An angiosperm NLR Atlas reveals that NLR gene reduction is associated with ecological specialization and signal transduction component deletion

作     者：Yang Liu Zhen Zeng Yan-Mei Zhang Qian Li Xing-Mei Jiang Zhen Jiang Ji-Hong Tang Dijun Chen Qiang Wang Jian-Qun Chen Zhu-Qing Shao Yang Liu;Zhen Zeng;Yan-Mei Zhang;Qian Li;Xing-Mei Jiang;Zhen Jiang;Ji-Hong Tang;Dijun Chen;Qiang Wang;Jian-Qun Chen;Zhu-Qing Shao

作者机构：State Key Laboratory of Pharmaceutical BiotechnologySchool of Life SciencesNanjing UniversityNanjing 210023China Jiangsu Key Laboratory for the Research and Utilization of Plant ResourcesInstitute of BotanyJiangsu Province and Chinese Academy of SciencesNanjing 210014China 

出 版 物：《Molecular Plant》 (分子植物（英文版）)

年 卷 期：2021年第14卷第12期

页      面：2015-2031页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 09[农学] 071007[理学-遗传学] 0901[农学-作物学] 090102[农学-作物遗传育种] 

基　　金：supported by the National Natural Science Foundation of China(32070243 to Z.Q.S.and 31770245 to J.Q.C.) the Fundamental Research Funds for the Central Universities(020814380169 to Z.Q.S.) 

主　　题：NLR genes plant disease resistance EDS1 gene family gene family evolution angiosperms 

摘      要：Nucleotide-binding leucine-rich-repeat(NLR)genes comprise the largest family of plant disease-resis-tance *** NLR genes are phylogenetically divided into the TNL,CNL,and RNL *** copy numbers and subclass composition vary tremendously across angiosperm ***,the evolutionary associations between genomic NLR content and ecological adaptation,or between NLR content and signal transduction components,are poorly characterized because of limited genome *** this study,we established an angiosperm NLR atlas(ANNA,https://***/ANNA/)that includes NLR genes from over 300 angiosperm *** ANNA,we revealed that NLR copy numbers differ up to 66-fold among closely related species owing to rapid gene loss and ***,NLR contraction was associated with adaptations to aquatic,parasitic,and carnivorous *** convergent NLR reduction in aquatic plants resembles the lack of NLR expansion during the long-term evolution of green algae before the colonization of land.A co-evolutionary pattern between NLR subclasses and plant immune pathway components was also identified,suggesting that immune pathway deficiencies may drive TNL ***,we identified a conserved TNL lineage that may function independently of the EDS1-SAG101-NRG1 ***,these findings provide new insights into the evolution of NLR genes in the context of ecological adaptation and genome content variation.