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基于高功率窄线宽掺镱全光纤超荧光源的光谱合束

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中国激光 2016年第4期43卷 28-34页

作者：魏守宇金东臣孙若愚曹镱侯玉斌王静刘江王璞北京工业大学激光工程研究院北京100124

全光纤结构超荧光光源各级均采用双包层掺镱光纤作为增益介质,中心波长为976 nm和915 nm的多模半导体激光器作为抽运源,利用窄线宽光纤布拉格光栅对宽带超荧光种子源进行滤波,经三级掺镱双包层光纤放大器放大,实现了中心波长分别为1060... 详细信息

全光纤结构超荧光光源各级均采用双包层掺镱光纤作为增益介质,中心波长为976 nm和915 nm的多模半导体激光器作为抽运源,利用窄线宽光纤布拉格光栅对宽带超荧光种子源进行滤波,经三级掺镱双包层光纤放大器放大,实现了中心波长分别为1060 nm和1078 nm的窄线宽超荧光稳定输出,输出功率分别达到57.4 W和56.6 W,斜效率分别为66.6%和66.7%,放大后的窄线宽超荧光光源3 d b光谱带宽均为0.05 nm。利用透射式衍射光栅对两路窄线宽超荧光进行光谱合束,实现了104.2 W窄线宽超荧光输出,合束效率为91.3%,光束质量M2<1.7。

关键词：激光光学光纤超荧光源光纤放大器掺镱光纤光谱合束

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铜-铝扩散焊时金属间化合物的行为

天津大学学报 1984年第S1期 18-28页

作者：赵裕民曾悦坚张炳范

本文研究了铜—铝扩散焊时焊接区内金属间化合物的形成和长大过程,各形成相的结构、成分和性能及其对接头机械性能的影响,并建立了金属间化合物层的厚度与扩散焊接规范参数之间的定量关系,最后分析了控制化合物层厚度的途径。

关键词：扩散焊金属间化合物化合物层规范参数焊接时间焊接温度接头形式显微硬度摩擦焊焊合

Effectiveness and safety of different amifostine regimens：Preliminary results of a phase Ⅱ multicenter randomized controlled trial

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Chinese Journal of Cancer Research 2018年第3期30卷 307-314页

作者： Hui Chang Wei Yi Xiaohui wang Yalan Tao Xin Yang Chen Chen Wenwen zhang Shu zhou Songran Liu Xiaohui Li Shirong Ding Jing Li Gong Li Xunfan Shao Yimin Liu Weishu Song Yunfei Xia Departrnent of Radiation Oncology Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center of Cancer Medicine Guangzhou 510060 China Department of Radiation Oncology the First Affiliated Hospital of Guangzhou Medical University Guangzhou 510120 China Department of Oneology People's Liberation Army 421 Hospital Guangzhou 510318 China Department of Oncology the Main Guangzhou Hospital of the Guangzhou Military Region Guangzhou 510010 China Department of Oneology Guangdong Provincial Hospital of Chinese Medicine Guangzhou 510530 China Department of Radiation Oneology the Affiliated Cancer Hospital of Guangzhou Medical College Guangzhou 510095 China Department of Radiation Ontology the Second Affiliated Hospital Sun Yat-Sen University Guangzhou 510120 China Department of Oneology Guangdong Second People's Hospital Guangzhou 510317 China

Objective：The radioprotective effects of amifostine remain uncertain in patients with nasopharyngeal carcinoma（NPC）,and adverse effects and cost limit generalization of its classical everyday *** phase II multicenter randomized controlled trial aimed to explore whether amifostine could ameliorate the toxicities of NPC patients in the era of intensity-modulated radiotherapy（IMRT）,and to compare different regimens of amifostine on effectiveness and ***：Patients with stage I–IVb NPC were involved prospectively from January 1st,*** patients received radical treatment based on *** a randomization stratified by their stage,these patients were allocated into 3 groups：the group treated without amifostine,the group treated with the everyday regimen of amifostine,and the group treated with the every-other-day *** 3 groups of patients were compared on radiotherapy-related acute toxicities,treatment effects of NPC,and amifostine-related *** trial was registered on the ***（ID：NCT01762514）.Results：Until August 31st,2017,totally 187 patients completed experimental *** amifostine of everyday regimen appeared to reduce the patient proportion of mucositis（79.1%vs.96.8%,P=0.002）.Hypocalcemia was less common in patients treated without amifostine than in those treated with amifostine（22.6%vs.53.4%vs.41.8%,P=0.002）.Neither complete remission rates nor the survivals were affected by ***：Amifostine of everyday regimen could reduce mucositis in NPC patients who received IMRT,though it also had the possibility to cause more hypocalcemia.

关键词： Nasopharyngeal carcinoma amifostine intensity-modulated radiotherapy acute toxicity

Silica Nanoparticles with Virus-Mimetic Spikes Enable Efficient siRNA Delivery In Vitro and In Vivo

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Research 2023年第3期2022卷 281-294页

作者： Jianye Fu Wenwei Han Xue zhang Yutong Sun Rajendra bhadane bo Wei Li Li Liangmin Yu Jinbo Yang Jessica MRosenholm Outi MHSalo-Ahen Taojian Fan bin zhang Wageh Swelm Ahmed AAl-Ghamdi Lin Xia Han zhang Meng Qiu Hongbo zhang Xin wang Key Laboratory of Marine Drugs Chinese Ministry of EducationSchool of Medicine and PharmacyOcean University of ChinaQingdao 266003China Collaborative Innovation Center for Optoelectronic Science&Technology International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of EducationInstitute of Microscale OptoelectronicsCollege of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhen 518060China Key Laboratory of Marine Chemistry Theory and Technology(Ocean University of China) Ministry of EducationQingdao 266100China College of Chemistry and Chemical Engineering China University of PetroleumQingdao 266555China. Pharmaceutical Sciences Laboratory Åbo Akademi University20520 TurkuFinland Structural bioinformatics Laboratory BiochemistryÅbo Akademi University20520 TurkuFinland. Center for Innovation Marine Drug Screening&Evaluation Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao 266237China Marine biomedical Research Institute of Qingdao Qingdao 266100China Department of Physics Faculty of ScienceKing Abdulaziz UniversityJeddah 21589Saudi Arabia Hangzhou No.14 High School Hangzhou 310000China Turku bioscience Centre University of Turku andÅbo Akademi University20520 TurkuFinland

Oligonucleotide-based therapy has experienced remarkable development in the past 2 decades,but its broad applications are severely hampered by delivery *** used viral vectors and lipid nanovectors are suffering from immune clearance after repeating usage or requiring refrigerated transportation and storage,*** this work,amino-modified virus-mimetic spike silica nanoparticles(NH_(2)-SSNs)were fabricated using a 1-pot surfactant-free approach with controlled spike lengths,which were demonstrated with excellent delivery performance and biosafety in nearly all cell types and *** indicated that NH2-SSNs entered cells by spike-dependent cell membrane docking and dynamin-dependent *** positively charged spikes with proper length on the surface can facilitate the efficient encapsulation of RNAs,protect the loaded RNAs from degradation,and trigger an early endosome escape during intracellular trafficking,similarly to the cellular internalization mechanism of *** the fantastic properties of NH_(2)-SSNs in nucleic acid delivery,it revealed that nanoparticles with solid spikes on the surface would be excellent vehicles for gene therapy,presenting self-evident advantages in storage,transportation,modification,and quality control in large-scale production compared to lipid nanovectors.

关键词： surfactant loaded transportation

食管癌放疗两种不同固定体位对摆位误差的影响

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中华放射肿瘤学杂志 2014年第4期23卷 336-339页

作者：惠周光王群韩伟孙帅王敏戴建荣王绿化中国医学科学院肿瘤医院放疗科北京100021 湖北省武汉市第五医院肿瘤科 430050

目的探讨双臂平放置身体两侧（A组）与双臂交叉抱肘上举置额前（b组）两种不同体位对食管癌分次放疗摆位误差的影响.方法采用病例对照研究,患者仰卧双臂A或b体位,热塑体膜固定.放疗前3次及其后至少1次/周CbCT扫描,骨配准并结合人工校... 详细信息

目的探讨双臂平放置身体两侧（A组）与双臂交叉抱肘上举置额前（b组）两种不同体位对食管癌分次放疗摆位误差的影响.方法采用病例对照研究,患者仰卧双臂A或b体位,热塑体膜固定.放疗前3次及其后至少1次/周CbCT扫描,骨配准并结合人工校对获得患者左右、上下、前后方向线性摆位误差并行成组t检验.结果每组各11例,A组CbCT共92人次,b组共87人次.摆位绝对误差只有左右方向（x轴）A组大于b组,分别为（2.46±1.79）、（1.91±1.71） mm（P =0.036）.摆位相对误差只有上下方向（y轴）A组小于b组,分别为（0.09±3.90）、（1.91±4.12） mm （P=0.003）.三维矢量摆位误差A、b组相近（P=0.751）.放疗中每周绝对摆位误差和三维矢量摆位误差A、b组均相近（P＞0.05）.结论两种体位对食管癌分次放疗的摆位误差各有优劣,但均在可控范围内.可根据临床实际选用合适的治疗体位.

关键词：食管肿瘤放射疗法体位摆位误差

鱼油微胶囊射流空化制备工艺优化及理化性质研究

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农业工程学报 2019年第15期35卷 312-320页

作者：江连洲王朝云王中江张馨心郭增旺左锋刘军东北农业大学食品学院哈尔滨150030 黑龙江八一农垦大学大庆158308 临邑禹王植物蛋白有限公司和山东禹王生态食业有限公司德州253000

研究目的是以大豆分离蛋白为壁材,对射流空化制备鱼油微胶囊的工艺进行优化。采用喷雾干燥法,研究壁材添加量、乳化剂添加量、芯材添加量及射流空化处理时间对乳液稳定性和鱼油微胶囊包埋率的影响,通过响应面试验分析各因素,得到最优微... 详细信息

研究目的是以大豆分离蛋白为壁材,对射流空化制备鱼油微胶囊的工艺进行优化。采用喷雾干燥法,研究壁材添加量、乳化剂添加量、芯材添加量及射流空化处理时间对乳液稳定性和鱼油微胶囊包埋率的影响,通过响应面试验分析各因素,得到最优微胶囊制备工艺,并对制备的微胶囊产品同市售产品的结构、理化特性及稳定性进行对比分析。结果表明:在壁材添加量3.21%、乳化剂添加量0.21%、芯材添加量19.70%、射流空化处理时间11.25 min工艺条件下得到的乳液稳定性较好,鱼油微胶囊的包埋率达到94.14%。微胶囊产品微观结构呈球形颗粒,结构致密,颗粒形态完整,粒径小,表面含油率较低,包埋效果好;水分含量为3.07%,溶解度为96.30%,休止角为40.39°,溶解性较好;差示扫描量热分析结果显示,微胶囊热溶解温度较高,可用于常温贮藏。包埋后的鱼油经加速贮藏试验表明微胶囊化可以提高鱼油的氧化稳定性,延长鱼油贮藏期。

关键词：农产品试验优化鱼油微胶囊

复合系WSC-6的菌种组成特性及其木质纤维素分解能力

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农业工程学报 2007年第10期23卷 210-215页

作者：王伟东王小芬李玉花刘长莉李文哲崔宗均东北林业大学生命学院中国农业大学农学与生物技术学院北京100094 东北农业大学工程学院哈尔滨150030

利用平板分离法与变性梯度凝胶电泳(DGGE)法研究了高效分解木质纤维素的微生物复合系WSC-6的菌种组成,平板法分离得到了9株好气性的细菌,它们与Pseudoxanthomonas taiwanensis、Tepidiphilus margaritif er、bacillus sp.E53-10、Proteobacterium S072、beta proteobacterium HMD444、Rhizobiaceae str.M100、Petrobacter succinimandens bON4、bacillus thermoamylovorans、Paenibacillus ***-016的相似率分别达到了97.5%,99.0%,98.4%,100%,98.9%,99.3%,98.1%,99.5%,99.8%。利用DGGE分析表明,复合系中还存在利用平板法难以培养的5株厌氧或者兼性厌氧细菌,它们的16SrDNA V3区的序列与Ureibacillus thermosphaericu、Clostridium thermosuccinogenes、Clostridium thermopalmarium、Uncultured Clostridium *** A1-3、Uncultured bacterium tbr4-24具有很高的相似率。在50℃静置培养条件下,接种3d后复合系WSC-6可以分解添加稻秆总量的81.3%。好氧菌与厌氧菌共存于复合系中,复合系表现出了高的细菌组成多样性,从而保证了复合系具有强的稳定性和多菌协同分解木质纤维素的能力,明确菌种组成多样性对于研究复合系高效分解木质纤维素的机理意义重大。

关键词：木质纤维素分解微生物复合系菌种组成多样性变性梯度凝胶电泳

Evaluation of Related Traits of GmTST2.1 and zmGIF1 Genes in Soybean (Glycine Max)

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Journal of Northeast Agricultural University(English Edition) 2020年第4期27卷 1-8页

作者： Dong Hai-ran Chang Hong wang Jun bao Dong-fang zhao Xue Han Ying-peng Key Laboratory of Soybean biology in Chinese Ministry of Education Key Laboratory of Soybean biology and breeding/Genetics of Chinese Agriculture Ministry Northeast Agricultural UniversityHarbin 150030China

Soybean(Glycine max)is one of the most important food crops and oil crops in the *** to the role of sucrose transporter in sugar accumulation,GmTST2.1(Glyma.04G000300)and zmGIF1 of sugar transport related genes were separately overexpressed in the soybean cultivar Heihe 43 from the perspective of regulatory source to library relationship in the *** function of soluble sugar accumulation in grains layed a theoretical foundation for the cultivation of new varieties of high-yield genetically modified *** results showed that the height and 100-seed weight of the over-expressed GmTST2.1 gene were increased with 7%and 17.7%and the soluble sugar content was increased with 1.575 times as much as that of the wild-type *** overexpressed zmGIF1 gene was found to be 10%higher than that of plant height,1.8%higher than that of 100-seed weight and larger seed size and 1.3 times higher than that of soluble sugar *** yields were increased in both GmTST2.1 and zmGIF1 genes.

关键词： Glycine max soluble sugar GmTST2.1 gene zmGIF1 gene

路南海菜花的核型分析及其海菜花属的演化探讨

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湖泊科学 2010年第5期22卷 735-738页

作者：翟书华王斌王定康张光飞昆明学院生命科学与技术系昆明650031 云南大学生态与地植物研究所昆明650091

海菜花属(Ottelia Pers.)为沉水单子叶植物,只生长于淡水生境中,具有重要的生态价值、环境指示作用以及植物系统学研究意义.本文首次报道了特产于我国云南石林湖泊中的路南海菜花(Ottelia acuminata *** ***)的体细胞染色体数目为22条,... 详细信息

海菜花属(Ottelia Pers.)为沉水单子叶植物,只生长于淡水生境中,具有重要的生态价值、环境指示作用以及植物系统学研究意义.本文首次报道了特产于我国云南石林湖泊中的路南海菜花(Ottelia acuminata *** ***)的体细胞染色体数目为22条,核型属"1b"型,核型公式2n=2x=22=18m+4sm.结合已研究的花部特征和核型资料讨论海菜花属种间的亲缘关系及演化,为海菜花(Ottelia)的利用和保护提供细胞生物学证据.

关键词：路南海菜花海菜花属核型系统演化