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Expert Consensus on the Care and Management of Patients with Cognitive Impairment in China

Neuroscience Bulletin 2020年第3期36卷 307-320页

作者：无 Yuliang Han Jianjun Jia Xia Li Yang Lv Xuan Sun Shanshan Wang Yongjun Wang Zhiwen Wang Jintao Zhang Jiong zhou yuying zhou Academy of Cognitive Disorders of China(ACDC) The 305 Hospital of People’s Liberation Army Beijing 100017China The Second Medical Center People’s Liberation Army(PLA)General HospitalBeijing 100853China Shanghai Mental Health Center Shanghai JiaoTong University School of MedicineShanghai 200030China The First Affiliated Hospital of Chongqing Medical University Chongqing 630014China The Second Medical Center PLA General HospitalBeijing 100853China Shenzhen Institute of Mental Health Shenzhen Kangning HospitalShenzhen 518020China Peking University School of Nursing Beijing 100191China The 960th Hospital of People’s Liberation Army Taian 271000China The Second Affiliated Hospital Zhejiang University School of MedicineHangzhou 310009China HuanHu Hospital of Nankai University Tianjin 300350China

The cognitive disease consensus was prepared by panels of health and public representatives based on actual clinical practice in Geriatric Departments in Chinese hospitals and a systematic literature review. This consensus reflects the medical knowledge accumulated by those experts and provides information about professional medical care and advice.A multidisciplinary panel of specialists(neurologists,psychiatrists, and nursing specialists) reports an expert consensus on the medical knowledge accumulated from those experts and provides information about professional medical care and advice. The recommendations focus on the care and management of older adults with mild cognitive impairment,the objectives and methods of maintaining cognition and training, the assessments and measures of daily care for patients at different stages of dementia, the assessments and coping strategies for the behavioral and psychological symptoms of dementia, principles and suggestions for an appropriate living environment, arrangements for recreational activities, the care and management of patients with endstage dementia, and suggestions for addressing stress in caregivers.

关键词： Consensus Healthcare Management Cognitive disorders

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Effect of Carotid Artery Stenting and Extracranial-Intracranial By-Pass on Cognitive Function: Preliminary Results

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International Journal of Clinical Medicine 2015年第6期6卷 377-383页

作者： Li Liu yuying zhou Department of Radiology Tianjin Huan Hu Hospital Tianjin China Department of Neurology Tianjin Huan Hu Hospital Tianjin China

Background: To compare the neuropsychological consequences after carotid artery stenting (CAS) and extracranial-intracranial by-pass (EC-IC by-pass). Methods: A total of 43 patients referred to CAS, 32 patients referred to EC-IC by-pass and 43 control subjects were enrolled in the study. Neuropsychologic testing was performed before and three months after procedure. A paired Student t test was used to compare neuropsychologic test scores at baseline and three months after procedure in each group. Cognitive changes in a three-month follow-up were not normally distributed and compared among/between groups with Kruskal-Wallis test. Results: Three months after the treatment both the CAS and EC-IC by-pass groups showed improved cognitive performance compared to baseline, whereas the same improvement wasn’t seen in the control group. The scores from Activities of Daily Living also improved in all three groups in a three-month follow-up, and EC-IC group presented a more distinct increase in daily life abilities comparing to the other two groups. Conclusions: CAS and EC-IC by-pass in patients with a carotid or intracranial stenosis may result in cognitive improvement three months after surgery.

关键词： Carotid Artery Stenting Extracranial-Intracranial By-Pass Cognition

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Neutrophil-derived heparin binding protein triggers vascular leakage and synergizes with myeloperoxidase at the early stage of severe burns(With video)

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Burns & Trauma 2021年第1期9卷 240-254页

作者： Lu Liu Yiming Shao Yixuan Zhang Yunxi Yang Jiamin Huang Linbin Li Ran Sun yuying zhou Yicheng Su Bingwei Sun School of Medicine Jiangsu UniversityZhenjiang 212001Jiangsu ProvinceChina Department of Burns and Plastic Surgery Affiliated Suzhou Hospital of Nanjing Medical UniversitySuzhou 215002Jiangsu ProvinceChina

Background:Burn shock caused by vascular leakage is one of the main causes of high mortality in severe burn ***,the pathophysiological mechanism of vascular leakage is still *** purpose of this study was to explore the molecular mechanism of vascular leakage in the early stage of severe burn and provide a new target for the treatment of severe ***:Neutrophils were isolated from human peripheral blood by magnetic beads *** was used to detect neutrophil-derived granule proteins and glycocalyx injury products in *** vascular leakage and neutrophil movement were assessed by in vivo laser confocal imaging in mice,and high-quality video were ***-related molecules were investigated by *** damage to glycocalyx of mice vascular endothelial cellswas observed by transmission electron microscope and scanning electron *** analysis,flow cytometry and immunofluorescence were used to further study the relationship between human peripheral blood neutrophil-derived hypochlorite(HOCl)and CD44 of human vascular endothelial ***:In this study,we found that rapidly increasing activated neutrophils secrete heparin binding protein(HBP)andmyeloperoxidase(MPO)after severe burn *** HBP triggers vascular leakage with synergy of MPO,results in systemic edema and burn ***,we found that the MPO catalytic product HOCl but not MPO triggers CD44 extracellular domain shedding from vascular endothelial cells to damage the *** to the glycocalyx results in firm adhesion of neutrophils and increases vascular ***,MPO inhibitors partially protect the glycocalyx of vascular endothelial *** combination of HBP and MPO inhibitors markedly reduces vascular leakage and systemic edema in the early stage of severe ***:Taken together,these data reveal that neutrophil-derived HBP and MPO play an important synergies role in triggering vascular leakage a

关键词： Severe burn Heparin binding protein Myeloperoxidase Vascular leakage Glycocalyx

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论全球气候治理中FAO援助机制的嬗变及中国应对

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重庆大学学报（社会科学版） 2019年第6期25卷 109-117页

作者：周钰颖四川外国语大学商务英语学院

《巴黎协定》明确了“自下而上”型的温室气体贡献目标,因此,应对气候变化更需包括FAO在内的多元主体予以共同治理。事实上,FAO已将援助发展中国家应对粮食安全的传统工作范围延伸至应对气候变化领域,但客观而言,其仍存在国际合作模式... 详细信息

《巴黎协定》明确了“自下而上”型的温室气体贡献目标,因此,应对气候变化更需包括FAO在内的多元主体予以共同治理。事实上,FAO已将援助发展中国家应对粮食安全的传统工作范围延伸至应对气候变化领域,但客观而言,其仍存在国际合作模式僵化、机构设置与整体目标不匹配、行动能力不强、工作透明度不高等一系列问题。对此,FAO宜在自身改革和治理中更突出应对气候变化工作的重要地位,加强与《联合国气候变化框架公约》体系的互动与衔接,创建发展中国家关于气候变化和粮食安全的数据库。同时,作为最大的发展中国家、农业大国和温室气体排放大国,中国亦应积极参与全球气候治理进程,推动应对气候变化机制的完善,并创新农业发展战略和碳融资方案。

关键词： FAO 全球气候治理援助机制发展中国家《巴黎协定》

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ASAF: altered spontaneous activity fingerprinting in Alzheimer’s disease based on multisite fMRI

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Science Bulletin 2019年第14期64卷 998-1010页

作者： Jiachen Li Dan Jin Ang Li Bing Liu Chengyuan Song Pan Wang Dawei Wang Kaibin Xu Hongwei Yang Hongxiang Yao Bo zhou Alexandre Bejanin Gael Chetelat Tong Han Jie Lu Qing Wang Chunshui Yu Xinqing Zhang yuying zhou Xi Zhang Tianzi Jiang Yong Liu Ying Han Department of Neurology Xuanwu Hospital of Capital Medical University Beijing 100053 China Department of Radiology Chinese PLA General Hospital Beijing 100853 China Université Normandie Inserm Université de Caen-Normandie Inserm UMR-S U1237 GIP Cyceron Caen 14000 France Department of Radiology Tianjin Huanhu Hospital Tianjin 300350 China Department of Radiology Tianjin Medical University General Hospital Tianjin 300052 China Center of Alzheimer's Disease Beijing Institute for Brain Disorders Beijing 100053 China Beijing Institute of Geriatrics Beijing 100053 China National Clinical Research Center for Geriatric Disorders Beijing 100053 China Brainnetome Center & National Laboratory of Pattern Recognition Institute of Automation Chinese Academy of Sciences Beijing 100190 China School of Artificial Intelligence University of Chinese Academy of Sciences Beijing 100049 China Center for Excellence in Brain Science and Intelligence Technology Institute of Automation Chinese Academy of Sciences Beijing 100190 China Department of Neurology Qilu Hospital of Shandong University Ji'nan 250012 China Department of Neurology Tianjin Huanhu Hospital Tianjin 300350 China Institute of Geriatrics and Gerontology Chinese PLA General Hospital Beijing 100853 China Department of Radiology Qilu Hospital Ji'nan 250012 China Department of Radiology Xuanwu Hospital of Capital Medical University Beijing 100053 China

Several monocentric studies have noted alterations in spontaneous brain activity in Alzheimer's disease (AD), although there is no consensus on the altered amplitude of low-frequency fluctuations in AD patients. The main aim of the present study was to identify a reliable and reproducible abnormal brain activity pattern in AD. The amplitude of local brain activity (AM), which can provide fast mapping of spontaneous brain activity across the whole brain, was evaluated based on multisite rs-fMRI data for 688 subjects (215 normal controls (NCs), 221 amnestic mild cognitive impairment (aMCI) 252 AD). Two-sample t-tests were used to detect group differences between AD patients and NCs from the same site. Differences in the AM maps were statistically analyzed via the Stouffer's meta-analysis. Consistent regions of lower spontaneous brain activity in the default mode network and increased activity in the bilateral hippocampus/parahippocampus, thalamus, caudate nucleus, orbital part of the middle frontal gyrus and left fusiform were observed in the AD patients compared with those in NCs. Significant correlations (P?

关键词： Brain spontaneous activity Multisite Biomarkers Leave-one-site-out cross-validation Alzheimer's disease

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Topological Degree for Nonlinear Mappings of Monotone Type

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内江师范学院学报 1991年第4期6卷 1-12页

作者： Yang Rongxian zhou yuying(NeiJiang Teacher’s Collge) (Yunnan Educational College)

The topologioal degree are constructed for generalized pseudo-monotone mappings and for the sum of a maximal monotone mapwith a generalized pseudomnotone from a refelxive Banach space toits dual *** generalizes topological degree for pseudomon-otone mappings and for the sum of a maximal monotone map witha bounded pseudomonotone mop from a reflexive Banach space to itsdual space which have been studied earlier by Browder and

关键词： monotone maximal topological earlier convex assume proof uniformly nonempty hence

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Focusing in solids and application in acoustic imaging

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Chinese Journal of Acoustics 1992年第4期11卷 335-343页

作者： QIAO Donghai, WANG Chenghao zhou yuying(Institute of Acoustics, Academia Sinica, Beijing 100080)

Focusing in solids by surface transducer arrays ( STA ) and the acoustic field distribution on the focal axis are studied in this paper. The relation between the source element width and the field strength at different order focuses is also discussed. Numerical calculation is used to get the focal field distribution as the element width is changed. Some practical problems such as the minimum distinguishable frequency, the transversal and longitudinal resolution are investigated when this kind of focusing is used for NDT and acoustic imaging. Some explorative experiments have been done to demonstrate the theory.

关键词： Focusing in solids and application in acoustic imaging

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借助光刻成像仿真软件的μDBO穿线套刻标记

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清华大学学报（自然科学版） 2023年第12期63卷 2057-2075页

作者：陈天元周钰颖高安上海微电子装备(集团)股份有限公司前道系统集成部上海201203 上海微电子装备(集团)股份有限公司量测产品部上海201203 上海市光刻光学与检测重点实验室上海201203

在光刻机的对准、曝光和量测等过程中,存在量程范围小,测量精度要求极高的套刻标记。这些套刻标记在实现特定功能的同时,会受到多种误差的影响,比如标记线宽与设计差异、标记线条边缘粗糙度、标记边缘效应等。该文旨在解决光刻套刻量测... 详细信息

在光刻机的对准、曝光和量测等过程中,存在量程范围小,测量精度要求极高的套刻标记。这些套刻标记在实现特定功能的同时,会受到多种误差的影响,比如标记线宽与设计差异、标记线条边缘粗糙度、标记边缘效应等。该文旨在解决光刻套刻量测领域中的问题,特别是针对业界常用的微型衍射套刻(micro diffraction-based overlay,μDBO)标记,通过对穿线套刻情形进行量测过程的仿真研究,提出了一种借助光刻成像仿真软件进行标记量测结果仿真的方法。该文运用自制代码的DrM软件和商业仿真软件HyperLith作为工具,两者的仿真结果均定性还原了实验中探测到的特殊亮暗线现象,验证了该方法用于量测仿真的可行性。此外,该文还对匹配实验仪器的穿线套刻μDBO标记设计、照明波长、照明配置和待测信号区域等参数进行仿真优化,输出了基于目前实验配置的优化标记与方案。

关键词：计算光刻光刻成像仿真软件微型衍射套刻标记穿线套刻

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