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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2023年第5期24卷 418-429页

作者： Shuang li Zhenzhen CHEN Chuanxin CHEN yuyu NIU State Key Laboratory of Primate Biomedical Research Institute of Primate Translational MedicineKunming University of Science and TechnologyKunming 650500China Faculty of life Science and Technology Kunming University of Science and TechnologyKunming 650500China Yunnan Key Laboratory of Primate Biomedical Research Kunming 650500China Bioland Laboratory Guangzhou 510005China Guangzhou Laboratory Guangzhou 510005China

Efforts have been made to establish various human pluripotent stem cell lines.However,such methods have not yet been duplicated in non-human primate cells.Here,we introduce a multiplexed single-cell sequencing technique to profile the molecular features of monkey pluripotent stem cells in published culture conditions.The results demonstrate suboptimized maintenance of pluripotency and show that the selected signaling pathways for resetting human stem cells can also be interpreted for establishing monkey cell lines.Overall,this work legitimates the translation of novel human cell line culture conditions to monkey cells and provides guidance for exploring chemical cocktails for monkey stem cell line derivation.

关键词： Monkey pluripotent stem cell Multiplexed single-cell sequencing Naive pluripotency Extended pluripotent stem cells

Parathyroid hormone increases alveolar bone homoeostasis during orthodontic tooth movement in rats with periodontitis via crosstalk between STAT3 and β-catenin

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International Journal of Oral Science 2020年第4期12卷 356-366页

作者： Cheng Zhang Tiancheng li Chenchen Zhou li Huang Yuyu Li Han Wang Peipei Duan Shujuan Zou li Mei State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases&Department of Orthodontics West China Hospital of StomatologySichuan UniversityChengduChina Discipline of Orthodontics Faculty of DentistryDepartment of Oral SciencesSir John Walsh Research InstituteUniversity of OtagoOtagoNew Zealand

Periodontitis patients are at risk of alveolar bone loss during orthodontic treatment.The aim of this study was to investigate whether intermittent parathyroid hormone(1–34)treatment(iPTH)could reduce alveolar bone loss during orthodontic tooth movement(OTM)in individuals with periodontitis and the underlying mechanism.A rat model of OTM in the context of periodontitis was established and alveolar bone loss was observed.The control,iPTH and iPTH+stattic groups received injections of vehicle,PTH and vehicle,or PTH and the signal transducer and activator of transcription 3(STAT3)inhibitor stattic,respectively.iPTH prevented alveolar bone loss by enhancing osteogenesis and suppressing bone resorption in the alveolar bone during OTM in rats with periodontitis.This effect of iPTH was along with STAT3 activation and reduced by a local injection of stattic.iPTH promoted osteoblastic differentiation and might further regulate the Wnt/β-catenin pathway in a STAT3-dependent manner.The findings of this study suggest that iPTH might reduce alveolar bone loss during OTM in rats with periodontitis through STAT3/β-catenin crosstalk.

关键词： STAT3 period crosstalk

lithium-ion insertion kinetics of Na-doped li2TiSiO5 as anode materials for lithium-ion batteries

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Journal of Materials Science & Technology 2020年第22期54卷 18-25页

作者： Yueni Mei Yuyu Li Fuyun li Yaqian li Yingjun Jiang Xiwei Lan Songtao Guo Xianluo Hu State Key Laboratory of Materials Processing and Die&Mould Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074China

li2TiSiO5 receives much interest recently in lithium-ion battery anodes because of its attractive liinsertion/extraction potential at 0.28 V(vs. li+/li), which bridges the potential gap between graphite and li4 Ti5 O12. However, li2TiSiO5 suffers from the low intrinsic electronic conductivity and sluggish liion transfer kinetics. In this work, we report lithium-ion insertion kinetics of li2TiSiO5 by Na doping,achieving high-rate capability. Rietveld refinement of X-ray diffraction results reveals that Na doping can enlarge the space of li slabs, thus reducing the li-ion transfer barrier and enhancing the li-ion diffusion kinetics. According to first-principles calculations, Na doping can tune the band structure of li2TiSiO5 from indirect to direct band, leading to improved electronic conductivity and electrochemical performance. In particular, the Na-doped li2TiSiO5(li1.95 Na(0.05)TiSiO5) electrode exhibits outstanding rate capability with a high capacity of 101 m A h g^(-1) at 5 A g^(-1) and superior cyclability with a reversible capacity of 137 m A h g^(-1) under 0.5 A g^(-1) over 150 cycles.

关键词： lithium-ion batteries li2TiSiO5 Anode lithium-ion diffusion Na doping

An improved urban cellular automata model by using the trend-adjusted neighborhood

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Ecological Processes 2020年第1期9卷 314-326页

作者： Xuecao li yuyu Zhou Wei Chen Department of Geological and Atmospheric Sciences Iowa State UniversityAmesIA 50011USA

Background:Cellular automata(CA)-based models have been extensively used in urban sprawl modeling.Presently,most studies focused on the improvement of spatial representation in the modeling,with limited efforts for considering the temporal context of urban sprawl.In this paper,we developed a Logistic-Trend-CA model by proposing a trend-adjusted neighborhood as a weighting factor using the information of historical urban sprawl and integrating this factor in the commonly used Logistic-CA model.We applied the developed model in the Beijing-Tianjin-Hebei region of China and analyzed the model performance to the start year,the suitability surface,and the neighborhood size.Results:Our results indicate the proposed Logistic-Trend-CA model outperforms the traditional Logistic-CA model significantly,resulting in about 18%and 14%improvements in modeling urban sprawl at medium(1 km)and fine(30 m)resolutions,respectively.The proposed Logistic-Trend-CA model is more suitable for urban sprawl modeling over a long temporal interval than the traditional Logistic-CA model.In addition,this new model is not sensitive to the suitability surface calibrated from different periods and spaces,and its performance decreases with the increase of the neighborhood size.Conclusion:The proposed model shows potential for modeling future urban sprawl spanning a long period at regional and global scales.

关键词： Cellular automata(CA)model Temporal context Urban sprawl Logistic regression Neighborhood

Towards machine-learning-driven effective mashup recommendations from big data in mobile networks and the Internet-of-Things

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Digital Communications and Networks 2023年第1期9卷 138-145页

作者： Yueshen Xu Zhiying Wang Honghao Gao Zhiping Jiang yuyu Yin Rui li School of Computer Science and Technology Xidian UniversityXi'an710126China School of Computer Engineering and Science Shanghai UniversityShanghai200444China School of Computer Science and Technology Hangzhou Dianzi UniversityHangzhou310018China

A large number of Web APIs have been released as services in mobile communications,but the service provided by a single Web API is usually limited.To enrich the services in mobile communications,developers have combined Web APIs and developed a new service,which is known as a mashup.The emergence of mashups greatly increases the number of services in mobile communications,especially in mobile networks and the Internet-of-Things(IoT),and has encouraged companies and individuals to develop even more mashups,which has led to the dramatic increase in the number of mashups.Such a trend brings with it big data,such as the massive text data from the mashups themselves and continually-generated usage data.Thus,the question of how to determine the most suitable mashups from big data has become a challenging problem.In this paper,we propose a mashup recommendation framework from big data in mobile networks and the IoT.The proposed framework is driven by machine learning techniques,including neural embedding,clustering,and matrix factorization.We employ neural embedding to learn the distributed representation of mashups and propose to use cluster analysis to learn the relationship among the mashups.We also develop a novel Joint Matrix Factorization(JMF)model to complete the mashup recommendation task,where we design a new objective function and an optimization algorithm.We then crawl through a real-world large mashup dataset and perform experiments.The experimental results demonstrate that our framework achieves high accuracy in mashup recommendation and performs better than all compared baselines.

关键词： Mashup recommendation Big data Machine learning Mobile networks Internet-of-Things

Effects of cerium doping position on physicochemical properties and catalytic performance in methanol total oxidation

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Journal of Rare Earths 2018年第8期36卷 811-818页

作者： Shen Zhang yuyu Guo Xingying li Zhe li College of Chemistry and Chemical Engineering Taiyuan University of Technology

The physicochemical properties of Pd and Pd-Pt catalysts which possess different Ce doping position were investigated by techniques of TEM, XRD, N2 adsorption-desorption, XPS and FT-IR. The catalytic performance for methanol total oxidation was examined to study the effects of Ce adding position.CeO2-Al2 O3-TiO2（CAT） catalysts that Ce is directly introduced into support show higher reactivity and CO2 selectivity than CeO2/Al2 O3-TiO2（Ce/AT） samples in which Ce is loaded by impregnation method.The characterization results reveal that the Ce doping position does not cause obvious otherness of basic crystalline phase and mesoporous structure of support. However, the Ce doping position affects the pore shapes of support and then influences the pore diameter. CAT catalysts possess more abundant adsorbed oxygen and more Ti3＋ can transform the more gaseous oxygen into the active oxygen species on the catalyst surface, which is beneficial to the reaction. The Al-O-Ti bridges in CAT facilitate the cooperation of Al and Ti species, which further speeds up the reaction rate.

关键词： Ce doping position Methanol total oxidation Adsorbed oxygen Al-O-Ti bridges Rare earths

Highly stable and antifouling graphene oxide membranes prepared by bio-inspired modification for water purification

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Chinese Chemical Letters 2020年第10期31卷 2651-2656页

作者： Weiming Zhong yuyu Zhang ling Zhao Wanbin li Guangdong Key Laboratory of Environmental Pollution and Health School of EnvironmentJinan UniversityGuangzhou 511443China

Graphene oxide(GO)membranes show great potential in molecular separation for water treatment.However,the inferior stability of GO membranes is a major bottleneck for practical applications.In this study,bio-inspired polydopamine(PDA)deposition is reported for enhancing the stability of GO membranes.Through simple and mild immersion,PDA is self-polymerized on GO membranes.The blocking of PDA chains to membrane defects improves the rejections for various molecules.Because the inherently strong adhesion and crosslinking of PDA greatly strengthen the interactions of substrates to GO layers and the binding force of GO nanosheets,the prepared PDA-GO membranes exhibit impressive long-te rm stability in cross-flow filtration,and maintain good nanofiltration perfo rmance at various feed pressures,tangential velocities,and eve n after external scratching.Moreover,because the deposited PDA layers obstruct the direct contact between GO and contaminants,the antifouling property of the PDA-GO membranes increases substantially,with recovery ratio about 98%.

关键词： Graphene oxide Nanofiltration Polydopamine Stability Antifouling

Paving the road for biomedicine: genome editing and stem cells in primates

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National Science Review 2017年第4期4卷 543-549页

作者： yuyu Niu Tianqing li Weizhi Ji Yunnan Key Laboratory of Primate Biomedicine Research Institute of Primate Translational Medicine Kunming University of Science and Technology

Non-human primates(NHPs) are similar with humans in their anatomy, physiology, genetics and neural functions, and in their cognition, emotions and social behavior. The NHP model has played an important role in the biomedical research, development of vaccines and drugs and new therapies for many diseases.Recent advances in genome editing have generated NHP models for human diseases. Genome editing integrated with derivation of NHP pluripotent stem cells now provides an optimal resource to regenerate medicine.

关键词： genome editing stem cells non-human primate

Oxygen-assisted spinodal structure achieves 1.5 GPa yield strength in a ductile refractory high-entropy alloy

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Journal of Materials Science & Technology 2023年第26期157卷 11-20页

作者： Dingcong Cui yuyu Zhang linxiang liu Yue li Lei Wang Zhijun Wang Junjie li Jincheng Wang Feng He State Key Laboratory of Solidification Processing Northwestern Polytechnical UniversityXi’an 710072China Research&Development Institute of Northwestern Polytechnical University in Shenzhen Shenzhen 518063China

Refractory high-entropy alloys(RHEAs)with room-temperature ductility are drawing growing attention for potential high-temperature applications.However,the most widely used metallurgical mechanisms appear weak in optimizing their strength and ductility.Here,we report that the nanoscale spinodal struc-ture in Ti_(41)V_(27)Hf_(15)Nb_(15)O_(2)leads to the highest tensile yield strength(∼1.5 GPa)among the existing RHEAs and good elongation of∼12%.With the aid of thermodynamic calculations,we show that oxygen plays a dominant role in controlling the formation of the spinodal structure by influencing the spinodal gap of the Ti-V-Hf-Nb system.Exploring the atomic structure of the spinodal structure(β+β^(∗)),we showed that the large lattice misfit of the spinodal phases is mainly responsible for the excellent strengthen-ing effect while the planar to wavy dislocation glide mode transition accounts for the retained ductility.This work provides a novel strategy to improve the mechanical properties of the RHEAs and deepens the understanding of their phase stabilities.

关键词： High entropy alloys Spinodal decomposition Strengthening mechanisms

Targeting metabolism to improve CAR-T cells therapeutic efficacy

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中华医学杂志(英文版) 2024年第8期137卷 909-920页

作者： liu Shasha Zhao yuyu Gao Yaoxin li Feng Zhang Yi Biotherapy Center and Cancer Center the First Affiliated Hospital of Zhengzhou University 3. Zhengzhou 4. Henan 450052 5. China

Chimeric antigen receptor T (CAR-T) cell therapy achieved advanced progress in the treatment of hematological tumors. However, the application of CAR-T cell therapy for solid tumors still faces many challenges. Competition with tumor cells for metabolic resources in an already nutrient-poor tumor microenvironment is a major contributing cause to CAR-T cell therapy’s low effectiveness. Abnormal metabolic processes are now acknowledged to shape the tumor microenvironment, which is characterized by increased interstitial fluid pressure, low pH level, hypoxia, accumulation of immunosuppressive metabolites, and mitochondrial dysfunction. These factors are important contributors to restriction of T cell proliferation, cytokine release, and suppression of tumor cell-killing ability. This review provides an overview of how different metabolites regulate T cell activity, analyzes the current dilemmas, and proposes key strategies to reestablish the CAR-T cell therapy’s effectiveness through targeting metabolism, with the aim of providing new strategies to surmount the obstacle in the way of solid tumor CAR-T cell treatment.

关键词： CAR-T cell therapy Metabolism Tumor microenvironment Immunotherapy Mitochondrial fitness