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Alterations of gut microbiota diversity, composition and metabonomics in testosterone-induced benign prostatic hyperplasia rats

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Military Medical Research 2023年第1期10卷 1-16页

作者： Lu-Yao Li Jie han Lan Wu Cheng Fang Wei-guang Li Jia-Min Gu Tong Deng Chang-Jiang Qin Jia-Yan Nie Xian-Tao zeng Center for Evidence‑Based and Translational Medicine Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Gastrointestinal Surgery Huaihe Hospital of Henan UniversityKaifeng 475000HenanChina Department of Gastroenterology Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Stomatology Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Urology Zhong‑nan Hospital of Wuhan UniversityWuhan 430071China

Background: Studies had shown many diseases affect the stability of human microbiota, but how this relates to benign prostatic hyperplasia(BPH) has not been well understood. hence, this study aimed to investigate the regulation of BPH on gut microbiota composition and ***: We analyzed gut samples from rats with BPH and healthy control rats, the gut microbiota composition and metabonomics were detected by 16S rDNA sequencing and liquid chromatography tandem mass spectrometry(LC–MS/MS).Results: High-throughput sequencing results showed that gut microbiota beta-diversity increased(Phe BPH group vs. control group. Muribaculaceae(Phe BPH group, whereas that of Mollicutes(Phe control group. Despite profound interindividual variability, the levels of several predominant genera were different. In addition, there were no statistically significant differences in several bacteria. BPH group vs. control group: Firmicutes(52.30% vs. 57.29%, P>0.05), Bacteroidetes(46.54% vs. 41.64%,P>0.05), Clostridia(50.89% vs. 54.66%, P>0.05), Ruminococcaceae(25.67% vs. 20.56%, P>0.05). LC–MS/MS of intestinal contents revealed that differential metabolites were mainly involved in cellular processes, environmental information processing, metabolism and organismal systems. The most important pathways were global and overview maps, lipid metabolism, amino acid metabolism, digestive system and endocrine system. Through enrichment analysis, we found that the differential metabolites were significantly enriched in metabolic pathways, steroid hormone biosynthesis,ovarian steroidogenesis, biosynthesis of unsaturated fatty acids and bile secretion. Pearson correlation analysis(R=0.94) showed that there was a strong correlation between Prevotellaceae, Corynebacteriaceae, Turicibacteraceae,Bifid

关键词： Benign prostatic hyperplasia Gut microbiota Intestinal metabolites Microbial diversity

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π-Conjugated Unit-Dependent Optical Properties of Linear Conjugated Oligomers

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Chinese Journal of Chemical Physics 2014年第3期27卷 315-320页

作者： Ning Sui Lu Zou Yun-fei Song Qiu-lin Zhong Ying-hui Wang Xiao-gang Wei zeng-bin Wang Yu-guang Ma Yan-qiang Yang han-zhuang Zhang Femtosecond Laser Laboratory College of Physics Jilin University Changchun 130012 China Quantum Enginerring Center Beingjing Institute of Control Device Beijing 100854 China State Key Laboratory of Supramolecular Structure and Materials Jilin University Changchun 130012 China State Key Laboratory of Inorganic Synthesis and Preparative Chemistry Jilin University Changchun 130012 China Department of Physics Harbin Institute of Technique Harbin 150000 China

The optical properties of three linear conjugated oligomers （F-P, F-P-F, and P-F-P-F-P）, where phenothiazine （P） and fluorene （F） groups arrange alternately, are investigated. With the enhancement of the π-conjugated system, their absorption and emission bands both gradually red shift, and their two-photon properties are also improved. Meanwhile, their fluorescence dynamic traces are analyzed with continuous rate distribution model, exhibiting that their decay rates gradually accelerate and the rate distribution width become narrower. The quantum chemical calculation offers their molecular structures and transition mechanism, showing that the enhancement of π-conjugated system should be responsible for tile improvement of two-photon properties.

关键词： Oligomer Z-scan Fluorescence dynamics

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Features of the Real Structure of Lanthanum hexaboride Polycrystalline

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Chinese Physics Letters 2001年第7期18卷 942-943页

作者： ZheNG Shu-Qi MIN guang-Hui ZOU zeng-Da YU Pu-Lian han Jian-De Y.B.Paderno College of Materials Science and Engineering Shandong UniversityJi’nan 250061 Institute for Problems of Materials Science National Academy of Sciences of UkraineKiev 03142Ukraine

The Microstructure of lanthanum hexaboride(LaB6)polycrystalline has been studied by using transmission electron *** shows that the ideal LaB6 polycrystalline can be obtained by sintering ingots at the temperature of 2273 K for holding time of 120 min in Ar pressure of 800 Torr,where the ingots are formed by pressing LaB6 powder at room temperature at a pressure of 0.4-0.5 *** particles in LaB6 polycrystalline hardly bind;there are only a few of pores at the joint parts of three particles and a few of impurities exist in some *** sintering process for fabricating LaB6 polycrystalline is analysed and the formation of the pore and the impurities are studied from the point of surface tension.

关键词： LaB6 polycrystalline lanthanum

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Oxyphyllones A and B,novel sesquiterpenes with an unusual 4,5-secoeudesmane skeleton from Alpinia oxyphylla

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Chinese Chemical Letters 2009年第8期20卷 945-948页

作者： Jun Ju Xu Ning Hua Tan Jiang Xiong Abiodun Humphrey Adebayo Hong Jin han guang Zhi zeng Chang Jiu Ji Yu Mei Zhang Mei Ju Zhu State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of Sciences Kunming 650204 PR China Department of Biological Sciences College of Science and Technology Covenant University Ota P.M.B. 1023 Ogun State Nigeria Graduate University of the Chinese Academy of Sciences Beijing 100049 PR China

Two novel 4,5-secoeudesmane sesquiterpenoids, oxyphyllones A （1） and B （2） were isolated from the fruits of Alpinia oxyphylla. Their structures were established by spectroscopic methods including 1D and 21） NMR spectra. These two compounds are the first example of naturally occurring sesquiterpenoids with a 4,5-secoeudesmane skeleton in the family of Zingiberaceae and oxyphyllone A （1） is the first 4,5-secoeudesmane type of 13-norsesquiterpenoid. Compounds 1 and 2 exhibited no cytotoxicities against three cancer cell lines at 10 μg/mL. ？ 2009 Ning Hua Tan. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

关键词： Alpinia oxyphylla Zingiberaceae 4,5-Secoeudesmane sesquiterpenoid Oxyphyllone A Oxyphyllone B

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危险废物焚烧炉含氟废物焚烧过程中氟的演化及分布特征（英文）

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2019年第8期20卷 564-576页

作者： Wen-han LI zeng-yi MA Jian-hua YAN Qun-xing HUANG Xu-guang JIANG State Key Laboratory of Clean Energy Utilization Institute for Thermal Power EngineeringZhejiang University

目的:含氟废物焚烧过程排放的氟化物会危害人体健康,造成环境污染。本文旨在探究含氟废物焚烧过程中氟的析出特性、氟在焚烧系统中的分布特征以及氟在焚烧灰渣中的赋存形态。这对评估含氟废物在焚烧过程中造成的氟污染以及污染控制具有... 详细信息

目的:含氟废物焚烧过程排放的氟化物会危害人体健康,造成环境污染。本文旨在探究含氟废物焚烧过程中氟的析出特性、氟在焚烧系统中的分布特征以及氟在焚烧灰渣中的赋存形态。这对评估含氟废物在焚烧过程中造成的氟污染以及污染控制具有重要意义。创新点:1.系统研究了氟在焚烧过程中的释放特征以及氟在整个焚烧系统中的质量流,对评估焚烧过程中的氟污染及污染控制具有重要意义;2.系统研究了焚烧灰渣中氟的赋存形态,为后续灰渣中氟污染控制研究奠定基础。方法:1.采用热重红外联用方法,分析研究含氟废物热解过程中氟的析出特性(图4和6);2.采用高温燃烧水解-离子色谱的方法,测定焚烧灰渣中的氟含量,并结合灰渣量等数据,得到氟在焚烧系统的分布特征(图10和11);3.采用连续化学萃取法,得到焚烧灰渣中氟的赋存形态(图12和13)。结论:1.热解过程中,含氟废物中氟主要以氟化氢和氟化硅形式释放;氟化氢的释放可以分为3个温度区:123.5~757.5°C、757.5~959.6°C及959.6°C以上;氟化硅的释放主要集中在132.6~684.0°C。2.焚烧过程中,超过79.17%的氟被湿法脱酸系统吸收,不到20.73%的氟存在于焚烧灰渣中;排放到大气中的氟占比小于0.12%。3.底渣和燃尽室灰中的氟主要以残余态存在;余热锅炉灰和布袋飞灰中水溶态、交换态和酸溶态氟的比例之和均在80%以上。

关键词：氟污染危废焚烧含氟废物释放特性分布特性

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Role of nitric oxide during early phase myocardial ischemic preconditioning in rats

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Chinese Medical Journal 2008年第13期121卷 1210-1214页

作者： han Hong-guang WANG zeng-wei ZhanG Nan-bin ZHU Hong-yu Department of Cardiovascular Surgery Xijing Hospital of Fourth Military Medical University Xi'an Shaanxi 710032 China Department of Cardiovascular Surgery General Hospital of Shenyang Military Command Shenyang Liaoning 110016 China

Background To date, there have been no reports on altered nitric oxide （NO） content in ischemia/reperfusion with regard to in vivo preconditioning procedures. These studies are important for understanding the mechanisms of NO during early myocardial ischemic preconditioning. The aim of the present study was to investigate the mechanisms of NO during early myocardial ischemic preconditioning by measuring levels of NO and cyclic guanosine monophosphate （cGMP）, as well as activity of nitric oxide synthase （NOS） in ischemia/reperfusion with respect to preconditioning in rats. Methods Sixty-six female Sprague-Dawley rats were randomly divided into four groups： ischemic preconditioning group （IP）, ischemia/reperfusion group （I/R）, control group （CON）, and preconditioning procedure group （PC）. In the PC group, rats were further divided into PC1-, PC1＋, PC2-, PC2＋, PC3-, and PC3＋ subgroups. Rats underwent left coronary artery occlusion and reperfusion, and subsequently, NOS activity and levels were assessed with spectrophotometric analysis. cGMP contents were measured with radioimmunoassay. Results The level of NO and cGMP, as well as the activity of NOS, were significantly higher in the IP group compared to the I/R and CON groups （P 〈0.05）. During preconditioning prior to prolonged ischemia, NO and cGMP levels varied markedly with ischemia and reperfusion. The levels of NO repeatedly increased when the heart was exposed to three episodes of 5-minute ischemia, and were almost completely reversed during each reperfusion period. NO and cGMP levels were significantly different between the 5-minute period of ischemia and the same period of reperfusion during preconditioning. Conclusions NO plays an important role during early phase myocardial ischemic preconditioning in rats. NO and cGMP could be triggers and mediators of early phase myocardial ischemic preconditioning. Altered NOS activity following ischemic stress could be the primary inducer of higher NO levels detecte

关键词： ischemic preconditioning nitric oxide nitric oxide synthase cyclic guanosine monophosphate rats

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Relationships among androgen receptor CAG repeat polymorphism, sex hormones and penile length in han adult men from China： a cross-sectional study

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Asian Journal of Andrology 2014年第3期16卷 478-481页

作者： Yan-Min Ma Kai-Jie Wu Liang Ning Jin zeng Bo Kou Hong-Jun Xie Zhen-Kun Ma Xin-Yang Wang Yong-guang Gong Da-Lin he Department of Urology First Affiliated Hospital of Medical School Xi'an Jiaotong University Xi'an Oncology Research Lab Key Laboratory of Environment and Genes Related to Diseases Ministry of Education of the People's Republic of China Xi'an China.

This study aimed to investigate the correlations among androgen receptor （AR） CAG repeat polymorphism, sex hormones and penile length in healthy Chinese young adult men. Two hundred and fifty-three healthy men （aged 22.8 ± 3.1years） were enrolled. The individuals were grouped as CAG short （CAGs） if they harbored repeat length of 〈20 or as CAG long （CAGL） if their CAG repeat length was 〉20. Body height/weight, penile length and other parameters were examined and recorded by the specified physicians; CAG repeat polymorphism was determined by the polymerase chain reaction （PCR） method; and the serum levels of the sex hormones were detected by radioimmunoassay. Student＇s t-test or linear regression analysis was used to assess the associations among AR CAG repeat polymorphism, sex hormones and penile length. This investigation showed that the serum total testosterone （T） level was positively associated with the AR CAG repeat length （P = 0.01）; whereas, no significant correlation of T or AR CAG repeat polymorphism with the penile length was found （P = 0.593）. Interestingly, an inverse association was observed between serum prolactin （PRL） levels and penile length by linear regression analyses （β = -0.024, P = 0.039, 95% confidence interval （CI）： -0.047, 0）. Collectively, this study provides the first evidence that serum PRL, but not T or AR CAG repeat polymorphism, is correlated with penile length in the han adult population from northwestern China.

关键词： androgen receptor CAG repeat testosterone prolactin penile length

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A Convenient Method for the Stereoselective Synthesis of 7αHydroxycholesterol

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Chinese Chemical Letters 1998年第8期9卷 715-716页

作者： Ling Jie GAO and Tian zeng ZHAO guang Dian han(The Institute of Chemistry, henan Academy of Sciences, Zhengzhou, 450002)(Institute of Materia Medica, Peking Union Medical College,Chinese Academy of Medical Sciences, Beijing 100050) henan Acad Sci Inst Chem Zhengzhou 450002 Peoples R China Chinese Acad Med Sci Inst Mat Med Oeking Union Med Coll Beijing 100050 Peoples R China

7α-Hydroxycholesterol was prepared from cholesteryl acetate via allylic browhnation followed by hydroxylation in 73% overall yield.

关键词： 7α-hyrdoxycholesterol cholesteryl acetate stereoselective hydroxylation

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Syntheses, Characterization and Anti-HIVActivity of Charge Transferheteropolycomplexes

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Chemical Research in Chinese Universities 2001年第2期17卷 127-133页

作者： LIU Shu-xia, LI Yang-guang, han zeng-bo, HUANG Ru-dan and WANG En-bo (Department of Chemistry, Northeast Normal Univertsity, Changchun 130024, P. R. China) zeng Yi and LI Ze-lin (Chinese Academy of Preventive Medicine, Beijing 100050, P. R. China) NE Normal Univ Dept Chem Changchun 130024 Peoples R China Chinese Acad Prevent Med Beijing 100050 Peoples R China

Each of Keggin type heteropolytungstosilicic and heteropolytungstogermanic acids reacted with 8-quinolinol, p-aminodimethylaniline and pyridine, respectively, yielding six charge trans- fer heteropolycomplexes (CTHPCs), which were purified and characterized by elemental analy- sis, IR, UV and 183W NMR. The anti-HIV-1 activities of CTHPCs were evaluated by ELISA of HIV-P24 antigen. The toxicity against MT-4 cells was measured by MTT. The results show that median inhibitory concentration (IC50) for each CTHPC to inhibit HIV-P24 antigen in cell culture was lower than 5 μg/mL, while median toxicity concentration (IC50) against MT-4 cells was higher than 268 μg/mL. The following mechanisms might be considered for their anti-HIV- 1 activity, namely, (1) inhibiting the penetration of HIV- 1 virus into target cells for it can blockade CD4 receptor of MT-4 cells and (2) inhibition of syncytium formation.

关键词： heteropolycomplexes Synthesis Anti-HIV activity Mechanism

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导热能力损耗的机理及其数学表述

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中国电机工程学报 2007年第17期27卷 98-102页

作者：韩光泽过增元华南理工大学物理科学与技术学院广东省广州市510640 清华大学航天航空学院北京市海淀区100084

热量传递势容(势容,又称为火积)反映了物体的导热能力,它等于物体的热容量与温度乘积的一半。提出了热力功的概念,它被定义为传热温度与被传递热量的乘积。传热过程中的热力功等于势容的改变量,热力功就是传递过程中的势容。在导热过程... 详细信息

热量传递势容(势容,又称为火积)反映了物体的导热能力,它等于物体的热容量与温度乘积的一半。提出了热力功的概念,它被定义为传热温度与被传递热量的乘积。传热过程中的热力功等于势容的改变量,热力功就是传递过程中的势容。在导热过程中势容会出现损耗,势容损耗的机理是,传热物体的温度高于吸热物体的温度,传热物体的温度所做的热力功多于吸热物体的温度所做的热力功。导热过程中的势容损耗被定义为传热物体的温度与吸热物体温度的差所做的热力功。单位时间单位体积内的势容损耗等于导热系数与温度梯度平方的乘积,该表达式可作为导热系统优化的目标函数。势容可同时作为热力学中导热过程可逆性的判据。

关键词：热力功热量传递势容损耗 [火积] 导热优化过程可逆性

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