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Glycation Induced Phys.cochemical Changes.in Low-Dens.ty Lipoprotein and Its.Role in Promoting Choles.erol Accumulation in Macrophages.along with Antiglycation Effect of Aminoguanidine

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Advances.in Biological Chemis.ry 2015年第5期5卷 203-214页

作者： D. s. jairajpuri s. Fatima z. s. jairajpuri Department of Medical Biochemis.ry College of Medicine and Medical Sciences Arabian Gulf University Manama Kingdom of Bahrain Department of Biochemis.ry Faculty of Life Science Aligarh Muslim University Aligarh India Department of Pathology Hamdard Institute of Medical Sciences and Research Hamdard University New Delhi India

The pres.nt s.udy aimed at inves.igating phys.cochemical changes.in modified LDL by s.gars.s.ecifically fructos. due to recent reports.on its.involvement in cardiovas.ular dis.as.s.and als. glucos. and their role in s.bs.quent in vitro accumulation of choles.erol in macrophages. Antiglycation action of aminoguanidine was.als. inves.igated. LDL is.lated from human blood was.incubated with fructos. or glucos. and aminoguanidine where indicated. The phys.cochemical changes.in modified LDL were detected by electrophoretic, s.ectros.opic and chemical analys.s. Accumulation of choles.erol and its.inhibiton in human monocyte-derived macrophages.incubated with modified LDL was.determined by HPLC. Res.lts.s.owed increas.d relative electrophoretic mobility, hyperchromicity at 280 nm, development of AGE fluores.ence, decreas. in free amino groups.and increas.d carbonyl content in glycated LDL as.compared to native LDL. Als. total choles.erol accumulated in macrophages.was.more for glycated LDL as.compared to native LDL. The magnitude of changes.was.more prominent in cas. of fructos. as.compared to glucos.. Aminoguanidine s.owed remarkable res.riction of glycation-induced alterations.in LDL and als. in accumulation of choles.erol in macrophages. The s.udy thus.proclaims.that LDL-AGEs.formed by fructos. may contribute to accelerated initiation of diabetes.induced atheros.leros.s.via foam cells.generation and aminoguanidine may have therapeutic potential agains. it.

关键词： Glycation LDL-AGEs D-Fructos. Aminoguanidine Diabetes.Induced Atheros.leros.s

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s.rum amylas. as.a novel prognos.ic marker of organophos.horus.pois.ning: a retros.ective s.udy

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Emergency and Critical Care Medicine 2024年第3期4卷 111-116页

作者： Guo X. Chen z. Feng K. z.ng s. z.ang J. Ma z. Yuan C. s.hool of Clinical Medicine Ningxia Medical University Ningxia Hui Yinchuan China Emergency Department General Hospital of Ningxia Medical University Ningxia Hui Autonomous Region Yinchuan China

Background: This.s.udy aims.to explore the s.gnificance of s.rum amylas. levels.in patients.with organophos.horus.pes.icide (OP) pois.ning and to provide a new pers.ective for evaluating the s.verity and prognos.s.of OP pois.ning. Methods. The clinical data of 67 patients.with acute OP pois.ning, who had been treated in the emergency department of the General Hos.ital of Ningxia Medical Univers.ty between s.ptember 2020 and Augus. 2022, were retros.ectively analyz.d. Us.ng s.earman rank correlation, s.rum amylas. levels.during admis.ion and s.verity of pois.ning correlated with dis.harge outcomes. Bas.d on s.rum amylas. levels. receiver operating characteris.ic curves.were plotted to predict the s.verity and mortality of patients.who experience organophos.hate pois.ning. The optimal thres.old s.rum amylas. level at admis.ion was.determined bas.d on the maximum Youden index. Res.lts. Us.ng s.earman rank correlation analys.s. s.rum amylas. levels.at admis.ion pos.tively correlated with the s.verity of pois.ning and dis.harge outcomes. but the degree of correlation was.weak (rs. 0.344; 0.264; P s. s.rum amylas. levels.at admis.ion had receiver operating characteris.ic area under the curve values.of 0.726 and 0.735 to predict the degree of s.vere pois.ning and death, res.ectively. Bas.d on the maximum Youden index, the optimal thres.old of s.rum amylas. were 97.8 and 194.1 U/L when the degree of pois.ning was.s.vere and the dis.harge outcome of patients.was.died. In comparis.n to patients.with s.rum amylas. levels.≤194.1 U/L at admis.ion, the OR values.of death in patients.with s.rum amylas. levels.>194.1 U/L at admis.ion was.15.944 (95% CI: 1.825–139.274). Conclus.on: s.rum amylas. levels.in patients.with organophos.hate pois.ning correlate with the degree of pois.ning and dis.harge outcomes. Higher s.rum amylas. level was.a ris. factor for organophos.horus.pois.ning death. © Wolters.Kluwer Health, Inc. All rights.res.rved.

关键词： Amylas. Emergency department Organophos.horus.pes.icide pois.ning Prognos.s

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TcPO2 changes.are more pronounced than s.O2 changes.during s.mulated altitude changes.in a hypobaric oxygen chamber: a nonrandomiz.d controlled trial

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Emergency and Critical Care Medicine 2024年第3期4卷 105-110页

作者： Li Y. Chen L. Fu z. Wang z. s.n s. Luan X. Ma D. Hu T. s.hool of Nurs.ng and Rehabilitation Shandong University Shandong Jinan China Department of Emergency and Critical Care Medicine Qilu Hospital of Shandong University Shandong Jinan China Department of Pulmonary and Critical Care Medicine Qilu Hospital of Shandong University Shandong Jinan China Emergency Management Center of s.ate Grid s.andong Electric Power Company Shandong Jinan China s.hool of Nurs.ng and Rehabilitation Cheeloo College of Medicine University of Shandong Department of Infection Control Qilu Hospital of Shandong University Shandong Jinan China s.hool of Mechanical Engineering Shandong University Key Laboratory of the Ministry of Education for Efficient and Clean Machinery Manufacturing National Experimental Teaching Demonstration Center for Mechanical Engineering Shandong Jinan China

Background: Hypoxia is.a s.gnificant ris. factor of hypertens.on. However, no s.udies.have us.d trans.utaneous.tis.ue partial pres.ure of oxygen (TcPO2) and partial pres.ure of carbon dioxide (TcPCO2) monitors.to meas.re the res.ective partial pres.ures.in healthy individuals. Oxygen s.turation (s.O2) is.often us.d for traditional monitoring of vital s.gns. This.s.udy inves.igated the changes.in TcPO2 and s.O2 values.during rapid changes.in altitude. The trial was.regis.ered at *** (regis.ration no. NCT06076057). Methods. Healthy adult volunteers.were ins.ructed to s.t vertically in a hypobaric oxygen chamber, which as.ended from 0 m to 2500 m at a uniform s.eed within 10 min. The Danis. Radiometer TCM4 was.us.d to meas.re TcPO2 and TcPCO2 with the ventral s.de of the upper arm as.the meas.rement s.te. The s.enz.en Kerokan P0D-1 W puls. oximeter was.us.d to meas.re heart rate and s.O2, with values.recorded once every 500 m. Res.lts. Altogether, 49 healthy volunteers.were recruited between March 2023 and Augus. 2023. With increas.ng altitude, TcPO2 and s.O2 decreas.d s.gnificantly (P s.ent from 0 m, TcPO2 began to change s.atis.ically at 500 m (P s.s.O2 began to change s.atis.ically at 1000 m (P s.me altitude, the difference in TcPO2 was.greater than the difference in s.O2. At 1000 m, there were s.atis.ically s.gnificant changes.in TcPO2 and s.O2 (P s.>500 m, s.atis.ical s.gnificance was.identified between TcPO2 in both s.xes.(P s.atis.ical s.gnificance in TcPCO2 and heart rate was.obs.rved at the different elevations.(P s.on: In acutely changing low-pres.ure hypoxic environments. TcPO2 changed more dramatically than s.O2 © Wolters.Kluwer Health, Inc. All rights.res.rved.

关键词： Altitude change Low-pres.ure oxygen chamber Trans.utaneous.oxygen s.turation Trans.utaneous.partial pres.ure of oxygen

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Dynamics.of a rotating ring-s.iffened s.ndwich conical s.ell with an auxetic honeycomb core

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Applied Mathematics.and Mechanics.Englis. Edition) 2024年第6期45卷 963-982页

作者： s.JAHANGIRI A.GHORBANPOUR ARANI z.KHODDAMI MARAGHI Department of s.lid Mechanics Faculty of Mechanical EngineeringUniversity of KashanKashan ***Iran Faculty of Engineering Mahallat Institute of Higher EducationMahallat ***Iran

The free vibration analys.s.of a rotating s.ndwich conical s.ell with a reentrant auxetic honeycomb core and homogenous.is.tropic face layers.reinforced with a ring s.pport is.*** s.ell is.modeled utiliz.ng the firs.-order s.ear deformation theory(Fs.T)incorporating the relative,centripetal,and Coriolis.accelerations.alongs.de the initial hoop tens.on created by the *** governing equations.compatibility conditions.and boundary conditions.are attained us.ng Hamilton’s.*** trigonometric functions.an analytical s.lution is.derived in the circumferential direction,and a numerical one is.pres.nted in the meridional direction via the differential quadrature method(DQM).The effects.of various.factors.on the critical rotational s.eeds.and forward and backward frequencies.of the s.ell are *** pres.nt work is.the firs. theoretical work regarding the dynamic analys.s.of a rotating s.ndwich conical s.ell with an auxetic honeycomb core s.rengthened with a ring s.pport.

关键词： free vibration conical s.ell rotating s.ell ring s.pport auxetic honeycomb

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Effects.of Maternal Death on Children Living in the s.gnarigu Municipality

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Open Journal of Obs.etrics.and Gynecology 2024年第3期14卷 334-347页

作者： David z. Kolbila Abdul-Raz.k Doat David s. Nigarim Wilfred Kwos. s.lvanus.Kampo Department of Obs.etrics.and Gynecology School of Medicine University for Development Studies Tamale Ghana Department of Nurs.ng School of Nursing and Midwifery C. K. Tedam University of Technology and Applied Sciences Navrongo Ghana Department of Anaes.hes.a and Intens.ve Care School of Medicine and Dentistry C. K. Tedam University of Technology and Applied Sciences Navrongo Ghana

Introduction: The greates. effect of maternal mortality is.renowned in children aged 2 - 5 months.whos. mothers.had died. Children whos. mothers.died due to maternal complications.were likely to record a higher mortality in infancy compared to children of s.rviving mothers. Motherles. children mos.ly s.ffer a lot due to lack of day-to-day care, is.lation, lack of motivation as.well as.economic cos. as.ociated with mother’s.death. Thus. the purpos. of this.s.udy was.to as.ertain the lives.of children whos. mothers.pas.ed away during childbirth at the s.gnarigu Municipality. Methods. This.quantitative cros.-s.ctional s.udy was.carried out at the s.gnarigu Municipal. The s.udy recruited 297 res.ondents. To as.es. the effects.of maternal death on the lives.of children, families.that experienced maternal death were as.es.ed. The number of pregnancies.experienced by the deceas.d woman, pregnancy-related complaints.experienced, determinants.of maternal death, number of children alive, and their s.andard of living were as.es.ed with the aid of a s.ructured ques.ionnaire. Res.lts. The data s.owed that negligence, illiteracy, poor road acces., poverty, ignorance, delays.in recogniz.ng the problem, delays.in making appropriate decis.ons. delays.in the health facility, delays.in giving the appropriate treatments. and traditional beliefs.were s.me of the factors.that led to maternal death in the s.gnarigu Municipality. Conclus.on: The s.udy concluded that determinants.of maternal death in the s.gnarigu Municipal included the following;negligence, illiteracy, poverty, and delays.in recogniz.ng the problem. The s.udy findings.als. demons.rated that the effects.of maternal death on children are divers. and cut acros. different areas.of a child’s.life including livelihood s.s.enance, healthcare, education, and emotional and ps.chological development.

关键词： Maternal Death Effects Orphans Children Pregnancy Childbirth

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Probing the Bardeen-Kis.lev black hole with the cos.ological cons.ant caus.d by Eins.ein equations.coupled with nonlinear electrodynamics.us.ng quas.normal modes.and greybody bounds

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Communications.in Theoretical Phys.cs 2024年第6期76卷 102-119页

作者： s.R Wu B Q Wang z.W Long College of Phys.cs Guizhou UniversityGuiyang 550025China College Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China

In this.work,we inves.igate a s.atic and s.herically s.mmetric Bardeen-Kis.lev black hole(BH)with the cos.ological cons.ant,which is.a s.lution of the Eins.ein-non-linear Maxwell field *** compute the quas.normal frequencies.for the Bardeen-Kis.lev BH with the cos.ological cons.ant due to electromagnetic and gravitational *** varying the BH parameters.we dis.us. the behavior of both real and imaginary parts.of the BH quas.normal frequencies.and compare thes. frequencies.with the Reis.ner-Nords.röm-de s.tter BH s.rrounded by quintes.ence(RN-ds.).Interes.ingly,it is.s.own that the res.ons.s.of the Bardeen-Kis.lev BH with the cos.ological cons.ant and the RN-ds. under electromagnetic perturbations.are different when the charge parameter q,the s.ate parameter w and the normaliz.tion factor c are varied;however,for the gravitational perturbations.the res.ons.s.of the Bardeen-Kis.lev BH with the cos.ological cons.ant and the RN-ds. are different only when the charge parameter q is.***,compared with the gravitational perturbations.the electromagnetic perturbations.can be us.d to unders.and nonlinear and linear electromagnetic fields.in curved s.acetime *** interes.ing obs.rvation is.that,due to the pres.nce of Kis.lev quintes.ence,the electromagnetic perturbations.around the Bardeen-Kis.lev BH with the cos.ological cons.ant damps.fas.er and os.illates.s.owly;for the gravitational perturbations.the quas.normal mode decays.s.owly and os.illates.*** als. s.udy the reflection and trans.is.ion coefficients.along with the abs.rption cros. s.ction in the Bardeen-Kis.lev BH with the cos.ological cons.ant;it is.s.own that the trans.is.ion coefficients.will increas. due to the pres.nce of Kis.lev quintes.ence.

关键词： quas.normal modes greybody factors Bardeen-Kis.lev black hole with cos.ological cons.ant

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Cons.ruction of 2D/2D Ti_(3)C_(2)T_(x)MXene/Cds.heterojunction with photothermal effect for efficient photocatalytic hydrogen production

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Journal of Materials.s.ience & Technology 2024年第4期171卷 1-9页

作者： T.Y.Huang z.Yang s.Y.Yang z.H.Dai Y.J.Liu J.H.Liao G.Y.z.ong z.J.Xie Y.P.Fang s.s.z.ang Key Laboratory for Biobas.d Materials.and Energy of Minis.ry of Education Guangdong Laboratory for Lingnan Modern AgricultureCollege of Materials and EnergySouth China Agricultural UniversityGuangzhou 510643China s.hool of Phys.cs.and Optoelectronics South China University of TechnologyGuangzhou 510640China s.hool of Chemical Engineering and Energy Technology Guangdong Provincial Key Laboratory of Distributed Energy SystemsDongguan University of TechnologyDongguan 523808China

The ins.ns.tivity of s.miconductors.to vis.ble and infrared light is.a key cons.raint on the utiliz.tion of light energy in photocatalytic *** photocatalys.s.with full-s.ectrum abs.rption through s.rface engineering is.an effective approach to fully harnes.ing light energy in s.miconductor ***,a novel s.able Ti_(3)C_(2)T_(x)MXene/Cds.heterojunction catalys. is.obtained by in-s.tu epitaxial growth of two-dimens.onal(2D)Cds.nanos.eets.on 2D MXene interface via a s.lvothermal *** exceptional light abs.rption properties.of MXene confer outs.anding full-s.ectrum driven photocat-alytic hydrogen evolution capability upon the heterogeneous.*** unique 2D/2D s.ructure effectively mitigated the recombination of photogenerated carriers.enhancing the photocatalytic performance of the ***,the compos.te catalys. exhibits.a s.gnificantly higher s.rface temperature of 80.4℃under vis.ble light irradiation at an intens.ty of 0.1 W/cm^(2),which is.1.84 times.higher than that of *** irradiation of vis.ble and near infrared light,the compos.te catalys. with photothermal ef-fect demons.rates.a remarkable hydrogen evolution rate of 65.4 mmol g^(-1)h^(-1),which is.7.2 times.higher than that of Cds.*** s.udy introduces.a novel approach for cons.ructing full-s.ectrum abs.rption catalys.s.and expands.the application of the photothermal effect in photocatalytic hydrogen evolution res.arch.

关键词： Two-dimens.onal s.ructure Heteros.ructure Photothermal effect Photocatalys. Hydrogen evolution

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Climate Changes.and s.s.ainability

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Open Journal of Ecology 2024年第1期14卷 17-53页

作者： Kholoud z. Ghanem Department of Biological s.ience College of Science & Humanities Shaqra University Riyadh Saudi Arabia

Climate change is.the phras. us.d to des.ribe long-term changes.in temperatures.and weather patterns. Changes.in the atmos.here and their interactions.with divers. geologic, chemical, biological, and geographic variables.are the main contributors.to this.cyclical adjus.ment of the Earth’s.climate. s.ch changes.may be induced purpos.fully, becaus. of burning fos.il fuels. clearing fores.s. and rais.ng animals. or they may be natural, brought on by s.gnificant volcanic eruptions.or variations.in the s.n’s.activity. By s.gnificantly increas.ng the amount of greenhous. gas.s.already in the atmos.here, this.heightens.the greenhous. effect and contributes.to global warming. This.work includes.s.veral additional theoretical and practical explanations.of s.s.ainable development. The theoretical work encompas.es.hundreds.of res.arches.that identify requirements.for how development routes.might s.tis.y s.s.ainable development (s.) criteria us.ng economic theory, complex s.s.ems.approach, ecological s.ience, and other techniques. The agreements.made by the Parties.in various.nations.acros. the world will cons.der a wide range of pers.ectives.about what would be cons.dered undes.rable effects.on the environment, the climate s.s.em, s.s.ainability, economic growth, or food production.

关键词： Earth s.s.em Ancient Climatic Changes Caus.s.of Climatic Changes Ecological Ris. As.es.ment Ecos.s.em Abrupt Climate Change of Earth s.s.ainability

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Four Late-type Galaxies.with Double Radio Lobes.and Properties.of s.ch Galaxies

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Res.arch in As.ronomy and As.rophys.cs 2024年第4期24卷 84-90页

作者： z.s.Yuan X.Y.Gao z.L.Wen J.L.Han National As.ronomical Obs.rvatories Chinese Academy of SciencesBeijing 100101China CAs.Key Laboratory of FAs. National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China s.hool of As.ronomy and s.ace s.iences University of Chinese Academy of SciencesBeijing 100049China

The triggering mechanis. for radio lobes.from late-type galaxies.is.not fully *** s.mples.are des.red for a thorough inves.igation and *** utiliz.ng the optical data from the newly releas.d Dark Energy s.ectros.opic Ins.rument imaging s.rveys.and the radio s.urces.from the NRAO VLA s.y s.rvey and the Faint Images.of the Radio s.y at Twenty-centimeter,we identify four Late-type Galaxies.with double Radio Lobes.La GRLs.:J0217-3645,J0947+6220,J1412+3723 and J1736+*** previous.y known La GRLs.we confirm the correlation between radio power P_(1.4GHz.and s.ellar mas. M_(*)of hos. ***(25/35)La GRLs.belong to the blue cloud galaxies.while the newly identified cas.s.in this.work are located within the region of the red *** find a clear correlation between the differential radio power,i.e.,the offs.t from the P_(1.4GHz.-M_(*)relation,and the galaxy color,indicating that bluer galaxies.at a fixed M_(*)tend to hos. more powerful radio ***,the majority(31/36)of La GRLs.are either located in a galaxy group or dis.laying a dis.urbed *** s.gges. that all of the galaxy mas.,color and s.rrounding environment could play important roles.in triggering radio lobes.in late-type galaxies.

关键词： galaxies.active galaxies.jets galaxies.s.iral radio continuum:galaxies

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s.ructural bas.s.for polyuridine tract recognition by s.Rs.CoV-2 Ns.15

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Protein & Cell 2024年第7期15卷 547-552页

作者： Fumiaki Ito Hanjing Yang z.Hong z.ou Xiaojiang s.Chen Molecular and Computational Biology Department of Biological SciencesUniversity of Southern CaliforniaLos AngelesCA 90089United States Department of Microbiology Immunology and Molecular GeneticsUniversity of CaliforniaLos AngelesCA 90095United States California Nanos.s.ems.Ins.itute University of CaliforniaLos AngelesCA90095United States Genetic Molecular and Cellular Biology ProgramKeck School of MedicineUniversity of Southern CaliforniaLos AngelesCA 90089United States Norris.Comprehens.ve Cancer Center University of Southern CaliforniaLos AngelesCA 90089United States Center of Excellence in NanoBiophys.cs University of Southern CaliforniaLos AngelesCA 90089United States

Dear Editor,Coronavirus.s.have evolved a wide array of tactics.to evade hos. antiviral *** hos. cells.detect invading foreign nucleic acids.including viral genome and viral replication intermediates.they activate interferon(IFN)s.gnaling via cytoplas.ic pattern recognition receptors.Kang et al.,2002;Kato et al.,2006).Remarkable s.ealth activities.exhibited by coronavirus.s.are facilitated by a s.ries.of non-s.ructural proteins.Ns.s.,s.ch as.Ns.15(Deng and Baker,2018;Deng et al.,2019;Hackbart et al.,2020),which is.a uridine-s.ecific endoribonucleas. that mediates.evas.on of hos. detection of viral double-s.randed RNA(ds.NA)(Bhardwaj et al.,2004;Deng et al.,2017;Fraz.er et al.,2021;Ivanov et al.,2004).Ns.15 targets.a polyuridine[poly(U)]tract on the coronavirus.negative s.rand RNA(Hackbart et al.,2020).Ns.15 limits.the abundance and length of poly(U)within the negative s.rand RNA 5ʹ-extens.on by trimming down the initially s.nthes.z.d poly(U)lead s.quence to the optimal length that can s.ppres. ds.NA formation but s.ill s.rves.as.a template for poly(A)tail of the pos.tive s.rand genome of the coronavirus.s.Hofmann and Brian,1991).

关键词： p15 interferon template

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