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Exploring a natural MDR reversal agent: potential of medicinal food supplement Nerium oleander leaf distillate

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Asian Pacific Journal of Tropical Biomedicine 2013年第8期3卷 644-649页

作者： Meltem Demirel Kars Ufuk Gündüz Kamilüney AhmetLevent ba Seluk University Saraynü Vocational High School42430 KonyaTurkey Seluk University Advanced Technology Research and Application Center42075 KonyaTurkey Middle East Technical University Department of Biological Sciences06531 AnkaraTurkey Selcuk University Faculty of Veterinary MedicineDepartment of Toxicology and Pharmacology42075KonyaTurkey Selcuk University Faculty of Veterinary MedicineDepartment of Toxicology and Pharmacology42075KonyaTurkeyy

Objective:To investigate the molecular effects ofNerium oleanderleaf distillate on paclitaxel and vincristine resistant(MCF-7/Pac and MCF-7/Vinc)cells and sensitive(MCF-7/S)cell ***:Nerium oleander(***)leaf extract was obtained by hydrodistillation *** toxicological effects ***,previously suggested as medicinal food supplement,on drug resistant cells were evaluated by XTT *** modulation potential of the plant material was evaluated by flow cytometry and fluorescent *** and vincristine were applied to the sublines in combination with ***:Fractional inhibitory indices show *** did not increase the antiproliferative effects of anticancer *** in to MCF-7/Pac and MCF-7/Vinc did not inhibit P-gp activity and MDR1 gene expression ***:As a result it may be suggested that *** has some medicinal effects as food supplement it may not be suitable as an MDR modulator for drug resistant breast cancer cells.

关键词： Nerium oleander MCF-7 FRSA activity MDR reversal Medicinal food supplement

The Durability of Epoxy Resin Coating

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Journal of Wuhan University of Technology(Materials Science) 2008年第2期23卷 242-244页

作者： zHAO Fujun ba Hengjing GAO Xiaojian School of Civil Engineering Harbin Institute of Technology Harbin 150090 China Daqing Oilfield Construction Group Daqing 163453 China

The durability of epoxy resin coating was studied under environments with relative humidity （RH） of 98%-100%, at 55 ℃ for 900 h, at 65 ℃ for 700 h and at 75 ℃ for 400 h, respectively. Peel strength test, dynamical mechanical thermal analysis （DMTA）, infrared spectroscopy （IR） and energy dispersive X-ray spectroscopy （EDX） were employed for measurements. Peel strength indicated the development of adhesive property of the coating, DMTA indicated the development of physical property, IR revealed the development of chemical structure, and EDX showed surface element change of the coating. All these results show a good time- temperature equivalence characteristic between humidity aging time and temperature.

关键词： epoxy resin coating durability time-temperature equivalence

SPME as a green sample-preparation technique for the monitoring of phytocannabinoids and endocannabinoids in complex matrices

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Journal of Pharmaceutical Analysis 2023年第10期13卷 1117-1134页

作者： Katarzyna Wozniczka PawełKonieczynski Alina Plenis Tomasz ba˛czek Anna Roszkowska Department of Pharmaceutical Chemistry Medical University of GdanskGdanskPoland Department of Analytical Chemistry Medical University of GdanskGdanskPoland

The endocannabinoid system(ECS),particularly its signaling pathways and ligands,has garnered considerable interest in recent *** with clinical work investigating the ECS’functions,including its role in the development of neurological and inflammatory conditions,much research has focused on developing analytical protocols enabling the precise monitoring of the levels and metabolism of the most potent ECS ligands:exogenous phytocannabinoids(PCs)and endogenous cannabinoids(endocannabinoids,ECs).Solid-phase microextraction(SPME)is an advanced,non-exhaustive sample-preparation technique that facilitates the precise and efficient isolation of trace amounts of analytes,thus making it appealing for the analysis of PCs and ECs in complex matrices of plant and animal/human *** this paper,we review recent forensic medicine and toxicological studies wherein SPME has been applied to monitor levels of PCs and ECs in complex matrices,determine their effects on organism physiology,and assess their role in the development of several diseases.

关键词： Phytocannabinoids Endocannabinoids Solid-phase microextraction Plant material Biological matrix

Recent progress in the research on magnesium and magnesium alloy foils:A short review

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International Journal of Minerals,Metallurgy and Materials 2024年第5期31卷 842-854页

作者： Qiuyan Shen Yongxing ba Peng zhang Jiangfeng Song Bin Jiang Fusheng Pan National Engineering Research Center for Magnesium Alloys Chongqing UniversityChongqing 400044China College of Materials Science and Engineering Chongqing UniversityChongqing 400044China National Key Laboratory of Advanced Casting Technologies Chongqing UniversityChongqing 400044China

Magnesium and magnesium alloy foils have great potential for application in battery anodes,electromagnetic shielding,optics and acoustics,and biology because of their excellent specific damping,internal dissipation coefficients,magnetic and electrical conductivities,as well as high theoretical specific ***,magnesium alloys exhibit poor deformation ability due to their hexagonal close-packed crystal *** magnesium and magnesium alloy foils with thicknesses of less than 0.1 mm is difficult because of surface oxidation and grain growth at high temperatures or severe anisotropy after cold rolling that leads to *** methods have been applied to prepare magnesium alloy *** include warm rolling,cold rolling,accumulative roll bonding,electric plastic rolling,and on-line heating *** of magnesium and magnesium alloy foils during preparation,such as edge cracks and breakage,are important factors for ***,the current status of the research on magnesium and magnesium alloy foils is summarized from the aspects of foil preparation,defect control,performance characterization,and application *** advantages and disadvantages of different preparation methods and defect(edge cracks and breakage)mechanisms in the preparation of foils are identified.

关键词： magnesium alloy foil rolling defect performance application

Anti-cd TCR antibody-expanded cd T cells:a better choice for the adoptive immunotherapy of lymphoid malignancies

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Cellular & Molecular Immunology 2012年第1期9卷 34-44页

作者： Jianhua zhou Ning Kang Lianxian Cui Denian ba Wei He Department of Immunology Institute of Basic Medical SciencesChinese Academy of Medical Sciences and School of Basic MedicinePeking Union Medical CollegeNational Key Laboratory of Medical Molecular BiologyBeijingChina

Cell-based immunotherapy for lymphoid malignancies has gained increasing attention as patients develop resistance to conventional *** T cells,which have major histocompatibility complex(MHC)-unrestricted lytic activity,have become a promising candidate population for adoptive cell transfer *** previously established a stable condition for expanding cd T cells by using anti-cd T-cell receptor(TCR)*** this study,we found that adoptive transfer of the expanded cd T cells to Daudi lymphoma-bearing nude mice significantly prolonged the survival time of the mice and improved their living *** further investigated the characteristics of these antibody-expanded cd T cells compared to the more commonly used phosphoantigen-expanded cd T cells and evaluated the feasibility of employing them in the treatment of lymphoid *** but sustained proliferation of human peripheral blood cd T cells was observed upon stimulation with anti-cd TCR *** to phosphoantigen-stimulated cd T cells,the antibody-expanded cells manifested similar functional phenotypes and cytotoxic activity towards lymphoma cell *** is noteworthy that the anti-cd TCR antibody could expand both the Vd1 and Vd2 subsets of cd T *** in vitro-expanded Vd1 T cells displayed comparable tumour cell-killing activity to Vd2 T ***,owing to higher C–C chemokine receptor 4(CCR4)and CCR8 expression,the Vd1 T cells were more prone to infiltrate CCL17-or CCL22-expressing lymphomas than the Vd2 T *** the peripheral blood cd T cells from lymphoma patients further confirmed that the anti-cd TCR antibody-expanded cd T cells could be a more efficacious choice for the treatment of lymphoid malignancies than phosphoantigen-expanded cd T cells.

关键词： adoptive cell therapy anti-cd TCR antibody cd T cells lymphoid malignancies Vd1 subset

Is the polydispersity exponent of the hyperbranched polymers the 3/2 or 5/2?

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Chinese Science Bulletin 2006年第12期51卷 1526-1528页

作者： ba Xinwu LIU Ying WANG Sujuan WANG Haijun College of Chemistry and Environment Science Hebei University Baoding 071002 China Department of Chemistry Hebei Normal University of Science and Technology Qinhuangdao 066600 China

The number of the hyperbranched polymers in the system is investigated for the polymerization process to give the asymptotic form of the concentration of the n-mer. The polydispersity exponent is calculated, which coincides with that of the classical result. Finally, the asymptotic forms of the number, the weight and the z-average degrees of the polymerization were evaluated analytically to obtain polydispersity index, which is close to 1 as the reaction is quantitatively completed.

关键词：超分支聚合体多分散指数聚合过程渐近形式

FOXG1 Directly Suppresses Wnt5a During the Development of the Hippocampus

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Neuroscience Bulletin 2021年第3期37卷 298-310页

作者： Yang Ni Bin Liu Xiaojing Wu Junhua Liu Ru ba Chunjie zhao Key Laboratory of Developmental Genes and Human Diseases Ministry of EducationSchool of MedicineSoutheast UniversityNanjing 210009China

The Wnt signaling pathway plays key roles in various developmental ***5a,which activates the non-canonical pathway,has been shown to be particularly important for axon guidance and outgrowth as well as dendrite ***,the mechanism underlying the regulation of Wnt5a remains ***,through conditional disruption of Foxg1 in hippocampal progenitors and postmitotic neurons achieved by crossing Foxg1~(fl/fl)with Emx1-Cre and Nex-Cre,respectively,we found that Wnt5a rather than Wnt3a/Wnt2b was markedly *** of Foxg1 had the opposite effects along with decreased dendritic complexity and reduced mossy fibers in the *** further demonstrated that FOXG1 directly repressed Wnt5a by binding to its promoter and one enhancer *** results expand our knowledge of the interaction between Foxg1 and Wnt signaling and help elucidate the mechanisms underlying hippocampal development.

关键词： Wnt5a Foxg1 hippocampus granule cell pyramidal neuron dendritic arborization mossy fiber Wnt

Development and Control Strategy of Subsea All-Electric Actuators

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Journal of Ocean University of China 2022年第5期21卷 1133-1146页

作者： LIU Peng SHEN Dagang ba Yaoji CAO Jinfeng LIU Jie WANG Lihui School of Mechanical and Automotive Engineering Qingdao University of TechnologyQingdao 266520China Shandong Meichen Industry Group Co. Ltd.Weifang 262200China

The development of subsea all-electric Christmas trees is an area of focus in the offshore oil industry *** main difficulties are associated with the development and control strategies for subsea all-electric actuators,which are the most criti-cal components of subsea Christmas trees.A single-motor-level fuzzy PID control with an integrated working condition detection mod-ule and a three-motor redundant-level deviation strategy with coupled joint synchronous control were proposed in this paper to real-ize the real time determination of algorithm parameters according to the working conditions,solve the rapid redistribution problems,and maintain the fast speed of the servo motor of the subsea all-electric tree valve actuator.A synchronous control electrical system was built,tested,and verified through simulation *** results show that the two redundant servo motors can still control the all-electric valve actuator and provide good synchronization control capabilities despite the failure of one servo motor,and the verti-cal and horizontal vibration values of the system are within reasonable *** synchronous control strategy can be applied to the synchronous control problem of subsea all-electric production systems,which is of considerable importance for the development of subsea all-electric production systems.

关键词： subsea all-electric actuator redundant-level deviation strategy synchronous control model synchronous control strategy load shocks strong robustness

In-situ construction of z-scheme g-C_(3)N_(4)/WO_(3) composite with enhanced visible-light responsive performance for nitenpyram degradation

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Chinese Chemical Letters 2021年第7期32卷 2179-2182页

作者： Shiqiao zhou Ye Wang Kun zhou Dongyang ba Yanhui Ao Peifang Wang Key Laboratory of Integrated Regulation and Resource Development on Shallow Lakes of Ministry of Education College of EnvironmentHohai UniversityNanjing 210098China

Developing an excellent photocatalysis system to remove pesticides from water is an urgent problem in current environment purification ***,a z-scheme WO_(3)/g-C_(3)N_(4) photocatalyst was prepared by a facile in-situ calcination method,and the photocatalytic activity was investigated for degradation of nitenpyram(NTP)under visible *** optimal z-scheme WO_(3)/g-C_(3)N_(4) photocatalyst displayed the highest rate constant(0.036 min-1),which is about 1.7 and 25 times higher than that of pure g-C_(3)N_(4) and WO_(3),*** improvement of photocatalytic performance is attributed to fast transfer of photogene rated carriers in the z-scheme structure,which are testified by electron spin resonance(ESR)experiments,photocurrent and electrochemical impedance spectra(EIS)***,the effects of typical water environmental factors on the degradation NTP were systematically *** the possible degradation pathways of NTP were deduced by the intermediates detected by highperformance liquid chro matography-mass spectrometry(HPLC-MS).This work will not only contribute to understand the degradation mechanism of pesticides in real water environmental condition,but also promote the development of new technologies for pesticide pollution control as well as environmental remediation.

关键词： Photocatalysis z-scheme Nitenpyram Photogenerated carriers Environmental remediation