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Epidemio-Clinical-Histopathological Aspects and Therapeutics of Squamous Cell Carcinoma of the Conjunctival at the University Hospital Center of Bouake

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Open Journal of Ophthalmology 2024年第2期14卷 159-167页

作者： Philippe Emile France Koffi Bile Pierre Windinmanegde Djiguimde Gossé François Diomandé Zana Diabate Kouassi Franck-Hermann Koffi Liliale Ella Godé Ange Mickael Goule Opeyemi Babayeju yves Ouattara Ibrahim Abib Diomande Ophthalmology Department University Hospital Center Bouake C&#244te d&#8217Ivoire Ophthalmology Department University Hospital Center Bogodogo Ouagadougou Burkina Faso

Introduction: Squamous cell carcinoma of the conjunctiva is one of the most common malignancies in the elderly. Purpose: To describe the specific aspects of squamous cell carcinoma of the conjunctiva and to determine the therapeutic modalities. Materials and Methods: Descriptive cross-sectional retrospective study carried out at the University Hospital Center of Bouake over a period of 9 years (From January 2015 to December 2023). We identified all malignant oculo-adnexal and orbital tumors whose histopathological diagnosis was confirmed;monitoring the sorting of squamous cell carcinomas of the conjunctiva among these cancers and studying the different parameters linked to them. Results: The average age of patients is 44.3 years. Male predominance with a sex ratio of 1.12. HIV was the majority ATCD with 64.7%. The main reason for consultation was exophthalmos (36.11%). The average consultation time was 10 months 13 days. Invasive differentiated conjunctival squamous cell carcinoma was predominant at 55.56%. Enucleation was the most performed surgical method. Conclusion: Squamous cell carcinoma of the conjunctiva is a malignant ocular tumor of the elderly whose frequency increases in young adults infected with HIV-AIDS. Invasive differentiated forms are increasingly encountered, limiting treatment to mutilating surgery.

关键词： Malignant Tumor Ocular Carcinoma Conjunctiva

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Effect of vertical electromagnetic stirring on solute distribution in billet continuous casting process

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Journal of Iron and Steel Research(International) 2022年第1期29卷 132-143页

作者： Tao Wang En-gang Wang yves Delannoy yves Fautrelle Olga Budenkova Key Laboratory of Electromagnetic Processing of Materials(Ministry of Education) Northeastern UniversityShenyang 110004LiaoningChina CNRS Grenoble INPSIMAPUniversité Grenoble AlpesGrenoble 38000France School of Metallurgy Northeastern UniversityShenyang 110004LiaoningChina CNRS Grenoble INPLEGIUniversité Grenoble AlpesGrenoble 38000France

A volume averaged columnar solidification model,which couples the flow,temperature and solute concentration fields,is applied to simulate experimental continuous casting cases with and without vertical electromagnetic stirring(V-EMS).The calculated distribution of magnetic induction intensity and final macrosegregation maps are consistent with the experimental *** results reveal that the V-EMS promotes longitudinal melt flow,accelerates heat dissipation and solidification and finally reduces the central segregation of ***,when V-EMS is applied,the solute distribution becomes asymmetric because the melt flow shows opposite directions between the near and far sides from *** obvious positive segregation band is observed at about 1/4 width of the billet near the stirrer in both calculated and experimental *** position and degree of such positive segregation could be affected by installation height of stirrer,as demonstrated by additional simulation cases.

关键词： Vertical electromagnetic stirring Macrosegregation Volume averaged method Continuous casting

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Trigonometric multiplicative chaos and applications to random distributions

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Science China Mathematics 2023年第1期66卷 3-36页

作者： Aihua Fan yves Meyer School of Mathematics and Statistics Central China Normal UniversityWuhan 430079China LAMFA CNRSUMR7352University of PicardieAmiens 80039France CMLA ENS-CachanCNRSUniversityof Paris-SaclayParis 91190France

The random trigonometric series∑∞n=1ρn cos(nt+ωn)on the circle T are studied under the conditions∑|ρn|^(2)=∞andρn→0,where{ωn}are independent and uniformly distributed random variables on *** are almost surely not Fourier-Stieltjes series but determine *** leads us to develop the theory of trigonometric multiplicative chaos,which produces a class of random *** kernel and the image of chaotic operators are fully studied and the dimensions of chaotic measures are exactly *** behavior of the partial sums of the above series is proved to be *** theory holds on the torus Tdof dimension d≥1.

关键词： multiplicative chaos random Fourier series Hausdorff dimension Riesz potential

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The notion of dominant terminology in bibliometric research

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Journal of Data and Information Science 2023年第4期8卷 1-7页

作者： yves Fassin Ronald Rousseau Department of Marketing Innovationand OrganisationFaculty of Economics and Business AdministrationGhent UniversityB-9000 GentBelgium University of Antwerp Middelheimlaan 1Faculty of Social SciencesB-2020 Antwerp KU Leuven MSIFacultair Onderzoekscentrum ECOOMNaamsestraat 61Leuven B-3000Belgium

In this opinion paper, we introduce the expressions of dominant terminology and dominant term in the quantitative studies of science in analogy to the notion of dominant design in product development and innovation.

关键词： Dominant design Dominant terminology Science of science Bibliometrics Scientometrics

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Thermo-Mechanical Calculation of Printed Circuit Heat Exchanger Using Homogenization

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Journal of Thermal Science 2022年第6期31卷 2309-2328页

作者： GARNIER Christophe VINCENT Sébastien LAMAGNERE Pierre LEJEAIL yves CACHON Lionel CEA DESIRESNENuclear Technology DepartmentCadarache F-13108 Saint-Paul-Lez-DuranceFrance

The Finite-Element Method(FEM) is mainly used to design Compact Heat Exchanger structures. However, the narrow channel structures require fine mesh to accurately compute stress and strain. Combined with the dimensions of the overall component, this leads to an excessively large numerical model and therefore long computing time. This is especially true for transient thermal analyses, which require taking into account the full geometry. It is therefore interesting to reduce the size of the mesh. Periodic homogenization is an efficient method for achieving this goal. It can be applied to the core of the structure when periodic patterns(identified on basis of the arrangement of the channels) exist. A method based on this technique, with some improvements, is proposed in this paper for thermal loading without internal pressure. In addition to the Equivalent Homogenous Medium(EHM) replacing the periodic patterns, some explicit channels are interposed between the EHM and the cover plates. This has two advantages. The first is to smooth the transition of stiffness between the cover plates and the homogenized medium. The second one is to be able to directly compute stress and strain on the most critical channels located in this area. This paper assesses the method’s effectiveness for thermal loadings in order to conduct thermal stress analyses. First, the equivalent elastic constants of the EHM are obtained with a numerical Finite Elements Method. Then, two 2D cases using EHM are compared against a 2D explicit model(i.e. explicit geometry for the core channels). These cases are chosen to validate the EHM itself and its effectiveness for a real section of the heat exchanger. Results show very good agreement with a relative difference lower than 1%. In addition, the sensitivity to the number of layers added between the EHM and the cover plates is analysed. It is recommended interposing at least two layers of patterns to obtain converged results for the considered configuration

关键词： compact heat exchanger thermal stress finite element method homogenization

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Optimal Control of Hepatitis B in a sub-Saharan African rural area

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Applied Mathematics(A Journal of Chinese Universities) 2023年第4期38卷 523-544页

作者： Jean Pierre II KOUENKAM Joseph MBANG Gilbert CHENDJOU yves EMVUDU Department of Mathematics Faculty of ScienceUniversity of Yaounde IP.O.Box 812 YaoundeCameroon

In this paper,we ameliorate the model proposed in[13],by incorporating the influence of hepatitis B e antigen(HBeAg)status of mothers on vertical *** use the improved model to fit reported HBV new infections in the Zhejiang Province of *** to predict the course of the Hepatitis B(HBV)infection in this Chinese area,and in Tokombere,located in sub-Saharan Africa(SSA).Furthermore,we apply optimal control techniques in view to re-examine the effects of the newborn vaccination,the universal vaccination and the treatment of chronic carriers in preventing the HBV *** results show that treatment slightly steps in the optimal strategy,while immunisation is an effective *** the other hand,they indicate that the control measures and immunization programs implemented in Zhejiang Province are ***,they suggest that in SSA,a package of several policies centred on birth dose vaccination should be implemented.

关键词： hepatitis B virus chronic carriers vaccine treatment Pontryagin

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WNT/β-catenin pathway and circadian rhythms in obsessive-compulsive disorder

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Neural Regeneration Research 2022年第10期17卷 2126-2130页

作者： Alexandre Vallée yves Lecarpentier Jean-Noël Vallée Department of Clinical Research and Innovation(DRCI) Foch HospitalSuresnesFrance Centre de Recherche Clinique Grand Hôpital de l’Est Francilien(GHEF)MeauxFrance Laboratoire de Mathématiques et Applications(LMA) Universitéde PoitiersPoitiersFrance Centre Hospitalier Universitaire(CHU)Amiens Picardie UniversitéPicardie Jules Verne(UPJV)AmiensFrance

The neuropsychiatric disease named obsessive-compulsive disorder is composed by obsessions and/or ***-compulsive disorder etiologies are ***,numerous mechanisms in several localizations are *** studies showed that both glutamate,inflammatory factors and oxidative stress could have main functions in obsessive-compulsive *** synthase kinase-3β,the major negative controller of the WNT/β-catenin pathway is upregulated in obsessive-compulsive *** obsessive-compulsive disorder,some studies presented the actions of the different circadian clock ***/β-catenin pathway and circadian clock genes appear to be ***,this review focuses on the interaction between circadian clock genes and the WNT/β-catenin pathway in obsessive-compulsive disorder.

关键词： circadian rhythms glutamatergic pathway inflammation obsessive-compulsive disorder oxidative stress WNT/β-catenin pathway

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Recent advances in the management of autoimmune pancreatitis in the era of artificial intelligence

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World Journal of Gastroenterology 2022年第48期28卷 6867-6874页

作者： Sahar Mack yves Flattet Philippe Bichard Jean Louis Frossard Division of Gastroenterology Department of Medical SpecialtiesUniversity Hospital of GenevaGeneva 1205Switzerland

Autoimmune pancreatitis(AIP)is a type of immune-mediated pancreatitis subdivided into two subtypes,type 1 and type 2 ***,type 1 AIP is considered to be the pancreatic manifestation of the immunoglobulin G4(IgG4)-related ***,AIP is increasingly researched and recognized,although its diagnosis represents a challenge for several reasons:False positive ultrasound-guided cytological samples for a neoplastic process,difficult to interpret levels of IgG4,the absence of biological markers to diagnose type 2 AIP,and the challenging clinical identification of atypical ***,60%and 78%of type 1 and type 2 AIP,respectively,are retrospectively diagnosed on surgical specimens of resected pancreas for suspected *** distinguishing AIP from pancreatic ductal adenocarcinoma can be challenging,obtaining a definitive diagnosis can therefore prove difficult,since endoscopic ultrasound fine-needle aspiration or biopsy of the pancreas are *** paper focuses on recent innovations in the management of AIP with regard to the use of artificial intelligence,new serum markers,and new therapeutic approaches,while it also outlines the current management recommendations.A better knowledge of AIP can reduce the recourse to surgery and avoid its overuse,although such an approach requires close collaboration between gastroenterologists,surgeons and *** knowledge on AIP and IgG4-related disease remains necessary to diagnose and manage patients.

关键词： Autoimmune pancreatitis Pancreatic ductal adenocarcinoma Immunoglobulin G4-related disease Prednisone Rituximab Artificial intelligence Plasmablasts

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Modeling Drug Concentration in Blood through Caputo-Fabrizio and Caputo Fractional Derivatives

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Computer Modeling in Engineering & Sciences 2023年第6期135卷 2767-2785页

作者： Muath Awadalla Kinda Abuasbeh yves Yannick Yameni Noupoue Mohammed S.Abdo Department of Mathematics and Statistics College of ScienceKing Faisal UniversityHafufAl Ahsa31982Saudi Arabia Institute of Statistics Biostatistics and Actuarial ScienceFaculty of ScienceUniversite Catholique de LouvainLouvain-La-Neuve1348Belgium Department of Mathematics Hodeidah UniversityAl-Hudaydah3114Yemen

This study focuses on the dynamics of drug concentration in the *** general,the concentration level of a drug in the blood is evaluated by themean of an ordinary and first-order differential *** precisely,it is solved through an initial value *** proposed a newmodeling technique for studying drug concentration in blood *** technique is based on two fractional derivatives,namely,Caputo and Caputo-Fabrizio *** first provided comprehensive and detailed proof of the existence of at least one solution to the problem;we later proved the uniqueness of the existing *** proof was written using the Caputo-Fabrizio fractional derivative and some fixed-point *** via theUlam-Hyers(UH)technique was also *** application of the proposedmodel on two real data sets revealed that the Caputo derivative wasmore suitable in this ***,for the first data set,the model based on the Caputo derivative yielded a Mean Squared Error(MSE)of 0.03095 with a corresponding best value of fractional order of derivative of ***-Fabrizio-basedderivative appeared to be the second-best method for the problem,with an MSE of 0.04324 for a corresponding best fractional derivative order of *** the second experiment,Caputo derivative-based model still performed the best as it yielded an MSE of 0.04066,whereas the classical and the Caputo-Fabrizio methods were tied with the same MSE of *** interesting finding was that the MSE yielded by the Caputo-Fabrizio fractional derivative coincided with the MSE obtained from the classical approach.

关键词： Pharmacokinetics caputo fractional derivative stability study Caputo-Fabrizio fractional derivative

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Dental stem cell-conditioned medium for tissue regeneration: Optimization of production and storage

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World Journal of Stem Cells 2022年第4期14卷 287-302页

作者： Batoul Chouaib Frédéric Cuisinier Pierre-yves Collart-Dutilleul Laboratory Bioengineering and Nanosciences UR_UM104 University of MontpellierMontpellier 34000France

BACKGROUND Mesenchymal stem cells(MSC)effects on tissue regeneration are mainly mediated by their secreted substances(secretome),inducing their paracrine *** Conditioned medium(CM),including soluble factors(proteins,nucleic acids,lipids)and extracellular vesicles is emerging as a potential alternative to cell ***,the manufacturing of CM suffers from variable procedures and protocols leading to varying results between ***,there is no welldefined optimized procedure targeting specific applications in regenerative *** To focus on conditioned medium produced from dental MSC(DMSC-CM),we reviewed the current parameters and manufacturing protocols,in order to propose a standardization and optimization of these manufacturing *** We have selected all publications investigating the effects of dental MSC secretome in in vitro and in vivo models of tissue regeneration,in accordance with the PRISMA *** A total of 351 results were *** based on the inclusion criteria described above,118 unique articles were included in the systematic ***-CM production was considered at three stages:before CM recovery(cell sources for CM),during CM production(culture conditions)and after production(CM treatment).CONCLUSION No clear consensus could be recovered as evidence-based methods,but we were able to describe the most commonly used protocols:donors under 30 years of age,dental pulp stem cells and exfoliated deciduous tooth stem cells with cell passage between 1 and 5,at a confluence of 70%to 80%.CM were often collected during 48 h,and stored at-80°*** is important to point out that the preconditioning environment had a significant impact on DMSCCM content and efficiency.

关键词： Tissue engineering Mesenchymal stem cells Dental Conditioned medium Secretome Regeneration

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