生态功能区生态状况变化与保护成效评估——以海南岛中部山区国家重点生态功能区为例

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地理学报 2018年第3期73卷 429-441页

作者：侯鹏翟俊曹巍杨旻蔡明勇李静环境保护部卫星环境应用中心北京100094 中国科学院地理科学与资源研究所北京100101

自2.00年提出生态功能保护区的概念以来,历时17年不断探索和发展完善,中国已经形成了一批国家重点生态功能区和相关配套政策,成为生态保护红线划定的重要依据和主体功能区战略实施的主要组成,对保障国家生态安全和优化国土空间格局具有... 详细信息

自2.00年提出生态功能保护区的概念以来,历时17年不断探索和发展完善,中国已经形成了一批国家重点生态功能区和相关配套政策,成为生态保护红线划定的重要依据和主体功能区战略实施的主要组成,对保障国家生态安全和优化国土空间格局具有十分重要的意义。海南岛中部山区在2.01年成为国家生态功能保护区试点,2.10年被确定为国家重点生态功能区,是较早实施生态功能保护的重点管控区域之一。本文以海南岛中部山区热带雨林重点生态功能区为研究区域,综合利用多源卫星遥感数据和地面观测统计数据,集成地统计学和生态评估模型模拟方法,以生态系统格局、植被长势、服务功能为主要评估内容,通过时空尺度拓展和多维时空对比分析,探讨了该重点生态功能区生态系统变化和保护成效。结果发现:(1)2.13.功能区森林面积占比为84.5%,显著高于海南岛平均水平。1990-2.13.功能区内建设用地逐渐增加。2.10年功能区实施后,人类活动强度仍然呈现持续增加态势,面积比例从0.5%增加到0.8%,主要表现为城镇建设和耕地开垦。(2.功能区水源涵养服务功能明显优于功能区外部,1990-2.13.水源涵养服务功能总体上略有增加,但是不同时间段的波动变化明显,特别是1990-2.00年和2.00-2.13.两个时间段内均表现为先减少后增加的变化特征。功能区单位面积的水源涵养量为51.78万m2.km2.明显高于功能区外部。(3.功能区土壤保持服务功能明显要优于功能区外部,1990-2.13.表现出剧烈波动、稳定性较差。功能区单位面积的土壤保持量为1.95万t/km2.明显高于功能区外部。(4)功能区人类扰动指数明显小于功能区外部,生物多样性威胁程度明显偏小,有利于生物多样性的保护。功能区平均人类扰动指数为0.3.64,比功能区外部低0.1152.1990-2.13.功能区外部人类扰动指数变化幅度为0.0152.约为功能区内部变化幅度的5.3.倍。特别是2.10-2.13.,功能区内部人类扰动指数增加幅度要明显小于功能区外部。

关键词：生态功能区生态系统服务功能保护成效

SHRIMP U-Pb dating and Hfisotopic analyses of zircons from the mafic dyke swarms in central Qiangtang area,Northern Tibet

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Chinese Science Bulletin 2009年第21期54卷 2279-2285页

作者： zhai qingguo {2. {3. {2. jun JI ZhanSheng {2. Yong institute of Geology Chinese Academy of Geological Sciences Beijing 100037 China College of Earth Sciences Jilin University Changchun 130061 China

In the "Central Uplift" of Qiangtang,Northern Tibet,a large scale of mafic dyke swarms extended in E-W *** SHRIMP U-Pb dating on two representative samples of diabase dyke yield weighted mean ages of 2.4 ± 3.Ma and 3.2.± 4 Ma,respectively,{3.ggesting they emplaced in the Late Carboniferous to Early *** 176Hf/177Hf ratios range from 0.2.2.52.to 0.2.3.41,with εHf(t) values of +12.1 to +12.2.and Hf modal(TDM) ages of ～440―460 *** data indicate that these mafic dykes were mainly derived from the depleted *** addition,geochemical data {3.ggest that these mafic dyke swarms are ofintra-plate ***,the mafic dyke swarms represent products during the extensional process associated with the opening of the Paleo-Tethys Ocean in the area.

关键词：锆石SHRIMP 镁铁质岩墙群同位素分析中部地区羌塘 Pb 藏北平均年龄

CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-{3. Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua cai Wenyong cai Wu{3. cai Yijian cai Yizhou cai Yuchen cai Haiying cai Huacheng cai Lorenzo Calibbi {3.song Cang Guofu Cao Jianshe Cao Antoine Chance Xue{3. Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen Ming{3. Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research institute Co. LtdBeijing Beijing institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central china Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan china academy of engineering physics MianyangSichuan china building materials academy Beijing china Center of Advanced Science and Technology Beijing china institute of Atomic Energy Beijing china Jiliang University HangzhouZhejiang china Nuclear Instrument CO. LTDBeijing china University of Geosciences Beijing china University of Geosciences WuhanHubei china University of Mining and Technology XuzhouJiangsu china West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint institute for Nuclear Research(DLNP JINR) Dubna East china University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by china,fostered through extensive collaboration with international *** complex comprises four accelerators:a 3. GeV linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 3. MW per beam,it can achieve a luminosity of 5×10^(3.)cm^(-2.s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13.ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3.million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2.15)and the Conceptual Design Report(CDR,2.18),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2.2.-2.2.,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2.3.s.

关键词： initiated exceeding precise