Mitochondrial sensitive probe with aggregation-induced emission characteristics for early brain diagnosis of Parkinson’s disease

作     者：Liwen Huang Yutong Zhou Di Jiao Jing Ren Yilin Qi Heping Wang Yang Shi Dan Ding Xue Xue 

作者机构：State Key Laboratory of Medicinal Chemical BiologyCollege of PharmacyNankai UniversityTianjinP.R.China State Key Laboratory of Medicinal Chemical BiologyKey Laboratory of Bioactive MaterialsMinistry of Educationand College of Life SciencesNankai UniversityTianjinP.R.China 

出 版 物：《Aggregate》 (聚集体（英文）)

年 卷 期：2024年第5卷第1期

页      面：216-227页

核心收录：

学科分类：1002[医学-临床医学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 10[医学] 

基　　金：National Natural Science Foundation of China,Grant/Award Numbers:82241058,31922045,31771031 Natural Science Foundation of Tianjin Province of China,Grant/Award Number:21JCZDJC00290 State Key Laboratory of Medicinal Chemical Biology in Nankai University,Grant/Award Number:2020017 State Key Laboratory of Biochemical Engineering Open Funding Project of State Key Laboratory of Biochemical Engineering,Grant/Award Number:2021KF-01 

主　　题：aggregation-induced emission early diagnosis Parkinson’s disease 

摘      要：The early diagnosis of Parkinson’s disease(PD)provides opportunities for early intervention to slow the progression of neurological degeneration in patients,particularly as the aging population increases in our *** a series of pathological features of PD,mitochondria abnormalities have been identified as central event that occurs at the early stage of ***,the method for detecting mitochondrial abnormalities-associated early PD has not been fully *** herein report a specifically mitochondrial targeting probe(named TPA-BT-SCP)that is able to characterize mitochondria abnormalities for early diagnosis of PD and monitor PD neurodegenerative *** probe is an aggregation-induced emission(AIE)probe with a strong positive charge,a 3D distorted molecular structure,and a separated HOMO-LUMO distribution,designed with unique molecular design *** research demonstrated that TPA-BT-SCP could emit stable and strong fluorescence,and rapidly accumulate in mitochondria due to the negative *** intranasal administration of 1-methy-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)-induced PD mice,TPA-BT-SCP successfully bypassed the blood−brain barrier to light up the brain,allowing the grading of PD severity based on its high *** together,this work develops a novel AIE probe that exhibits dramatically high sensitivity to mitochondrial changes and enables noninvasive diagnosis of early PD in the brain.