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Timing and Spectral Analysis of the Black Hole X-Ray Binary MAXI j1803-298 with Insight-HXMT Data

Research in Astronomy and Astrophysics 2024年第6期24卷 209-224页

作者： Ying-Chen Xu jin-Lu Qu MMéndez Rui-Can Ma Long ji Liang zhang Yue Huang Qing-cui Bu Li-Ming Song Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China Kapteyn Astronomical Institute University of GroningenP.O.BOX 8009700 AV GroningenThe Netherlands Dongguan Neutron Science Center Dongguan 523808China School of Physics and Astronomy Sun Yat-Sen UniversityZhuhai 519082China Institut für Astronomie und Astrophysik Kepler Center for Astro and Particle PhysicsEberhard Karls UniversitätSand 1D-72076 TübingenGermany

We present a comprehensive analysis of the 2021 outburst of MAXI j1803–298 utilizing observations of the Insight-Hard X-ray Modulation Telescope(Insight-HXMT)spanning from the low hard state to the high soft *** the Insight-HXMT data set,compared to the previous work,we identify a more prolonged presence of typeC quasi-periodic oscillations(QPOs)with centroid frequencies ranging from~0.16 to 6.3 Hz,which present correlations with the hardness ratio and the photon index of the Comptonized *** QPO frequencies less than~2 Hz,the QPO phase lags are hard(photons of 10–19 keV arrive later than those of 1–4 keV),while at higher frequencies,the lags become soft at and above~4 ***,the spectra in all Insight-HXMT observations consist of a multi-color blackbody component and a Comptonized component,as commonly observed in classical black hole X-ray *** analyze state transitions and the evolution of accretion geometry in this *** fitted inner disk radius increases abnormally during the low hard state,hypothesized to result from the corona condensing onto the inner ***,two significant drops in flux are observed during the soft intermediate state,maybe implying changes in the corona/jet and the disk,respectively.

关键词： X-rays:binaries accretion accretion disks stars:black holes

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Charge adaptive phytochemical-based nanoparticles for eradication of methicillin-resistant staphylococcus aureus biofilms

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Asian journal of Pharmaceutical Sciences 2024年第3期19卷 160-176页

作者： Xilong cui Fanhui Liu Shuang Cai Tingting Wang Sidi zheng Xinshu zou Linlin Wang Siqi He Yanhua Li zhiyun zhang College of Veterinary Medicine Northeast Agricultural UniversityHarbin 150030China Heilongjiang Key Laboratory for Animal Disease Control and Pharmaceutical Development Harbin 150030China

The intrinsic resistance of MRSA coupled with biofilm antibiotic tolerance challenges the antibiotic treatment of MRSA biofilm ***-based nanoplatform is a promising emerging approach for treatment of biofilm ***,their therapeutic efficacy was restricted by the low drug loading capacity and lack of ***,we constructed a surface charge adaptive phytochemical-based nanoparticle with high isoliquiritigenin(ISL)loading content for effective treatment of MRSA biofilm.A dimeric ISL prodrug(ISL-G2)bearing a lipase responsive ester bond was synthesized,and then encapsulated into the amphiphilic quaternized *** obtained ISL-G2loaded NPs possessed positively charged surface,which allowed cis-aconityl-D-tyrosine(CA-Tyr)binding via electrostatic interaction to obtain ISL-G2@TMDCOS-Tyr *** NPs maintained their negatively charged surface,thus prolonging the blood circulation *** response to low pH in the biofilms,the fast removal of CA-Tyr led to a shift in their surface charge from negative to positive,which enhanced the accumulation and penetration of NPs in the ***,the pH-triggered release of D-tyrosine dispersed the biofilm and lipase-triggered released of ISL effectively kill biofilm *** in vivo study was performed on a MRSA biofilm infected wound *** phytochemical-based system led to~2log CFU(>99%)reduction of biofilm MRSA as compared to untreated wound(P<0.001)with negligible biotoxicity in *** phytochemical dimer nanoplatform shows great potential for long-term treatment of resistant bacterial infections.

关键词： MRSA biofilm Isoliquiritigenin Dimer prodrug Charge adaptive Responsive nanoparticles

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COVID-19 vaccination produces exercise-responsive SARS-CoV-2 specific T-cells regardless of infection history

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journal of Sport and Health Science 2024年第1期13卷 99-107页

作者： Kyle A.Smith Tiffany M.zúñiga Forrest L.Baker Helena Batatinha Charles R.Pedlar Shane C.Burgess Michael P.Gustafson Emmanuel Katsanis Richard j.Simpson School of Nutritional Sciences and Wellness The University of ArizonaTucsonAZ 85721USA Department of Pediatrics The University of ArizonaTucsonAZ 85724USA Faculty of Sport Allied Health and Performance ScienceSt.Mary's UniversityTwickenham TW14SXUK Institute of Sport Exercise and Health University College LondonLondon WC1E 7HUUK Department of Animal and Comparative Biomedical Sciences The University of ArizonaTucsonAZ 85721USA The University of Arizona Cancer Center The University of ArizonaTucsonAZ 85719USA Laboratory Medicine and Pathology Mayo Clinic ArizonaPhoenixAZ 85054USA Department of Immunobiology The University of ArizonaTucsonAZ 85724USA Department of Medicine The University of ArizonaTucsonAZ 85724USA Department of Pathology The University of ArizonaTucsonAZ 85724USA

Background:The mobilization and redistribution of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)specific T-cells and neutralizing antibodies(nAbs)during exercise is purported to increase immune surveillance and protect against severe coronavirus disease 2019(COVID-19).We sought to determine if COVID-19 vaccination would elicit exercise-responsive SARS-CoV-2 T-cells and transiently alter nAb ***:Eighteen healthy participants completed a 20-min bout of graded cycling exercise before and/or after receiving a COVID-19 *** major leukocyte subtypes were enumerated before,during,and after exercise by flow cytometry,and immune responses to SARS-CoV-2 were determined using whole blood peptide stimulation assays,T-cell receptor(TCR)-βsequencing,and SARS-CoV-2 nAb ***:COVID-19 vaccination had no effect on the mobilization or egress of major leukocyte subsets in response to intensity-controlled graded ***,non-infected participants had a significantly reduced mobilization of CD4+and CD8+naive T-cells,as well as CD4+central memory T-cells,after vaccination(synthetic immunity group);this was not seen after vaccination in those with prior SARS-CoV-2 infection(hybrid immunity group).Acute exercise after vaccination robustly mobilized SARS-CoV-2 specific T-cells to blood in an intensity-dependent *** groups mobilized T-cells that reacted to spike protein;however,only the hybrid immunity group mobilized T-cells that reacted to membrane and nucleocapsid *** increased significantly during exercise only in the hybrid immunity ***:These data indicate that acute exercise mobilizes SARS-CoV-2 specific T-cells that recognize spike protein and increases the redistribution of nAbs in individuals with hybrid immunity.

关键词： Anti-viral COVID-19 Exercise immunology SARS-CoV-2 T-Cells Vaccine

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Night warming increases wheat yield by improving pre-anthesis plant growth and post-anthesis grain starch biosynthesis

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journal of Integrative Agriculture 2024年第2期23卷 536-550页

作者： Yonghui Fan Boya Qin jinhao Yang Liangliang Ma Guoji cui Wei He Yu Tang Wenjing zhang Shangyu Ma Chuanxi Ma zhenglai Huang College of Agronomy Anhui Agricultural University/Key Laboratory of Wheat Biology and Genetic Improvement in South Yellow&Huai River ValleyMinistry of Agriculture and Rural AffairsHefei 230036China Xianyang Central Station for Agricultural Technology Extension Xianyang 712000China

Global climate change is characterized by asymmetric warming,i.e.,greater temperature increases in winter,spring,and nighttime than in summer,autumn,and *** experiments were conducted using four wheat cultivars,namely‘Yangmai 18’(YM18),‘Sumai 188’(SM188),‘Yannong 19’(YN19),and‘Annong 0711’(AN0711),in the two growing seasons of 2019-2020 and 2020-2021,with passive night warming during different periods in the early growth *** treatments were night warming during the tillering-jointing(NW_(T-j)),jointing-booting(NWj-B),and booting-anthesis(NWB-A)stages,with ambient temperature(NN)as the *** effects of night warming during different stages on wheat yield formation were investigated by determining the characteristics of dry matter accumulation and translocation,as well as sucrose and starch accumulation in wheat *** wheat yields of all four cultivars were significantly higher in NW_(T-j)than in NN in the 2-year *** yield increases of semi-winter cultivars YN19 and AN0711 were greater than those of spring cultivars YM18 and *** NW_(T-j)increased wheat yield mainly by increasing the 1,000-grain weight and the number of fertile spikelets,and it increased dry matter accumulation in various organs of wheat at the anthesis and maturity stages by increasing the growth rate at the vegetative growth *** flag leaf and spike showed the largest increases in dry matter ***_(T-j)also increased the grain sucrose and starch contents in the early and middle grain-filling stages,promoting yield ***,night warming between the tillering and jointing stages increased the pre-anthesis growth rate,and thus,wheat dry matter production,which contributed to an increase in wheat yield.

关键词： wheat asymmetric warming dry matter accumulation and translocation starch yield

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A New Approach to Suppress Tip Leakage Flow Utilizing Induced Shock Wave in Tip Region of a Transonic Compressor Rotor

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journal of Thermal Science 2024年第06期33卷 2059-2074页

作者： cui Weiwei YAO Fei LI zongming WANG Xiaonan CHANG Guozhang WANG cuiping College of Energy Storage Technology Shandong University of Science and Technology Clean energy laboratory Shandong University of Science and Technology College of Civil Engineering and Architecture Shandong University of Science and Technology

Tip leakage flow affects the flow stability of high-loading compressors ***,a novel approach via induced shock wave near suction-side edge of blade tip was proposed to suppress the strength and influence range of leakage flow in a transonic *** new schemes with different circumferentially diverging degrees of clearance were designed to reveal the mechanism of the new *** the action of the circumferentially diverging clearance(from the pressure side to the suction side over blade tip),a much more dramatic acceleration of the supersonic leakage jet flow appeared over blade tip of the new *** induced shock wave was produced near the suction side edge of blade tip due to the pressure difference between the discharging leakage flow and the surrounding high-pressure mainflow in tip *** a result,both the mass flow rate and the outlet velocity of leakage flow were reduced significantly via the induced shock ***,the suppressing effect of the new approach on the tip leakage jet flow was closely related to the strength and circumferential location of the induced shock *** the aids of the induced shock wave,the largest improvement of tip flow characteristics with an over 5% increase in stall margin was realized in new transonic rotor when the circumferential divergence angle equals 8°,accompanied with no more than a 0.4%decrease in isentropic efficiency.

关键词： circumferentially diverging clearance induced shock wave leakage flow low-velocity region stall margin enhancement

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In vivo and in vitro study of resorbable magnesium wires for medical implants:Mg purity,surface quality,zn alloying and polymer coating

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journal of Magnesium and Alloys 2024年第6期12卷 2472-2488页

作者： K.Tesar j.Luňácková M.jex M.Žaloudková R.Vrbová M.Bartoš P.Klein L.Vištejnová j.Dušková E.Filová z.Sucharda M.Steinerová S.Habr K.Balík A.Singh Department of Materials Faculty of Nuclear Sciences and Physical EngineeringCzech Technical University in PragueTrojanova 13Prague 12000Czech Republic Institute of Physics Czech Academy of SciencesNa Slovance 2Prague 18221Czech Republic Institute of Dental Medicine First Faculty of MedicineCharles University and General University Hospital in PragueKaterinská32Prague 12801Czech Republic Department of Physics Faculty of Nuclear Sciences and Physical EngineeringCzech Technical University in PragueBrehová7Prague 11519Czech Republic Department of Composites and Carbon Materials Institute of Rock Structure and MechanicsCzech Academy of SciencesV Holešovickách 41Prague 18209Czech Republic Institute of Anatomy First Faculty of MedicineCharles UniversityU Nemocnice 3Prague 12800Czech Republic Biomedical Center Faculty of Medicine in PilsenCharles UniversityAlej Svobody 76Pilsen 32300Czech Republic Department of Pathological Physiology Faculty of Medicine in PilsenCharles UniversityAlej Svobody 7632300 PilsenCzech Republic Department of Histology and Embryology Faculty of Medicine in PilsenCharles UniversityAlej Svobody 7632300 PilsenCzech Republic Institute of Pathology First Faculty of MedicineCharles University and General University Hospital in PragueStudnickova 2Prague 12800Czech Republic Department of Biomaterials and Tissue Engineering Institute of PhysiologyCzech Academy of SciencesVidenska 1083Prague 14200Czech Republic Research Center for Structural Materials National Institute for Materials Science1-2-1 SengenTsukuba 305-0047Japan

Magnesium is an excellent material in terms of biocompatibility and its corrosion products can serve as an active source for new bone ***,localized corrosion and H_(2)generation limit the potential of Mg-based *** low-alloyed Mg-zn wires can strongly reduce problems with large H_(2)bubbles and improve the mechanical properties considerably while maintaining excellent long-term *** pickling and a polymer coating can be effectively used to lower the rate of in vivo *** this work,microstructural,mechanical,and in vitro characterization of 250μm and 300μm extruded wires made from ultra-pure Mg,commercially pure Mg,Mg-0.15zn,Mg-0.4zn and Mg-1zn was ***,Mg-0.4zn wires together with a variant coated with a copolymer of L-lactide andε-caprolactone were tested in vivo on artificially damaged Wistar rat *** on the observed Mg-induced osteogenesis,polymer-coated Mg wires with a small addition of zn are a perspective material for bone-support applications,such as cerclage and fixation wires.

关键词： Magnesium Resorbable Mg wire Mg-zn implant degradation Biocompatibility study zn grain boundary segregation

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Effect of plateletcrit and methylenetetrahydrofolate reductase(MTHFR)C677T genotypes on folic acid efficacy in stroke prevention

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2694-2701页

作者： Yuncong Shi zhengzhipeng zhang Binyan Wang Yu Wang Xiangyi Kong Yong Sun Aimin Li Yimin cui Yan zhang jianping Li Yong Huo Hui Huang Cardiovascular Department The Eighth Affiliated HospitalJoint Laboratory of Guangdong-Hong Kong-Macao Universities for Nutritional Metabolism and Precise Prevention and Control of Major Chronic DiseasesSun Yat-sen UniversityShenzhenChina Shenzhen Evergreen Medical Institute ShenzhenChina Shenzhen Tailored Medical Laboratory ShenzhenChina Department of Cardiology Beijing Anzhen HospitalCapital Medical UniversityBeijingChina Department of Neurosurgery The First Affiliated Hospital of Kangda College of Nanjing Medical UniversityLianyungangChina Institute of Clinical Pharmacology Peking University First HospitalBeijingChina Department of Cardiology Peking University First HospitalBeijingChina

Previous studies have shown that low platelet count combined with high plasma total homocysteine(tHcy)increased stroke risk and can be lowered by 73% with folic ***,the combined role of other platelet activation parameters and the methylenetetrahydrofolate reductase(MTHFR)C677T genotypes on stroke risk and folic acid treatment benefit remain to be *** study aimed to investigate if platelet activation parameters and MTHFR genotypes jointly impact folic acid treatment efficacy in first stroke *** were derived from the China Stroke Primary Prevention *** study includes a total of 11,185 adult hypertensive patients with relevant platelet activation parameters and MTHFR genotype *** simultaneously considering both platelet activation parameters(plateletcrit,platelet count,mean platelet volume,platelet distribution width)and MTHFR genotypes,patients with both low plateletcrit(Q1)and the TT genotype had the highest stroke incidence rate(5.6%)in the enalapril *** subgroup significantly benefited from folic acid treatment,with a 66% reduction in first stroke(HR:0.34;95%CI:0.14-0.82;p=0.016).Consistently,the subgroup with low plateletcrit(Q1)and the CC/CT genotype also benefited from folic acid treatment(HR:0.40;95%CI:0.23-0.70;p=0.001).In Chinese hypertensive adults,low plateletcrit can identify those who may greatly benefit from folic acid treatment,in particular,those with the TT genotype,a subpopulation known to have the highest stroke risk.

关键词： prevention treatment MTHFR

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Integrating evolutionary genomics of forest trees to inform future tree breeding amid rapid climate change

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Plant Communications 2024年第10期5卷 59-81页

作者： jiajun Feng Xuming Dan Yangkai cui Yi Gong Minyue Peng Yupeng Sang Par K.Ingvarsson jing Wang Key Laboratory for Bio-Resources and Eco-Environment of Ministry of Education College of Life SciencesSichuan UniversityChengduChina Department of Plant Biology Linnean Centre for Plant BiologySwedish University of Agricultural SciencesUppsalaSweden

Global climate change is leading to rapid and drastic shifts in environmental conditions,posing threats to biodiversity and nearly all life forms *** trees serve as foundational components of terrestrial ecosystems and play a crucial and leading role in combating and mitigating the adverse effects of extreme climate events,despite their own vulnerability to these ***,understanding and monitoring how natural forests respond to rapid climate change is a key priority for biodiversity conserva*** progress in evolutionary genomics,driven primarily by cutting-edge multi-omics technologies,offers powerful new tools to address several key *** include precise delineation of species and evolutionary units,inference of past evolutionary histories and demographic fluctuations,identification of environmentally adaptive variants,and measurement of genetic load *** the urgency to deal with more extreme environmental stresses grows,understanding the genomics of evolutionary history,local adaptation,future responses to climate change,and conservation and restoration of natural forest trees will be critical for research at the nexus of global change,population genomics,and conservation *** this review,we explore the application of evolutionary genomics to assess the effects of global climate change using multi-omics approaches and discuss the outlook for breeding of climate-adapted trees.

关键词： forest trees climate change multi-omics evolutionary genomics breeding

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Simultaneous microwave characterization of wafer-level optoelectronic transceiver chips based on photonic sampling and mapping

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Science China(Information Sciences) 2024年第2期67卷 337-338页

作者： Yutong HE Xinhai zOU Ying XU zhihui LI Naidi cui junbo FENG Yali zHANG zhiyao zHANG Shangjian zHANG Yong LIU Ninghua zHU Research Center for Microwave Photonics State Key Laboratory of Electronic Thin Films and Integrated DevicesSchool of Optoelectronic Science and EngineeringUniversity of Electronic Science and Technology of China Chongqing United Microelectronics Center (CUMEC) Xiongan Institute of Innovation Chinese Academy of Sciences

Photonic integrated circuits(PICs) promise future parallelism growths of high-performance communication, computation, and offer unprecedented bandwidth scalability with reduced power consumption as a viable replacement for an electrical wire with an optoelectronic transceiver consisting of a transmitter and a receiver integrated on the same wafer.

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Genome-editing of a circadian clock gene TaPRR95 facilitates wheat peduncle growth and heading date

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journal of Genetics and Genomics 2024年第10期51卷 1101-1110页

作者： Fu M. Liu S. Che Y. cui D. Deng z. Li Y. zou X. Kong X. Chen G. zhang M. Liu Y. Wang X. Liu W. Liu D. Geng S. Li A. Mao L. State Key Laboratory of Crop Gene Resources and Breeding and National Key Facility for Crop Resources and Genetic Improvement Institute of Crop Science Chinese Academy of Agricultural Sciences Beijing 100081 China College of Life Sciences Henan Normal University Henan Xinxiang 453007 China College of Agronomy Sichuan Agricultural University Sichuan Chengdu 610106 China College of Agronomy Henan Agricultural University Henan Zhengzhou 450002 China School of Life Science Shanxi University Shanxi Taiyuan 030006 China

Plant height and heading date are important agronomic traits in wheat (Triticum aestivum L.) that affect final grain yield. In wheat, knowledge of pseudo-response regulator (PRR) genes on agronomic traits is limited. Here, we identify a wheat TaPRR95 gene by genome-wide association studies to be associated with plant height. Triple allele mutant plants produced by CRISPR/Cas9 show increased plant height, particularly the peduncle, with an earlier heading date. The longer peduncle is mainly caused by the increased cell elongation at its upper section, whilst the early heading date is accompanied by elevated expression of flowering genes, such as TaFT and TaCO1. A peduncle-specific transcriptome analysis reveals up-regulated photosynthesis genes and down-regulated IAA/Aux genes for auxin signaling in prr95aabbdd plants that may act as a regulatory mechanism to promote robust plant growth. A haplotype analysis identifies a TaPRR95-B haplotype (Hap2) to be closely associated with reduced plant height and increased thousand-grain weight. Moreover, the Hap2 frequency is higher in cultivars than that in landraces, suggesting the artificial selection on the allele during wheat breeding. These findings suggest that TaPRR95 is a regulator for plant height and heading date, thereby providing an important target for wheat yield improvement. © 2024 Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, and Genetics Society of China

关键词： CRISPR/Cas9 Heading date Photosynthesis Phytohormone Plant height Pseudo-response regulator (PRR) TaPRR95 Wheat

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