Infectious etiopathogenesis of Crohn's disease

作     者：Jessica Carriere Arlette Darfeuille-Michaud Hang Thi Thu Nguyen 

作者机构：Clermont UniversiteM2iSHUMR 1071 Inserm University of Auvergne63001 Clermont-FerrandFrance INRA USC 201863000 Clermont-FerrandFrance Centre Hospitalier Universitaire63000 Clermont-FerrandFrance 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2014年第20卷第34期

页      面：12102-12117页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Ministere de la Recherche et de la Technologie,Inserm (UMR1071),INRA (USC-2018) Grants from the Association Francois Aupetit (to Darfeuille-Michaud A) the European Union FP7 People Marie Curie International Incoming Fellowship (to Nguyen HTT) 

主　　题：Crohn's disease Intestinal microbiota Dysbiosis Adherent-invasive Escherichia coli Probiotics Antibiotics Fecal microbiota transplantation 

摘      要：Important advances during the last decade have been made in understanding the complex etiopathogenesis of Crohn’s disease(CD).While many gaps in our knowledge still exist,it has been suggested that the etiology of CD is multifactorial including genetic,environmental and infectious *** most widely accepted theory states that CD is caused by an aggressive immune response to infectious agents in genetically predisposed *** rise of genome-wide association studies allowed the identification of loci and genetic variants in several components of host innate and adaptive immune responses to microorganisms in the gut,highlighting an implication of intestinal microbiota in CD ***,numerous independent studies reported a dysbiosis,i.e.,a modification of intestinal microbiota composition,with an imbalance between the abundance of beneficial and harmful *** microorganisms including viruses,yeasts,fungi and bacteria have been postulated as potential CD pathogens,based on epidemiological,clinicopathological,genetic and experimental evidence,their precise role in this disease is not clearly *** review summarizes the current knowledge of the infectious agents associated with an increased risk of developing *** approaches to modulate the intestinal dysbiosis and to target the putative CD-associated pathogens,as well as their potential mechanisms of action are also discussed.