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负载CCR5抗体的纳米颗粒治疗小鼠子宫内膜异位症的实验研究

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中华妇产科杂志 2019年第10期54卷 680-686页

作者：张玉毅李鹏湖北医药学院附属襄阳市第一人民医院妇产科 441000 湖北医药学院附属襄阳市第一人民医院普外科 441000

目的聚乳酸?羟基乙酸共聚物(PLGA)纳米颗粒作为蛋白质载体用来负载CC型趋化因子受体5抗体(anti-CCR5),合成负载anti-CCR5的PLGA纳米颗粒(简称:PLGA/anti-CCR5),分析其抑制小鼠子宫内膜异位症的动物实验研究.方法合成PLGA/anti-CCR5纳... 详细信息

目的聚乳酸?羟基乙酸共聚物(PLGA)纳米颗粒作为蛋白质载体用来负载CC型趋化因子受体5抗体(anti-CCR5),合成负载anti-CCR5的PLGA纳米颗粒(简称:PLGA/anti-CCR5),分析其抑制小鼠子宫内膜异位症的动物实验研究.方法合成PLGA/anti-CCR5纳米颗粒,分析纳米颗粒中anti-CCR5的累积释放.建立小鼠子宫内膜异位症模型,并分为对照组、anti-CCR5组、PLGA/anti-CCR5组,同时分离、培养异位内膜细胞(EEC)及腹腔液中的巨噬细胞;流式细胞仪检测各组腹腔液中巨噬细胞的比例,ELISA方法测定各组腹腔镜中细胞因子白细胞介素10(IL-10)和转化生长因子β(TGF-β)的水平.用5-溴脱氧尿苷细胞增殖检测试剂盒和人工基底膜基质凝胶matrigel侵袭检测试剂盒检测EEC的增殖、浸润情况,同时,检测IL-10抗体和TGF-β抗体作用后EEC的增殖和侵袭情况.结果成功合成了PLGA/anti-CCR5纳米颗粒,成功建立了小鼠子宫内膜异位症模型.PLGA/anti-CCR5纳米颗粒在第3~24天可持续释放***/anti-CCR5组巨噬细胞比例逐渐减少,第7天[(4.5±1.5)%]与第3天[(6.3±0.6)%]、第14天[(2.6±0.7)%]与第7天分别比较,差异均有统计学意义(P<0.01、P<0.05);在第7、14天,PLGA/anti-CCR5组的巨噬细胞比例较anti-CCR5组下降更明显(P<0.01).在第7、14天,PLGA/anti-CCR5组相比于anti-CCR5组IL-10和TGF?β的水平更低(P<0.01),且PLGA/anti-CCR5组在第3、7、14天IL-?10和TGF-β的水平逐渐减少(P<0.01).IL-10抗体+TGF-β抗体联合作用后EEC的增殖和侵袭[分别为(70.8±7.6)%、(50.2±9.1)%]相比于单用均降低(P<0.05).结论在小鼠子宫内膜异位症模型中,PLGA/anti-CCR5纳米颗粒可能通过抑制巨噬细胞分泌IL-10和TGF-β来抑制EEC的增殖和侵袭,PLGA/anti-CCR5纳米颗粒为子宫内膜异位症的治疗提供了新的思路.

关键词：子宫内膜异位症受体,CCR5 纳米粒子聚乳酸-羟基乙酸共聚物药物释放系统

Molecular fluorescence significantly enhanced by gold nanoparticles@zeolitic imidazolate framework-8

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Chinese Physics B 2023年第5期32卷 462-470页

作者：张钰伊卞亚杰张炜刘易婷张晓磊陈梦迪胡炳文金庆原 State Key Laboratory of Precision Spectroscopy Shanghai Key Laboratory of Magnetic ResonanceSchool of Physics and Electronic ScienceEast China Normal UniversityShanghai 200241China Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuan 030006China Department of Optical Science and Engineering Fudan UniversityShanghai 200433China

Noble metal nanoparticles exhibit unique surface plasmon resonance dependent optical *** this basis,gold nanoparticles(AuNPs)encapsulated in metal–organic frameworks(MOFs)can form AuNPs@MOFs composites to modulate the optical properties of fluorescent molecules,which is less *** this paper,based on the fluorescence enhancement effect of AuNPs on 2-(2-hydroxyphenyl)-1H-benzimidazole(HPBI)molecules,zeolitic imidazolate framework-8(ZIF-8)crystals with structural stability were ***@ZIF-8 exhibited a significantly pronounced fluorescence enhancement of the HPBI *** addition,by comparing the fluorescence characteristics of the HPBI molecules adsorbed on AuNPs@ZIF-8 and those captured in AuNPs@ZIF-8,we found that the ZIF-8 can act as a spacer layer with highly effective near-field *** our preliminary results shed light on future research on the composite structures of noble metal particles and MOFs for fluorescent probes and sensing applications.

关键词： ZIF-8 gold nanoparticles fluorescence spectra fluorescence lifetime

High-speed visible light communication systems based on Si-substrate LEDs with multiple superlattice interlayers

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PhotoniX 2021年第1期2卷 199-216页

作者： Fangchen Hu Shouqing Chen yuyi zhang Guoqiang Li Peng Zou Junwen zhang Chao Shen Xiaolei zhang Jian Hu Jianli zhang Zhixue He Shaohua Yu Fengyi Jiang Nan Chi Key Laboratory for Information Science of Electromagnetic Waves(MoE) Fudan UniversityShanghai 200433People’s Republic of China National Institute of LED on Silicon Substrate Nanchang UniversityNanchang 330096People’s Republic of China State Key Laboratory of Precision Spectroscopy East China Normal UniversityShanghai 200241People’s Republic of China State Key Laboratory of Optical Communication Technologies and Networks China Information Communication Technologies Group CorporationWuhan 430000People’s Republic of China Peng Cheng Laboratory Shenzhen 518055China.

High-speed visible light communication(VLC),as a cutting-edge supplementary solution in 6G to traditional radio-frequency communication,is expected to address the tension between continuously increased demand of capacity and currently limited supply of radio-frequency spectrum *** main driver behind the high-speed VLC is the presence of light emitting diode(LED)which not only offers energy-efficient lighting,but also provides a cost-efficient alternative to the VLC transmitter with superior modulation ***,the InGaN/GaN LED grown on Si substrate is a promising VLC transmitter to simultaneously realize effective communication and illumination by virtue of beyond 10-Gbps communication capacity and Watt-level output optical *** previous parameter optimization of Si-substrate LED,the superlattice interlayer(SL),especially its period number,is reported to be the key factor to improve the lighting performance by enhancing the wall-plug efficiency,but few efforts were made to investigate the influence of SLs on VLC ***,to optimize the VLC performance of Si-substrate LEDs,we for the first time investigated the impact of the SL period number on VLC system through experiments and theoretical *** results show that more SL period number is related to higher signal-to-noise ratio(SNR)via improving the wall-plug *** addition,by using Levin-Campello bit and power loading technology,we achieved a record-breaking data rate of 3.37 Gbps over 1.2-m free-space VLC link under given optimal SL period number,which,to the best of our knowledge,is the highest data rate for a Si-substrate LED-based VLC system.

关键词： Visible light communication InGaN/GaN LEDs design Silicon photonics Superlattice interlayers 6G

玻色-爱因斯坦凝聚体穿越高斯光场的透镜效应

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激光与光电子学进展 2017年第11期54卷 56-64页

作者：温歆张钰伊钱静华东师范大学物理与材料科学学院上海200241

在已有实验的基础上,从理论上研究了一维超冷玻色-爱因斯坦凝聚原子团横向穿越高斯型红(蓝)失谐光场后产生的位置超前(滞后)与聚焦(散焦)效应,重点考虑了加速度场、外加高斯光场与原子的偶极作用势和原子间s-波散射碰撞作用势,并分析比... 详细信息

在已有实验的基础上,从理论上研究了一维超冷玻色-爱因斯坦凝聚原子团横向穿越高斯型红(蓝)失谐光场后产生的位置超前(滞后)与聚焦(散焦)效应,重点考虑了加速度场、外加高斯光场与原子的偶极作用势和原子间s-波散射碰撞作用势,并分析比较了在这三种机制的相互竞争且共同作用下,探测原子波包的位置和高度变化。加速度场仅影响波包位置,并不引起形变,原子间的强相互吸引作用可导致波包剧烈形变,甚至崩塌,而排斥作用会加快波包扩散。数值模拟结果与文献实验结果在红失谐光场下十分吻合;通过数值模拟还得到了蓝失谐光场下的理论预测结果。研究结果为今后实验研究光与原子相干操控提供了可行性方案。

关键词：原子与分子物理学玻色爱因斯坦凝聚体透镜效应数值模拟原子波包超前与滞后

2种纤维素纳米纤维作为水基润滑添加剂的摩擦学性能研究

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摩擦学学报（中英文） 2024年第9期44卷 1295-1305页

作者：张彧一胡文敬李久盛中国科学院上海高等研究院先进润滑材料实验室上海201210 中国科学院大学北京100049 中国科学院上海高等研究院中国科学院低碳转化科学与工程重点实验室上海201210

为探索不同制备方法得到的纤维素纳米纤维作为水基润滑添加剂的摩擦学性能,选择TEMPO(2,2,6,6-四甲基哌啶-1-氧自由基)氧化法和机械法得到的2种纤维素纳米纤维(TO-CNF和C-CNF).采用光学显微镜(POM)、扫描电子显微镜(SEM)、激光粒度仪、... 详细信息

为探索不同制备方法得到的纤维素纳米纤维作为水基润滑添加剂的摩擦学性能,选择TEMPO(2,2,6,6-四甲基哌啶-1-氧自由基)氧化法和机械法得到的2种纤维素纳米纤维(TO-CNF和C-CNF).采用光学显微镜(POM)、扫描电子显微镜(SEM)、激光粒度仪、红外光谱(FT-IR)、X射线粉末衍射(XRD)和元素分析等方法对其形貌和结构进行表征,发现上述2种不同类型的CNF均为棒状结构,且为纤维素I型,其中氧化法制备的TO-CNF结构中含有一定量的羧基官能团.通过热重分析表明,C-CNF的热稳定性略优于TO-CNF.进一步通过UMT往复摩擦试验机研究了2种CNF作为水基润滑添加剂的摩擦学性能,结果表明,在添加量(质量分数,w)不超过1%时,2种CNF在不同添加浓度下均表现出显著的减摩性能.其中TO-CNF的减摩性能略优于C-CNF,添加w=1%可使摩擦系数相对于基础体系降低51%.通过钢板表面接触角和磨损后的表面分析对CNF的润滑作用机理进行分析,推测由于CNF结构中含有大量的羟基或羧基等极性官能团,作为添加剂能够在摩擦副表面发生不同程度的吸附从而形成润滑保护膜,防止滑动表面微凸体的直接接触进而改善摩擦学性能.

关键词：纤维素纳米纤维水基润滑添加剂极性基团摩擦学性能润滑膜

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Robust control for an uncertain Micro-hand actuator using passivity based robust right coprime factorization

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Robust control for an uncertain Micro-hand actuator using pa...

Strong coupling with absorption and emission features of Ag@Au hollow nanoshells interacting with J-aggregated dye molecules

第32届中国过程控制会议(CPCC2021)

作者： Ni Bu Haoyu Liu Xiaoguang Wang yuyi zhang Xiaoyong Li College of Automation and Electronic Engineering Qingdao University of Science and Technology

As an important research field in the field of robotics,the research of Micro-hand system has received more and more extensive attention in recent *** this paper,based on the operator-based robust right coprime factorization(RRCF),a dynamic model of the Micro-hand system is ***,the robust stability and passivity of the system are discussed;further,the robust control scheme based on internal model is proposed,by which the effect from the uncertainty is eliminated and the whole nonlinear systems hold robustness while the plant output tracks the reference ***,simulation is used to further verify its effectiveness.

关键词： Robust stability nonlinear system internal model robust tracking control

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Chinese Optics Letters 2021年第12期19卷 137-142页

作者： Tianchen Zhao Qiang Ma Yajie Bian yuyi zhang Yiting Liu Xiaolei zhang Botao Wu E Wu Shitao Lou Qingyuan Jin State Key Laboratory of Precision Spectroscopy East China Normal UniversityShanghai 200241China Collaborative Innovation Center of Extreme Optics Shanxi

We investigate the strong coupling from 5,5’,6,6’-tetrachloro-1,1’-diethyl-3,3’-di(4-sulfobutyl)-benzimidazolocarbocyanine(TDBC)molecules near pure nano-triangular Ag prisms or Ag@Au hollow *** TDBC molecules are deposited on pure Ag nanoprisms or Ag@Au hollow nanoshells with the plasmonic resonance peak,matching very closely with the absorption band of TDBC J-aggregates,obvious Rabi splitting can be observed due to the strong coupling ***,the photoluminescence intensity decreased with the increasing of the temperature,verifying the decreasing plasmon-exciton coupling interaction in the higher *** experimental results are coincident with the simulation results calculated by finite-difference time-domain method.

关键词： surface plasmon nanoshells plasmon-exciton coupling Rabi splitting

A Selection-route Model and Its Algorithm for Military Logistics Delivery in an Emergency

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A Selection-route Model and Its Algorithm for Military Logis...

空间光调制器扫描接收的距离选通成像激光雷达

2012年计算机应用与系统建模国际会议

作者： Wang guiqiang Qi Jidong zhang yuyi Li Jinhua Yang Fuqian Dept.of Handling Facilities Military Transportation University

A vehicle routing problem in a war is discussed, in which some routes may be destroyed uncertainly by competitor. A two-stage integer program model is constructed. The value of a route in a uncertain situation is analyzed. Find a method to simply the computation of the object value of the model. In the method, only the maximum value and the minimum value are countered into the object value. A two-stage taboo search algorithm is designed. In the end, an example is given.

关键词： Emergency logistics vehicle routing problem uncertain decision taboo search algorithm

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光学学报 2020年第12期40卷 1-7页

作者：何志毅黄裕张雨益何宁桂林电子科技大学信息与通信学院广西桂林541004 桂林电子科技大学广西无线宽带通信与信号处理重点实验室广西桂林541004

激光距离选通的扫描式成像技术具有低成本、能避免多次散射等特点,成像扫描与激光束扫描的同步配合是扫描成像技术的难点。设计了一个基于空间光调制器(SLM)的扫描式距离选通激光雷达系统,保证目标反射光的可靠接收,并在时间上和空间上... 详细信息

激光距离选通的扫描式成像技术具有低成本、能避免多次散射等特点,成像扫描与激光束扫描的同步配合是扫描成像技术的难点。设计了一个基于空间光调制器(SLM)的扫描式距离选通激光雷达系统,保证目标反射光的可靠接收,并在时间上和空间上屏蔽后向散射光。在具有不同衰减长度的光散射环境中对本系统进行了测量,实现二维和三维成像。实验结果表明,本系统能够有效地实现光束扫描与距离选通成像扫描的同步,适用于光散射环境中光学成像的可视距离扩展。

关键词：大气光学扫描激光雷达距离选通成像空间光调制器多次光散射