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The RNA-binding protein Musashi2 governs osteoblast-adipocyte lineage commitment by suppressing PPARγsignaling

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Bone Research 2022年第3期10卷 536-547页

作者： Jinlong suo Sihai z.u Jinghui Wang Yujiao Han Lingli z.ang Chenchen Lv Bo Jiang Qian Ren Long Chen Lele Yang Ping Ji Xianyou z.eng Ping Hu Weiguo z.u Department of Orthopedic Surgery and Institute of Microsurgery on Extremities Shanghai Jiaotong University Affiliated Sixth People’s Hospital200233 ShanghaiChina Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher EducationStomatological Hospital of Chongqing Medical University401147 ChongqingChina State Key Laboratory of Cell Biology Shanghai Institute of Biochemistry and Cell BiologyCAS Center for Excellence in Molecular Cell SciencesChinese Academy of SciencesUniversity of Chinese Academy of Sciences200031 ShanghaiChina Guangz.ou Laboratory No.9 XingDaoHuan RoadGuanghzou International Bio lsland510005 GuangzhouChina Colorectal Cancer Center/Department of Gastrointestinal Surgery Shanghai Tenth People’s Hospital Affiliated to Tongji UniversityShanghaiChina Institute for Stem Cell and Regeneration Chinese Academy of Sciences100101 BeijingChina Bio-Research Innovation Center Shanghai Institute of Biochemistry and Cell BiologySuzhouChina

Osteoporosis caused by aging is characteriz.d by reduced bone mass and accumulated adipocytes in the bone marrow cavity. How the balance between osteoblastogenesis and adipogenesis from bone marrow mesenchymal stem cells(BMSCs) is lost upon aging is still unclear. Here, we found that the RNA-binding protein Musashi2(Msi2) regulates BMSC lineage commitment. Msi2 is commonly enriched in stem cells and tumor cells. We found that its expression was downregulated during adipogenic differentiation and upregulated during osteogenic differentiation of BMSCs. Msi2 knockout mice exhibited decreased bone mass with substantial accumulation of marrow adipocytes, similar to aging-induced osteoporosis. Depletion of Msi2 in BMSCs led to increased adipocyte commitment. Transcriptional profiling analysis revealed that Msi2 deficiency led to increased PPARγ ***-interacting protein immunoprecipitation assays demonstrated that Msi2 could inhibit the translation of the key adipogenic factor Cebpα, thereby inhibiting PPAR signaling. Furthermore, the expression of Msi2 decreased significantly during the aging process of mice, indicating that decreased Msi2 function during aging contributes to abnormal accumulation of adipocytes in bone marrow and osteoporosis. Thus, our results provide a putative biochemical mechanism for aging-related osteoporosis, suggesting that modulating Msi2 function may benefit the treatment of bone aging.

关键词： adipocyte osteoporosis inhibiting

一种面向多核处理器粗粒度的应用级Cache划分方法

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计算机工程与科学 2009年第A1期31卷 101-103页

作者：所光国防科技大学计算机学院湖南长沙410073

Cache划分技术是解决共享Cache访问冲突的重要方法,但是已有的Cache划分技术具有开销高、Cache划分时机难以确定的缺点。本文提出了面向应用的Cache划分框架(ACP)。ACP的优点是能够使用程序员提供的应用最外层循环的边界信息,更好地获... 详细信息

Cache划分技术是解决共享Cache访问冲突的重要方法,但是已有的Cache划分技术具有开销高、Cache划分时机难以确定的缺点。本文提出了面向应用的Cache划分框架(ACP)。ACP的优点是能够使用程序员提供的应用最外层循环的边界信息,更好地获取应用的失效率信息,因此Cache划分算法具有更高的精度,从而降低了划分的频率,进而提高系统性能。实验结果表明,和传统的固定周期的Cache划分方向相比,ACP具有更好的性能。

关键词： Cache划分多道应用多核处理器

Analysis for Pathogenicity and Development of Transgenic Eimeria tenella Expressing both Yellow Fluorescent Protein and TgDHFR-TS Genes

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畜牧兽医学报 2010年第S1期41卷 93-96页

作者： YAN Wen-chao WANG Tian-qi suo Xun HAN Li-fang DING Ke DONG Fa-ming z.ANG Long-xian College of Animal Science and Technology Henan University of Science and TechnologyLuoyang 471003China College of Veterinary Medicine China Agricultural UniversityBeijing 100193China College of Animal Science and Veterinary Medicine Henan Agricultural UniversityZhengzhou 450002China

In order to determine the effect of foreign genes on a transgenic parasite,the pathogenicity and development in chickens of transgenic *** strain TE1,which expresses yellow fluorescent protein (YFP) and dihydrofolate reductase thymidylate synthase derived from Toxoplasma gondii(TgDHFR-TS), were compared with that of the parental strain *** indicated that the fecundity of the transgenic parasite(TE1) was reduced at least 4 times relative to that of the BJ *** dosage of the TE1 strain induced less pathogenesis in chickens than did the BJ strain,but chickens inoculated with a higher dosage of TE1 oocysts displayed severe pathogenicity and mortality as did the BJ *** addition,trophoz.ites, the first generation and the second generation meronts and meroz.ites,microgamonts and macrogamonts of the transgenic parasite TE1 were seen by fluorescence *** interestingly,not all four sporonts in the sporulating transgenic oocysts express *** findings suggest that the expression of YFP and TgDHFR-TS genes to some extent reduced pathogenicity and reproductive potential of transgenic *** between homologous or non-homologous chromosomes occurred during z.gotic meiosis in *** strain TE1.

关键词： Eimeria tenella transfection fecundity pathogenicity live vaccine vector

面向多线程多道程序的加权共享Cache划分

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计算机学报 2008年第11期31卷 1938-1947页

作者：所光杨学军国防科学技术大学计算机学院长沙410073

并行应用在共享Cache结构的多核处理器执行时,会因为对共享Cache的冲突访问而产生性能下降和执行时间不确定的现象.共享Cache划分技术可以把共享Cache互斥地分配给多个进程使用,是解决该问题的有效方法.由于线程间的数据共享,线程数目... 详细信息

并行应用在共享Cache结构的多核处理器执行时,会因为对共享Cache的冲突访问而产生性能下降和执行时间不确定的现象.共享Cache划分技术可以把共享Cache互斥地分配给多个进程使用,是解决该问题的有效方法.由于线程间的数据共享,线程数目不同的应用对共享Cache的利用率不同,但传统的以失效率最低为目标的共享Cache划分算法(例如UCP)没有区分应用线程数目的不同.文中设计了一种面向多线程多道程序的加权共享Cache划分框架(Weighted Cache Partitioning,WCP),包括面向应用的失效率监控器和加权Cache划分算法.失效率监控器以进程为单位动态监控在不同的Cache容量下应用的失效率;而加权Cache划分算法扩展了传统的失效率最优的Cache划分算法,根据应用线程数目的不同在进行Cache划分时给应用赋予不同的权值,以使具有更多线程的应用获得更多的共享Cache,从而提高系统的整体性能.实验结果表明:加权Cache划分算法虽然失效率有所增高,但却改进了IPC吞吐率、加权加速比和公平性.在由科学和工程计算应用组成的多道程序测试用例中,WCP-1的IPC吞吐率比以失效率最低为目标函数的共享Cache划分算法最高高出10.8%,平均高出5.5%.

关键词：多核处理器多线程多道程序加权共享Cache划分 AMRM

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基于融合指标与作者贡献度的z.数优化研究

情报理论与实践 2022年第5期45卷 28-36页

作者：索传军牌艳欣中国人民大学信息资源管理学院北京100872

[目的/意义]针对z.数评价学者学术影响力存在的问题,提出融合引文分析与Altmetrics改进z.数得到z.(new)指数方法,以提高对学者影响力评价的科学性与合理性。[方法/过程]文章融合学术论文被引频次、下载量和期刊影响因子指标,考虑作者... 详细信息

[目的/意义]针对z.数评价学者学术影响力存在的问题,提出融合引文分析与Altmetrics改进z.数得到z.(new)指数方法,以提高对学者影响力评价的科学性与合理性。[方法/过程]文章融合学术论文被引频次、下载量和期刊影响因子指标,考虑作者贡献度,构建学术论文综合学术影响力综合指标(AC),以替代z.数评价的基本单元——被引频次(C)单一指标,改进得到z.(new)指数。以图书情报学领域2016—2020年的发文为数据来源,统计获得发文量排名前50位的学者,分别计算他们的z.(new)指数、z.数、p指数、h指数、总发文量N、加权综合学术影响力(AC)、篇均影响力(AC/N)、体现论文影响力分布的一致性指标μ,并实证分析了z.(new)指数评价学者学术影响力的效果。[结果/结论]z.(new)指数在继承z.数优势的基础上,同时也具有自身特有的优势和特点,可较公平和客观地对学者的影响力进行评价。

关键词： z.数学者影响力评价 Altmetrics 引文分析作者贡献度

A novel lean alloy of biodegradable Mg-2z. with nanograins

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Bioactive Materials 2021年第12期6卷 4333-4341页

作者： Wenhui Wang Carsten Blawert Rui z.n Yu Sun Hongz.ou Peng Jiahua Ni Pei Han Tao suo Yang Song Shaoxiang z.ang Mikhail L.z.eludkevich Xiaonong z.ang State Key Laboratory of Metal Matrix Composites School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai200240China Magnesium Innovation Centre(MagIC) Institute of Materials ResearchHelmholtz-Zentrum GeesthachtGeesthacht21502Germany Department of Mechanical Engineering Massachusetts Institute of TechnologyCambridgeMA02139United States Orthopaedic Department Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai200233China z.ongshan Hospital Fudan University Shanghai200233China Suz.ou Origin Medical Technology Co.Ltd. Jiangsu215513China

Lean alloy(low alloyed)is beneficial for long-term sustainable development of metal *** a nanocrystalline microstructure is a desirable approach to improve biodegradability and mechanical properties of lean biomedical Mg alloy,but it is nearly impossible to *** the present study,the bulk nanocrystalline Mg alloy(average grain siz.:~70 nm)was successfully obtained by hot rolling process of a lean Mg-2wt.%z.(z.)alloy and both high strength((223 MPa(YS)and 260 MPa(UTS))and good corrosion resistance(corrosion rate in vivo:0.2 mm/year)could be *** microstructure evolution during the rolling process was analyz.d and *** factors including large strain,fine grains,strong basal texture,high temperature and z. segregation conjointly provided the possibility for the activation of pyramidalslip to produce *** finding could provide a new development direction and field of application for lean biomedical Mg alloys.

关键词： Magnesium alloy Nanocrystal Biodegradable Rolling Microstructure

Nonresonant Optical Nonlinearities of Surface Chemically Modified z.O Composite Nanoparticles

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Chinese Physics Letters 1998年第1期15卷 27-29页

作者： WANG Rong-yao WU Xiao-chun z.U Bing-suo WANG Li WU Peng-fei LIU Shao-mei WANG Jin-guo XU Ji-ren Optical Physics Laboratory Institute of PhysicsChinese Academy of SciencesBeijing 100080

With surface chemical modification,we have obtained core-shell structure z.O *** nonresonant third-order nonlinear optical refraction of this new composite material was found to be-3.8×10^(-10) esu by z.scan measurements with a femtosecond pulsed *** ultrafast nonlinear response time~250 fs measured by time-resolved pump-probe techniques suggests that the nonlinearity of this new material originates mainly from a rapid electronic polariz.tion process or virtual process such as the optical Stark effect.

关键词： polariz.tion pump Nonlinear

800nm FBG sensing interrogation system based on tilted FBG

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Optoelectronics Letters 2007年第1期3卷 62-64页

作者： LIU Bo suo Rui z.OU Kai-ming JIN Long z.ANG Jian LIU Yan-ge KAI Gui-yun DONG Xiao-yi Institute of Modern Optics Nankai Univ. Tianjin 300071 P.R.China Photonics Research Group Aston University Birmingham UK B4 7ET

An 800 nm band fiber Bragg grating sensing interrogation system using tilted FBG as the core wavelength division compo- nent is presented. A charge coupled device (CCD) linear array is put on the focal plane of the lens to detect the light. TFBG is used to tap light out of the fiber core to fiber cladding. The sensing wavelength is 795 to 830 nm, with accuracy of 20 pm and scan speed 100Hz. Using FBG sensor, we achieve the temperature sensitivity of 1.8 ℃ and strain sensitivity of 18 με.

关键词：倾斜FBG 光纤布拉格光栅传感解调系统波长温度敏感性

Effect of swimming training on neural microcirculation in rats with sciatic nerve compression A study based on laser Doppler flowmetry

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Neural Regeneration Research 2010年第19期5卷 1510-1514页

作者： Yueming Gao Xinglin Wang Senyang Lang Lining z.ang Wei suo Tianyu Jiang Jingping Fan Department of Physical Therapy General Hospital of Chinese PLA Beijing 100853 China

Microcirculation of the peripheral nerve is necessary for neural growth and regeneration. However, technical limitations have limited studies in this area. The few studies conducted have concerned active exercise effects on microcirculation of the peripheral nerve. Using an animal experiment, this study evaluated the effect of swimming training on microcirculation of injured peripheral nerve by laser Doppler flowmetry. The results showed that the blood vessel at the distal end of the peripheral nerve was the main blood supply for the nerve, and the internal blood supply for the nerve had strong compensatory ability. Swimming training promoted the functional recovery of rats with sciatic nerve injury and the regeneration of myelin sheath and blood vessels, but had no impact on neural blood flow.

关键词： sciatic neuropathy angiogenesis swimming autogenic training blood flow velocity laser Doppler flowrnetry