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TcPO2 changes are more pronounced than SpO2 changes during simulated altitude changes in a hypobaric oxygen chamber: a nonrandomized controlled trial

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Emergency and Critical Care Medicine 2024年第3期4卷 105-110页

作者： Li Y. Chen L. Fu z. wang z. Sun S. Luan X. Ma D. Hu T. School of Nursing and rehabilitation Shandong University Shandong Jinan China Department of Emergency and Critical Care Medicine Qilu Hospital of Shandong University Shandong Jinan China Department of Pulmonary and Critical Care Medicine Qilu Hospital of Shandong University Shandong Jinan China Emergency Management Center of State Grid Shandong Electric Power Company Shandong Jinan China School of Nursing and rehabilitation Cheeloo College of Medicine University of Shandong Department of Infection Control Qilu Hospital of Shandong University Shandong Jinan China School of Mechanical Engineering Shandong University Key Laboratory of the Ministry of Education for Efficient and Clean Machinery Manufacturing National Experimental Teaching Demonstration Center for Mechanical Engineering Shandong Jinan China

Background: Hypoxia is a significant risk factor of hypertension. However, no studies have used transcutaneous tissue partial pressure of oxygen (TcPO2) and partial pressure of carbon dioxide (TcPCO2) monitors to measure the respective partial pressures in healthy individuals. Oxygen saturation (SpO2) is often used for traditional monitoring of vital signs. This study investigated the changes in TcPO2 and SpO2 values during rapid changes in altitude. The trial was registered at *** (registration no. NCT06076057). Methods: Healthy adult volunteers were instructed to sit vertically in a hypobaric oxygen chamber, which ascended from 0 m to 2500 m at a uniform speed within 10 min. The Danish radiometer TCM4 was used to measure TcPO2 and TcPCO2 with the ventral side of the upper arm as the measurement site. The Shenzhen Kerokan P0D-1 W pulse oximeter was used to measure heart rate and SpO2, with values recorded once every 500 m. results: Altogether, 49 healthy volunteers were recruited between March 2023 and August 2023. With increasing altitude, TcPO2 and SpO2 decreased significantly (P ring the ascent from 0 m, TcPO2 began to change statistically at 500 m (P reas SpO2 began to change statistically at 1000 m (P rence in TcPO2 was greater than the difference in SpO2. At 1000 m, there were statistically significant changes in TcPO2 and SpO2 (P 500 m, statistical significance was identified between TcPO2 in both sexes (P rt rate was observed at the different elevations (P ressure hypoxic environments, TcPO2 changed more dramatically than SpO2 © Wolters Kluwer Health, Inc. All rights reserved.

关键词： Altitude change Low-pressure oxygen chamber Transcutaneous oxygen saturation Transcutaneous partial pressure of oxygen

Importance of diet and intestinal microbiota in the prevention of colorectal cancer-colonoscopy early screening diagnosis

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3428-3435页

作者： Miljana z Jovandaric Department of Neonatology Clinic for Gynecology and ObstetricsUniversity Clinical Center of SerbiaBelgrade 11070Serbia

Colorectal cancer is a term used to describe colon and rectal cancer,which is the third most common type of cancer.A MEDLINE and PubMed search resulted in the inclusion of manuscripts written in the last 10 years,using keywords relevant to the topic of the *** analyzing the aim of the searched studies and manuscripts,adequate articles were included that described the stated *** frequency of colorectal cancer varies with climate,nutrition,and many other factors,primarily endogenous,hereditary,intestinal microbiome,as well as external factors,such as exposure of the individual to stress,and bad eating *** cancer and rectal cancer or colorectal cancer in general in the early stages of the disease,may not show symptoms or are barely *** cancer symptoms will most often not develop until the disease has progressed to stage 2 or *** screening tests for colon or rectal cancer,especially colonoscopy,are recommended as part of a regular checkup for people aged 50 years or younger who are at high risk due to a family history of the disease or other *** and colonoscopy as an early screening method play an important role in the prevention of colorectal cancer.

关键词： Colorectal cancer Causes Symptoms Screening Diet and colonoscopy

Effects of multiple shapes for steady flow with transformer oil+Fe_(3)O_(4)+TiO_(2) between two stretchable rotating disks

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Applied Mathematics and Mechanics(English Edition) 2024年第2期45卷 373-388页

作者： M.rAHMAN M.TUrKYILMAzOGLU z.MUSHTAQ Department of Mathematics Mirpur University of Science and TechnologyMirpur 10250Pakistan Department of Mathematics Hacettepe UniversityBeytepeAnkara 06532Turkiye

In this study,we examine the effects of various shapes of nanoparticles in a steady flow of hybrid nanofluids between two stretchable rotating *** steady flow of hybrid nanofluids with transformer oil as the base fluid and Fe_(3)O_(4)+TiO_(2)as the hybrid nanofluid is *** shapes of Fe_(3)O_(4)+TiO_(2)hybrid nanofluids,including sphere,brick,blade,cylinder,and platelet,are *** shape exists in the same volume of a *** leading equations(partial differential equations(PDEs))are transformed to the nonlinear ordinary differential equations(ODEs)with the help of similarity *** system of equations takes the form of ODEs depending on the boundary conditions,whose solutions are computed numerically by the bvp4c MATLAB *** outputs are compared with the previous findings,and an intriguing pattern is discovered,such that the tangential velocity is increased for the rotation parameter,while it is decreased by the stretching values because of the lower *** the reaction rate parameter,the concentration boundary layer becomes shorter,and the activation energy component increases the rate at which mass transfers come to the higher disk but have the opposite effect on the bottom *** ranges of various parameters taken into account are Pr=6.2,re=2,M=1.0,φ_(1)=φ_(2)=0.03,K=0.5,S=-0.1,Br=0.3,Sc=2.0,α_(1)=0.2,γ=0.1,E_(n)=2.0,and q=1.0,and the rotation factor K is within the range of 0 to 1.

关键词： transformer oil Brinkman number skin friction coefficient double rotating disk Nusselt number Sherwood number

Four Late-type Galaxies with Double radio Lobes and Properties of Such Galaxies

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research in Astronomy and Astrophysics 2024年第4期24卷 84-90页

作者： z.S.Yuan X.Y.Gao z.L.Wen J.L.Han National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China CAS Key Laboratory of FAST National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China School of Astronomy and Space Sciences University of Chinese Academy of SciencesBeijing 100049China

The triggering mechanism for radio lobes from late-type galaxies is not fully *** samples are desired for a thorough investigation and *** utilizing the optical data from the newly released Dark Energy Spectroscopic Instrument imaging surveys and the radio sources from the NrAO VLA Sky Survey and the Faint Images of the radio Sky at Twenty-centimeter,we identify four Late-type Galaxies with double radio Lobes(La GrLs):J0217-3645,J0947+6220,J1412+3723 and J1736+*** previously known La GrLs,we confirm the correlation between radio power P_(1.4GHz)and stellar mass M_(*)of host ***(25/35)La GrLs belong to the blue cloud galaxies,while the newly identified cases in this work are located within the region of the red *** find a clear correlation between the differential radio power,i.e.,the offset from the P_(1.4GHz)-M_(*)relation,and the galaxy color,indicating that bluer galaxies at a fixed M_(*)tend to host more powerful radio ***,the majority(31/36)of La GrLs are either located in a galaxy group or displaying a disturbed *** suggest that all of the galaxy mass,color and surrounding environment could play important roles in triggering radio lobes in late-type galaxies.

关键词： galaxies:active galaxies:jets galaxies:spiral radio continuum:galaxies

reply to “Beyond microbial carbon use efficiency”

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National Science review 2024年第4期11卷 35-37页

作者： Feng Tao Johannes Lehmann Ying-Ping wang Lifen Jiang Bernhard Ahrens Kostiantyn Viatkin Stefano Manzoni Benjamin z.Houlton Yuanyuan Huang Xiaomeng Huang Yiqi Luo Department of Ecology and Evolutionary Biology Cornell University Soil and Crop Sciences Section School of Integrative Plant ScienceCornell University CSIrO Environment Max Planck Institute for Biogeochemistry Department of Physical Geography and Bolin Centre for Climate research Stockholm University Department of Global Development Cornell University Key Laboratory of Ecosystem Network Observation and Modeling Institute of Geographic Sciences and Natural Resources Research Chinese Academy of Sciences Department of Earth System Science Ministry of Education Key Laboratory for Earth System Modelling Institute for Global Change Studies Tsinghua University

In their commentary, Xiao et al.[1]cautioned that the conclusions on the critical role of microbial carbon use efficiency (CUE) in global soil organic carbon (SOC) storage in the paper by Tao et al.[2] might be too *** claimed that Tao et al.’s study lacked mechanistic consideration of SOC formation and excluded important data *** et al. brought up important points,which can be largely reconciled with our findings by understanding the differences in expressing processes in empirical studies and in models.

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rNA modifications in the progression of liver diseases:from fatty liver to cancer

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Science China(Life Sciences) 2024年第10期67卷 2105-2119页

作者： Simiao Li Wajahat z Mehal Xinshou Ouyang Department of Internal Medicine Section of Digestive DiseasesYale University School of MedicineNew Haven CT 06520USA

Non-alcoholic fatty liver disease(NAFLD)has emerged as a prominent global health concern associated with high risk of metabolic syndrome,and has impacted a substantial segment of the *** disease spectrum ranges from simple fatty liver to non-alcoholic steatohepatitis(NASH),which can progress to cirrhosis and hepatocellular carcinoma(HCC)and is increasingly becoming a prevalent indication for liver *** existing therapeutic options for NAFLD,NASH,and HCC are limited,underscoring the urgent need for innovative treatment *** into gene expression,particularly rNA modifications such as N6methyladenosine(m^(6)A),hold promising avenues for *** modifications play integral roles in rNA metabolism and cellular functions,encompassing the entire NAFLD-NASH-HCC *** review will encompass recent insights on diverse rNA modifications,including m^(6)A,pseudouridine(Ψ),N^(1)-methyladenosine(m^(1)A),and 5-methylcytidine(m^(5)C)across various rNA *** will uncover their significance in crucial aspects such as steatosis,inflammation,fibrosis,and ***,prospective research directions and therapeutic implications will be explored,advancing our comprehensive understanding of the intricate interconnected nature of these pathological conditions.

关键词： m^(6)A rNA modification NASH NAFLD HCC fatty liver

Nitrogen mineralization in the oldest climax communities in the eastern Mediterranean region

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Journal of Forestry research 2024年第1期35卷 213-228页

作者： Fatma Selcen Sakar Gürcan Güleryüz Department of Biology Section Ecology GörükleGraduate School of Natural and Applied ScienceUniversity of Bursa Uludağ16059 NilüferBursaTurkey Department of Biology Section Ecology GörükleFaculty of Science and ArtsUniversity of Bursa Uludağ16059 NilüferBursaTurkey

In this study,we investigated how tree species affect N mineralization in connection to some soil properties and seconder metabolite levels of litter,in the soil of the old-est native forest *** the oldest pure communi-ties of Pinus nigra(PN),Fagus orientalis(FO),and Abies bornmuelleriana(AB)in the mountain range of Mount Uludağ,Bursa,Turkey,annual net yield and N mineraliza-tion in the 0-5-and 5-20-cm soil layers were determined in a field incubation study over 1 *** locations were chosen from 1300 to 1600 m a.s.l.,and moisture content(%),pH,water-holding capacity(%),organic C,total N,and C/N ratio,and annual net mineral N yield of the soil and hydro-lyzed tannic acid and total phenolic compounds in litter were compared for these forest *** had the highest annual net Nmin yield(43.9±4.8 kg ha^(-1) a^(-1)),*** the lowest(30.5±4.2 kg ha^(-1) a^(-1)).Our findings show that in the oldest forest ecosystems,the seasonal soil moisture content and tree species play an essential role in N cycling and that hydrolyzed tannic acids and total phenolic compounds effectively control N *** acid and total phenolics in the litter were found to inhibit nitrification,but total phenolics were found to stimulate ammonification.

关键词： Oldest forest communities Nitrogen mineralization Nitrification Tannic acid Total phenolic Litter

Fire resistance evaluation through synthetic fire tests and generative adversarial networks

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Frontiers of Structural and Civil Engineering 2024年第4期18卷 587-614页

作者： Aybike Özyüksel Çiftçioğlu M.z.Naser Department of Civil Engineering Manisa Celal Bayar University45140Türkiye School of Civil&Environmental Engineering and Earth Sciences(SCEEES) Clemson UniversityClemsonSC 29631USA Artificial Intelligence research Institute for Science and Engineering(AIrISE) Clemson UniversityClemsonSC 29631USA

This paper introduces a machine learning approach to address the challenge of limited data resulting from costly and time-consuming fire experiments by enlarging small fire test data sets and predicting the fire resistance of reinforced concrete *** approach begins by creating deep learning models,namely generative adversarial networks and variational autoencoders,to learn the spatial distribution of real fire *** then use these models to generate synthetic tabular samples that closely resemble realistic fire resistance values for reinforced concrete *** generated data are employed to train state-of-the-art machine learning techniques,including Extreme Gradient Boost,Light Gradient Boosting Machine,Categorical Boosting Algorithm,Support Vector regression,random Forest,Decision Tree,Multiple Linear regression,Polynomial regression,Support Vector Machine,Kernel Support Vector Machine,Naive Bayes,and K-Nearest Neighbors,which can predict the fire resistance of the columns through regression and *** learning analyses achieved highly accurate predictions of fire resistance values,outperforming traditional models that relied solely on limited experimental *** study highlights the potential for using machine learning and deep learning analyses to revolutionize the field of structural engineering by improving the accuracy and efficiency of fire resistance evaluations while reducing the reliance on costly and time-consuming experiments.

关键词： deep learning fire resistance generative adversarial networks machine learning

Dynamics of a rotating ring-stiffened sandwich conical shell with an auxetic honeycomb core

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Applied Mathematics and Mechanics(English Edition) 2024年第6期45卷 963-982页

作者： S.JAHANGIrI A.GHOrBANPOUr ArANI z.KHODDAMI MArAGHI Department of Solid Mechanics Faculty of Mechanical EngineeringUniversity of KashanKashan ***Iran Faculty of Engineering Mahallat Institute of Higher EducationMahallat ***Iran

The free vibration analysis of a rotating sandwich conical shell with a reentrant auxetic honeycomb core and homogenous isotropic face layers reinforced with a ring support is *** shell is modeled utilizing the first-order shear deformation theory(FSDT)incorporating the relative,centripetal,and Coriolis accelerations alongside the initial hoop tension created by the *** governing equations,compatibility conditions,and boundary conditions are attained using Hamilton’s *** trigonometric functions,an analytical solution is derived in the circumferential direction,and a numerical one is presented in the meridional direction via the differential quadrature method(DQM).The effects of various factors on the critical rotational speeds and forward and backward frequencies of the shell are *** present work is the first theoretical work regarding the dynamic analysis of a rotating sandwich conical shell with an auxetic honeycomb core strengthened with a ring support.

关键词： free vibration conical shell rotating shell ring support auxetic honeycomb