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The nonlinear mechanism for the same responses of neuronal bursting to opposite self-feedback modulations of autapse

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Science China(Technological Sciences) 2021年第7期64卷 1459-1471页

作者： li yuye GU HuaGuang JIA Bing DING Xueli College of Mathematics and Computer Science Chifeng UniversityChifeng024000China School of Aerospace Engineering and Applied Mechanics Tongji UniversityShanghai200092China Department of Physiology and Biophysics School of Life SciencesFudan UniversityShanghai200438China Department of Basic Education Fuyang Institute of TechnologyFuyang236031China

In the traditional viewpoint,inhibitory and excitatory effects always induce opposite *** the present study,the enhanced bursting activities induced by excitatory autapses,which are consistent with the recent experimental observations,and those induced by inhibitory autapses,which is a paradoxical phenomenon,were simulated using the Chay *** same bifurcations and different ionic currents for the same responses were acquired with fast-slow variable dissection and current decomposition,*** the inhibitory or excitatory autaptic conductance increased,the ending phase of the burst related to a homoclinic bifurcation of the fast subsystem changed to widen the burst duration to contain more spikes,which was induced by an elevated minimal potential(V_(min)) of spiking of the fast *** inhibitory and excitatory autaptic conductances induced smaller and larger maximal potentials(V_(max)) of spiking,*** the downstroke,a weaker potassium current induced by the smaller V_(max) played a dominant role for the inhibitory autapse,and the stronger potassium current induced by the larger V_(max) became weaker due to the opposite autaptic current of the excitatory autapse,which induced the V_(min) *** results present the nonlinear and biophysical mechanisms of the same responses to opposite effects,which extends nonlinear dynamics knowledge and provides potential modulation measures for the nervous system.

关键词： bifurcation bursting autapse inhibitory effect excitatory effect fast-slow variable dissection

Delayed excitatory self-feedback-induced negative responses of complex neuronal bursting patterns

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Chinese Physics B 2021年第5期30卷 236-246页

作者： Ben Cao Huaguang Gu yuye li School of Aerospace Engineering and Applied Mechanics Tongji UniversityShanghai 200092China College of Mathematics and Computer Science Chifeng UniversityChifeng 024000China Institute of Applied Mathematics Chifeng UniversityChifeng 024000China

In traditional viewpoint,excitatory modulation always promotes neural firing *** contrary,the negative responses of complex bursting behaviors to excitatory self-feedback mediated by autapse with time delay are acquired in the present *** representative bursting patterns which are identified respectively to be“Fold/Big Homoclinic”bursting and“Circle/Fold cycle”bursting with bifurcations are *** both burstings,excitatory modulation can induce less spikes per burst for suitable time delay and strength of the self-feedback/autapse,because the modulation can change the initial or termination phases of the *** the former bursting composed of quiescent state and burst,the mean firing frequency exhibits increase,due to that the quiescent state becomes much shorter than the ***,for the latter bursting pattern with more complex behavior which is depolarization block lying between burst and quiescent state,the firing frequency manifests decrease in a wide range of time delay and strength,because the duration of both depolarization block and quiescent state becomes ***,the decrease degree of spike number per burst is larger than that of the bursting period,which is the cause for the decrease of firing *** reduced bursting activity is explained with the relations between the bifurcation points of the fast subsystem and the bursting *** present paper provides novel examples of paradoxical phenomenon that the excitatory effect induces negative responses,which presents possible novel modulation measures and potential functions of excitatory self-feedback/autapse to reduce bursting activities.

关键词： bifurcation bursting excitatory autapse time delay

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干旱胁迫下硅和丛枝菌根对甘草根的影响

北方园艺 2024年第20期 99-109页

作者：郝胜杰霍嘉兴李玉叶杜雨欣李金跃康俊宇甘肃农业大学干旱生境作物学国家重点实验室

以甘草为试材，采用2个外源硅（Si）浓度水平、2个丛枝菌根真菌（AMF）接种水平和5个不同湿度处理的方法进行随机组合，并对甘草的产量、矿物质吸收、抗氧化潜力和次生代谢产物进行检测评估，研究了干旱胁迫下Si和AMF对甘草根系的影响... 详细信息

以甘草为试材，采用2个外源硅（Si）浓度水平、2个丛枝菌根真菌（AMF）接种水平和5个不同湿度处理的方法进行随机组合，并对甘草的产量、矿物质吸收、抗氧化潜力和次生代谢产物进行检测评估，研究了干旱胁迫下Si和AMF对甘草根系的影响，以期为甘草产业的可持续发展提供参考依据。结果表明：在干旱胁迫条件下，与对照相比，甘草的根长、直径和干质量（DG）显著降低（P<0.05）。Si和AMF显著（P<0.05）增加了根面积并提高了甘草根系的定殖水平。在G40处理下，Si和AMF的交互作用显著提高了甘草酸（GA）含量(26.62 mg·g-1DG)。在严重干旱条件下，甘草的总黄酮（TF）和酚类物质（TP）含量减少，但Si和AMF显著增加了没食子酸(16.46 mg·g-1DG)和反式阿魏酸（SA）(1.11 mg·g-1DG)的含量。此外，Si和AMF的协同作用对根系中的氮（N）和磷（P）浓度产生了正向影响，分别增加了53.51%和74.07%。在低灌水条件下，根系中的磷和硅浓度显著增加，而在Si处理的植物中，钾（K）浓度在G100、G80和G40处理下也有所增加，幅度为38.5%～44.7%。综上，外源Si和AMF对改善植物生长和增强甘草代谢物积累具有协同作用，有助于减轻干旱胁迫的不利影响，为甘草产业应对干旱问题提供了重要的启示。

关键词：干旱胁迫甘草施用硅丛枝菌根真菌次生代谢

两栖动物生物活性肽对皮肤的保护作用研究进展

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皮肤病与性病 2024年第3期46卷 157-162页

作者：黄买银李哲张单李玉叶昆明医科大学第一附属医院皮肤科云南昆明650032

皮肤是人体最大的器官,具有多种生理功能,对人体健康至关重要。然而,皮肤经常面临外部环境压力,常常导致创伤、感染、炎症和肿瘤等问题。近年来,两栖动物生物活性肽因具有抗氧化、促进伤口愈合、抗感染、抗炎和抗癌等作用,在治疗皮肤损... 详细信息

皮肤是人体最大的器官,具有多种生理功能,对人体健康至关重要。然而,皮肤经常面临外部环境压力,常常导致创伤、感染、炎症和肿瘤等问题。近年来,两栖动物生物活性肽因具有抗氧化、促进伤口愈合、抗感染、抗炎和抗癌等作用,在治疗皮肤损伤中展现出巨大的研究和应用潜力,是开发皮肤科新药的宝库。本文综述了两栖动物生物活性肽对皮肤的保护作用及其未来应用的可能性,为两栖动物生物活性肽在治疗皮肤损伤方面的研究提供参考。

关键词：两栖动物生物活性肽皮肤保护抗氧化伤口愈合

Programmable Analytical Feature of Ratiometric Electrochemical Biosensor by Alternating the Binding Site of Ferrocene to DNA Duplex for the Detection of Aflatoxin B1

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Chinese Journal of Chemistry 2022年第18期40卷 2232-2238页

作者： Dong liu Fan Jia Ya Wei yuye li Shuyun Meng Tianyan You Key Laboratory of Modern Agricultural Equipment and Technology Ministry of EducationSchool of Agricultural EngineeringJiangsu UniversityZhenjiangJiangsu212013 China

Ratiometric biosensor is among the promising strategies for the advanced analysis;its applicability in multiple scenarios,however,is seriously limited for the fixed analytical ***,we reported ratiometric electrochemical biosensors with programmable analytical feature by alternating the binding site of ferrocene(Fc)to DNA duplex for the detection of aflatoxin B1(AFB1).DNA duplex was synthesized with AFB1 aptamer and its complementary DNA(cDNA)with Fc molecular tagged on aptamer or *** analysis,aptamer-AFB1 complex stripped from the electrode,and free cDNA triggered hybridization chain reaction to produce double-stranded DNA for methylene blue(MB)*** this way,redox currents of Fc(I_(Fc))and absorbed MB(I_(MB))at the electrode were collected to produce the ratiometric signal of I_(MB)/I_(Fc)as a yardstick for *** Fc was tagged on aptamer,IFc decreased with higher concentration of AFB1(C_(AFB1)),the resultant biosensor allowed detection with an On/Off(I_(MB)/I_(Fc))mode;when Fc was tagged on cDNA,I_(Fc) kept constant as C_(AFB1)varying,offering an On/Constant(I_(MB)/I_(Fc))mode for the ***,biosensor with On/Off mode showed a linear range of 0.1—100 pg/mL with a limit of detection(LOD)of 0.0650 pg/mL,while biosensor with On/Constant mode offered a wider linear rang of 1—10000 pg/mL but a relatively poor LOD of 0.330 pg/*** work revealed the vital importance of binding site of probes to DNA,and this principle can endow ratiometric biosensor with programmable analytical feature(e.g.,linear range,LOD),allowing detections in various scenarios.

关键词： Electrochemistry Biosensors Aptamers Ratiometric detection Aflatoxins

A Novel 2-dimensional Multiplex qPCR Assay for Single-Tube Detection of Nine Human Herpesviruses

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Virologica Sinica 2021年第4期36卷 746-754页

作者： Yingxue li Zhenzhou Wan Lulu Zuo Shenwei li Honglian liu Yingying Ma lianqun Zhou Xia Jin yuye li Chiyu Zhang Shanghai Public Health Clinical Center Fudan UniversityShanghai201508China CAS Key Laboratory of Bio-Medical Diagnostics Suzhou Institute of Biomedical Engineering and TechnologyChinese Academy of SciencesSuzhou215163China School of Biomedical Engineering University of Science and Technology of ChinaHefei260026China Medical Laboratory of Taizhou Fourth People's Hospital Taizhou225300China Viral Hemorrhagic Fevers Research Unit Institut Pasteur of ShanghaiChinese Academy of SciencesShanghai200031China Shanghai International Travel Healthcare Center Shanghai200335China Department of Dermatology and Venereology First Affiliated Hospital of Kunming Medical UniversityKunming650032China

Human herpesviruses are double-stranded DNA viruses that are classified into nine *** than 90%of adults are ever infected with one or more *** symptoms of infection with different herpesviruses are diverse ranging from mild or asymptomatic infections to deadly diseases such as aggressive lymphomas and *** and accurate detection of herpesvirus infection is critical for clinical management and *** this study,we established a single-tube nonuple qPCR assay for detection of all nine herpesviruses using a 2-D multiplex qPCR method with a house-keeping gene as the internal *** novel assay can detect and distinguish different herpesviruses with 30 to 300 copies per 25µL single-tube reaction,and does not cross-react with 20 other human viruses,including DNA and RNA *** robustness of the novel assay was evaluated using 170 clinical *** novel assay showed a high consistency(100%)with the single qPCR assay for HHVs *** features of simple,rapid,high sensitivity,specificity,and low cost make this assay a high potential to be widely used in clinical diagnosis and patient treatment.

关键词： Human herpesviruses(HHVs) 2-D multiplex qPCR Melting temperature(Tm) Fluorescence probe Melting curve

宿主免疫与HIV相关隐球菌性脑膜炎预后研究进展

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皮肤病与性病 2024年第3期46卷 168-171页

作者：赵树伟苏瑞李钰春董天祥李玉叶李红宾昆明医科大学第一附属医院皮肤科云南昆明650032 昆明医科大学海源学院云南昆明650106

即使在全球开展抗逆转录病毒治疗和抗真菌药物治疗背景下,HIV相关隐球菌性脑膜炎仍然是艾滋病患者死亡的重要原因。宿主免疫状态是决定HIV相关隐球菌性脑膜炎预后的关键因素,近年来宿主免疫与HIV相关隐球菌性脑膜炎预后相关性的研究取... 详细信息

即使在全球开展抗逆转录病毒治疗和抗真菌药物治疗背景下,HIV相关隐球菌性脑膜炎仍然是艾滋病患者死亡的重要原因。宿主免疫状态是决定HIV相关隐球菌性脑膜炎预后的关键因素,近年来宿主免疫与HIV相关隐球菌性脑膜炎预后相关性的研究取得一些进展,本文就宿主先天免疫、适应性免疫、中枢神经系统免疫及免疫重建综合征对HIV相关隐球菌性脑膜炎预后的影响进行综述。

关键词： HIV相关隐球菌性脑膜炎先天免疫适应性免疫中枢神经系统免疫免疫重建综合征

HIV相关隐球菌脑膜炎免疫重建综合征研究进展

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皮肤病与性病 2024年第4期46卷 245-247页

作者：苏瑞赵树伟李钰春李玉叶董天祥李红宾昆明医科大学第一附属医院皮肤科云南昆明650032 昆明医科大学海源学院云南昆明650106

免疫重建综合征是HIV相关隐球菌脑膜炎常见的并发症,该并发症的发生增加了HIV相关隐球菌脑膜炎的死亡率。目前,对于HIV相关隐球菌脑膜炎免疫重建综合征的发病机制尚不清楚,给该病的防治带来了困难。本文综述了HIV相关隐球菌脑膜炎免疫... 详细信息

免疫重建综合征是HIV相关隐球菌脑膜炎常见的并发症,该并发症的发生增加了HIV相关隐球菌脑膜炎的死亡率。目前,对于HIV相关隐球菌脑膜炎免疫重建综合征的发病机制尚不清楚,给该病的防治带来了困难。本文综述了HIV相关隐球菌脑膜炎免疫重建综合征发病机制、危险因素及诊疗新进展。

关键词： HIV相关隐球菌脑膜炎免疫重建综合征发病机制危险因素诊断与处理

云南省文山州2013-2022年新发麻风患者残疾情况及影响因素分析

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中国皮肤性病学杂志 2024年第9期38卷 994-999页

作者：甘丽平陶思铮杨溪张春雨尹丽娇罗红叶李玉叶昆明医科大学第一附属医院皮肤性病科云南昆明650032 文山壮族苗族自治州皮肤病防治所皮肤性病科云南文山663000

目的了解文山州新发麻风病例残疾情况及其影响因素,为减少麻风残疾发生、减小麻风危害提供理论依据。方法以云南省文山州2013—2022年确诊的所有麻风患者为研究对象,收集患者的流行病学信息及病例资料。建立Excel数据库,采用SPSS26.0软... 详细信息

目的了解文山州新发麻风病例残疾情况及其影响因素,为减少麻风残疾发生、减小麻风危害提供理论依据。方法以云南省文山州2013—2022年确诊的所有麻风患者为研究对象,收集患者的流行病学信息及病例资料。建立Excel数据库,采用SPSS26.0软件对数据进行分析。结果共收集366例新发麻风病例资料,其中64例发生残疾,残疾率为17.49%,1级残疾率6.28%,2级残疾率11.20%。目前皮肤科门诊发现仍为麻风患者的主要发现方式(49.80%),诊断延迟期>2年、少菌型麻风(PB)是麻风患者发生残疾的危险因素(P2年及PB患者有更高的残疾发生风险,医疗机构应加强对麻风疑似症状的筛查,早发现、早诊断、早治疗,减少麻风延迟诊断,降低新发麻风发生残疾比例,提高麻风患者生活质量。

关键词：云南文山麻风残疾影响因素