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Treg Immunomodulation Contributes to the Anti-atherosclerotic Effects of Huxin Formula in ApoE^(-/-)Mice

Chinese Journal of Integrative Medicine 2024年第10期30卷 896-905页

作者： OU Xiao-min CAI Jing HU Xiao-yue zeng qiao-huang LAN Tao-hua JIANG Wei The Second Clinical College of Guangzhou University of Chinese Medicine Guangzhou510405China Department of Cardiology Guangdong Provincial Hospital of Chinese Medicinethe Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou510020China Guangdong Provincial Key Laboratory of Chinese Medicine for Prevention and Treatment of Refractory Chronic Diseases Guangzhou510020China

Objective:To explore the effects of Huxin formula(HXF)in curtailing atherosclerosis and its underlying ***:According to random number table method,24 specific pathogen free male ApoE^(-/-)mice were randomly divided into model group,HXF low-dose(HXF-L)group(8.4 g/kg daily),HXF high-dose(HXF-H)group(16.8 g/kg daily),and pravastatin(8 mg/kg daily)group in ExperimentⅠ(n=6 per group).C57BL/6J mice served as the control group(n=6).ApoE^(-/-)mice in HXF-L,HXF-H,pravastatin groups were fed a Western diet and administered continuously by gavage for 12 weeks,while C57BL/6J mice in the control group were fed conventional lab mouse chow for 12 ***,Tregs were depleted by weekly intraperitoneal injection of purified anti-mouse CD25 antibody(PC61,250μg per mouse)for 4 weeks in ExperimentⅡ(n=6 per group).Oil Red O and Masson staining were used to evaluate the plaque area and aortic root *** CD4^(+)CD25^(+)Foxp3^(+)Treg counts in the lymph nodes and spleen cells were detected using flow cytometric *** transforming growth factor-β1(TGF-β1),interleukin(IL)-10,and IL-6 serum levels were examined by MILLIPLEX?MAP *** real-time reverse transcription PCR(qRT-PCR)and Western blot were utilized to assess the expression of TGF-βmRNA and protein in the *** expression of CD4^(+)T lymphocytes,macrophages and smooth muscle cells in the aortic root were detected by immunofluorescence ***:HXF reduced plaque area in ApoE^(-/-)mice(P0.05).Also,HXF upregulated the expression of TGF-βmRNA and protein in the aorta(P<0.05).Additionally,HXF attenuated CD4^(+)T lymphocytes,macrophages and smooth muscle cells in aortic root plaque(P<0.01).Furthermore,the depletion of Tregs with CD25

关键词： atherosclerosis Huxin Formula Tregs immune responses inflammation

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Regulatory T Cells: A New Target of Chinese Medicine in Treatment of Atherosclerosis

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Chinese Journal of Integrative Medicine 2021年第11期27卷 867-873页

作者： LIANG Zhao-ying QIAN Cai-wen LAN Tao-hua zeng qiao-huang LU Wei-hui JIANG Wei State Key Laboratory of Dampness Syndrome of Chinese Medicine Department of Cardiologythe Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou510020China Guangdong Provincial Key Laboratory of Chinese Medicine for Prevention and Treatment of Refractory Chronic Diseases Guangzhou510020China The Second Clinical Medical College of Guangzhou University of Chinese Medicine Guangzhou510405China The Second Affiliated Hospital of Guangzhou University of Chinese Medicine Guangzhou510020China

Inflammation and immune disorders are integral to the occurrence and progression of atherosclerosis(AS).With the role of regulatory T cells(Tregs)in immune regulation attracting attention,it has been widely accepted that Treg decrease and dysfunction are involved in AS *** medicine(CM)has the advantages of being dual-directional,multi-targeted,and having minimal side effects in immune *** anti-atherosclerosis effects of CM via Treg modulation have been revealed in clinical and animal ***,this article reviews existing research on Tregs,the relationship between Tregs and AS,and the progress of CM for treating and prevention of atherosclerotic cardio-cerebrovascular diseases by regulating *** the underlying mechanisms remain to be elucidated,CM treatment targeting Treg cells might provide a promising and novel future approach for prevention and treatment of AS.

关键词： Chinese medicine atherosclerosis regulatory T cells immunization inflammation

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LOX-1 Regulation in Anti-atherosclerosis of Active Compounds of Herbal Medicine:Current Knowledge and the New Insight

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Chinese Journal of Integrative Medicine 2023年第2期29卷 179-185页

作者： YAO Si-jie LAN Tao-hua ZHANG Xin-yu zeng qiao-huang XU Wen-jing LI Xiao-qing huang Gui-bao LIU Tong LYU Wei-hui JIANG Wei State Key Laboratory of Dampness Syndrome of Chinese Medicine Department of Cardiologythe Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510020China Guangdong Provincial Key Laboratory of Chinese Medicine for Prevention and Treatment of Refractory Chronic Diseases Guangzhou 510020China The Second Clinical Medical College of Guangzhou University of Chinese Medicine Guangzhou 510405China

Lectin-like oxidized low-density lipoprotein receptor-1(LOX-1)have recently been identified to be closely related to the occurrence and development of atherosclerosis(AS).A growing body of evidence has suggested Chinese medicine takes unique advantages in preventing and treating *** this review,the related research progress of AS and LOX-1 has been *** the anti-As effects of 10 active components of herbal medicine through LOX-1 regulation have been further *** a potential biomarker and target for intervention in AS,LOX-1 targeted therapy might provide a promising and novel approach to atherosclerotic prevention andtreatment.

关键词： atherosclerosis herbal medicine lectin-like oxidized low-density lipoprotein receptor-1 targeted therapy

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Modeling of multiphase flow in low permeability porous media:Effect of wettability and pore structure properties

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第4期16卷 1127-1139页

作者： Xiangjie Qin Yuxuan Xia Juncheng qiao Jiaheng Chen Jianhui zeng Jianchao Cai National Key Laboratory of Petroleum Resources and Engineering China University of PetroleumBeijing102249China Research Institute of Petroleum Exploration and Development Beijing10083China

Multiphase flow in low permeability porous media is involved in numerous energy and environmental ***,a complete description of this process is challenging due to the limited modeling scale and the effects of complex pore structures and *** address this issue,based on the digital rock of low permeability sandstone,a direct numerical simulation is performed considering the interphase drag and boundary slip to clarify the microscopic water-oil displacement *** addition,a dual-porosity pore network model(PNM)is constructed to obtain the water-oil relative permeability of the *** displacement efficiency as a recovery process is assessed under different wetting and pore structure *** show that microscopic displacement mechanisms explain the corresponding macroscopic relative *** injected water breaks through the outlet earlier with a large mass flow,while thick oil films exist in rough hydrophobic surfaces and poorly connected *** variation of water-oil relative permeability is significant,and residual oil saturation is high in the oil-wet *** flooding is extensive,and the residual oil is trapped in complex pore networks for hydrophilic pore surfaces;thus,water relative permeability is lower in the water-wet *** the displacement efficiency is the worst in mixed-wetting systems for poor water *** negatively correlates with invading oil volume fraction due to strong capillary resistance,and a large microporosity corresponds to low residual oil *** work provides insights into the water-oil flow from different modeling perspectives and helps to optimize the development plan for enhanced recovery.

关键词： Low permeability porous media Water-oil flow Wettability Pore structures Dual porosity pore network model(PNM) Free surface model

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Effects of formal credit on pastoral household expense: Evidence from the Qinghai-Xizang Plateau of China

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Journal of Integrative Agriculture 2024年第5期23卷 1774-1785页

作者： Yan Zhang Yi huang Fan Zhang zeng Tang State Key Laboratory of Herbage Improvement and Grassland Agro-ecosystems College of Pastoral Agriculture Science and TechnologyLanzhou UniversityLanzhou 730020China

Formal credit is critical in agricultural production,allowing more expenditure and productive input,thereby improving farmers'*** pastoral China,formal financial institutions are gradually ***,a limited understanding remains of how formal credit affects herders'household *** on a survey of 544 herders from the Qinghai-Xizang Plateau of China,this study adopted the propensity score matching approach to identify the effect of formal credit on herders'total household expenses,daily expenses,and productive *** results found that average age,grassland mortgage,and other variables significantly affected herders'participation in formal *** credit could significantly improve household expenses,especially productive expenses.A heterogeneity analysis showed that formal credit had a greater impact on the household total expense for those at higher levels of wealth;however,it significantly affected the productive expense of herders at lower wealth ***,the mediating effect indicated that formal credit could affect herders'household income,thus influencing their household ***,this study suggests that policies should improve herders'accessibility to formal credit.

关键词： formal credit herders expense Qinghai-Xizang Plateau

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Printed Biosensors for the Detection of Alzheimer’s Disease Based on Blood Biomarkers

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Journal of Analysis and Testing 2024年第2期8卷 133-142页

作者： Yu zeng Zhen huang Yibiao Liu Tailin Xu Longgang Central Hospital of Shenzhen Shenzhen518116China School of Biomedical Engineering Shenzhen UniversityShenzhen518060China

Alzheimer’s disease(AD)is a chronic neurodegenerative disorder,and early diagnosis plays a crucial role in its prevention and *** recent years,blood-based biomarkers for early AD diagnosis have gained attention due to their non-invasiveness and minimal adverse reactions,which make them an attractive *** the onset of the COVID-19 pandemic,visiting large medical examination centers for blood tests has become increasingly *** trend is shifting towards community or home-based sampling,which relies on the development and application of portable,miniaturized,and highly sensitive *** the various sensors used for detecting blood biomarkers in AD,printed sensors demonstrate great potential in AD blood biomarker detection due to their ease of miniaturization,scalability for mass production,and compatibility with various detection *** this review,we focus on discussing the application of printed sensors in the analysis of blood biomarkers for *** also explore the challenges faced by printed sensors in early diagnosis based on AD blood biomarkers and propose potential solutions to address these challenges.

关键词： Printed biosensors Alzheimer’s disease Blood biomarkers Printing technology

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Two-dimensional precise figuring of 500 mm-long X-ray mirror using one-dimensional ion beam system

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Advances in Manufacturing 2024年第1期12卷 177-184页

作者： Qiu-Shi huang Han-Dan huang qiao-Yu Wu Jun Yu Zhong Zhang Zhan-Shan Wang MOE Key Laboratory of Advanced Micro-Structured Materials Institute of Precision Optical Engineering(IPOE)School of Physics Science and EngineeringTongji UniversityShanghai200092People’s Republic of China Shanghai Professional Technical Service Platform for Full-Spectrum and High-Performance Optical Thin Film Devices and Applications Tongji UniversityShanghai200092People’s Republic of China Shanghai Frontiers Science Center of Digital Optics Tongji UniversityShanghai200092People’s Republic of China

In this study,a new method was developed to realize two-dimensional(2D)figure correction of grazing-incidence X-ray mirrors using a one-dimensional(1D)ion-beam figuring system.A mask of holes was specifically designed to generate removal functions at different widths and extend the figuring capability over a wide ***,a long mirror could be *** this method,the surface height root-mean-square(RMS)error of the center area of 484 mm×16 mm was reduced from 11.49 nm to 2.01 nm,and the 1D meridional RMS error reached 1.0 *** proposed method exhibits high precision and cost effectiveness for production of long X-ray mirrors.

关键词： Long-size mirrors Ion beam figuring Two-dimensional figure correction Mask

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Dynamic response of mountain tunnel,bridge,and embankment along the Sichuan-Tibet transportation corridor to active fault based on model tests

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Journal of Mountain Science 2024年第1期21卷 182-199页

作者： huang Beixiu qiao Sijia CHEN Xulei LI Lihui QI Shengwen Key Laboratory of Shale Gas and Geoengineering Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China Innovation Academy for Earth Science Chinese Academy of SciencesBeijing 100029China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China

The Sichuan-Tibet transportation corridor is prone to numerous active faults and frequent strong *** extensive studies have individually explored the effect of active faults and strong earthquakes on different engineering structures,their combined effect remains *** research employed multiple physical model tests to investigate the dynamic response of various engineering structures,including tunnels,bridges,and embankments,under the simultaneous influence of cumulative earthquakes and stick-slip misalignment of an active *** prototype selected for this study was the Kanding No.2 tunnel,which crosses the Yunongxi fault zone within the Sichuan-Tibet transportation *** results demonstrated that the tunnel,bridge,and embankment exhibited amplification in response to the input seismic wave,with the amplification effect gradually decreasing as the input peak ground acceleration(PGA)*** PGAs of different engineering structures were weakened by the fault rupture ***,the misalignment of the active fault may decrease the overall stiffness of the engineering structure,leading to more severe damage,with a small contribution from seismic ***,the seismic vibration effect might be enlarged with the height of the engineering structure,and the tunnel is supposed to have a smaller PGA and lower dynamic earth pressure compared to bridges and embankments in strong earthquake zones crossing active *** findings contribute valuable insights for evaluating the dynamic response of various engineering structures crossing an active fault and provide an experimental reference for secure engineering design in the challenging conditions of the Sichuan-Tibet transportation corridor.

关键词： Dynamic response Engineering structure Sichuan-Tibet transportation corridor Active fault Earthquake Model test

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A Federated Learning Framework with Blockchain-Based Auditable Participant Selection

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Computers, Materials & Continua 2024年第6期79卷 5125-5142页

作者： huang zeng Mingtian Zhang Tengfei Liu Anjia Yang College of Cyber Security Jinan UniversityGuangzhou510632China

Federated learning is an important distributed model training technique in Internet of Things(IoT),in which participant selection is a key component that plays a role in improving training efficiency and model *** module enables a central server to select a subset of participants to performmodel training based on data and device *** doing so,selected participants are rewarded and actively perform model training,while participants that are detrimental to training efficiency and model accuracy are ***,in practice,participants may suspect that the central server may have miscalculated and thus not made the selection *** lack of trustworthiness problem,which can demotivate participants,has received little *** problem that has received little attention is the leakage of participants’private information during the selection *** will therefore propose a federated learning framework with auditable participant *** supports smart contracts in selecting a set of suitable participants based on their training loss without compromising the *** the possibility of malicious campaigning and impersonation of participants,the framework employs commitment schemes and zero-knowledge proofs to counteract these malicious ***,we analyze the security of the framework and conduct a series of experiments to demonstrate that the framework can effectively improve the efficiency of federated learning.

关键词： Federated learning internet of things participant selection blockchain auditability privacy

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Urban Flood Mitigation Strategies with Coupled Gray–Green Measures: A Case Study in Guangzhou City, China

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International Journal of Disaster Risk Science 2024年第3期15卷 467-479页

作者： Jiayue Li Jiajun zeng Guoru huang Wenjie Chen School of Civil Engineering and Transportation South China University of Technology School of Architecture South China University of Technology State Key Laboratory of Subtropical Building and Urban Science South China University of Technology College of Water Conservancy and Civil Engineering South China Agricultural University

The integration of gray and green infrastructure has proven to be a feasible approach for managing stormwater in established urban areas. However, evaluating the specific contributions of such coupled strategies is challenging. This study introduced a novel integrated hydrological-hydrodynamic model that takes into account the layout of low-impact development(LID)facilities along with pipeline alignment and rehabilitation. Reliable results from modeling were used to assess the individual contribution of LID and improved drainage facilities to urban flooding mitigation. We selected a natural island in Guangzhou City, China, as the study site. The results indicate that combining three LID measures, namely green roofs, sunken green spaces, and permeable pavements, can reduce total runoff by 41.7% to 25.89% for rainfall recurrence periods ranging from 1year to 100 years, and decrease the volume of nodal overflow by nearly half during rainfall events of less than 10-year return period. By integrating LID measures with the upgraded gray infrastructure, the regional pipeline overloading condition is substantially alleviated, resulting in a significant improvement in pipeline system resilience. For urban flooding control, it is recommended to integrate sufficient green space and avoid pipe-laying structural issues during urban planning and construction. The findings may assist stakeholders in developing strategies to best utilize gray and green infrastructure in mitigating the negative eff ects of urban flooding.

关键词： Coupled hydrodynamic model Gray–green approach Guangzhou City LID Pipe renovation Urban inundation

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