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NIR-triggered on-site NO/ROS/RNS nanoreactor:Cascade-amplified photodynamic/photothermal therapy with local and systemic immune responses activation

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Opto-Electronic Advances 2024年第6期7卷 58-73页

作者： Ziqing Xu Yakun Kang Jie zhang Jiajia Tang Hanyao Sun Yang Li Doudou He Xuan Sha yuxia Tang Ziyi Fu Feiyun Wu Shouju Wang Laboratory of Molecular Imaging Department of RadiologyThe First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China Department of Breast Surgery The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China Department of Women&Children Research Center The First Affiliated HospitalNanjing Medical UniversityNanjing 210029China

Photothermal and photodynamic therapies(PTT/PDT)hold promise for localized tumor treatment,yet their full potential is hampered by limitations such as the hypoxic tumor microenvironment and inadequate systemic immune *** these challenges,we present a novel near-infrared(NIR)-triggered RNS nanoreactor(PBNO-Ce6)to amplify the photodynamic and photothermal therapy efficacy against triple-negative breast cancer(TNBC).The designed PBNOCe6 combines sodium nitroprusside-doped Prussian Blue nanoparticles with Chlorin e6 to enable on-site RNS production through NIR-induced concurrent NO release and ROS *** not only enhances tumor cell eradication but also potentiates local and systemic antitumor immune responses,protecting mice from tumor *** in vivo evaluations revealed that treatment with PBNO-Ce6 leads to a remarkable 2.7-fold increase in cytotoxic T lymphocytes and a 62%decrease in regulatory T cells in comparison to the control PB-Ce6(Prussian Blue nanoparticles loaded with Chlorin e6),marking a substantial improvement over traditional PTT/*** such,the PBNO-Ce6 nanoreactor represents a transformative approach for improving outcomes in TNBC and potentially other malignancies affected by similar barriers.

关键词： photothermal therapy photodynamic therapy nitric oxide reactive nitrogen species triple-negative breast cancer immune response nanoreactor

19世纪60年代北高加索穆斯林山民向土耳其移民的动因分析——基于“推-拉理论”的分析视角

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世界民族 2018年第6期 88-95页

作者：张玉霞西北师范大学历史文化学院

高加索战争结束后,北高加索穆斯林山民大规模向土耳其移民是诸多因素相互作用导致的结果,其中包括高加索战争带来的影响、北高加索土地问题的尖锐化、俄国当局的推动、土耳其和英国等国密使在山民中进行的反俄宣传、山区封建主的威逼利... 详细信息

高加索战争结束后,北高加索穆斯林山民大规模向土耳其移民是诸多因素相互作用导致的结果,其中包括高加索战争带来的影响、北高加索土地问题的尖锐化、俄国当局的推动、土耳其和英国等国密使在山民中进行的反俄宣传、山区封建主的威逼利诱等。在"推力"与"拉力"相互作用中,前者是主要的,即沙皇政府在北高加索推行的殖民政策是导致大规模移民现象产生的最重要因素。

关键词：北高加索穆斯林山民移民土耳其

Microscopic characteristics and geological significance of pyrite in shales of the Wufeng-Longmaxi formations,southeastern Chongqing,China

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Energy Geoscience 2024年第3期5卷 203-211页

作者： Xiao Cai Wei Xia yuxia Liu Shunzhou Liao Lei zhang Weixue Hu Li Liu Wei Li Fanwu Zeng Research Institute of Exploration and Development East China Oil and Gas CompanyYangzhou225007China

Shales of the Wufeng-Longmaxi formations in the basin-margin transition zone of southeastern Chongqing,China are characterized by high organic matter content and a significant presence of pyrite *** examining numerous scanning electron microscope(SEM)images and considering the crystal and aggregate characteristics of minerals,we identified four types of pyrite in the study area:euhedral crystals,irregular aggregates,framboidal aggregates,and metasomatized *** these types,framboidal aggregates are the most *** formation mechanism of framboidal pyrite can be categorized into inorganic and organic *** inferred from the pyrite characteristics in the study area,the formation mechanism of the metasomatized organisms aligns with the biologically induced mineralization mode of organic origin,whereas the framboidal aggregates are more associated with the biologically controlled mineralization mode of organic *** underscores a close relationship between the pyrite formation and organic matter,which in turn indicates that an organic origin is more consistent with the pyrite characteristics observed in this study *** pyrite morphology can reflect reactive iron *** pyrite crystals tend to form under a low reactive iron concentration,whereas the formation of framboidal pyrite requires a high reactive iron ***,the type and grain size of pyrite aggregates can reflect variations in the redox conditions of the depositional *** produces positive effects on reservoir storage space,with intercrystalline organic pores,intercrystalline pores,and mold pores associated with pyrite contributing greatly to the storage spaces.

关键词： Wufeng-Longmaxi formations Shale Pyrite Microscopic characteristics Geological significance

Unanchored ubiquitin chain sustains RIG-I-induced interferon-I activation and controls selective gene expression

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Science Bulletin 2021年第8期66卷 794-802,M0004页

作者： Huifang Xian Wanming Huang Tingzhe Sun Shuai Yang Chuanxia zhang Jun Wang yuxia zhang Jun Cui MOE Key Laboratory of Gene Function and Regulation State Key Laboratory of BiocontrolSchool of Life SciencesSun Yat-sen UniversityGuangzhou 510275China Department of Gastroenterology Guangzhou Institute of PediatricsGuangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangzhou 510623China School of Life Sciences Anqing Normal UniversityAnqing 246133China

Ubiquitination plays a crucial role in retinoic acid-inducible gene I(RIG-I)-induced antiviral ***, the precise regulatory mechanisms of RIG-I activity mediated by conjugated and unanchored ubiquitin chains remain to be determined. In this study, we discovered that T55 of RIG-I was required for its binding ability for the unanchored ubiquitin chains. Experimental and mathematical analysis showed that unanchored ubiquitin chains associated with RIG-I were essential for sustained activation of type I interferon(IFN) signaling. Transcriptomics study revealed that the binding of RIG-I with unanchored ubiquitin chains additionally regulated the expression of a subset of metabolic and cell fate decision genes. Moreover, we found that ubiquitin-specific peptidase 21(USP21) and USP3 deubiquitinate conjugated and unanchored ubiquitin chains on RIG-I respectively. Taken together, characterization of the regulation mode and functions of conjugated ubiquitination and the unconjugated ubiquitin chainbinding of RIG-I may provide means to fine-tune RIG-I-mediated type I IFN signaling.

关键词： Antiviral immunity Type I interferon Ubiquitination RIG-I Unanchored ubiquitin chains Cellular homeostasis

认知性访谈在患者护理服务体验量表编制中的应用

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中华护理杂志 2022年第1期57卷 83-89页

作者：陈潇张玉侠复旦大学附属中山医院护理部上海市200032

目的探讨认知性访谈在患者护理服务体验量表编制中的应用。方法在患者护理服务体验概念框架的指导下,通过患者访谈、专家函询形成初测量表。采用目的抽样选取2021年2月—4月就诊于上海市某三级甲等综合医院的23例住院患者作为访谈对象,... 详细信息

目的探讨认知性访谈在患者护理服务体验量表编制中的应用。方法在患者护理服务体验概念框架的指导下,通过患者访谈、专家函询形成初测量表。采用目的抽样选取2021年2月—4月就诊于上海市某三级甲等综合医院的23例住院患者作为访谈对象,共进行3轮认知性访谈,了解使用人群对量表各条目的理解情况及建议,并结合访谈结果,通过专家小组讨论,在不改变句意的基础上对条目进行修订。修订后通过方便抽样法选取427例于2021年5月—6月在复旦大学附属中山医院就诊的住院患者进行测量学检验,通过项目分析和探索性因子分析,找出量表潜在结构。结果第1轮访谈结果显示,8个条目句意模糊、表达不清,进行修订;第2轮访谈结果显示,1个条目关键词难以理解,进行修订;第3轮访谈结果显示,受访者能够正确理解条目。最终正式量表包括7个维度,分别为出入院管理、信息与教育、情感支持、病情观察与处理、安全与隐私、应答需求、沟通与协调,累计方差贡献率为70.785%。量表的Cronbach’sα系数为0.945,平均内容效度指数为0.959,具有良好的信效度。结论通过采用认知性访谈,了解目标人群对患者护理服务体验量表各条目的理解情况,有效解决了量表编制过程中的理解差异及测量误差问题,提高了患者护理服务体验测评量表的科学性、准确性与适用性。

关键词：患者体验量表编制认知性访谈护理管理研究

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科技时代下的护理融合、创新与展望

科技导报 2020年第10期38卷 78-81页

作者：张玉侠复旦大学附属中山医院护理部上海200032

科学技术与护理人文关怀要实现融合发展与协同创新,亟需在人才培养、技术合作等方面进行新的突破和探索。当前全球人口老龄化、环境改变和新发传染病不断暴发,世界比以往任何时候都更需要护士充分运用教育和培训的手段更新知识,提升能力... 详细信息

科学技术与护理人文关怀要实现融合发展与协同创新,亟需在人才培养、技术合作等方面进行新的突破和探索。当前全球人口老龄化、环境改变和新发传染病不断暴发,世界比以往任何时候都更需要护士充分运用教育和培训的手段更新知识,提升能力,促进科技和护理人文关怀的融合,让更有人文关怀的最新、最强科技服务于人类生命周期的全过程。

关键词：科学技术护理人文关怀

Recovery of Flavor Perception and Umami Taste Sensitivity in Young Chinese Adults Following SARS-CoV-2 Omicron Infection: A Case-Control Series

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Food Science and Human Wellness 2024年

作者： Yiwen Zhu Xiaoxiao Feng yuxia Fan Yin zhang Ye Liu Yuan Liu Department of Food Science & Technology， School of Agriculture & Biology， Shanghai Jiao Tong University Key Laboratory of Meat Processing of Sichuan， Chengdu University Beijing Engineering and Technology Research Center of Food Additives， School of Food and Health， Beijing Technology and Business University School of Food and Health， Beijing Technology and Business University

SARS-CoV-2， particularly the Omicron variant， often leads to flavor perception dysfunction in infected individuals， making a comprehensive understanding of its duration and recovery patterns a critical part of disease management. This study surveyed a cohort of 199 mildly-to-moderately affected SARS-CoV-2 Omicron-infected patients， focusing on the alterations in their olfaction， taste， and chemesthesis perception. Further， a subset of 36 participants (18 healthy and 18 infected) underwent sensory evaluations to check the variation of umami taste sensitivity. The results demonstrated that most of the infected cohort experienced chemosensory disorders， with the recovery period varying between one week and over a month. Intriguingly， the severity of flavor perception changes during infection significantly correlated with the length of the recovery period. Furthermore， this study explored the specific manifestations of flavor perception dysfunction， potential contributing factors， and potential mechanistic explanations for chemosensory disorders. These include local damage， inflammatory responses， and virus-induced neural damage. However， this study revealed no significant change (P > 0.05) in umami taste sensitivity among infected patients 55 days post-infection. While this research faces limitations related to its self-reported， cross-sectional design， and regional focus， it offers valuable insights into the multifaceted impact of COVID-19， particularly the Omicron variant， on chemosensory perception.

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从遁世到经世:明遗民图像中桃源意象的蜕变

美术学报 2020年第3期 104-110页

作者：张玉霞宿州学院

明清鼎革巨变,陶渊明笔下的桃花源成为明遗民画家反复称引和尊崇的对象。明遗民画家对于桃花源的表现经历了"再现桃源→隐寓桃源→隐居山水"的蜕变。桃花源主题表现内容的蜕变,反映了明遗民画家由遁世到经世的思想转变,体现出汉族士人... 详细信息

明清鼎革巨变,陶渊明笔下的桃花源成为明遗民画家反复称引和尊崇的对象。明遗民画家对于桃花源的表现经历了"再现桃源→隐寓桃源→隐居山水"的蜕变。桃花源主题表现内容的蜕变,反映了明遗民画家由遁世到经世的思想转变,体现出汉族士人尤其是江南士人拥有高度的文化优越感,抒发了他们在长期文化政治高压政策下所郁积的愤懑之情。这种蜕变既是明遗民画家精神自救的尝试,又是明遗民画家身处绝境而不放弃儒者身份,以天下为己任的责任感与使命感的外在呈现。

关键词：明遗民桃花源隐居山水精神自救经世致用

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可见波段超快脉冲激光研究进展

中国激光 2019年第5期46卷 126-135页

作者：张玉霞于浩海张怀金山东大学晶体材料研究所晶体材料国家重点实验室

超快脉冲激光因具有超短的响应时间及较高的峰值功率而在激光加工及强场物理学等领域有重要应用。随着蓝光激光二极管及掺杂镨离子激光增益介质的发展,可见波段超快脉冲激光迅速发展,主要综述了可见波段超快脉冲激光的研究进展及现状,... 详细信息

超快脉冲激光因具有超短的响应时间及较高的峰值功率而在激光加工及强场物理学等领域有重要应用。随着蓝光激光二极管及掺杂镨离子激光增益介质的发展,可见波段超快脉冲激光迅速发展,主要综述了可见波段超快脉冲激光的研究进展及现状,详细描述了克尔透镜锁模、高重复频率吉赫兹自锁模及基于可饱和吸收体的锁模等技术在可见光波段的应用,并展望了可见波段超快激光的发展方向及前景。

关键词：非线性光学超快光学可见激光锁模