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Journal of Energy Chemistry 2024年第8期95卷 428-439页

作者： yuying fan Ying Gu Dongxu Wang Yanqing Jiao Aiping Wu Chungui Tian Key Laboratory of Functional Inorganic Material Chemistry Ministry of Education of the People's Republic of China Heilongjiang University College of Chemistry Chemical Engineering and Resource Utilization Northeast Forestry University

Hydrogen evolution reaction（HER） and urea oxidation reaction（UOR） are key reactions of the watercycling associated catalytic process/device.The design of catalysts with a super-hydrophilic/aerophobic structure and optimized electron distribution holds great promise.Here,we have designed a threedimensional（3D） hollow Ni/NiMoN hierarchical structure with arrayed-sheet surface based on a onepot hydrothermal route for efficient urea-assisted HER based on a simple hydrothermal process.The Ni/NiMoN catalyst exhibits super-hydrophilic/aerophobic properties with a small droplet contact angle of 6.07° and an underwater bubble contact angle of 155.7°,thus facilitating an escape of bubbles from the electrodes.Density functional theory calculations and X-ray photoelectron spectroscopy results indicate the optimized electronic structure at the interface of Ni and NiMoN,which can promote the adsorption/desorption of reactants and intermediates.The virtues combining with a large specific surface area endow Ni/NiMoN with efficient catalytic activity of low potentials of 25 mV for HER and 1.33 V for UOR at10 mA cm-2.The coupled HER and UOR system demonstrates a low cell voltage of 1.42 V at 10 mA cm-2,which is approximately 209 mV lower than water electrolysis.

关键词： Hollow heterojunctions Hydrogen evolution Super hydrophilic/aerophobic Transition metal nitrides Urea electrooxidation

Mannogalactoglucan from mushrooms protects pancreatic islets via restoring UPR and promotes insulin secretion in TIDM mice

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Food Science and Human Wellness 2024年第3期13卷 1390-1401页

作者： Ting Liu Si Chen Yunhe Qu Lujuan Zheng Xiaoxuan Yang Shuhan Men Yuanning Wang Hanrui Ma Yifa Zhou yuying fan Engineering Research Center of Glycoconjugates Ministry of EducationJilin Provincial Key Laboratory of Chemistry and Biology of Changbai Mountain Natural DrugsSchool of Life SciencesNortheast Normal UniversityChangchun 130024China

Type 1 diabetes mellitus(T1DM) lacks insulin secretion due to autoimmune deficiency of pancreaticβ-cells.Protecting pancreatic islets and enhancing insulin secretion has been therapeutic approaches.Mannogalactoglucan is the main type of polysaccharide from natural mushroom,which has potential medicinal prospects.Nevertheless,the antidiabetic property of mannogalactoglucan in T1DM has not been fully elucidated.In this study,we obtained the neutral fraction of alkali-soluble Armillaria mellea polysaccharide(AAMP-N) with the structure of mannogalactoglucan from the fruiting body of A.mellea and investigated the potential therapeutic value of AAMP-N in T1DM.We demonstrated that AAMP-N lowered blood glucose and improved diabetes symptoms in T1DM mice.AAMP-N activated unfolded protein response(UPR) signaling pathway to maintain ER protein folding homeostasis and promote insulin secretion in vivo.Besides that,AAMP-N promoted insulin synthesis via upregulating the expression of transcription factors,increased Ca^(2+) signals to stimulate intracellular insulin secretory vesicle transport via activating calcium/calmodulin-dependent kinase Ⅱ(CamkⅡ) and cAMP/PKA signals,and enhanced insulin secretory vesicle fusion with the plasma membrane via vesicle-associated membrane protein 2(VAMP2).Collectively,these studies demonstrated that the therapeutic potential of AAMP-N on pancreatic islets function,indicating that mannogalactoglucan could be natural nutraceutical used for the treatment of T1DM.

关键词： Mannogalactoglucan Mushroom Pancreatic islets Insulin secretion Insulin synthesis Unfolded protein response(UPR) Type 1 diabetes mellitus(T1DM)

Ginsenoside F1 administration promotes UCP1-dependent fat browning and ameliorates obesity-associated insulin resistance

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Food Science and Human Wellness 2023年第6期12卷 2061-2072页

作者： Yuhan Meng Weili Li Chenxing Hu Si Chen Haiyang Li Feifei Bai Lujuan Zheng Ye Yuan yuying fan Yifa Zhou Engineering Research Center of Glycoconjugates of Ministry of Education Jilin Provincial Key Laboratory of Chemistry and Biology of Changbai Mountain Natural DrugsSchool of Life SciencesNortheast Normal UniversityChangchun 130024China

Obesity-induced type 2 diabetes is mainly due to excessive free fatty acids leading to insulin resistance.Increasing thermogenesis is regarded as an effective strategy for hypolipidemia and hypoglycemia.Ginsenoside is a natural active component in Panax ginseng C.A.Meyer,and some of them enhance thermogenesis.However,there are few studies on the mechanism and target of ginsenosides enhancing thermogenesis.Using thermogenic protein uncoupling protein 1(UCP1)-luciferase reporter assay,we identifi ed ginsenoside F1 as a novel UCP1 activator in the ginsenosides library.Using pull down assay and inhibitor interference,we found F1 binds toβ3-adrenergic receptors(β3-AR)to enhance UCP1 expression via cAMP/PKA/CREB pathway.We also investigated the ability of F1 on energy metabolism in obesity-induced diabetic mice,including body weight,body composition and energy expenditure.The results of proteomics showed that F1 signifi cantly up-regulated thermogenesis proteins and lipolytic proteins,but down-regulated fatty acid synthesis proteins.Ginsenoside F1 increased thermogenesis and ameliorated insulin resistance specifi cally by promoting the browning of white adipose tissue in obese mice.Additionally,ginsenoside F1 improves norepinephrine-induced insulin resistance in adipocytes and hepatocytes,and shows a stronger mitochondria respiration ability than norepinephrine.These fi ndings suggest that ginsenoside F1 is a promising lead compound in the improvement of insulin resistance.

关键词： Ginsenoside F1 Uncoupling protein 1 β3-Adrenergic receptor White adipose tissue browning Insulin resistance

正常小鼠血清通过抑制focal adhesion信号通路减轻小鼠放射性肺炎

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南方医科大学学报 2024年第5期44卷 801-809页

作者：苑通郭玉莹张俊伶樊赛军中国医学科学院//北京协和医学院放射医学研究所天津市放射医学与分子核医学重点实验室天津300192

目的探讨正常小鼠血清(NMS)对放射性肺炎的治疗作用及可能机制。方法建立胸腔照射诱导的放射性肺炎模型,将小鼠分为对照组、静脉注射血清组、照射组和照射后静脉注射血清组。注射血清组小鼠在照射后立即静脉注射正常小鼠血清100μL,对... 详细信息

目的探讨正常小鼠血清(NMS)对放射性肺炎的治疗作用及可能机制。方法建立胸腔照射诱导的放射性肺炎模型,将小鼠分为对照组、静脉注射血清组、照射组和照射后静脉注射血清组。注射血清组小鼠在照射后立即静脉注射正常小鼠血清100μL,对照组小鼠注射100μL生理盐水,隔天注射1次,共注射8次。照射后15 d取材,HE染色检测肺组织形态学变化,ELISA检测小鼠肺组织和血清中炎症因子肿瘤坏死因子-α(TNF-α)、转化生长因子-β(TGF-β)、白细胞介素-1α(IL-1α)、白细胞介素-6(IL-6)水平;流式细胞术检测肺组织内淋巴细胞比例变化。外泌体miRNA高通量测序探索处理后小鼠的信号通路变化,qRT-PCR检测免疫相关基因的表达水平,使用Western blotting检测黏着斑通路talin-1、tensin 2、FAK、vinculin、α-actinin和paxillin蛋白的表达。结果与照射组相比,照射后注射血清组小鼠肺脏器系数、血清及肺组织上清液中炎症因子TNF-α、TGF-β、IL-1α、IL-6水平显著降低(P<0.05),CD45^(+)、CD4^(+)、T_(reg)淋巴细胞在小鼠肺组织中的浸润程度显著下降(P<0.05);肺中Egfr和Pik3cd的mRNA和蛋白表达水平显著下调,talin-1、tensin 2、FAK、vinculin、α-actinin和paxillin蛋白的表达水平也显著降低(P<0.05)。结论正常小鼠血清通过抑制focal adhesion信号通路关键蛋白的表达减轻电离辐射诱发的小鼠放射性肺炎。

关键词：正常小鼠血清放射性肺炎外泌体粘着斑途径

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Abusive supervision and turnover intention: Mediating effects of psychological empowerment of nurses

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International Journal of Nursing Sciences 2019年第2期6卷 198-203页

作者： Dongmei Lyu Lingling Ji Qiulan Zheng Bo Yu yuying fan The Second Affiliated Hospital&College of Nursing Harbin Medical UniversityHarbinChina Second Affiliated Hospital of ChongQing Medical University

Objective: This study aims to determine the mediating effects of psychological empowerment on abusive supervision and turnover intention as perceived by nurses to provide information to change the status of nurse turnover.Methods: A cross-sectional survey (a questionnaire examining perceptions of abusive supervision,measurement of psychological empowerment,and questionnaire for turnover intention) was used to collect data.A total of 1127 clinical nurses,who were recruited through convenience sampling,participated in the survey.Results: Nurses' average perceived abusive supervision,psychological empowerment,and turnover intention scores were 1.62 ± 0.95,3.24 ± 0.83,and 14.17 ± 3.78,respectively.Psychological empowerment was found to mediate the relationship between abusive supervision and turnover intention (P< 0.01).Turnover intention tends to be stronger and psychological empowerment reduced when nurse managers adopt an abusive leadership style.Conclusions: Nurses' psychological empowerment is an intermediary variable that predicts the relationship between abusive supervision and turnover intention.Nurse managers should manage abusive supervision to increase nurses' psychological empowerment and decrease turnover intention.

关键词： Abusive supervision Nurse administrators Perception Psychological empowerment Surveys and questionnaires Turnover intention

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数字经济、劳动力资源配置与高质量就业

调研世界 2024年第6期 41-51页

作者：范玉莹郑浩天青岛大学经济学院

数字经济作为一种新型经济形态,对劳动力市场运转以及劳动者就业质量产生影响。本文利用2008—2021年省级面板数据,从劳动力资源配置角度解释数字经济发展对高质量就业的影响的内在机理。结果表明:数字经济发展会显著促进高质量就业。其... 详细信息

数字经济作为一种新型经济形态,对劳动力市场运转以及劳动者就业质量产生影响。本文利用2008—2021年省级面板数据,从劳动力资源配置角度解释数字经济发展对高质量就业的影响的内在机理。结果表明:数字经济发展会显著促进高质量就业。其中,劳动力资源配置效率在两者关系间发挥机制作用,即数字经济发展会通过改善劳动力错配程度来实现高质量就业。进一步分析表明,数字经济发展促进高质量就业具备“边际效应”递增的非线性特征,且地区劳动力错配程度在其中发挥门槛作用,会负向调节两者间的非线性关系。因此,推动数字经济与实体经济深度融合,引导劳动力要素合理畅通有序流动,对实现更高质量充分就业具有重要意义。

关键词：数字经济劳动力资源配置高质量就业

省域经济增长质量:基于山西省的测评及推进路径

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商业观察 2024年第17期10卷 55-60页

作者：樊钰莹西安明德理工学院陕西西安710000

通过测度山西省2010—2020年经济增长质量水平的动态变化,选取衡量经济增长质量的一级指标,主要包括结构、稳定性、福利变化与成果分配、绿色发展以及国民经济素质五大指标,并逐渐将其具体细化,最后采用主成分分析法对综合指标进行测评... 详细信息

通过测度山西省2010—2020年经济增长质量水平的动态变化,选取衡量经济增长质量的一级指标,主要包括结构、稳定性、福利变化与成果分配、绿色发展以及国民经济素质五大指标,并逐渐将其具体细化,最后采用主成分分析法对综合指标进行测评,为实现山西省经济高质量发展提供可行路径。对山西省经济高质量发展的定量分析更易全面客观地掌握经济运行状态,对于加快经济转型、实现经济增长意义颇深。

关键词：高质量发展经济增长质量测评推进路径

New Record Ocean Temperatures and Related Climate Indicators in 2023

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Advances in Atmospheric Sciences 2024年第6期41卷 1068-1082页

作者： Lijing CHENG John ABRAHAM Kevin E.TRENBERTH Tim BOYER Michael EMANN Jiang ZHU fan WANG Fujiang YU Ricardo LOCARNINI John FASULLO Fei ZHENG Yuanlong LI Bin ZHANG Liying WAN Xingrong CHEN Dakui WANG Licheng FENG Xiangzhou SONG Yulong LIU Franco RESEGHETTI Simona SIMONCELLI Viktor GOURETSKI Gengxin CHEN Alexey MISHONOV Jim REAGAN Karina VON SCHUCKMANN yuying PAN Zhetao TAN Yujing ZHU Wangxu WEI Guancheng LI Qiuping REN Lijuan CAO Yayang LU International Center for Climate and Environment Sciences Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China University of St.Thomas School of EngineeringMinnesota 55105USA NSF National Center for Atmospheric Research BoulderColorado 80307USA University of Auckland Auckland 1010New Zealand National Oceanic and Atmospheric Administration National Centers for Environmental InformationSilver SpringMaryland 20910USA Department of Earth and Environmental Science University of PennsylvaniaPhiladelphiaPennsylvania 19104USA Institute of Oceanology Chinese Academy of SciencesQingdao 266071China National Marine Environmental Forecasting Center Ministry of Natural Resources of ChinaBeijing 100081China Oceanographic Data Center Chinese Academy of SciencesQingdao 266071China College of Oceanography Hohai UniversityNanjing 210098China National Marine Data and Information Service Tianjin 300171China Italian National Agency for New Technologies Energy and Sustainable Economic DevelopmentS.Teresa Research CenterLerici 19032Italy Istituto Nazionale di Geofisica e Vulcanologia Sede di BolognaBologna 40128Italy South China Sea Institute of Oceanology Chinese Academy of SciencesGuangzhou 510301China ESSIC/CISESS-MD University of MarylandCollege ParkMD20740USA Mercator Ocean International Toulouse 31400France Eco-Environmental Monitoring and Research Center Pearl River Valley and South China Sea Ecology and Environment AdministrationMinistry of Ecology and EnvironmentPRCGuangzhou 510611China National Meteorological Information Center China Meteorological AdministrationBeijing 100081China International Research Center of Big Data for Sustainable Development Goals Beijing 100094China

The global physical and biogeochemical environment has been substantially altered in response to increased atmospheric greenhouse gases from human activities.In 2023,the sea surface temperature(SST)and upper 2000 m ocean heat content(OHC)reached record highs.The 0–2000 m OHC in 2023 exceeded that of 2022 by 15±10 ZJ(1 Zetta Joules=1021 Joules)(updated IAP/CAS data);9±5 ZJ(NCEI/NOAA data).The Tropical Atlantic Ocean,the Mediterranean Sea,and southern oceans recorded their highest OHC observed since the 1950s.Associated with the onset of a strong El Niño,the global SST reached its record high in 2023 with an annual mean of~0.23℃ higher than 2022 and an astounding>0.3℃ above 2022 values for the second half of 2023.The density stratification and spatial temperature inhomogeneity indexes reached their highest values in 2023.

关键词： ocean heat content salinity stratification global warming climate

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沟通案例比赛在护理临床实习教学中的应用

继续医学教育 2024年第5期38卷 90-93页

作者：姜宇英范恒丹浙江大学医学院附属金华医院耳鼻咽喉头颈外科浙江金华321000 浙江大学医学院附属金华医院肝胆胰外科浙江金华321000

目的探讨沟通案例比赛在护理临床实习教学中的应用效果。方法便利抽样选取2021年7—11月在浙江大学医学院附属金华医院的153名护生作为研究对象,将参加沟通案例比赛的护生设为试验组,未参加沟通案例比赛的护生设为对照组。在4个月的实... 详细信息

目的探讨沟通案例比赛在护理临床实习教学中的应用效果。方法便利抽样选取2021年7—11月在浙江大学医学院附属金华医院的153名护生作为研究对象,将参加沟通案例比赛的护生设为试验组,未参加沟通案例比赛的护生设为对照组。在4个月的实习过程中,试验组采用医院的沟通与冲突的理论培训及带教老师的实践指导,2个月后参加沟通案例比赛,比赛后继续实习2个月;对照组采用医院的沟通与冲突的理论培训及带教老师的实践指导。4个月后比较2组护生的沟通能力,同时调查试验组护生对沟通案例比赛教学方式的评价。结果试验组护生沟通能力测评得分为(87.31±10.26)分,高于对照组[(82.76±10.98)分],差异有统计学意义(P<0.05);试验组护生对沟通案例比赛教学方式的认可度均高于95.0%。结论沟通案例比赛的实施不仅提升了护生临床沟通能力,还有助于提高临床教学效果,优化教学过程。

关键词：沟通案例比赛教学方式护生护患沟通临床教学沟通能力

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基于双层链的个人隐私数据保护和授权框架

郑州大学学报（理学版） 2024年第2期56卷 1-8页

作者：刘靖宇曹兴旺颜钰莹范小芹武优西河北工业大学人工智能与数据科学学院天津300401

针对隐私泄露事件频繁发生且当前的保护方法无法避免恶意收集和恶意攻击的问题,提出了基于双层链的个人隐私数据保护和授权框架。该框架由验证链和授权链构成,通过跨链技术进行通信,不需要用户向服务商提供隐私数据就能获得服务。验证... 详细信息

针对隐私泄露事件频繁发生且当前的保护方法无法避免恶意收集和恶意攻击的问题,提出了基于双层链的个人隐私数据保护和授权框架。该框架由验证链和授权链构成,通过跨链技术进行通信,不需要用户向服务商提供隐私数据就能获得服务。验证层负责验证数据并生成数据证明,授权层负责用户的授权,避免服务商得到用户隐私数据。此外,提出了基于顺序选举的RAFT改进算法和代理受益证明算法,分别应用在验证层和授权层,从而提高了共识速度和数据处理速度,解决了在没有激励机制的情况下如何维护公有链的问题。实验结果表明,所提框架保证了数据的真实性、安全性和可扩展性,平衡了隐私性和可追溯性。

关键词：区块链跨链技术双层链隐私安全授权