Mitochondrial sensitive probe with aggregation-induced emission characteristics for early brain diagnosis of Parkinson’s disease
作者机构:State Key Laboratory of Medicinal Chemical BiologyCollege of PharmacyNankai UniversityTianjinP.R.China State Key Laboratory of Medicinal Chemical BiologyKey Laboratory of Bioactive MaterialsMinistry of Educationand College of Life SciencesNankai UniversityTianjinP.R.China
出 版 物:《Aggregate》 (聚集体(英文))
年 卷 期:2024年第5卷第1期
页 面:216-227页
核心收录:
学科分类:1002[医学-临床医学] 0805[工学-材料科学与工程(可授工学、理学学位)] 0703[理学-化学] 10[医学]
基 金:National Natural Science Foundation of China,Grant/Award Numbers:82241058,31922045,31771031 Natural Science Foundation of Tianjin Province of China,Grant/Award Number:21JCZDJC00290 State Key Laboratory of Medicinal Chemical Biology in Nankai University,Grant/Award Number:2020017 State Key Laboratory of Biochemical Engineering Open Funding Project of State Key Laboratory of Biochemical Engineering,Grant/Award Number:2021KF-01
主 题:aggregation-induced emission early diagnosis Parkinson’s disease
摘 要:The early diagnosis of Parkinson’s disease(PD)provides opportunities for early intervention to slow the progression of neurological degeneration in patients,particularly as the aging population increases in our *** a series of pathological features of PD,mitochondria abnormalities have been identified as central event that occurs at the early stage of ***,the method for detecting mitochondrial abnormalities-associated early PD has not been fully *** herein report a specifically mitochondrial targeting probe(named TPA-BT-SCP)that is able to characterize mitochondria abnormalities for early diagnosis of PD and monitor PD neurodegenerative *** probe is an aggregation-induced emission(AIE)probe with a strong positive charge,a 3D distorted molecular structure,and a separated HOMO-LUMO distribution,designed with unique molecular design *** research demonstrated that TPA-BT-SCP could emit stable and strong fluorescence,and rapidly accumulate in mitochondria due to the negative *** intranasal administration of 1-methy-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)-induced PD mice,TPA-BT-SCP successfully bypassed the blood−brain barrier to light up the brain,allowing the grading of PD severity based on its high *** together,this work develops a novel AIE probe that exhibits dramatically high sensitivity to mitochondrial changes and enables noninvasive diagnosis of early PD in the brain.