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Baseline susceptibility of Helicoverpa armigera,Plutella xylostella,and Spodoptera frugiperda to the meta-diamide insecticide broflanilide

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Insect Science 2023年第4期30卷 1118-1128页

作者： Xingliang Wang Tailong Shi Ping Tang Shengnan Liu Bofeng Hou Dong Jiang Jingde Lu Yihua Yang yves carriere Yidong Wu Key Laboratory of Integrated Pest Management on Crops in East China(MARA) College of Plant ProtectionNanjing Agricultural UniversityNanjingChina Department of Entomology the University of ArizonaTucsonAZzUSA

Broflanilide is a novel meta-diamide insecticide that acts as a y-aminobutyric acid-gated chloride channel allosteric *** its unique mode of action,broflanilide has no known cross-resistance with existing insecticides and is expected to be an effective tool for the management of insecticide *** the base-line susceptibility to this insecticide is an essential step for developing and implementing effective resistance management *** we evaluated the baseline susceptibil-ity to broflanilide for 3 cosmopolitan lepidopteran pest species,Helicoverpa armigera,Plutella xylostella,and Spodoptera *** exhibited high activity against populations sampled in the major distribution range of these pests in China,with median lethal concentrations(LCso)ranging between 0.209 and 0.684,0.076 and 0.336,and 0.075 and 0.219 mg/L for ***,P xylostella,and ***,***-population variability in susceptibility to broflanilide was moderate for ***(3.3-fold),P xylostella(4.4-fold),and ***(2.9-fold).The recommended diagnostic concentrations for ***,P xylostella,and *** were 8,4,and 2 mg/L,*** or no cross-resistance to broflanilide was detected in 3 diamide-resistant strains of P xylostella and 1 spinosyns-resistant strain of *** results provide critical information for the development of effective resistance management programs to sustain efficacy of broflanilide against these key lepidopteran pests.

关键词： broflanilide diagnostic concentration resistance monitoring cotton boll-worm diamondback moth fall armyworm

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Predicting Competitive Displacement between Whiteflies:Linking Theory with Data

Predicting Competitive Displacement between Whiteflies:Linki...

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The 5th International Bemisia Workshop

作者： David W.Crowder Rami A.Horowitz Paul De Barro yves carriere

＜正＞Australia,often leads to competitive displacement of indigenous ***,the factors that Invasions by exotic whitefly biotypes,such as the B biotype in the United States, China,and drive competitive displacement between whitefly biotypes are often poorly ***,we investigated the effect of life-history,mating behavior,and adaptation to insecticides on competitive displacement between biotypes of Bemisia *** conducted population cage experiments independently in China,Australia,the United States,and Israel to observe patterns of competitive displacement between the invasive B biotype and three

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How the interplay among the tumor microenvironment and the gut microbiota influences the stemness of colorectal cancer cells

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World Journal of Stem Cells 2023年第5期15卷 281-301页

作者： María Belén Novoa Díaz Pedro carriere Claudia Gentili Departamento de Biología Bioquímica y FarmaciaUniversidad Nacional del SurBahía Blanca 8000Buenos AiresArgentina Instituto de Ciencias Biológicas y Biomédicas del Sur Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET)-Universidad Nacional del Sur(UNS)Bahía Blanca 8000Buenos AiresArgentina

Colorectal cancer(CRC)remains the third most prevalent cancer disease and involves a multi-step process in which intestinal cells acquire malignant *** is well established that the appearance of distal metastasis in CRC patients is the cause of a poor prognosis and treatment ***,in the last decades,CRC aggressiveness and progression have been attributed to a specific cell population called CRC stem cells(CCSC)with features like tumor initiation capacity,self-renewal capacity,and acquired multidrug *** data highlight the concept of this cell subtype as a plastic entity that has a dynamic status and can be originated from different types of cells through genetic and epigenetic *** alterations are modulated by complex and dynamic crosstalk with environmental factors by paracrine *** is known that in the tumor niche,different cell types,structures,and biomolecules coexist and interact with cancer cells favoring cancer growth and ***,these components constitute the tumor microenvironment(TME).Most recently,researchers have also deepened the influence of the complex variety of microorganisms that inhabit the intestinal mucosa,collectively known as gut microbiota,on *** TME and microorganisms participate in inflammatory processes that can drive the initiation and evolution of *** in the last decade,crucial advances have been made concerning to the synergistic interaction among the TME and gut microorganisms that condition the identity of CCSC,the data exposed in this review could provide valuable insights into the biology of CRC and the development of new targeted therapies.

关键词： Colorectal cancer Colorectal cancer stem cells Tumor microenvironment factors Tumor stroma Gut microbiota Cancer progression

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Radioisotope production using lasers:From basic science to applications

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Matter and Radiation at Extremes 2024年第3期9卷 31-44页

作者： M.R.D.Rodrigues A.Bonasera M.Scisciò J.A.Pérez-Hernández M.Ehret F.Filippi P.L.Andreoli M.Huault H.Larreur D.Singappuli D.Molloy D.Raffestin M.Alonzo G.G.Rapisarda D.Lattuada G.L.Guardo C.Verona Fe.Consoli G.Petringa A.McNamee M.La Cognata S.Palmerini T.carriere M.Cipriani G.Di Giorgio G.Cristofari R.De Angelis G.A.P.Cirrone D.Margarone L.Giuffrida D.Batani P.Nicolai K.Batani R.Lera L.Volpe D.Giulietti S.Agarwal M.Krupka S.Singh Fa.Consoli Cyclotron Institute Texas A&M UniversityCollege StationTexas 77840USA Laboratori Nazionali del Sud Istituto Nazionale di Fisica Nucleare(LNS-INFN)CataniaItaly ENEA Fusion and Technologies for Nuclear Safety and Security Department-CFrascatiItaly Centro de Láseres Pulsados(clpu) VillamayorSpain Universidad de Salamanca SalamancaSpain Centre Lasers Intenses et Applications(CELIA) Universitéde BordeauxCNRSCEATalenceFrance HB11 Energy Holdings Pty FreshwaterNew South WalesAustralia School of Mathematics and Physics Queen’s University BelfastBelfastUnited Kingdom Dipartimento di Fisica e Astronomia“E.Majorana ”Università di CataniaCataniaItaly Facoltàdi Ingegneria e Architettura Universitàdegli Studi di Enna“Kore”EnnaItaly Dipartimento di Ingegneria Industriale Universitàdi Roma“Tor Vergata”RomaItaly Dipartimento di Fisica e Geologia Universitàdegli Studi di PerugiaPerugiaItaly Istituto Nazionale di Fisica Nucleare Sezione di PerugiaPerugiaItaly ELI Beamlines Facility the Extreme Light Infrastructure ERICDolni BrezanyCzech Republic ETSIA Universidad Politécnica de MadridMadridSpain Dipartimento Fisica “E.Fermi”Universitàdi Pisa and INFNPisaItaly FZU–Institute of Physics of Czech Academy of Sciences PragueCzech Republic Institute of Plasma Physics of Czech Academy of Sciences PragueCzech Republic

The discovery of chirped pulse amplification has led to great improvements in laser technology,enabling energetic laser beams to be compressed to pulse durations of tens of femtoseconds and focused to a few *** with energies of tens of MeV can be accelerated using,for instance,target normal sheath acceleration and focused on secondary *** such conditions,nuclear reactions can occur,with the production of radioisotopes suitable for medical *** use of high-repetition lasers to produce such isotopes is competitive with conventional methods mostly based on *** this paper,we study the production of^(67)Cu,^(63)Zn,^(18)F,and^(11)C,which are currently used in positron emission tomography and other *** the same time,we study the reactions^(10)B(p,α)^(7)Be and^(70)Zn(p,4n)^(67)Ga to put further constraints on the proton distributions at different angles,as well as the reaction^(11)B(p,α)^(8)Be relevant for energy *** experiment was performed at the 1 PW laser facility at VegaⅢin Salamanca,*** distributions of radioisotopes in the forward(with respect to the laser direction)and backward directions were measured using a high purity germanium *** results are in reasonable agreement with numerical estimates obtained following the approach of Kimura and Bonasera[*** ***.,Sect.A 637,164–170(2011)].

关键词： purity estimates backward

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Involvement of Met receptor pathway in aggressive behavior of colorectal cancer cells induced by parathyroid hormone-related peptide

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World Journal of Gastroenterology 2022年第26期28卷 3177-3200页

作者： María Belén Novoa Díaz Pedro carriere Graciela Gigola Ariel Osvaldo Zwenger Natalia Calvo Claudia Gentili Departamento de Biología Bioquímica y FarmaciaUniversidad Nacional del Sur(UNS)-INBIOSUR(CONICET-UNS)Bahía Blanca 8000Buenos AiresArgentina Centro de Estudios Clínicos SAGA CEC SAGASantiago de Chile 8320000Chile

BACKGROUND Parathyroid hormone-related peptide(PTHrP)plays a key role in the development and progression of many *** found that in colorectal cancer(CRC)HCT116 cells,the binding of PTHrP to its receptor PTHR type 1(PTHR1)activates events associated with an aggressive *** HCT116 cell xenografts,PTHrP modulates the expression of molecular markers linked to tumor *** evidence suggests that the Met receptor is involved in the development and evolution of *** on these data,we hypothesized that the signaling pathway trigged by PTHrP could be involved in the transactivation of Met and consequently in the aggressive behavior of CRC *** To elucidate the relationship among PTHR1,PTHrP,and Met in CRC *** For in vitro assays,HCT116 and Caco-2 cells derived from human CRC were incubated in the absence or presence of PTHrP(1-34)(10-8 M).Where indicated,cells were pre-incubated with specific kinase inhibitors or dimethylsulfoxide,the vehicle of the *** protein levels were evaluated by Western blot ***-time polymerase chain reaction(RT-qPCR)was carried out to determine the changes in gene *** healing assay and morpho logical monitoring were performed to evaluate cell migration and changes related to the epithelialmesenchymal transition(EMT),*** number of viable HCT116 cells was counted by trypan blue dye exclusion test to evaluate the effects of irinotecan(CPT-11),oxaliplatin(OXA),or doxorubicin(DOXO)with or without *** in vivo tests,HCT116 cell xenografts on 6-wk-old male N:NIH(S)_nu mice received daily intratumoral injections of PTHrP(40μg/kg)in 100μL phosphate-buffered saline(PBS)or the vehicle(PBS)as a control during 20 *** slaughter was carried out and the tumors were removed,weighed,and fixed in a 4%formaldehyde solution for subsequent treatment by *** evaluate the expression of molecular markers in human tumor samples,we studied 23 specimens ob

关键词： PTHrP MET receptor tyrosine kinase Parathyroid hormone receptor type 1 Colorectal cancer Drug resistance

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Association of types of diabetes and insulin dependency on birth outcomes

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World Journal of Clinical Cases 2022年第7期10卷 2147-2158页

作者： Pamela K Xaverius Steven W Howard Deborah Kiel Jerry E Thurman Ethan Wankum Catherine Carter Clairy Fang Romi carriere Department of Epidemiology and Biostatistics Saint Louis UniversitySt.LouisMO 63104United States Department of Health Management and Policy Saint Louis UniversitySt.LouisMO 63104United States Department of Endocrinology Diabetes and MetabolismSSM HealthSt.CharlesMO 63303United States Division of Epidemiology Institute for Health and EquityMedical College of WisconsinMilwaukeeWI 53226United States Department of Epidemiology Fielding School of Public HealthUniversity of CaliforniaLos AngelesCA 90095United States Population Health Sciences Institute Centre for Ageing and VitalityNewcastle UniversityNewcastle upon TyneEngland NE45PLUnited Kingdom

BACKGROUND Diabetes rates among pregnant women in the United States have been increasing and are associated with adverse pregnancy *** To investigate differences in birth outcomes(preterm birth,macrosomia,and neonatal death)by diabetes *** Cross-sectional design,using linked Missouri birth and death certificates(singleton births only),2010 to 2012(n=204057).Exposure was diabetes non-diabetic,pre-pregnancy diabetes-insulin dependent(PD-I),pre-pregnancy diabetes-non-insulin dependent(PD-NI),gestational diabetes-insulin dependent(GD-I),and gestational diabetes-non-insulin dependent(GD-NI).Outcomes included preterm birth,macrosomia,and infant *** included demographic characteristics,adequacy of prenatal care,body mass index,smoking,hypertension,and previous preterm *** and multivariate logistic regression assessed differences in outcomes by diabetes *** Women with PD-I,PD-NI,and GD-I remained at a significantly increased odds for preterm birth(aOR 2.87,aOR 1.77,and aOR 1.73,respectively)and having a very large baby[macrosomia](aOR 3.01,aOR 2.12,and aOR 1.96,respectively);in reference to non-diabetic *** with GDNI were at a significantly increased risk for macrosomia(aOR1.53),decreased risk for their baby to die before their first birthday(aOR 0.41)and no difference in risk for preterm birth in reference to non-diabetic *** Diabetes is associated with the poor birth *** management of diabetes during pregnancy and healthy lifestyle behaviors before pregnancy can reduce the risk for diabetes and poor birth outcomes.

关键词： Epidemiology Pregnancy Health care delivery Birth outcomes Gestational diabetes Insulin

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Survival effect of probiotics in a rat model of colorectal cancer treated with capecitabine

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World Journal of Gastrointestinal Oncology 2021年第10期13卷 1518-1531页

作者： Graciela Gigola Pedro carriere María Belén Novoa Díaz Gabriela Perdigon Ariel Osvaldo Zwenger Claudia Gentili Biología Bioquímica y FarmaciaUniversidad Nacional del Sur(UNS)-INBIOSUR(CONICET-UNS)Bahía Blanca 8000Buenos Aires ProvinciaArgentina San Miguel de Tucumán 4000Argentina Centro de Estudios Clínicos SAGA CEC SAGASantiago de Chile 8320000Chile

BACKGROUND Probiotics are used to manage a number of gastrointestinal disorders due to their beneficial *** reports showed that probiotics also improve the life quality of patients with colorectal cancer(CRC)subjected to oncologic *** a CRC animal model,probiotics supplementation has the potential to decrease the formation of aberrant crypts and ameliorate tumor malignancy,enhancing the antitumor effect of 5-fluorouracil(5-FU)*** on these data,we hypothesize that the administration of probiotics impact positively in the overall survival and life quality of rats with CRC under the treatment of capecitabine,which is the pro drug of *** To evaluate the probiotics effects in a rat CRC model treated with capecitabine and followed until the end of *** 1,2-Dimethylhidrazine dihydrochloride(1,2-DMH)was employed as carcinogen inductor of *** male Wistar-Lewis rats were randomly assigned to one of five following groups:Control(n=5),Control+probiotics(Control-P group,n=5),1,2-DMH alone(DMH group,n=10),1,2-DMH+capecitabine(DMH-C group,n=10),1,2-DMH+probiotics(DMH-P group,n=10)and 1,2-DMH+capecitabine+probiotics(DMH-C-P group,n=10).All parametric data were expressed as the mean±*** statistical significance of differences was analyzed using one-way *** were analyzed with InfoStat *** results were considered statistically significant at P<*** survival was evaluated with the Kaplan-Meier estimator with the log-rank *** The data of mean overall survival for DMH,DMH-P,DMH-C,DMH-C-P,Control and Control-P groups were 250 d[95%confidence interval(CI):242.5-253.1],268 d(95%CI:246.3-271.4),380 d(95%CI:337.8-421.9),480 d(95%CI:436.9-530.7),588 d(95%CI:565.8-609.3)and 590 d(95%CI:564.3-612.9),respectively,with a significant difference between DMH-C and DMH-C-P groups(P=0.001).Comparing all groups by Kaplan-Meier estimator,we found a significantly different in the overall survival of DMH and DMH-

关键词： Colorectal cancer Capecitabine Probiotics Survival Life quality Animal experimentation

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Involvement of parathyroid hormone-related peptide in the aggressive phenotype of colorectal cancer cells

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World Journal of Gastroenterology 2021年第41期27卷 7025-7040页

作者： María Belén Novoa Díaz Pedro Matías carriere María Julia Martín Natalia Calvo Claudia Gentili Departamento de Biología Bioquímica y FarmaciaUniversidad Nacional del Sur(UNS)-INBIOSUR(CONICET-UNS)Bahía Blanca 8000Buenos AiresArgentina Departamento de Química Universidad Nacional del Sur(UNS)-INQUISUR(CONICET-UNS)Bahía Blanca 8000Buenos AiresArgentina

Colorectal cancer(CRC)remains one of the leading causes of mortality from malignant diseases *** general terms,CRC presents high heterogeneity due to the influence of different genetic and environmental factors;also,the neoplastic cells are strongly influenced by the extracellular matrix and several surrounding cells,known together as the tumor microenvironment(TME).Bidirectional communication takes place between the tumor and the TME through the release of autocrine and paracrine *** hormone-related peptide(PTHrP)is a cytokine secreted by a wide variety of tissues and is able to regulate several cellular functions both in physiological as well as in pathological *** exerts its effects as a paracrine/autocrine factor,although its mode of action is mainly *** has been shown that this peptide is expressed by several tumors and that the tumor secretion of PTHrP is responsible for the malignant humoral *** years ago,when our research group started studying PTHrP effects in the experimental models derived from intestinal tumors,the literature available at the time addressing the effects of PTHrP on colorectal tumors was limited,and no articles had been published regarding to the paracrine action of PTHrP in CRC *** on this and on our previous findings regarding the role of PTH in CRC cells,our purpose in recent years has been to explore the role of PTHrP in *** analyzed the behavior of CRC cells treated with exogenous PTHrP,focalizing in the study of the following events:Survival,cell cycle progression and proliferation,migration,chemoresistance,tumor-associated angiogenesis,epithelial to mesenchymal transition program and other events also associated with invasion,such us the induction of cancer stem cells *** work summarizes the major findings obtained by our investigation group using in vitro and in vivo CRC models that evidence the participation of PTHrP in the acquisition of an aggressiv

关键词： Parathyroid hormone-related protein Colorectal cancer Tumor biomarkers Neoplastic processes Drug resistance Tumor microenvironment

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A Comparison of Statistical Methods for Analyzing Discrete Hierarchical Data: A Case Study of Family Data on Alcohol Abuse

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Open Journal of Statistics 2013年第4期3卷 1-6页

作者： Yuanyuan Liang Keumhee Chough carriere Department of Epidemiology and Biostatistics University of Texas Health Science Center at San Antonio San Antonio USA Department of Mathematical and Statistical Sciences University of Alberta Edmonton Canada

Although hierarchical correlated data are increasingly available and are being used in evidence-based medical practices and health policy decision making, there is a lack of information about the strengths and weaknesses of the methods of analysis with such data. In this paper, we describe the use of hierarchical data in a family study of alcohol abuse conducted in Edmonton, Canada, that attempted to determine whether alcohol abuse in probands is associated with abuse in their first-degree relatives. We review three methods of analyzing discrete hierarchical data to account for correlations among the relatives. We conclude that the best analytic choice for typical correlated discrete hierarchical data is by nonlinear mixed effects modeling using a likelihood-based approach or multilevel (hierarchical) modeling using a quasilikelihood approach, especially when dealing with heterogeneous patient data.

关键词： Non-Linear Mixed Effects Model Multilevel Model Generalized Estimating Equations Mantel-Haenszel Odds Ratio Specificity Sensitivity

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Infectious etiopathogenesis of Crohn's disease

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World Journal of Gastroenterology 2014年第34期20卷 12102-12117页

作者： Jessica carriere Arlette Darfeuille-Michaud Hang Thi Thu Nguyen Clermont Universite M2iSHUMR 1071 Inserm University of Auvergne 63001 Clermont-FerrandFrance INRA USC 2018 63000 Clermont-FerrandFrance Centre Hospitalier Universitaire 63000 Clermont-FerrandFrance

Important advances during the last decade have been made in understanding the complex etiopathogenesis of Crohn’s disease(CD).While many gaps in our knowledge still exist,it has been suggested that the etiology of CD is multifactorial including genetic,environmental and infectious *** most widely accepted theory states that CD is caused by an aggressive immune response to infectious agents in genetically predisposed *** rise of genome-wide association studies allowed the identification of loci and genetic variants in several components of host innate and adaptive immune responses to microorganisms in the gut,highlighting an implication of intestinal microbiota in CD ***,numerous independent studies reported a dysbiosis,i.e.,a modification of intestinal microbiota composition,with an imbalance between the abundance of beneficial and harmful *** microorganisms including viruses,yeasts,fungi and bacteria have been postulated as potential CD pathogens,based on epidemiological,clinicopathological,genetic and experimental evidence,their precise role in this disease is not clearly *** review summarizes the current knowledge of the infectious agents associated with an increased risk of developing *** approaches to modulate the intestinal dysbiosis and to target the putative CD-associated pathogens,as well as their potential mechanisms of action are also discussed.

关键词： Crohn's disease Intestinal microbiota Dysbiosis Adherent-invasive Escherichia coli Probiotics Antibiotics Fecal microbiota transplantation

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