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Effects of exosomes from mesenchymal stem cells on functional recovery of a patient with total radial nerve injury: A pilot study

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World Journal of Stem Cells 2024年第1期16卷 19-32页

作者： ErdinçCivelek Serdar Kabatas Eyüp Can Savrunlu Furkan Diren Necati Kaplan Demet Ofluoğlu Erdal Karaöz Department of Neurosurgery University of Health SciencesGaziosmanpaşa Training and Research HospitalGaziosmanpaşa 34255IstanbulTurkey Department of Neurosurgery University of Health Sciences TurkeyGaziosmanpaşa Training and Research HospitalGaziosmanpaşa 34255IstanbulTurkey Center for Stem Cell&Gene Therapy Research and Practice University of Health Sciences TurkeyGaziosmanpaşa 34255IstanbulTurkey Department of Neurosurgery Nevşehir State HospitalNevşehir 50300Turkey Department of Neurosurgery Istanbul Rumeli UniversityÇorlu Reyap HospitalÇorlu 59860TekirdağTurkey Department of Physical medicine and Rehabilitation Ofluoğlu KlinikGöztepe 34728IstanbulTurkey Liv Hospital Center for Regenerative Medicine and Stem Cell Research&Manufacturing(LivMedCell)Beşiktaş34340IstanbulTurkey Department of Histology and Embryology Istinye UniversityFaculty of MedicineZeytinburnu 34010IstanbulTurkey Istinye University Center for Stem Cell and Tissue Engineering Research and PracticeBeşiktaş34340IstanbulTurkey

BACKGROUND Peripheral nerve injury can result in significant clinical complications that have uncertain ***,there is a lack of effective pharmacological interventions for nerve damage,despite the existence of several small compounds,Despite the objective of achieving full functional restoration by surgical intervention,the persistent challenge of inadequate functional recovery remains a significant concern in the context of peripheral nerve *** To examine the impact of exosomes on the process of functional recovery following a complete radial nerve *** A male individual,aged 24,who is right-hand dominant and an immigrant,arrived with an injury caused by a knife *** cut is located on the left arm,specifically below the *** neurological examination and electrodiagnostic testing reveal evidence of left radial nerve *** sural autograft was utilized for repair,followed by the application of 1 mL of mesenchymal stem cell-derived exosome,comprising 5 billion *** exosome was split into four equal volumes of 0.25 mL each and delivered microsurgically to both the proximal and distal stumps using the subepineural *** patient was subjected to a period of 180 d during which they had neurological examination and electrodiagnostic *** The duration of the patient’s follow-up period was 180 *** increasing Tinel’s sign and sensory-motor recovery were detected even at the 10th wk following nerve *** the conclusion of the 6-mo post-treatment period,an evaluation was conducted to measure the extent of improvement in motor and sensory functions of the *** assessment was based on the British medical Research Council scale and the mackinnon-Dellon *** results indicated that the level of improvement in motor function was classified as m5,denoting an excellent ***,the level of improvement in sensory function was classified as S3+,indicating a good *** is

关键词： mesenchymal stem cell Exosomes Radial nerve Sural nerve

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HIGHLY ACTIVE CATALYSTS FOR CYCLOPROPANATION OF TETRAmETHYLETHYLENE

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Chinese Chemical Letters 1996年第8期7卷 739-740页

作者： zheng, z Han, m Chen, HL CHINESE ACAD SCI DALIAN INST CHEM PHYSDALIAN 116023PEOPLES R CHINA

Copper(II) Schiff base complexes derived from aromatic amine and salicylaldehyde were found to be highly active catalysts for the cyclopropanation of tetramethylethylene with ethyl diazoacetate. 82% yield of cycloprop...

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Single-fundamental-mode cryogenic(3.6 K)850-nm oxideconfined VCSEL

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Journal of Semiconductors 2024年第10期45卷 69-73页

作者： Anjin Liu Chenxi Hao Jingyu Huo Hailong Han minglu Wang Bao Tang Lingyun Li Lixing You Wanhua zheng Key Laboratory of Optoelectronic materials and Devices Institute of SemiconductorsChinese Academy of SciencesBeijing 100083China Center of materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Shanghai Key Laboratory of Superconductor Integrated Circuit Technology Shanghai Institute of Microsystem and Information TechnologyChinese Academy of SciencesShanghai 200050China Accelink technologies co. LtdWuhan 430205China Key Laboratory of Solid-State Optoelectronics Information Technology Institute of SemiconductorsChinese Academy of SciencesBeijing 100083China

Cryogenic oxide-confined vertical-cavity surface-emitting laser(VCSEL)has promising application in cryogenic optical interconnect for cryogenic *** this paper,we demonstrate a cryogenic 850-nm oxide-confined VCSEL at around 4 *** cryogenic VCSEL with an optical oxide aperture of 6.5μm in diameter can operate in single fundamental mode with a side-mode suppression-ratio of 36 dB at 3.6 K,and the fiber-coupled output power reaches 1 mW at 5 *** small signal modulation measurements at 298 and 292 K show the fabricated VCSEL has the potential to achieve a high modulation bandwidth at cryogenic temperature.

关键词： VCSEL cryogenic temperature cryogenic computing optical interconnect

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Integrated Approaches of mechanical Barrier, Insecticide and Botanicals against mango mealybug (Drosicha mangiferae)

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Advances in Entomology 2024年第3期12卷 195-202页

作者： N. Akhter m. z. Alam m. A. Rahaman m. R. U. miah I. H. mian m. A. Latif Department of Entomology Faculty of Agriculture Sher-e-Bangla Agricultural University Dhaka Bangladesh Department of Entomology Faculty of Agriculture Bangabandhu Sheikh Mujibur Rahman Agricultural University Gazipur Bangladesh Department of Plant Pathology Faculty of Agriculture Sher-e-Bangla Agricultural University Dhaka Bangladesh Department of Plant Pathology Bangabandhu Sheikh Mujibur Rahman Agricultural University Gazipur Bangladesh

An experiment was conducted to test the efficacy of a mechanical barrier around the tree trunk with one spray of Cypermethrin @ 1 ml/l and turmeric powder extract @ 15 g/500ml of water applied in integrated approaches against mango mealybug on mango tree. There were 7 treatments including a control. The treatments were mechanical barrier, Cypermethrin spray @ 1 ml/l, Turmeric powder spray @ 15 g/500ml of water, Cypermethrin spray + Turmeric spray, Cypermethrin spray + mechanical barrier, Turmeric + mechanical barrier and untreated control. Three-year-old mango plants grafted from a 5-year-old mango tree (Variety Amropali) and planted in pots were used in the experiment. The treatment, Cypermethrin spray + mechanical barrier gave the highest reduction of mango mealybug population 87.06% to 93.90% followed by Turmeric spray + mechanical barrier and showed 81.13% to 86.04% and mechanical barrier alone showed 81.13% to 84.59% population reduction. Turmeric powder extract showed only (8.42% to 23.77%) population reduction of mango mealybug which was lowest compared to other treatments.

关键词： mango mealybug Integrated management

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Characterization of bright betatron radiation generated by direct laser acceleration of electrons in plasma of near critical density

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matter and Radiation at Extremes 2024年第2期9卷 26-35页

作者： J.Cikhardt m.Gyrdymov S.zähter P.Tavana m.m.Günther N.Bukharskii N.Borisenko J.Jacoby X.F.Shen A.Pukhov N.E.Andreev O.N.Rosmej Faculty of Electrical Engineering Czech Technical University in Prague16627 Prague 6Czech Republic Goethe University FrankfurtMax-von-Laue-Straße 160438 Frankfurt am MainGermany GSI Helmholtzzentrum für Schwerionenforschung GmbH Planckstraße 164291 DarmstadtGermany Focused Energy GmbH Im Tiefen See 4564293 DarmstadtGermany National Research Nuclear University mEPhI Kashirskoe shosse 31115409 MoscowRussian Federation Lebedev Physical Institute RAS Leninskiy Prospekt 53119991 MoscowRussian Federation Heinrich-Heine-University Düsseldorf Universitätsstrasse 1DüsseldorfGermany Joint Institute for High Temperatures RASIzhorskaya st.13Bldg.2125412 MoscowRussian Federation moscow Institute of Physics and Technology Institutskiy Pereulok 9141700 DolgoprudnyRussia

Directed x-rays produced in the interaction of sub-picosecond laser pulses of moderate relativistic intensity with plasma of near-critical density are investigated. Synchrotron-like (betatron) radiation occurs in the process of direct laser acceleration (DLA) of electrons in a relativisticlaser channel when the electrons undergo transverse betatron oscillations in self-generated quasi-static electric and magnetic fields. In anexperiment at the PHELIX laser system, high-current directed beams of DLA electrons with a mean energy ten times higher than the ponderomotive potential and maximum energy up to 100 meV were measured at 10^(19) W/cm^(2)laser intensity. The spectrum of directed x-raysin the range of 5–60 keV was evaluated using two sets of Ross filters placed at 0°and 10°to the laser pulse propagation axis. The differential x-ray absorption method allowed for absolute measurements of the angular-dependent photon fluence. We report 10^(13) photons/sr withenergies >5 keV measured at 0°to the laser axis and a brilliance of 10^(21) photons s^(−1) mm^(−2) mrad−2(0.1%BW)−1. The angular distributionof the emission has an FWHm of 14°–16°. Thanks to the ultra-high photon fluence, point-like radiation source, and ultra-short emissiontime, DLA-based keV backlighters are promising for various applications in high-energy-density research with kilojoule petawatt-class laserfacilities.

关键词： laser acceleration critical

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Comprehensive Bile Acid Profiling of ABCB4-mutated Patients and the Prognostic Role of Taurine-conjugated􀀖􀄮􀀏􀀙􀄮􀀏􀀚􀄮􀀏􀀔􀀕􀄮􀀐􀀷􀁈􀁗􀁕􀁄􀁋􀁜􀁇􀁕􀁒􀁛􀁜􀁏􀁄􀁗􀁈􀁇􀀃􀀥􀁌􀁏􀁈􀀃􀀤􀁆􀁌􀁇􀀃􀁌􀁑􀀃􀀦􀁋􀁒􀁏􀁈􀁖􀁗􀁄􀁖􀁌􀁖

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Journal of Clinical and Translational Hepatology 2024年第2期12卷 151-161页

作者： Teng Liu Ren-Xue Wang Jun Han zhong-Die Li Jonathan ASheps Li-Juan zheng Xiao-Xiao Xu Victor Ling Jian-She Wang Department of Pediatrics Shanghai Medical CollegeFudan UniversityThe Center for Pediatric Liver DiseasesChildren’s Hospital of Fudan UniversityShanghaiChina BC Cancer Agency VancouverBritish Columbia V5Z 1L3Canada University of Victoria-Genome BC Proteomics Center University of VictoriaVictoriaBritish Columbia V8Z 7X8Canada Shanghai Key Laboratory of Birth Defect ShanghaiChina

Background and Aims:We asked if comprehensive bile acid profiling could provide insights into the physiopathology of ABCB4-mutated patients and evaluated the prognostic value of taurine-conjugated tetrahydroxylated bile acid(tauro-THBA)in ***:Serum bile acid profiles were evaluated in 13 ABCB4-mutated patients with 65 healthy controls by ultra-high-performance liquid chromatography/multiple-reaction monitoring-mass spectrometry(UPLC/mRm-mS).The concentration of tauro-THBA was compared between ABCB4-mutated patients with different *** areas under the curve(AUCs)of tauro-THBA were compared between ABCB11-mutated patients with native liver survival and those who died or underwent liver transplantation before 3 years of age by receiver operating characteristic curve(ROC),with another patient cohort for further ***:The overall hydrophobicity indices of bile acids in ABCB4-mutated patients(12.99±3.25 m)were significantly lower than those of healthy controls(14.02±1.74 m,pmarkedly increased bile acid modifications including conjugation,sulfation,and *** in the tauro-THBA concentration in ABCB4-mutated patients with different prognoses were not *** analysis indicated that levels of tauro-THBA ofm yielded an AUC of 0.900 with a sensitivity of 80%and specificity of 87.5%for ABCB11-mutated patients with different prognoses(p=0.0192).Of the 15 patients with good prognosis,14 were classified correctly and four of the five patients with a poor prognosis were classified correctly(14:15 vs.1:5,p=0.005)with tauro-THBA as a ***:Tauro-THBA concentration may be a biomarker for predicting the clinical outcome in low gammaglutamyl transferase intrahepatic cholestasis patients.

关键词： Bile acids mDR3 BSEP PFIC Liquid chromatography-mass spectrometry

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Higgs-like(pseudo)scalars in AdS_(4),marginal and irrelevant deformations in CFT_(3),and instantons on S^(3)

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Chinese Physics C 2024年第4期48卷 68-81页

作者： m.Naghdi Department of Physics Faculty of Basic SciencesUniversity of IlamIlamIran

Employing a 4-form ansatz of 11-dimensional supergravity over a non-dynamical AdS_(4)×S^(7)/z_(k)background and setting the internal space as an S1 Hopf fibration on CP3,we obtain a consistent ***(pseudo)scalars,in the resulting scalar equations in Euclidean AdS_(4)space,may be considered to arise from(anti)m-branes wrapping around the internal directions in the(Wick-rotated)skew-whiffed m2-brane background(as the resulting theory is for anti-m2-branes),thus realizing the modes after swapping the three fundamental representations 8_(s),8_(c),and 8_(v) of SO(8).Taking the backreaction on the external and internal spaces,we obtain the massless and massive modes,corresponding to exactly marginal and marginally irrelevant deformations on the boundary CFT3,***,we obtain a closed solution for the bulk equation and compute its correction with respect to the background ***,considering the Higgs-like(breathing)mode m^(2)=18,having all supersymmetries as well as parity and scale-invariance broken,solving the associated bulk equation with mathematical methods,specifically the Adomian decomposition method,and analyzing the behavior near the boundary of the solutions,we realize the boundary duals in the SU(4)×U(1)-singlet sectors of the ABJm ***,introducing the new dual deformationΔ_(+)=3,6 operators made of bi-fundamental scalars,fermions,and U(1)gauge fields,we obtain the SO(4)-invariant solutions as small instantons on a three-sphere with the radius at infinity,which correspond to collapsing bulk bubbles leading to big-crunch singularities.

关键词： AdS_(4)/CFT_(3)correspondence scalar equations in AdS_(4) instantons marginal and irrelevant operators (anti)m-branes

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前、中、后路小麦淀粉精制前后组成及特性差异性分析

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食品科学 2024年第11期45卷 84-90页

作者：王轶郑学玲河南工业大学粮油食品学院河南郑州450001

以小麦加工生产线的4种加工精度不同的小麦粉为原料,采用面团法从前、中、后路粉中制备粗小麦淀粉,通过去除黄浆得到精淀粉(R-S-1、R-S-2、R-S-3、R-S-4)和粗淀粉(C-S-1、C-S-2、C-S-3、C-S-4)共8种淀粉。研究黄浆保留与否对前、中、后... 详细信息

以小麦加工生产线的4种加工精度不同的小麦粉为原料,采用面团法从前、中、后路粉中制备粗小麦淀粉,通过去除黄浆得到精淀粉(R-S-1、R-S-2、R-S-3、R-S-4)和粗淀粉(C-S-1、C-S-2、C-S-3、C-S-4)共8种淀粉。研究黄浆保留与否对前、中、后路淀粉理化指标、糊化特性、凝胶特性、颗粒形态及晶体结构的影响。结果表明,在粗淀粉和精(去黄浆)淀粉颗粒特性分析中,粗淀粉的粒径(D10:7.51~8.26 μm)大于精淀粉(D10:6.46~7.70 μm)。粗淀粉的杂质含量高,灰分、粗蛋白和戊聚糖含量均高于相应的精淀粉。X射线衍射分析结果表明,粗淀粉和精淀粉都为A型晶型结构,精淀粉的相对结晶度比粗淀粉高。淀粉糊品质分析结果表明,粗淀粉与精淀粉具有显著性差异。精淀粉的透明度、峰值黏度、终值黏度、谷值黏度及回生值高于粗淀粉,而溶解度及膨润力低于粗淀粉。前、中、后路小麦淀粉凝胶质构特性无显著差异,但是后路淀粉的硬度及凝胶强度高于前、中路淀粉。

关键词：小麦淀粉精淀粉粗淀粉黄浆理化特性

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Ultrahigh strength mg-Y-Ni alloys obtained by regulating second phases

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Journal of materials Science & Technology 2020年第10期42卷 117-124页

作者： S.z.Wu X.G.Qiao m.Y.zheng School of materials Science and Engineering Harbin Institute of TechnologyHarbin150001China

mg-Y-Ni alloys with different second phases were designed by changing Y/Ni atomic ratio from 1.5 to *** microstructure and mechanical properties of as-cast and as-extruded alloys were *** as-cast mg-Y-Ni alloy with Y/Ni ratio of 1.5 is composed ofα-mg and long period stacking ordered(LPSO)*** Y/Ni ratio is equal to 1,nanoscale lamellarγ’phase and eutectic mg2Ni phase are formed in addition to LPSO *** Y/Ni ratio decreases further,the amount of eutectic mg2Ni phase increases,while the amount of LPSO phase *** extrusion,the LPSO andγ’phases are distributed along the extrusion direction,while eutectic mg2Ni phase is broken and dispersed in the as-extruded *** phase and mg2Ni phase in the alloys promote dynamic recrystallization(DRX)during extrusion,whileγ’phase inhibits ***,the mg96Y2Ni2(at.%)alloy with LPSO phase andγ’phase as the main second phases shows the strongest basal texture after *** tensile yield strength of the as-extruded mg-Y-Ni alloys increases first and then decreases with decreasing Y/Ni *** as-extruded mg96Y2Ni2(at.%)alloy with Y/Ni=1 exhibits excellent mechanical properties with tensile yield strength of 465 mPa,ultimate tensile strength of 510 mPa and elongation to failure of 7.2%,which is attributed to the synergistic effect of bulk LPSO phase and nanoscaleγ’phase.

关键词： mg-Y-Ni alloys LPSO γ’Phase mg2Ni mechanical properties

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青藏高原及其周边二叠纪综合地层、生物群以及古地理和古气候演化

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中国科学：地球科学 2024年第4期54卷 1125-1170页

作者：沈树忠张以春袁东勋徐海鹏琚琦张华郑全锋罗茂侯章帅南京大学地球科学与工程学院内生金属矿床成矿机制研究国家重点实验室关键地球物质循环前沿科学中心南京210023 中国科学院南京地质古生物研究所现代古生物学和地层学国家重点实验室南京210008 中国科学院大学南京学院南京210049 中国矿业大学资源与地球科学学院徐州221116

二叠纪是青藏高原各块体演化的关键时段,发生了一系列重大地质和生物事件,当时横跨南北半球统一的泛大陆演化到了鼎盛阶段,阻断了全球东西向的赤道暖流的同时,在泛大陆的东侧形成了一个半封闭的、具有重要历史意义的特提斯洋暖池,是古-... 详细信息

二叠纪是青藏高原各块体演化的关键时段,发生了一系列重大地质和生物事件,当时横跨南北半球统一的泛大陆演化到了鼎盛阶段,阻断了全球东西向的赤道暖流的同时,在泛大陆的东侧形成了一个半封闭的、具有重要历史意义的特提斯洋暖池,是古-中生代之交生物与环境演变的引擎.青藏高原二叠纪地层分布广泛、化石丰富,从南到北由于跨越不同的纬度带体现出不同的特点.雅鲁藏布江以南的喜马拉雅特提斯带当时位于冈瓦纳大陆印度板块北缘,整个二叠纪沉积含有典型的冈瓦纳冷水型生物群;雅鲁藏布江缝合带内的灰岩外来体时代集中在瓜德鲁普世(Guadalupian,中二叠世)中、晚期至早三叠世,古生物地理与喜马拉雅特提斯带有显著差异,最有可能为新特提斯洋中的海山型沉积.基墨里(Cimmerian)微地块群在乌拉尔世(Cisuralian,早二叠世)早期阿瑟尔期-萨克马尔期(Asselian-Sakmarian)全部位于冈瓦纳大陆北缘,均发育冰海相沉积及冈瓦纳型冷水生物群.乌拉尔世中期(约290~280ma)基墨里微地块群由于印度板块北缘Panjal Traps等大火成岩省岩浆活动与冈瓦纳大陆裂解,并以不同的速度向北漂移.可以分为两个条带,由南羌塘、保山和Sibuma地块组成的北基墨里微地块群漂移速度较快,在亚丁斯克期(Artinskian)就已经出现大量碳酸盐岩沉积和暖水生物群,因此,它们最先从冈瓦纳大陆裂解并进入低纬度暖水区域;而由拉萨、腾冲和Irrawaddy地块组成的南基墨里微地块群,漂移速度相对较慢,在空谷(Kungurian)晚期才开始出现大规模碳酸盐岩沉积,并延续至乐平世(Lopingian,晚二叠世),瓜德鲁普世和乐平世地层中含暖水生物为主的动物群,因此,这些地块至少在空谷晚期已经从冈瓦纳大陆北缘分离,裂解时间稍晚于北基墨里微地块群;这种沉积和古生物地理的时空演变差异性表明乌拉尔世的裂解事件造成了中特提斯洋和新特提斯洋的开启和形成.更北的北羌塘地块由于整个二叠纪地层中均含有典型的暖水生物群,与华南地区、思茅地块和印支地块等可以比较,属于古特提斯洋北部的块体.因此,二叠纪中、晚期特提斯域形成了古、中、新特提斯多岛洋共存的局面,是当时构造活动最活跃的地区和全球生物多样性的中心.此外,青藏高原多个块体在二叠纪位于南半球中高纬度地区,完整记录了晚古生代大冰期、亚丁斯克期全球变暖和二叠纪末快速变暖等重大古气候事件,对于阐明板块运动和全球气候演变对生物群时空分布的影响具有举足轻重的作用.

关键词：二叠纪特提斯洋青藏高原生物群古地理

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