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Synergistic coupling among Mg_(2)B_(2)O_(5),polycarbonate and N,Ndimethylformamide enhances the electrochemical performance of PVDF-HFP-based solid electrolyte

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Journal of Energy Chemistry 2024年第7期94卷 158-168页

作者： yutong jing Qiang Lv Yujia Chen Bo Wang Bochen Wu Cheng Li Shengbo Yang Zhipeng He Dianlong Wang Huakun Liu Shixue Dou MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage State Key Laboratory of Urban Water Resource and EnvironmentSchool of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbin 150001HeilongjiangChina Institute of Energy Material Science University of Shanghai for Science and TechnologyShanghai 200093China Institute for Superconducting&Electronic Materials Australian Institute of Innovative MaterialsUniversity of WollongongWollongongNSW 2500Australia

Polymer solid electrolytes(SPEs)based on the[solvate-Li+]complex structure have promising prospects in lithium metal batteries(LMBs)due to their unique ion transport mechanism.However,the solvation structure may compromise the mechanical performance and safety,hindering practical application of SPEs.In this work,a composite solid electrolyte(CSE)is designed through the organic-inorganic syner-gistic interaction among N,N-dimethylformamide(DMF),polycarbonate(PC),and Mg_(2)B_(2)O_(5) in poly(vinylidene fluoride-co-hexafluoropropylene)(PVDF-HFP).Flame-retardant Mg_(2)B_(2)O_(5) nanowires provide non-flammability to the prepared CSEs,and the addition of PC improves the dispersion of Mg_(2)B_(2)O_(5) nanowires.Simultaneously,the organic-inorganic synergistic action of PC plasticizer and Mg_(2)B_(2)O_(5) nanowires pro-motes the dissociation degree of LiTFSI and reduces the crystallinity of PVDF-HFP,enabling rapid Li ion transport.Additionally,Raman spectroscopy and DFT calculations confirm the coordination between Mg atoms in Mg_(2)B_(2)O_(5) and N atoms in DMF,which exhibits Lewis base-like behavior attacking adjacent C-F and C-H bonds in PVDF-HFP while inducing dehydrofluorination of PVDF-HFP.Based on the syner-gistic coupling of Mg_(2)B_(2)O_(5),PC,and DMF in the PVDF-HFP matrix,the prepared CSE exhibits superior ion conductivity(9.78×10^(-4) s cm^(-1)).The assembled Li symmetric cells cycle stably for 3900 h at a current density of 0.1 mA cm^(-2) without short circuit.The LFP||Li cells assembled with PDL-Mg_(2)B_(2)O_(5)/PC CSEs show excellent rate capability and cycling performance,with a capacity retention of 83.3%after 1000 cycles at 0.5 C.This work provides a novel approach for the practical application of organic-inorganic Synergistic CSEs in LMBs.

关键词： Composite solid electrolytes Safe Li metal batteries Synergistic coupling effect Poly(vinylidene fluoride-co-hexafluoropro pylene)

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Recent advances in cathodes for all-solid-state lithium-sulfur batteries

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Chinese Chemical Letters 2023年第7期34卷 58-69页

作者： Shengbo Yang Bo Wang Qiang Lv Nan Zhang Zekun Zhang yutong jing Jinbo Li Rui Chen Bochen Wu Pengfei Xu Dianlong Wang MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage State Key Laboratory of Urban Water Resource and EnvironmentSchool of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbin 150001China

Lithium-sulfur(Li-S)batteries have been regarded as the candidate for the next-generation energy storage system due to the high theoretical specific capacity(1675 m Ah/g), energy density(2600 Wh/kg)and the abundance of elemental sulfur, but the application of Li-S batteries is impeded by a series of problems. Recently, all-solid-state Li-S batteries(ASSLSBs) have drawn great attention because many drawbacks such as safety issues caused by metallic lithium anodes and organic liquid electrolytes can be overcome through the use of solid-state electrolytes(SEs). However, not only the problems brought by sulfur cathodes still exist, but more trouble arouses from the interfaces between SEs and cathodes, hampering the practical application of ASSLSBs. Therefore, in order to deal with the problems, enormous endeavors have been done on ASSLSB cathodes during the past few decades, including engineering of cathode active materials, cathode host materials, cathode binder materials and cathode structures. In this review, the electrochemical mechanism and existing problems of ASSLSBs are briefly introduced. Subsequently, the strategies for developing cathode materials and designing cathode structures are presented. Then there follows a brief discussion of SE problems and expectations, and finally, the challenges and perspectives of ASSLSBs are summarized.

关键词： All-solid-state Li-S battery Cathode active material Cathode host material Cathode structure Solid-state electrolyte

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Bifunctional flame retardant solid-state electrolyte toward safe Li metal batteries

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能源化学:英文版 2023年第6期81卷 613-622,I0014页

作者： Qiang Lv Yajie Song Bo Wang Shangjie Wang Bochen Wu yutong jing Huaizheng Ren Shengbo Yang Lei Wang Lihui Xiao Dianlong Wang Huakun Liu Shixue Dou MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage State Key Laboratory of Urban Water Resource and EnvironmentSchool of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbin 150001HeilongjiangChina School of Chemistry and Chemical Engineering Harbin Institute of TechnologyHarbin 150001HeilongjiangChina Institute for Superconducting&Electronic Materials Australian Institute of Innovative MaterialsUniversity of WollongongWollongongNSW 2500Australia Institute of Energy Material Science University of Shanghai for Science and TechnologyShanghai 200093China

Solid polymer electrolytes(SPEs)are one of the most promising alternatives to flammable liquid electrolytes for building safe Li metal batteries.Nevertheless,the poor ionic conductivity at room temperature(RT)and low resistance to Li dendrites seriously hinder the commercialization of SPEs.Herein,we design a bifunctional flame retardant SPE by combining hydroxyapatite(HAP)nanomaterials with Nmethyl pyrrolidone(NMP)in the PVDF-HFP matrix.The addition of HAP generates a hydrogen bond network with the PVDF-HFP matrix and cooperates with NMP to facilitate the dissociation of Li TFSI in the PVDF-HFP matrix.Consequently,the prepared SPE demonstrates superior ionic conductivity at RT,excellent fireproof properties,and strong resistance to Li dendrites.The assembled Li symmetric cell with prepared SPE exhibits a stable cycling performance of over 1200 h at 0.2 m A cm^(-2),and the solid-state LiFePO_4||Li cell shows excellent capacity retention of 85.3%over 600 cycles at 0.5 C.

关键词： Solid polymer electrolytes Safe Li metal batteries Li dendrites Hydroxyapatite N-methyl pyrrolidone PVDF-HFP Fireproof property

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Mitochondrial sensitive probe with aggregation-induced emission characteristics for early brain diagnosis of Parkinson’s disease

Aggregate

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Aggregate 2024年第1期5卷 216-227页

作者： Liwen Huang yutong Zhou Di Jiao jing Ren Yilin Qi Heping Wang Yang Shi Dan Ding Xue Xue State Key Laboratory of Medicinal Chemical Biology College of PharmacyNankai UniversityTianjinP.R.China State Key Laboratory of Medicinal Chemical Biology Key Laboratory of Bioactive MaterialsMinistry of Educationand College of Life SciencesNankai UniversityTianjinP.R.China

The early diagnosis of Parkinson’s disease(PD)provides opportunities for early intervention to slow the progression of neurological degeneration in patients,particularly as the aging population increases in our society.Among a series of pathological features of PD,mitochondria abnormalities have been identified as central event that occurs at the early stage of PD.However,the method for detecting mitochondrial abnormalities-associated early PD has not been fully developed.We herein report a specifically mitochondrial targeting probe(named TPA-BT-SCP)that is able to characterize mitochondria abnormalities for early diagnosis of PD and monitor PD neurodegenerative progress.The probe is an aggregation-induced emission(AIE)probe with a strong positive charge,a 3D distorted molecular structure,and a separated HOMO-LUMO distribution,designed with unique molecular design guidelines.Our research demonstrated that TPA-BT-SCP could emit stable and strong fluorescence,and rapidly accumulate in mitochondria due to the negative charge.After intranasal administration of 1-methy-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)-induced PD mice,TPA-BT-SCP successfully bypassed the blood−brain barrier to light up the brain,allowing the grading of PD severity based on its high sensitivity.Taken together,this work develops a novel AIE probe that exhibits dramatically high sensitivity to mitochondrial changes and enables noninvasive diagnosis of early PD in the brain.

关键词： aggregation-induced emission early diagnosis Parkinson’s disease

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First-in-human Results of the Novel Transcatheter Mitral Valve Repair System for Severe Mitral Regurgitation

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Cardiology Discovery 2024年第2期4卷 148-159页

作者： Zhi-Nan Lu yutong Ke Yingnan Bian jing He Wenhui Wu Xinmin Liu Yang Li Ran Liu Taiyang Luo Xunan Guo Guangyuan Song Interventional Center of vavular Heart Disease Beijing Anzhen HospitalCapital Medical UniversityBeijing 100029China Echocardiography Department Bejing Anzhen HospitalCapital Medical UniversityBeijing 100029China Research and Development Department Enlight MedicalShanghai 201209China

Objective:To evaluate the feasibility,safety,and effectiveness of a novel edge-to-edge mitral valve repair system(the NovoClasp system)in patients with severe mitral regurgitation.Methods:In this prospective,single-arm,first-in-human study conducted at Beijing Anzhen Hospital,data were collected from patients undergoing transcatheter edge-to-edge repair using the NovoClasp system.The study candidates were patients exhibiting a mitral regurgitation severity of 3+or more and were at high-risk or contraindicated for surgical intervention.Technical success and device success according to the Mitral Valve Academic Research Consortium definitions were used as primary outcomes.Other safety and efficacy outcomes were prospectively assessed at device implantation,discharge,and 30 d,6 months,and 12 months post-procedure.Results:Between October 1,2021,and January 31,2022,11 patients were treated for moderate-to-severe(grade 3+)or severe(grade 4+)mitral regurgitation using the NovoClasp system.All patients had a baseline New York Heart Association functional class oflll-lIV,with 7/11 exhibiting complex mitral valve disease.All patients achieved the primary endpoints of technical and device success,with a post-operative 30-d mitral regurgitation grade reduction to 2+or lower,which was maintained at 12 months.One patient had minor bleeding and hematoma at the access site before discharge,and 2 patients were readmitted due to fast atrial fibrillation within 12 months post-discharge.No additional cases of death,adverse cerebral or cardiovascular events,or device-related complications was observed during the follow-up.Conclusion:This study suggested the potential feasibility and safety of the NovoClasp system,showing a promising technical and device success rate,along with a decrease in mitral regurgitation severity.A further pivotal study is needed to assess the procedural and long-term outcomes.

关键词： Mitral valve insufficiency Transcatheter edge-to-edge repair Feasibility Safety

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果胶酶与半纤维素酶复合酶解制备费约果果汁的工艺优化

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食品工业科技 2024年第3期45卷 179-186页

作者：李远蓬朱棚伟何慧谢雨彤翁静陈其阳王丹西南科技大学生命科学与工程学院四川绵阳621010

为减少费约果细胞壁中果胶和半纤维素等物质对果汁品质的负面影响,提高果汁出汁率,本文研究了复合酶(半纤维素酶和果胶酶)比例、加酶量、温度、时间对“Unique U-100”费约果果汁出汁率和可溶性固形物的影响。在单因素实验的基础上,进... 详细信息

为减少费约果细胞壁中果胶和半纤维素等物质对果汁品质的负面影响,提高果汁出汁率,本文研究了复合酶(半纤维素酶和果胶酶)比例、加酶量、温度、时间对“Unique U-100”费约果果汁出汁率和可溶性固形物的影响。在单因素实验的基础上,进行四因素三水平的响应面优化。结果显示:在复合酶(半纤维素酶/果胶酶)比例为2.14:1,加酶量19.6 g/L,酶解温度56.8℃,酶解时间92 min的条件下,费约果果实出汁率最高,为79.5%,与模型预测值相对误差为5.67%;果汁中可溶性固形物含量为15.7%,与模型预测值相对误差为0.83%。此外,与直接压榨的费约果果汁相比,酶解后的果汁表现出更高的澄清度、总酚含量(24.4 mg GAE/100 g)和VC含量(2.42 mg/100 g)。因此,本研究优化了复合酶酶解制备费约果果汁的工艺,提高费约果果汁出汁率和营养品质,可为后续费约果果汁深加工提供理论依据。

关键词：费约果果汁果胶酶半纤维素酶工艺优化

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重组抗CD25人源化单克隆抗体挽救性治疗糖皮质激素耐药型急性移植物抗宿主病64例疗效分析

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中华血液学杂志 2023年第9期44卷 755-761页

作者：吴雅雪吴德沛马骁姜珊珊侯梦佳景雨童刘彬李茜王杏吴源兵胡晓慧苏州弘慈血液病医院苏州215000 苏州大学附属第一医院江苏省血液研究所国家血液系统疾病临床医学研究中心国家卫生健康委员会血栓与止血重点实验室苏州215006

目的分析重组抗CD25人源化单克隆抗体(人源化CD25单抗)治疗异基因造血干细胞移植后糖皮质激素耐药型急性移植物抗宿主病(SR-aGVHD)的疗效。方法纳入2019年6月至2020年10月在苏州弘慈血液病医院接受人源化CD25单抗治疗的64例异基因造血... 详细信息

目的分析重组抗CD25人源化单克隆抗体(人源化CD25单抗)治疗异基因造血干细胞移植后糖皮质激素耐药型急性移植物抗宿主病(SR-aGVHD)的疗效。方法纳入2019年6月至2020年10月在苏州弘慈血液病医院接受人源化CD25单抗治疗的64例异基因造血干细胞移植后SR-aGVHD患者,所有患者予人源化CD25单抗1 mg·kg^(-1)·d^(-1)第1、3、8天各1次,此后根据病情每周1次。在人源化CD25单抗治疗后第7、14、28天进行疗效评估。结果64例患者中男38例(59.4%),女26例(40.6%),中位年龄31(15~63)岁。64例SR-aGVHD患者人源化CD25单抗治疗后第7、14、28天有效率分别为48.4%(31/64)、53.1%(34/64)、79.7%(51/64)。肝脏受累是人源化CD25单抗治疗SR-aGVHD第28天疗效不佳的独立危险因素(OR=9.588,95%CI 0.004~0.291,P=0.002)。从人源化CD25单抗治疗开始随访,所有患者的中位随访时间为17.1(0.2~50.8)个月。治疗后12、24个月总生存率分别为63.2%(95%CI 57.1%~69.3%)、52.6%(95%CI 46.1%~59.1%),无病生存率分别为58.4%(95%CI 52.1%~64.7%)、49.8%(95%CI 43.4%~56.2%),非复发死亡率分别为28.8%(95%CI 23.1%~34.5%)、32.9%(95%CI 26.8%~39.0%)。多因素分析结果显示,肝脏受累(OR=0.308,95%CI 0.108~0.876,P=0.027)和Ⅲ/Ⅵ度aGVHD(OR=9.438,95%CI 1.211~73.577,P=0.032)是影响移植后总生存的独立危险因素。结论人源化CD25单抗对于异基因造血干细胞移植后SR-aGVHD有较好的疗效。

关键词：造血干细胞移植急性移植物抗宿主病重组抗CD25人源化单克隆抗体

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RHOBTB2基因突变诱发的癫痫性脑病1例报告及文献复习

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南京医科大学学报（自然科学版） 2024年第2期44卷 287-292页

作者：宋语桐陈静郝晶程志强潘晨缪红军葛许华南京医科大学附属儿童医院急诊与重症医学科江苏南京210008 南京医科大学附属儿童医院神经内科江苏南京210008

癫痫性脑病(epileptic encephalopathy,EE)是以顽固性癫痫发作和脑电活动严重异常为主要特征的一组疾病综合征。儿童期间起病的EE通常还伴有精神运动发育迟缓或倒退。2017年国际抗癫痫联盟(International League Against Epilepsy,ILAE... 详细信息

癫痫性脑病(epileptic encephalopathy,EE)是以顽固性癫痫发作和脑电活动严重异常为主要特征的一组疾病综合征。儿童期间起病的EE通常还伴有精神运动发育迟缓或倒退。2017年国际抗癫痫联盟(International League Against Epilepsy,ILAE)对癫痫分类进行更新,强调使用发育性和癫痫性脑病这一术语,EE用于在癫痫发生前没有发育落后,而且基因突变本身也不会导致发育迟缓的情况,发育性和癫痫性是发挥作用的两个因素[1]。

关键词： RHOBTB2基因癫痫癫痫性脑病儿童

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住院患儿肺炎支原体肺炎大环内酯类耐药情况及临床诊治

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临床儿科杂志 2024年第3期42卷 182-186,192页

作者：顾雨瞳杨芬叶剑敏华丽李菁丁国栋上海交通大学医学院附属新华医院儿童呼吸科上海200092

目的总结2023年4月至10月呼吸科住院儿童肺炎支原体(MP)感染流行病学特征和耐药率,并分析该段时期肺炎支原体肺炎(MPP)临床及治疗特征。方法采集社区获得性肺炎患儿住院当日咽拭子标本,行tNGS病原体及MP大环内酯类耐药基因突变检测,分... 详细信息

目的总结2023年4月至10月呼吸科住院儿童肺炎支原体(MP)感染流行病学特征和耐药率,并分析该段时期肺炎支原体肺炎(MPP)临床及治疗特征。方法采集社区获得性肺炎患儿住院当日咽拭子标本,行tNGS病原体及MP大环内酯类耐药基因突变检测,分析MP阳性率及大环内酯类耐药率。MPP患儿根据所处月份分为平日组(6月)和流行高峰组(9月);根据是否检出大环内酯类耐药基因分为敏感组和耐药组,比较各组间患儿临床特征。将耐药组分为平日耐药组和流行高峰耐药组,比较两组间治疗差异。结果在1 425例社区获得性肺炎患儿中,男686例、女739例,中位年龄为6(3~8)岁。MP阳性率57.1%(813例)。4至10月各月份间MP阳性率差异有统计学意义(P<0.001),MP阳性率逐月上升(12.5%~71.6%)。813例MPP住院患儿中627例检出大环内酯类耐药基因突变,MP总耐药率为77.1%。MP非流行期(4~6月)的耐药率93.9%,流行高峰期(8~10月)耐药率显著降低,为71.9%。4至10月各月份间MP耐药率差异有统计学意义(P<0.001)。平日组76例,流行高峰组189例。与平日组相比,流行高峰组住院天数延长,CRP和LDH水平更高,差异有统计学意义(P<0.05)。敏感组64例,耐药组201例。与敏感组相比,耐药组住院天数延长,LDH水平更高,差异有统计学意义(P<0.05)。201例耐药MPP患儿中,平日耐药组71例,流行高峰耐药组130例。与平日耐药组相比,流行高峰耐药组应用甲基泼尼松龙后退热所需时间更长,四环素类抗生素使用率更高,差异有统计学意义(P<0.05)。结论 2023年8—10月为MP流行高峰,感染率高于平日,但住院患儿的MP耐药率低于平日。与平日相比,流行高峰期的MPP免疫应答反应更强,表现为更长的住院时间和更高的炎症指标,需考虑存在新突变的可能。大环内酯类联合糖皮质激素治疗对流行高峰期耐药MPP治疗效果欠佳,需要加用四环素类药物控制感染。

关键词：肺炎支原体肺炎耐大环内酯类肺炎支原体流行病学临床特征治疗

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融合光学椭率判据的自由曲面望远镜设计方法

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光子学报 2024年第3期53卷 74-90页

作者：黄静许宁晏邹宇通乔文佑伦旭磊孔梅梅陆辰熙高志山袁群南京理工大学电子工程与光电技术学院南京210094 南京邮电大学电子与光学工程学院、柔性电子(未来技术)学院南京210023

光学椭率是联系天文望远镜光学设计与暗物质探测科学目标的一项核心性能指标,然而目前还没有将椭率作为指标融入光学系统优化设计过程的完整方法。提出了一种融合光学椭率判据的自由曲面望远镜光学设计方法,依据椭率与彗差、像散等非旋... 详细信息

光学椭率是联系天文望远镜光学设计与暗物质探测科学目标的一项核心性能指标,然而目前还没有将椭率作为指标融入光学系统优化设计过程的完整方法。提出了一种融合光学椭率判据的自由曲面望远镜光学设计方法,依据椭率与彗差、像散等非旋转对称像差的关系,提出了椭率关联性较强的像差分量优先校正原则,开拓了主要离轴像差校正后通过MZDDE在评价函数中融入椭率判据的设计思想,结合离轴三反系统中像差节点与椭率节点在优化过程中的演变规律,建立了自由曲面面型Zernike项的优化策略。据此设计了离轴三反自由曲面天文望远镜,系统有效焦距为600 mm,口径为200 mm,视场为4°×4°。通过波像差和椭率的联合优化,成像像质及光学椭率得到了同步有效控制,波像差近衍射极限,椭率最大值为0.030 3,平均值为0.015 6。与从低阶项到高阶项的传统像差校正优化方法相比,该方法采用相对较小的自由曲面偏差,设计的自由曲面望远镜成像质量和椭率性能得到了同步控制,充分发挥了自由曲面的效能,设计效率优势明显。

关键词：光学设计自由曲面光学椭率节点像差 Zernike多项式

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