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Inhibition of Ehr.ich ascites car.inoma gr.wth by melatonin:Studies with micr.-CT

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Oncology r.sear.h 2024年第1期32卷 175-185页

作者： SEHEr.YILMAz.z.LEYHA DOĞANYIĞIT MEr. OCAK EVr.M SUNA Ar.KAN SÖYLEMEz.ASLI OKAN OFLAMAz.SÜMEYYE UÇAr.ŞÜKr.ATEŞ AMMAD AHMAD FAr.OQI Depar.ment of Anatomy Faculty of MedicineYozgat Bozok UniversityYozgatTurkey Depar.ment of Mechanical and Aer.space Engineer.ng Case Western Reserve UniversityClevelandOhioUSA Depar.ment of Histology and Embr.ology Faculty of MedicineYozgat Bozok UniversityYozgatTurkey Depar.ment of Anatomy Faculty of DentistryAnkara UniversityAnkaraTurkey Depar.ment of Medical Biology Faculty of MedicineAfyonkarahisar Health Sciences UniversityAfyonTurkey Depar.ment of Anatomy Faculty of MedicineErciyes UniversityKayseriTurkey Depar.ment of Molecular.Oncology Institute of Biomedical and Genetic Engineering(IBGE)IslamabadPakistan

Melatonin is a ver.atile indolamine synthesiz.d and secr.ted by the pineal gland in r.sponse to the photoper.odic infor.ation r.ceived by the r.tinohypothalamic signaling *** has many benefits,such as or.aniz.ng cir.adian r.ythms and acting as a power.ul *** aimed to show the antitumor.effects of melatonin in both in vivo and in vitr. models thr.ugh the mammalian tar.et of r.pamycin(mTOr.signaling pathway and the Ar.yr.philic Nucleolar.r.gulator. r.gion(AgNOr.,using the Micr.computed Tomogr.phy(Micr. CT).Ehr.ich ascites car.inoma(EAC)cells wer. administer.d into the mice by subcutaneous *** with solid tumor. wer. injected intr.per.toneally with 50 and 100 mg/kg melatonin for.14 *** measur.ments for.the taken tumor. wer. made with micr.-CT imaging,immunohistochemistr.(IHC),r.al-time polymer.se chain r.action(PCr.and ***,the tumor.tissue volume in the Tumor.100 mg/kg melatonin gr.up was significantly lower.than that in the other.gr.ups in the data obtained fr.m micr.-CT *** the IHC analysis,the gr.ups tr.ated with Tumor.100 mg/kg melatonin wer. compar.d when the mTOr.signaling pathway and factor.8(F8)expr.ssion wer. compar.d with the contr.l *** was deter.ined that ther. was a significant decr.ase(pr.nces wer. found in the total AgNOr.ar.a/nuclear.ar.a(TAA/NA)r.tio in the tr.atment gr.ups(pr.her.or.,ther. wer. significant differ.nces between the amount of mTOr.mr.A for.the phosphatidylinositol 3-kinase(PI3K),AKT Ser.ne/Thr.onine Kinase(PKB/AKT)genes(pr. study with differ.nt doses of melatonin;It was obser.ed that 100µg/mL melatonin dose caused an incr.ase in the apoptotic cell *** this study,we have r.por.ed anti-tumor.effects of melatonin in cell cultur. studies as well as in mice *** char.cter.z.tion of the melatonin-mediated cancer.inhibitor. effects will be valuable in advanc

关键词： Signaling pathway Apoptosis r.al-time PCr AgNOr

Outcomes of long-acting injectable antipsychotics use in pr.gnancy:A liter.tur. r.view

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Wor.d Jour.al of Psychiatr. 2024年第4期14卷 582-599页

作者： Ana V Pejčić Sr.jan M Stefanović MilošN Milosavljević Vladimir.S Janjić Mar.o M Folić Nevena D Folić Jovana z.Milosavljević Depar.ment of Phar.acology and Toxicology Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Depar.ment of Phar.acy Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Depar.ment of Clinical Phar.acology University Clinical Center KragujevacKragujevac 34000Serbia Depar.ment of Psychiatr. Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Clinic for.Psychiatr. University Clinical Center KragujevacKragujevac 34000Serbia Center.for.Phar.aceutical and Phar.acological r.sear.h Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Depar.ment of Pediatr.cs Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia Pediatr.c Clinic University Clinical Center KragujevacKragujevac 34000Serbia Depar.ment of Anatomy Faculty of Medical SciencesUniversity of KragujevacKragujevac 34000Serbia

BACKGr.UND Women with a histor. of ser.ous psychotic disor.er. ar. at incr.ased r.sk of disease r.lapse dur.ng ***-acting injectable(LAI)antipsychotics have been widely used to impr.ve adher.nce and pr.vent r.lapse in patients with var.ous sever. psychotic disor.er.,but ther. is a lack of high-quality data fr.m pr.vious r.sear.h on the safety of LAI antipsychotics dur.ng *** To summar.z. r.levant data on mater.al,pr.gnancy,neonatal,and developmental outcomes fr.m published cases of LAI antipsychotic use in *** A liter.tur. sear.h was per.or.ed thr.ugh November.11,2023,using thr.e online databases:PubMed/MEDLINE,Scopus,and Web of *** r.por.s or.case ser.es that r.por.ed infor.ation about the outcomes of pr.gnancy in women who used LAI antipsychotics at any point in pr.gnancy,with available full texts,wer. *** statistics,nar.ative summation,and tabulation of the extr.cted data wer. *** A total of 19 publications satisfied the inclusion cr.ter.a:3 case ser.es,15 case r.por.s,and 1 confer.nce *** r.por.ed the outcomes of LAI antipsychotic use in 74 women and 77 *** use of secondgener.tion LAI antipsychotics was r.por.ed in the major.ty(n=47;61.0%)of ***-gener.tion LAI antipsychotics wer. administer.d dur.ng 30 pr.gnancies(39.0%).Most of the women(appr.ximately 64%)had either.satisfactor. contr.l of symptoms or.no infor.ation about r.lapse,while appr.ximately 12%of them had developed gestational diabetes mellitus.A minor.ty of cases r.por.ed adver.e outcomes such as stillbir.h,spontaneous abor.ion,pr.ter. bir.h,low bir.h weight,congenital anomalies,and neur.logical manifestations in ***,ther. wer. no r.por.s of negative long-ter. developmental *** Cur.ently available data seem r.assur.ng,but fur.her.well-designed studies ar. r.quir.d to pr.per.y evaluate the r.sks and benefits of LAI antipsychotic use dur.ng pr.gnancy.

关键词： Antipsychotic agents Long-acting injectable Pr.gnancy Outcome r.view

Development and application of functional gene ar.ays for. micr.bial community analysis

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中国有色金属学会会刊：英文版 2008年第6期18卷 1319-1327页

作者： z. L. HE J. D. VAN NOSTr.ND L.Y. WU J. z. z.OU Institute for.Envir.nmental Genomics Department of Botany and Microbiology University of Oklahoma Norman OK 73019 USA

功能的基因标记能关于功能的基因差异和微生物引起的社区的潜在的活动提供重要信息。尽管 micr.ar.ay 技术成功地被使用了为纯文化学习基因表示，简单、人工的微生物引起的社区，改编如此的一种技术分析复杂微生物引起的社区仍然以设计... 详细信息

功能的基因标记能关于功能的基因差异和微生物引起的社区的潜在的活动提供重要信息。尽管 micr.ar.ay 技术成功地被使用了为纯文化学习基因表示，简单、人工的微生物引起的社区，改编如此的一种技术分析复杂微生物引起的社区仍然以设计，样品准备，和数据分析提出很多挑战。这个工作集中于功能的基因数组(FGA ) 的开发和应用程序为微生物引起的社区研究指向关键功能的基因标记。一些与 FGA 有关明确地给问题调音，例如 oligonucleotide 探查设计， nucleic 酸抽取和纯化，数据分析，特性，敏感，和量的能力详细被讨论。最近的研究证明了 FGA 能从许多自然环境关于微生物引起的社区提供特定、敏感、潜在地量的信息并且控制生态系统。这种技术被期望革命化微生物引起的社区的分析，并且连接微生物引起的结构到生态系统工作。

关键词：微数列应用函数基因标记微生物种群

Machine Lear.ing Analysis of Impact of Wester. US Fir.s on Centr.l US Hailstor.s

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Advances in Atmospher.c Sciences 2024年第7期41卷 1450-1462页

作者： Xinming LIN Jiwen FAN Yuwei z.ANG z.ason HOU Pacific Nor.hwest National Labor.tor. RichlandWA 99354USA Ar.onne National Labor.tor. LemontIL 60439USA

Fir.s,including wildfir.s,har. air.quality and essential public ser.ices like tr.nspor.ation,communication,and *** fir.s can also influence atmospher.c conditions,including temper.tur. and aer.sols,potentially affecting sever. convective ***,we investigate the r.mote impacts of fir.s in the wester. United States(WUS)on the occur.ence of lar.e hail(siz.:≥2.54 cm)in the centr.l US(CUS)over.the 20-year.per.od of 2001–20 using the machine lear.ing(ML),r.ndom For.st(r.),and Extr.me Gr.dient Boosting(XGB)*** developed r. and XGB models demonstr.te high accur.cy(>90%)and F1 scor.s of up to 0.78 in pr.dicting lar.e hail occur.ences when WUS fir.s and CUS hailstor.s coincide,par.icular.y in four.states(Wyoming,South Dakota,Nebr.ska,and Kansas).The key contr.buting var.ables identified fr.m both ML models include the meteor.logical var.ables in the fir. r.gion(temper.tur. and moistur.),the wester.y wind over.the plume tr.nspor. path,and the fir. featur.s(i.e.,the maximum fir. power.and bur.ed ar.a).The r.sults confir. a linkage between WUS fir.s and sever. weather.in the CUS,cor.obor.ting the findings of our.pr.vious modeling study conducted on case simulations with a detailed physics model.

关键词： wildfir. sever. convective stor. hailstor. machine lear.ing

纳米级z.O/MgO固体的合成及其对CO的氧化活性(英文)

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催化学报 2008年第11期29卷 1079-1083页

作者： Olga z. DIDENKO Gulnar. r. KOSMAMBETOVA Peter.E. STr.z.AK L.V.Pisar.0}evsky Institute of Physical Chemistr. of the National Academy of Sciences of Ukr.ine

The z.O/MgO solid samples containing the z.O nanopar.icles of contr.llable siz. wer. pr.par.d using colloidal technique. The catalytic per.or.ance of the z.O/MgO samples for.the CO oxidation was measur.d. It was r.vealed that the r.te of the CO oxidation r.action on the z.O nanopar.icles with var.able aver.ge r.dius (2.01-2.29 nm) shows nonmonotonic dependence caused by the quantum-confinement effect.

关键词：纳米氧化锌氧化镁催化剂氧化活性一氧化碳

Utiliz.tion of Maxwell-Cattaneo law for.MHD swir.ing flow thr.ugh oscillator. disk subject to por.us medium

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Applied Mathematics and Mechanics(English Edition) 2019年第6期40卷 837-850页

作者： A. r.UF z. ABBAS S. A. SHEHz.D Depar.ment of Mathematics The Islamia University of BahawalpurBahawalpur 63100Pakistan Depar.ment of Mathematics COMSATS University IslamabadSahiwal 57000Pakistan

The pr.sent study aims to investigate the salient featur.s of incompr.ssible, hydr.magnetic, thr.e-dimensional flow of viscous fluid subject to the oscillator. motion of a disk. The r.tating disk is contained in a por.us medium. Fur.her.or., a time-invar.ant ver.ion of the Maxwell-Cattaneo law is implemented in the ener.y equation. The flow pr.blem is nor.aliz.d by obtaining similar.ty var.ables. The r.sulting nonlinear.system is solved numer.cally using the successive over.r.laxation method. The main r.sults ar. discussed thr.ugh gr.phical r.pr.sentations and tables. It is per.eived that the ther.al r.laxation time par.meter.decr.ases the temper.tur. cur.es and incr.ases the heat tr.ns- fer.r.te. The oscillator. cur.es for.the velocity field demonstr.te a decr.asing tendency with the incr.asing por.sity par.meter.values. Two- and thr.e-dimensional flow phenom- ena ar. also shown thr.ugh gr.phical r.sults.

关键词： time-dependent flow oscillator. disk por.us medium magnetohydr.dy-namic (MHD) Maxwell-Cattaneo law numer.cal solution

A new hybr.d decision suppor. tool for.evaluating the sustainability of mining pr.jects

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Inter.ational Jour.al of Mining Science and Technology 2018年第2期28卷 259-265页

作者： Kamenopoulos S. Agioutantis z. Komnitsas K. School of Miner.l r.sour.es Engineer.ng Technical University of Crete Depar.ment of Mining Engineer.ng University of Kentucky

The integr.tion of sustainable development challenges and oppor.unities into the decision making pr.cess dur.ng the design and/or.implementation of multi-disciplinar. mining pr.jects is gener.lly not suppor.ed by decision suppor. systems(DSS). A new hybr.d decision suppor. tool, which featur.s an integr.ted assessment of sustainable development issues as they apply to mining pr.jects, is her.by pr.posed. The pr.posed DSS fr.mewor., named ‘‘Acr.polis DSS", can be used to assist involved stakeholder. in cr.tical decisions, especially when addr.ssing issues such as stakeholder.par.icipation, tr.nspar.ncy,and tr.de-offs. The pr.posed DSS is based on a multi-cr.ter.a decision analysis combined with the multi-attr.bute utility theor..

关键词： Sustainable development Multi-cr.ter.a decision analysis Indicator. Stakeholder. r.r. ear.h elements

A note on hydr.dynamics fr.m dissipative par.icle dynamics

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Applied Mathematics and Mechanics(English Edition) 2018年第1期39卷 63-82页

作者： X. BIAN z. LI N.A. ADAMS Depar.ment of Mechanical Engineer.ng Technical University of Munich Munchen 85748 Germany Division of Applied Mathematics Brown University Rhode Island 02912 U. S. A.

We calculate cur.ent cor.elation functions （CCFs） of dissipative par.icle dy- namics （DPD） and compar. them with r.sults of molecular.dynamics （MD） and solutions of linear.z.d hydr.dynamic equations. In par.icular. we consider.thr.e ver.ions of DPD, the empir.cal/classical DPD, coar.e-gr.ined （CG） DPD with r.dial-dir.ction inter.ctions only and full （r.dial, tr.nsver.al, and r.tational） inter.ctions between par.icles. To fa- cilitate quantitative discussions, we consider.specifically a star.polymer.melt system at a moder.te density. For.bonded molecules, it is str.ightfor.ar. to define the CG var.ables and to fur.her.der.ve CG for.e fields for.DPD within the fr.mewor. of the Mor.-z.anz.g for.alism. For.both tr.nsver.al and longitudinal cur.ent cor.elation functions （TCCFs and LCCFs）, we obser.e that r.sults of MD, DPD, and hydr.dynamic solutions agr.e with each other.at the continuum limit. Below the continuum limit to cer.ain length scales, r.sults of MD deviate significantly fr.m hydr.dynamic solutions, wher.as r.sults of both empir.cal and CG DPD r.semble those of MD. This indicates that the DPD method with Mar.ovian for.e laws possibly has a lar.er.applicability than the continuum descr.ption of a Newtonian fluid. This is wor.h being explor.d fur.her.to r.pr.sent gen- er.liz.d hydr.dynamics.

关键词： dissipative par.icle dynamics (DPD) fluctuating hydr.dynamics molec-ular.dynamics (MD) coar.e-gr.ining Mor.-z.anz.g pr.jection

Sur.ace Wettability and Chemistr. of Oz.ne Per.usion Pr.cessed Por.us Collagen Scaffold

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Jour.al of Bionic Engineer.ng 2011年第3期8卷 223-233页

作者： Chaoz.ng Liu Shir.ey z. Shen 乙hiwu Han School of Mechanical and Systems Engineer.ng University of Newcastle Newcastle upon Tyne NEI 7R U UK Polymer.Composite & Nanomater.als CSIRO Manufacturing & Infrastructure Technology Highett Vic 3190 Australia Key Labor.tor. of Bionic Engineer.ng (Ministr. of Education China) Jilin University Changchun 130022 P. R. China

Cr.sslinking tr.atment of collagen has often been used to impr.ve the biological stability and mechanical pr.per.ies of 3D por.us collagen scaffolds. However. accompanying these impr.vements, the collagen fibr.l sur.ace becomes hydr.phobic natur. r.sulting in a r.duced sur.ace wettability. The wetting of the collagen fibr.l by cultur. medium is r.duced and it is difficult for.the medium to diffuse into the 3D str.ctur. of a por.us collagen scaffold. This paper.r.por.s a ＂per.usion pr.cessing＂ str.tegy using oz.ne to impr.ve the sur.ace wettability of chemical cr.sslinked collagen scaffolds. Sur.ace wettability, sur.ace composition and biological stability wer. analyz.d to evaluate the effectiveness of this sur.ace pr.cessing str.tegy. It was obser.ed that oz.ne per.usion pr.cessing impr.ved sur.ace wettability for.both exter.or.and inter.or.sur.aces of the por.us 3D collagen scaffold. The impr.vement in wettability is attr.buted to the incor.or.tion of oxygen-containing functional gr.ups onto the sur.ace of the collagen fibr.ls, as confir.ed by X-r.y Photoelectr.n Spectr.scopy （XPS） analysis. This leads to a significant impr.vement in water.taking capability without compr.mising the bulk biological stability and mechanical pr.per.ies, and confir.s that oz.ne per.usion pr.cessing is an effective tool to modify the wettability both for.inter.or.and exter.or.sur.aces thr.ughout the scaffold.

关键词： scaffold collagen sur.ace modification hydr.philicity oz.ne per.usion