检索结果-南通市图书馆

维普期刊数据库博看期刊

Roles of G protein-coupled receptors in inflammatory bowel disease

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2020年第12期26卷 1242-1261页

作者： zhen zeng Arjudeb Mukherjee Adwin Pidiyath Varghese Xiao-Li Yang Sha Chen Hu Zhang Department of Gastroenterology Centre for Inflammatory Bowel DiseaseWest China HospitalSichuan UniversityChengdu 410061Sichuan ProvinceChina West China School of Medicine Sichuan UniversityChengdu 410061Sichuan ProvinceChina

Inflammatory bowel disease(IBD)is a complex disease with multiple pathogenic *** the pathogenesis of IBD is still unclear,a current hypothesis suggests that genetic susceptibility,environmental factors,a dysfunctional immune system,the microbiome,and the interactions of these factors substantially contribute to the occurrence and development of *** existing and emerging drugs have been proven to be effective in treating IBD,none can cure IBD permanently.G protein-coupled receptors(GPCRs)are critical signaling molecules implicated in the immune response,cell proliferation,inflammation regulation and intestinal barrier *** in the understanding of the structures and functions of GPCRs have provided a driving force for exploring the roles of GPCRs in the pathogenesis of diseases,thereby leading to the development of GPCR-targeted *** date,a number of GPCRs have been shown to be associated with IBD,significantly advancing the drug discovery process for *** associations between GPCRs and disease activity,disease severity,and disease phenotypes have also paved new avenues for the precise management of patients with *** this review,we mainly focus on the roles of the most studied proton-sensing GPCRs,cannabinoid receptors,and estrogen-related GPCRs in the pathogenesis of IBD and their potential clinical values in IBD and some other diseases.

关键词： G protein-coupled receptors Inflammatory bowel disease Pathogenesis Signaling pathway Drug discovery

A large‐scalable spraying‐spinning process for multifunctional electronic yarns

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

SmartMat 2023年第2期4卷 131-141页

作者： Linli Gan zhen zeng Haojie Lu Daiqi Li Ke Wei Guangming Cai Yingying Zhang State Key Laboratory of New Textile Materials and Advanced Processing Technologies Wuhan Textile UniversityWuhanChina Key Laboratory of Organic Optoelectronics and Molecular Engineering of the Ministry of Education Department of ChemistryTsinghua UniversityBeijingChina

Electronic fibers/textiles have great potential for applications in smart wearables due to their excellent flexibility,air permeability,and wearing ***,it is still challenging to produce reliable electronic textiles at low cost and in a large ***,we report a spraying‐spinning process for fabricating electronic yarns with excellent stability and *** sliver,which is the raw material for spinning conventional cotton yarns,was spray coated with carbon nanotubes(CNTs)and spun on an Ag@nylon yarn,forming a sheath‐core structured CNT@cotton‐Ag@nylon yarn(CCAY).The process is continuous,large‐scalable,applicable to other raw fiber materials and compatible with traditional textile *** as‐prepared CCAY showed superior mechanical durability,washability,and conductivity to typical surface coated *** can be easily processed or integrated into textiles through weaving,knitting,sewing,and *** systematically studied the electromechanical,electro‐thermal,and photothermal performance of CCAY based yarns/fabrics,demonstrating its versatile applications in smart *** addition,CCAY can be further equipped with other features,such as electro‐thermochromic functions,pH sensing and flame resistant *** the large‐scalability,versatility,and low‐cost,we foresee that this spraying‐spinning process for electronic yarns may play important roles in the development of practical smart fibers/textiles.

关键词： electronic yarn e‐textiles large‐scalable multifunctional spraying‐spinning

Investigation of Direct Causes of Drug Relapse and Abstainers’ Demands in a Compulsive Detoxification Center in Wuhan City of China

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2007年第5期20卷 404-409页

作者： zeng-zhen WANG QING WANG Department of Epidemiology and Health Statistics School of Public Health Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 Hubei China Compulsive Detoxification Center Public Security Office Wuhan 430040 Hubei China

Objective To identify the direct causes of drug relapse and abstainers’ demand, and to develop programs for the prevention of drug relapse. Methods Abstainers in a Compulsive Detoxification Center in Wuhan City, capital of Hubei Province were randomly selected. An investigation on the direct causes of drug relapse and abstainers’ demands was conducted with multiple-choice questionnaires and face to face interviews. Data were analyzed with SPSS 12.0. Results The direct causes leading to drug relapse included： temptation to use drug again by themselves or by their drug mates, seeking pleasure and ecstasy from drug use, relatively well off living, mental stress, irritation, demoralization, family conflicts, unemployment, feeling distrusted by the family, lack of care and love from the family, and discrimination by others. abstainers’ demands after detoxification and returning to the society included： care and support from the family, employment assistance, changing living environment, understanding by others, support from the society, and keeping far away from drugs. Conclusions Environmental factors are the direct causes of drug relapse, and negative irritation is its predisposing causes. Leaving former residence, more care and help given by both the family and the society and raising their overall quality of life are the demands of abstainers.

关键词： Drug abuse Causes of drug relapse Demands

牡蛎多糖缓解体力疲劳及其对力竭小鼠肠道菌群的影响

在线全文

学校读者我要写书评

暂无评论

中国微生态学杂志 2024年第4期36卷 390-400页

作者：谭强来陆馨敏吴兰兰吴伟菁蔡依婕林宇杰郑伊婷曾臻厦门医学院福建厦门361023

目的研究牡蛎多糖缓解体力疲劳的功能及对力竭小鼠肠道菌群结构和多样性的调节作用。方法以总抗氧化、清除DPPH自由基、抑制超氧阴离子自由基和羟自由基能力为指标,分析抗氧化活性;采用共孵育法,以大肠埃希菌和金黄色葡萄球菌为指示... 详细信息

目的研究牡蛎多糖缓解体力疲劳的功能及对力竭小鼠肠道菌群结构和多样性的调节作用。方法以总抗氧化、清除DPPH自由基、抑制超氧阴离子自由基和羟自由基能力为指标,分析抗氧化活性;采用共孵育法,以大肠埃希菌和金黄色葡萄球菌为指示菌分析抑菌活性;选取SPF级8周龄Balb/c小鼠,分别给予纯净水以及低[200 mg/(kg·mb)]、中[400 mg/(kg·mb)]、高[800 mg/(kg·mb)]剂量牡蛎多糖,持续口服干预5周,以小鼠负重游泳时间以及血乳酸、血尿素氮、肝糖原为指标测定其缓解体力疲劳功能,采集力竭小鼠盲肠内容物进行16S rDNA高通量测序,分析肠道菌群组成与多样性。结果牡蛎多糖具有较好的抗氧化和抑菌活性,且与其浓度呈正相关。牡蛎多糖具有缓解体力疲劳功能,以高剂量效果最为显著。牡蛎多糖干预可影响肠道菌群的组成,高剂量组与对照组的beta多样性存在差异;两组间群落结构差异显著,高剂量组中Muribaculaceae的相对丰度显著增加,另枝菌属(Alistipes)、拟普雷沃菌属(Alloprevotella)、颤螺旋菌属(Oscillibacter)相对丰度也更高;线性判别分析差异贡献证实Alistipes在高剂量组中差异显著,发挥了重要作用。结论牡蛎多糖具有较好的抗氧化和抑菌活性,可缓解体力疲劳功能,且能调节小鼠肠道菌群结构和beta多样性,促进有益菌属而抑制有害菌属的生长,可为后续研发牡蛎多糖精准营养功效食品提供参考依据。

关键词：牡蛎多糖缓解体力疲劳肠道菌群抗氧化抑菌

COL1A1、KPNA2在三阴性乳腺癌组织中的表达及与远期预后的关系

在线全文

学校读者我要写书评

暂无评论

西部医学 2024年第5期36卷 713-718页

作者：廖登辉王婷甘霖闵杰王亚东曾真吕钢重庆市中医院乳腺科重庆400021

目的探讨Ⅰ型胶原蛋白α1链(COL1A1)、核转运蛋白α2(KPNA2)在三阴性乳腺癌(TNBC)组织中的表达及与远期预后的关系。方法收集2016年6月—2017年6月本院收治的87例TNBC患者为研究对象,患者均经手术留取癌组织及癌旁组织标本,采用免疫组... 详细信息

目的探讨Ⅰ型胶原蛋白α1链(COL1A1)、核转运蛋白α2(KPNA2)在三阴性乳腺癌(TNBC)组织中的表达及与远期预后的关系。方法收集2016年6月—2017年6月本院收治的87例TNBC患者为研究对象,患者均经手术留取癌组织及癌旁组织标本,采用免疫组织化学法检测COL1A1、KPNA2在各组织标本中的表达情况,分析两者表达情况与患者病理特征的关系,绘制生存曲线分析二者表达情况与患者5年预后的关系,采用COX回归模型分析影响患者预后生存的因素。结果COL1A1、KPNA2在TNBC患者癌组织中高表达率显著高于癌旁组织(P<0.05)。在TNBC癌组织中,COL1A1、KPNA2高表达与组织学分级、脉管侵犯、淋巴结转移情况有关(P<0.05),COL1A1高表达还与临床分期有关(P<0.05)。随访5年,87例患者总生存率78.16%(68/87),COL1A1高表达者生存期较低表达者更短(P<0.05),KPNA2高表达者较低表达者生存期更短(P<0.05)。COX回归分析显示,临床分期Ⅲ期、有淋巴结转移、COL1A1高表达、KPNA2高表达是三阴性乳腺癌患者预后生存的影响因素(P<0.05)。结论COL1A1、KPNA2在TNBC患者癌组织中表达均增加,两者高表达与患者组织学分级、脉管侵犯、淋巴结转移情况均有关,且影响患者远期预后。

关键词：三阴性乳腺癌 Ⅰ型胶原蛋白α1链核转运蛋白基因2 远期预后

PBL联合CBL教学法在乳腺影像诊断实验课教学中的应用

在线全文

学校读者我要写书评

暂无评论

中国继续医学教育 2024年第14期16卷 50-53页

作者：汤子建谢朝邦曾珍冉春艳张体江遵义医科大学附属医院放射科贵州遵义563000

目的探讨以问题为基础教学法(problem-based learning,PBL)联合案例教学法(case-based learning,CBL)在乳腺影像诊断实验课教学中的价值。方法选择2022年3月—6月遵义医科大学2019级影像诊断专业的96名学生为研究对象,按随机数字表法分... 详细信息

目的探讨以问题为基础教学法(problem-based learning,PBL)联合案例教学法(case-based learning,CBL)在乳腺影像诊断实验课教学中的价值。方法选择2022年3月—6月遵义医科大学2019级影像诊断专业的96名学生为研究对象,按随机数字表法分为对照组和试验组,每组48名。试验组采用PBL联合CBL教学法,对照组采用传统教学法。课后采用问卷调查联合成绩考核的方式对教学效果进行综合评估。结果试验组学生对课堂的感受包括激发学习兴趣、提高文献检索能力、培养团队协作能力、提高分析解决问题及影像诊断思维能力和总体满意度高于对照组[(91.7%vs.72.9%;72.9%vs.41.7%;81.3%vs.56.3%;79.2%vs.54.2%;87.5%vs.68.8%;83.3%vs.64.6%],差异均有统计学意义(P<0.05)。试验组学生理论考试、读片技能测评及总成绩均高于对照组[(43.13±2.18)分vs.(41.42±2.48)分;(44.96±2.28)分vs.(40.21±2.55)分;(88.08±4.00)分vs(.81.63±4.45)分],差异均有统计学意义(P<0.05)。结论PBL联合CBL教学法在乳腺疾病影像诊断实验课教学中应用效果确切,是一种值得尝试的教学模式。

关键词： PBL教学法 CBL教学法乳腺影像传统教学教学效果教育

绒毛皂荚特定森林环境育苗技术组合与常规育苗对比试验

在线全文

学校读者我要写书评

暂无评论

安徽农业科学 2024年第9期52卷 84-86页

作者：旷柏根曾臻谢咏红文儒仁周春桃湖南省南岳树木园湖南衡阳421900 衡阳市林业局湖南衡阳421200

[目的]提高绒毛皂荚场地发芽率,加速种群回归。[方法]在特定的森林环境进行育苗技术组合试验,并以苗圃常规育苗为对照,研究不破坏林地环境的小铲破土和地表播种+死地被物多种覆盖方式技术组合对发芽率与苗木生长的影响。[结果]小铲破土... 详细信息

[目的]提高绒毛皂荚场地发芽率,加速种群回归。[方法]在特定的森林环境进行育苗技术组合试验,并以苗圃常规育苗为对照,研究不破坏林地环境的小铲破土和地表播种+死地被物多种覆盖方式技术组合对发芽率与苗木生长的影响。[结果]小铲破土播种或地表播种加4种不同死地被物覆盖方式技术组合的场地发芽率分别为(A_(1))61.67%、(A_(2))55.56%、(A_(3))61.11%、(A_(4))57.22%,均高于常规育苗(CK)的35.03%;A_(1)小铲破土播种后,盖1 cm厚表层有机土+3 cm厚粗腐殖质+未分解的枯枝落叶组合和A_(3)种子直播土壤地表后,盖3 cm厚的粗腐殖质+未分解枯枝落叶同为最佳组合;常规育苗的苗木成苗率(成苗数与发芽数之比×100%)与苗木生长量略高于其他处理;但从成苗数的绝对数比较,CK小于A_(1)、A_(2)、A_(3)、A_(4)处理的106、85、95和88株。[结论]特定的森林环境母树下小铲破土或地表播种后+林地死地被物覆盖组合育苗是提高场地发芽率和成苗数的有效方法。

关键词：绒毛皂荚特定森林环境死地被物覆盖组合育苗

An angiosperm NLR Atlas reveals that NLR gene reduction is associated with ecological specialization and signal transduction component deletion

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Molecular Plant 2021年第12期14卷 2015-2031页

作者： Yang Liu zhen zeng Yan-Mei Zhang Qian Li Xing-Mei Jiang zhen Jiang Ji-Hong Tang Dijun Chen Qiang Wang Jian-Qun Chen Zhu-Qing Shao State Key Laboratory of Pharmaceutical Biotechnology School of Life SciencesNanjing UniversityNanjing 210023China Jiangsu Key Laboratory for the Research and Utilization of Plant Resources Institute of BotanyJiangsu Province and Chinese Academy of SciencesNanjing 210014China

Nucleotide-binding leucine-rich-repeat(NLR)genes comprise the largest family of plant disease-resis-tance *** NLR genes are phylogenetically divided into the TNL,CNL,and RNL *** copy numbers and subclass composition vary tremendously across angiosperm ***,the evolutionary associations between genomic NLR content and ecological adaptation,or between NLR content and signal transduction components,are poorly characterized because of limited genome *** this study,we established an angiosperm NLR atlas(ANNA,https://***/ANNA/)that includes NLR genes from over 300 angiosperm *** ANNA,we revealed that NLR copy numbers differ up to 66-fold among closely related species owing to rapid gene loss and ***,NLR contraction was associated with adaptations to aquatic,parasitic,and carnivorous *** convergent NLR reduction in aquatic plants resembles the lack of NLR expansion during the long-term evolution of green algae before the colonization of land.A co-evolutionary pattern between NLR subclasses and plant immune pathway components was also identified,suggesting that immune pathway deficiencies may drive TNL ***,we identified a conserved TNL lineage that may function independently of the EDS1-SAG101-NRG1 ***,these findings provide new insights into the evolution of NLR genes in the context of ecological adaptation and genome content variation.

关键词： NLR genes plant disease resistance EDS1 gene family gene family evolution angiosperms

3D-printed GelMA/CaSiO_(3)composite hydrogel scaffold for vascularized adipose tissue restoration

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Regenerative Biomaterials 2023年第1期10卷 1073-1084页

作者： Jupei Zhang zhen zeng Yanxin Chen Li Deng Yanxin Zhang Yumei Que Yiren Jiao Jiang Chang Zhihong Dong Chen Yang School of Mechanical Engineering Chengdu UniversityChengdu 610106China Joint Centre of Translational Medicine The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000China Wenzhou Institute University of Chinese Academy of SciencesWenzhou 325000China College of Materials Science and Opto-electronic Technology University of Chinese Academy of SciencesBeijing 100049China Shanghai Institute of Ceramics Chinese Academy of SciencesShanghai 200050China

The increased number of mastectomies,combined with rising patient expectations for cosmetic and psychosocial outcomes,has necessitated the use of adipose tissue restoration ***,the therapeutic effect of current clinical strategies is not satisfying due to the high demand of personalized customization and the timely vascularization in the process of adipose ***,a composite hydrogel scaffold was prepared by three-dimensional(3D)printing technology,applying gelatin methacrylate anhydride(GelMA)as printing ink and calcium silicate(CS)bioceramic as an active ingredient for breast adipose tissue *** in vitro experiments showed that the composite hydrogel scaffolds could not only be customized with controllable architectures,but also significantly stimulated both 3T3-L1 preadipocytes and human umbilical vein endothelial cells in multiple cell behaviors,including cell adhesion,proliferation,migration and ***,the composite scaffold promoted vascularized adipose tissue restoration under the skin of nude mice in *** findings suggest that 3D-printed GelMA/CS composite scaffolds might be a good candidate for adipose tissue engineering.

关键词： 3D-printing bioceramic composite scaffold adipogenesis angiogenesis