Delayed excitatory self-feedback-induced negative responses of complex neuronal bursting patterns

作     者：Ben Cao Huaguang Gu Yuye Li 曹奔;古华光;李玉叶

作者机构：School of Aerospace Engineering and Applied MechanicsTongji UniversityShanghai 200092China College of Mathematics and Computer ScienceChifeng UniversityChifeng 024000China Institute of Applied MathematicsChifeng UniversityChifeng 024000China 

出 版 物：《Chinese Physics B》 (中国物理B（英文版）)

年 卷 期：2021年第30卷第5期

页      面：236-246页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 08[工学] 

基　　金：the National Natural Science Foundation of China(Grant Nos.11872276 and 11762001) the Young Talents of Science and Technology in Universities of Inner Mongolia Autonomous Region,China(Grant No.NJYT-20-A09) 

主　　题：bifurcation bursting excitatory autapse time delay 

摘      要：In traditional viewpoint,excitatory modulation always promotes neural firing *** contrary,the negative responses of complex bursting behaviors to excitatory self-feedback mediated by autapse with time delay are acquired in the present *** representative bursting patterns which are identified respectively to be“Fold/Big Homoclinicbursting and“Circle/Fold cyclebursting with bifurcations are *** both burstings,excitatory modulation can induce less spikes per burst for suitable time delay and strength of the self-feedback/autapse,because the modulation can change the initial or termination phases of the *** the former bursting composed of quiescent state and burst,the mean firing frequency exhibits increase,due to that the quiescent state becomes much shorter than the ***,for the latter bursting pattern with more complex behavior which is depolarization block lying between burst and quiescent state,the firing frequency manifests decrease in a wide range of time delay and strength,because the duration of both depolarization block and quiescent state becomes ***,the decrease degree of spike number per burst is larger than that of the bursting period,which is the cause for the decrease of firing *** reduced bursting activity is explained with the relations between the bifurcation points of the fast subsystem and the bursting *** present paper provides novel examples of paradoxical phenomenon that the excitatory effect induces negative responses,which presents possible novel modulation measures and potential functions of excitatory self-feedback/autapse to reduce bursting activities.