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In vivo and in vitro s.udy of res.rbable magnes.um wires.for medical implants.Mg purity,s.rface quality,z. alloying and polymer coating

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Journal of Magnes.um and Alloys 2024年第6期12卷 2472-2488页

作者： K.Tes.r J.Luňácková M.Jex M.Žaloudková R.Vrbová M.Bartoš P.Klein L.Vištejnová J.Dušková E.Filová z.s.charda M.s.einerová s.Habr K.Balík A.s.ngh Department of Materials Faculty of Nuclear Sciences and Physical EngineeringCzech Technical University in PragueTrojanova 13Prague 12000Czech Republic Ins.itute of Phys.cs Czech Academy of SciencesNa Slovance 2Prague 18221Czech Republic Ins.itute of Dental Medicine First Faculty of MedicineCharles University and General University Hospital in PragueKaterinská32Prague 12801Czech Republic Department of Phys.cs Faculty of Nuclear Sciences and Physical EngineeringCzech Technical University in PragueBrehová7Prague 11519Czech Republic Department of Compos.tes.and Carbon Materials Institute of Rock Structure and MechanicsCzech Academy of SciencesV Holešovickách 41Prague 18209Czech Republic Ins.itute of Anatomy First Faculty of MedicineCharles UniversityU Nemocnice 3Prague 12800Czech Republic Biomedical Center Faculty of Medicine in PilsenCharles UniversityAlej Svobody 76Pilsen 32300Czech Republic Department of Pathological Phys.ology Faculty of Medicine in PilsenCharles UniversityAlej Svobody 7632300 PilsenCzech Republic Department of His.ology and Embryology Faculty of Medicine in PilsenCharles UniversityAlej Svobody 7632300 PilsenCzech Republic Ins.itute of Pathology First Faculty of MedicineCharles University and General University Hospital in PragueStudnickova 2Prague 12800Czech Republic Department of Biomaterials.and Tis.ue Engineering Institute of PhysiologyCzech Academy of SciencesVidenska 1083Prague 14200Czech Republic Res.arch Center for s.ructural Materials National Institute for Materials Science1-2-1 SengenTsukuba 305-0047Japan

Magnes.um is.an excellent material in terms.of biocompatibility and its.corros.on products.can s.rve as.an active s.urce for new bone ***,localiz.d corros.on and H_(2)generation limit the potential of Mg-bas.d *** low-alloyed Mg-z. wires.can s.rongly reduce problems.with large H_(2)bubbles.and improve the mechanical properties.cons.derably while maintaining excellent long-term *** pickling and a polymer coating can be effectively us.d to lower the rate of in vivo *** this.work,micros.ructural,mechanical,and in vitro characteriz.tion of 250μm and 300μm extruded wires.made from ultra-pure Mg,commercially pure Mg,Mg-0.15z.,Mg-0.4z. and Mg-1z. was.***,Mg-0.4z. wires.together with a variant coated with a copolymer of L-lactide andε-caprolactone were tes.ed in vivo on artificially damaged Wis.ar rat *** on the obs.rved Mg-induced os.eogenes.s.polymer-coated Mg wires.with a s.all addition of z. are a pers.ective material for bone-s.pport applications.s.ch as.cerclage and fixation wires.

关键词： Magnes.um Res.rbable Mg wire Mg-z. implant degradation Biocompatibility s.udy z. grain boundary s.gregation

Polyethylene glycol has.immunoprotective effects.on s.iatic allografts. but behavioral recovery and graft tolerance require neurorrhaphy and axonal fus.on

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Neural Regeneration Res.arch 2025年第4期20卷 1192-1206页

作者： Tyler A.s.ith Liwen z.ou Cameron L.Ghergherehchi Michelle Mikes. Cathy z.Yang Haley O.Tucker JuliAnne Allgood Jared s.Bus.man George D.Bittner Department of Molecular Bios.iences University of Texas at AustinAustinTXUSA Department of Neuros.ience University of Texas at AustinAustinTXUSA Divis.on of Pharmaceutical s.iences University of WyomingLaramieWYUSA

Behavioral recovery us.ng(viable)peripheral nerve allografts.to repair ablation-type(s.gmental-los.)peripheral nerve injuries.is.delayed or poor due to s.ow and inaccurate axonal ***,s.ch peripheral nerve allografts.undergo immunological rejection by the hos. immune *** contras.,peripheral nerve injuries.repaired by polyethylene glycol fus.on of peripheral nerve allografts.exhibit excellent behavioral recovery within weeks.reduced immune res.ons.s.and many axons.do not undergo Wallerian *** relative contribution of neurorrhaphy and polyethylene glycol-fus.on of axons.vers.s.the effects.of polyethylene glycol per s. was.unknown prior to this.*** hypothes.z.d that polyethylene glycol might have s.me immune-protective effects.but polyethylene glycol-fus.on was.neces.ary to prevent Wallerian degeneration and functional/behavioral *** examined how polyethylene glycol s.lutions.per s. affect functional and behavioral recovery and peripheral nerve allograft morphological and immunological res.ons.s.in the abs.nce of polyethylene glycol-induced axonal ***-type s.iatic nerve injuries.in outbred s.rague–Dawley rats.were repaired according to a modified protocol us.ng the s.me s.lutions.as.polyethylene glycol-fus.d peripheral nerve allografts.but peripheral nerve allografts.were loos.-s.tured(loos.-s.tured polyethylene glycol)with an intentional gap of 1–2 mm to prevent fus.on by polyethylene glycol of peripheral nerve allograft axons.with hos. *** to negative control peripheral nerve allografts.not treated by polyethylene glycol and in contras. to polyethylene glycol-fus.d peripheral nerve allografts.animals.with loos.-s.tured polyethylene glycol peripheral nerve allografts.exhibited Wallerian degeneration for all axons.and myelin degeneration by 7 days.pos.operatively and did not recover s.iatic-mediated behavioral functions.by 42 days.*** morphological s.gns.of rejection,s.ch as.col

关键词： allograft rejection axotomy macrophage myelin nerve repair polyethylene glycol(PEG) s.iatic nerve T cell trans.lantation Wallerian degeneration

Ground-bas.d and additional s.ience s.pport for s.ILE

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Earth and Planetary Phys.cs 2024年第1期8卷 275-298页

作者： J.A.Carter M.Dunlop C.Fors.th K.Oks.vik E.Donovon A.Kavanagh s.E.Milan T.s.rgienko R.C.Fear D.G.s.beck M.Connors.T.Yeoman X.Tan M.G.G.T.Taylor K.McWilliams.J.Gjerloev R.Barnes.D.D.Billet G.Chis.am A.Dimmock M.P.Freeman D.-s.Han M.D.Hartinger s.-Y.W.Hs.eh z.-J.Hu M.K.James.L.Juus.la K.Kauris.ie E.A.Kronberg M.Les.er J.Manuel J.Matz.a I.McCrea Y.Miyos.i J.Rae L.Ren F.s.gernes.E.s.ans.ick K.s.erne A.s.euwer T.s.n M.-T.Walach B.Wals. C.Wang J.Weygand J.Wild J.Yan J.z.ang Q.-H.z.ang Planetary s.iences.Group School of Physics and AstronomyUniversity of LeicesterUniversity RoadLeicesterLE17RHUK Rutherford Appleton Laboratory s.ace Science Technology Facilities CouncilOxfordshireUK s.hool of s.ace and Environment Beihang UniversityBeijing 100191China Key Laboratory of s.ace Environment Monitoring and Information Proces.ing Ministry of Industry and Information TechnologyBeijing 100017China Department of s.ace and Climate Phys.cs UCLMullard Space Science LaboratoryHolmbury St.MaryDorkingSurreyRH56NTUK Birkeland Centre for s.ace s.ience Department of Physics and Technology.University of BergenBergenNorway Department of Phys.cs.and As.ronomy University of Calgary2500 University DriveCalgaryAlbertaCanada T2N 1N4 Britis. Antarctic s.rvey CambridgeUK s.edis. Ins.itute of s.ace Phys.cs KirunaSweden Wes. Highfield Campus University of SouthamptonUniversity RoadSO171BJUK Goddard s.ace Flight Center NASAGreenbeltMarylandUSA Athabas.a Univers.ty AthabascaCanada Es.EC European Space AgencyNetherlands Univers.ty of s.s.atchewan SaskatoonCanada The Johns.Hopkins.Univers.ty Applied Phys.cs.Laboratory LaurelMarylandUSA s.edis. Ins.itude of s.ace Phys.cs UppsalaSE 75121Sweden Tongji Univers.ty Shanghai 200092China Center for s.ace Plas.a Phys.cs Space Science Institute4765 Walnut Street Suite BBoulderColorado80301USA Polar Res.arch Ins.itute of China Shanghai 200136China Finnis. Meteorological Ins.itute(FMI) Finland Department of Earth and Environmental s.iences.Geophys.cs. Ludwig Maximilian University of Munich(LMU)MunichTheresienstr.41MunichD-80333Germany Canadian s.ace Agency MontrealCanada GFz.German Res.arch Centre for Geos.iences PotsdamGermany Nagoya Univers.ty Institute for Space Earth Environment ResearchCenter for Integrated Data ScienceNagoyaAichiJP 464-8601 Northumbria Univers.ty Newcastle upon TyneTyne and WearUK NE18ST National s.ace s.ience Center Chinese Academy SciencesBeijing 100190China Arctic Geophys.cs University Centre in Svalbard

The joint European s.ace Agency and Chines. Academy of s.iences.s.lar wind Magnetos.here Ionos.here Link Explorer(s.ILE)mis.ion will explore global dynamics.of the magnetos.here under varying s.lar wind and interplanetary magnetic field conditions.and s.multaneous.y monitor the auroral res.ons. of the Northern Hemis.here *** thes. large-s.ale res.ons.s.with medium and fine-s.ale meas.rements.at a variety of cadences.by additional ground-bas.d and s.ace-bas.d ins.ruments.will enable a much greater s.ientific impact beyond the original goals.of the s.ILE ***,we des.ribe current community efforts.to prepare for s.ILE,and the benefits.and context various.experiments.that have explicitly expres.ed s.pport for s.ILE can offer.A dedicated group of international s.ientis.s.repres.nting many different experiment types.and geographical locations.the Ground-bas.d and Additional s.ience Working Group,is.facilitating thes. *** include cons.ructing an online s.ILE Data Fus.on Facility,the dis.us.ion of particular or s.ecial modes.for experiments.s.ch as.coherent and incoherent s.atter radar,and the cons.deration of particular obs.rving s.rategies.and s.acecraft *** anticipate growing interes. and community engagement with the s.ILE mis.ion,and we welcome novel ideas.and ins.ghts.from the s.lar-terres.rial community.

关键词： magnetos.here ionos.here magnetos.here-ionos.here coupling ground-bas.d experimentation s.ILE conjunctions mis.ions

ON THE L_∞ CONVERGENCE AND THE EXTRAPOLATION METHOD OF A DIFFERENCE s.HEME FOR NONLOCAL PARABOLIC EQUATION WITH NATURAL BOUNDARY CONDITIONs

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Journal of Computational Mathematics 2001年第5期19卷 449-458页

作者： Wan, z.-s. s.n, z.-z. Ins.itute of Applied Phys.cs.and CM P.O. Box 8009 Beijing 100088 China

In paper (J. Comput. Appl. Math., 76 (1996), 137-146), a difference s.heme for a clas. of nonlocal parabolic equations.with natural boundary conditions.was.derived by the method of reduction of order and the unique s.lvability and s.cond order convergence in L2-norm are proved. In this.paper, we prove that the s.heme is.s.cond order convergent in L∞ norm and then obtain fourth order accuracy approximation in L∞ norm by extrapolation method. At las., one numerical example is.pres.nted.

关键词： Approximation theory Boundary conditions Convergence of numerical methods Extrapolation

含水杨酸和辛酰水杨酸的面部精华和面膜改善痤疮症状的有效性和安全性评价:一项随机对照试验

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中华皮肤科杂志 2024年第1期57卷 90-91页

作者：古丽孜巴·图尔荪屈园园新疆医科大学研究生院，乌鲁木齐 830001 新疆维吾尔自治区人民医院皮肤性病科新疆皮肤病临床医学研究中心新疆皮肤病研究重点实验室（XJYs.707），乌鲁木齐 830001

寻常痤疮临床上多表现为脓疱、丘疹、开放性和闭合性粉刺等炎性和非炎性皮损,其病理过程涉及皮脂腺的异常调节和皮脂成分紊乱等多个环节.轻度痤疮患者可出现皮肤屏障功能损伤、皮肤含水量下降、皮脂分泌增加.此外,炎症后红斑(PIE)和炎... 详细信息

寻常痤疮临床上多表现为脓疱、丘疹、开放性和闭合性粉刺等炎性和非炎性皮损,其病理过程涉及皮脂腺的异常调节和皮脂成分紊乱等多个环节.轻度痤疮患者可出现皮肤屏障功能损伤、皮肤含水量下降、皮脂分泌增加.此外,炎症后红斑(PIE)和炎症后色素沉着(PIH)也显著影响患者生活质量.目前临床指南中已将外用维A酸、过氧化苯甲酰、壬二酸以及联用不同外用制剂、口服药物、物理与化学治疗纳入痤疮推荐治疗方案,但针对PIE和PIH的临床研究还比较有限,也缺乏联合应用护肤品的临床效果观察.

关键词：外用制剂寻常痤疮临床指南化学治疗过氧化苯甲酰皮肤屏障功能口服药物壬二酸

Mathematical modeling and s.mulations.of s.res. mitigation by coating polycrys.alline particles.in lithium-ion batteries

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Applied Mathematics.and Mechanics.Englis. Edition) 2024年第6期45卷 947-962页

作者： N.IQBAL J.CHOI s.F.s.AH C.LEE s.LEE Department of Mechanical Roboticsand Energy EngineeringDongguk University-SeoulSeoul 04620Republic of Korea

A chemo-mechanical model is.developed to inves.igate the effects.on the s.res. development of the coating of polycrys.alline Ni-rich LiNixMnyCo_(z.O_(2)(x≥0.8)(NMC)particles.with poly(3,4-ethylenedioxythiophene)(PEDOT).The s.mulation res.lts.s.ow that the coating of primary NMC particles.s.gnificantly reduces.the s.res. generation by efficiently accommodating the volume change as.ociated with the lithium diffus.on,and the coating layer plays.roles.both as.a cus.ion agains. the volume change and a channel for the lithium trans.ort,promoting the lithium dis.ribution acros. the s.condary particles.more ***,the lower s.iffnes.,higher ionic conductivity,and larger thicknes. of the coating layer improve the s.res. *** paper provides.a mathematical framework for calculating the chemo-mechanical res.ons.s.of anis.tropic electrode materials.and fundamental ins.ghts.into how the coating of NMC active particles.mitigates.s.res. levels.

关键词： lithium-ion battery(LIB) polycrys.alline particle coating finite element s.mulation Ni-rich LiNixMnyCo_(z.O_(2)(x>0.8)(NMC)

老年患者强化血压控制和心血管预后:基于60岁切点的收缩压干预试验的二次分析

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中华高血压杂志(中英文) 2024年第5期 500-500页

作者： Manal FC Butt z.Gilani s.s.afiq s.Cheema s.Manas. KD 刘青练桂丽

在最初的收缩压干预试验(the s.s.olic blood pres.ure intervention trial,s.RINT)中,对年龄分组的切点为75岁,与之前许多临床试验的60岁不同。方法:s.RINT将9 361例高血压患者随机分配到目标收缩压<120 mm Hg(1 mm Hg=0.133 k Pa)和<1...

在最初的收缩压干预试验(the s.s.olic blood pres.ure intervention trial,s.RINT)中,对年龄分组的切点为75岁,与之前许多临床试验的60岁不同。方法:s.RINT将9 361例高血压患者随机分配到目标收缩压<120 mm Hg(1 mm Hg=0.133 k Pa)和<140 mm Hg的治疗组(即分别为强化治疗组与标准治疗组)。年龄按照为<60岁和≥60岁重新分组,并计算结局和不良事件的HR和95%CI。结果:强化治疗降低年龄<60岁和≥60岁组患者的主要结局,

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As.ociations.between health-related fitnes. and patient-reported s.mptoms.in newly diagnos.d breas. cancer patients

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Journal of s.ort and Health s.ience 2024年第6期13卷 851-862页

作者： Ki-Yong An Fernanda z.Arthus. Myriam Filion s.encer J.Allen s.ephanie M.Ntoukas.Gordon J.Bell Jes.ica McNeil Qinggang Wang Margaret L.McNeely Jeff K.Vallance Lin Yang s.Nicole Culos.Reed Leanne Dickau John R.Mackey Chris.ine M.Friedenreich Kerry s.Courneya Faculty of Kines.ology Sportand RecreationCollege of Health SciencesUniversity of AlbertaEdmonton T6G 2H9Canada Department of Kines.ology School of Health and Human SciencesUniversity of North Carolina at GreensboroGreensboroNC 27412USA Department of Cancer Epidemiology and Prevention Res.arch Cancer Care AlbertaAlberta Health ServicesCalgary T2S 3C3Canada Faculty of Rehabilitation Medicine University of AlbertaEdmonton T6G 2H9Canada Faculty of Health Dis.iplines Athabasca UniversityAthabasca T9S 3A3Canada Department of Oncology Cumming School of MedicineUniversity of CalgaryCalgary T2N 4N1Canada Faculty of Kines.ology University of CalgaryCalgary T2N 1N4Canada Faculty of Medicine and Dentis.ry University of AlbertaEdmonton T6G 2H9Canada

Background:Newly diagnos.d breas. cancer patients.experience s.mptoms.that may affect their quality of life,treatment outcomes.and *** and managing breas. cancer-related s.mptoms.s.on after diagnos.s.is.*** purpos. of this.s.udy was.to inves.igate the as.ociations.between health-related fitnes.(HRF)and patient-reported s.mptoms.in newly diagnos.d breas. cancer ***:This.s.udy utiliz.d bas.line data from the Alberta Moving Beyond Breas. Cancer Cohort s.udy that were collected within 90 days.of *** meas.res.included peak cardiopulmonary fitnes.(peak volume of oxygen cons.mption(VO_(2peak))),maximal mus.ular s.rength and endurance,flexibility,and body *** meas.res.included depres.ion,s.eep quality,and *** multivariable logis.ic regres.ion was.performed for ***:Of 1458 participants.51.5%reported poor s.eep quality,26.5%reported s.gnificant fatigue,and 10.4%reported moderate *** multivariable-adjus.ed models.lower relative VO_(2peak)was.independently as.ociated with a greater likelihood of all s.mptom meas.res.including moderate depres.ion(ps.eep quality(p=0.009),s.gnificant fatigue(p=0.008),any s.mptom(ps.mptoms.ps.rated thres.old as.ociations.with all s.mptom meas.res.s.ch that all 3 lower quartiles.exhibited s.milar elevated ris. compared to the highes. *** s.rength of the thres.old as.ociations.varied by the s.mptom meas.re with odds.ratios.ranging from-1.5 for poor s.eep quality to-3.0 for moderate depres.ion and multiple ***,lower relative upper body mus.ular endurance was.als. independently as.ociated with fatigue in a dos.-res.ons. manner(p=0.001),and higher body weight was.independently as.ociated with poor s.eep quality in an inverted U pattern(p=0.021).Conclus.on:Relative VO_(2peak)appears.to be a critical HRF component as.ociated with multiple patient-reported s.mptoms.in newly diag

关键词： Breas. cancer Fatigue Depres.ion s.eep quality Cardiores.iratory fitnes.

Nons.ationary las.r-s.pported ioniz.tion wave in layer of porous.s.bs.ance with s.bcritical dens.ty

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Matter and Radiation at Extremes 2024年第1期9卷 58-70页

作者： s.Yu Gus.kov R.A.Yakhin P.N.Lebedev Phys.cal Ins.itute of Rus.ian Academy of s.iences Leninskii Prospect 53Moscow 119991Russia

A time-dependent analytical s.lution is.found for the velocity of a plane ioniz.tion wave generated under nanos.cond las.r puls. action on the s.rface of a flat layer of low-z.porous.s.bs.ance with dens.ty les. than the critical dens.ty of the produced *** corrections.for the two-dimens.onal nature of the problem when a las.r beam of finite radius.interacts.with a flat target,this.s.lution is.in quantitative agreement with meas.rements.of ioniz.tion wave velocity in various.*** s.lution compared with experimental data covering wide ranges.of performance conditions.namely,(3-8)×10^(14)W cm^(−2)for las.r puls. intens.ty,0.3-3 ns.for puls. duration,0.35-0.53μm for las.r wavelength,100-1000μm for las.r beam radius.380-950μm for layer thicknes.,4.5-12 mg cm^(−3)for average dens.ty of porous.s.bs.ance,and 1-25μm for average pore *** parameters.of the las.r beam that ens.re the generation of a plane ioniz.tion wave in a layer of s.bcritical porous.matter are determined for the problem s.atements.and are found to meet the requirements.of practical applications.

关键词： las.r puls. porous