Exploring a natural MDR reversal agent: potential of medicinal food supplement Nerium oleander leaf distillate

作     者：Meltem Demirel Kars Ufuk Gündüz Kamilüney AhmetLevent Ba 

作者机构：Seluk UniversitySaraynü Vocational High School42430 KonyaTurkey Seluk UniversityAdvanced Technology Research and Application Center42075 KonyaTurkey Middle East Technical UniversityDepartment of Biological Sciences06531 AnkaraTurkey Selcuk UniversityFaculty of Veterinary MedicineDepartment of Toxicology and Pharmacology42075KonyaTurkey Selcuk UniversityFaculty of Veterinary MedicineDepartment of Toxicology and Pharmacology42075KonyaTurkeyy 

出 版 物：《Asian Pacific Journal of Tropical Biomedicine》 (亚太热带生物医学杂志（英文版）)

年 卷 期：2013年第3卷第8期

页      面：644-649页

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：Supported by TUBITAK with the project number 111S039 by the Selcuk University Research Fund with the project number 11401014 

主　　题：Nerium oleander MCF-7 FRSA activity MDR reversal Medicinal food supplement 

摘      要：Objective:To investigate the molecular effects ofNerium oleanderleaf distillate on paclitaxel and vincristine resistant(MCF-7/Pac and MCF-7/Vinc)cells and sensitive(MCF-7/S)cell ***:Nerium oleander(***)leaf extract was obtained by hydrodistillation *** toxicological effects ***,previously suggested as medicinal food supplement,on drug resistant cells were evaluated by XTT *** modulation potential of the plant material was evaluated by flow cytometry and fluorescent *** and vincristine were applied to the sublines in combination with ***:Fractional inhibitory indices show *** did not increase the antiproliferative effects of anticancer *** in to MCF-7/Pac and MCF-7/Vinc did not inhibit P-gp activity and MDR1 gene expression ***:As a result it may be suggested that *** has some medicinal effects as food supplement it may not be suitable as an MDR modulator for drug resistant breast cancer cells.