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Indium-organic framework CPP-3(In)derived Ag/In_(2)O_(3) porous hexagonal tubes for H_(2)S detection at low temperature

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Chinese Chemical Letters 2022年第1期33卷 551-556页

作者： Sihan Li Lili Xie Guifang Luo yutong han Ming Zhou Rawat Jaisutti Zhigang Zhu School of Medical Instrument and Food Engineering University of Shanghai for Science and TechnologyShanghai 200093China Shanghai Normal University Tianhua College Shanghai 201815China School of Environmental and Materials Engineering College of EngineeringShanghai Polytechnic UniversityShanghai 201209China Department of Physics Faculty of Science and TechnologyThammasat UniversityPathumthani 12120Thailand Thammasat Research Unit in Innovative Sensor and Nanoelectronic Devices Thammasat UniversityPathumthani 12120Thailand

There is a great demand for high-performance hydrogen sulfide(H_(2)S)sensors with low operating ***/In_(2)O_(3)hexagonal tubes with different proportions were prepared by the calcination of Ag+-impregnated indium-organic frameworks(CPP-3(In)),and the developed sensors exhibit enhanced gas-sensing performance toward H_(2)*** sensing measurements indicate that the response of Ag/In_(2)O_(3)(2.5 wt%)sensor to 5 ppm H_(2)S has the highest response(119),operated at 70℃.The Ag/In_(2)O_(3)(2.5 wt%)based sensor exhibits short response time(20 s),low detection limit(300 ppb),and good selectivity toward H_(2)S gas,which imply that the CPP-3(In)-derived Ag/In_(2)O_(3)hexagonal tube is a promising candidate to be constructed a low power-consumption H_(2)S sensor.

关键词： Ag/In_(2)O_(3) Indium-organic framework(CPP-3(In)) H_(2)S Gas sensor Low power consumption

基于电子鼻技术的膀胱癌尿液VOCs标志物气体检测与识别

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国际生物医学工程杂志 2024年第2期47卷 115-122页

作者：黄志健韩雨彤孙宇帆朱志刚上海理工大学健康科学与工程学院上海200093

目的设计一款电子鼻,用于检测与识别膀胱癌尿液中的挥发性有机化合物(VOCs)标志物气体。方法选取异丙醇、乙苯、乙酸和氨气作为目标气体,由8款金属氧化物气体传感器构建传感器阵列进行测试收集实验数据,并对不同特征归一化处理。通过递... 详细信息

目的设计一款电子鼻,用于检测与识别膀胱癌尿液中的挥发性有机化合物(VOCs)标志物气体。方法选取异丙醇、乙苯、乙酸和氨气作为目标气体,由8款金属氧化物气体传感器构建传感器阵列进行测试收集实验数据,并对不同特征归一化处理。通过递归特征消除(RFE)筛选出最佳特征子集,进一步引入主成分分析(PCA)和线性判别分析(LDA)降低数据维度便于可视化分析。此外,结合支持向量机(SVM)、随机森林(RF)、K最近邻(KNN)3种机器学习算法进行模型训练和验证。结果特征数为12时,模型分类的准确率最高,特征子集由5个差值、5个灵敏度和2个积分组成,同时将数据降至12维;仅PCA无法区分4种气体,LDA分类效果明显好于PCA,除异丙醇与乙酸有小部分重叠区域,能够将乙苯、氨气很好地与前二者区分开,且样本点聚集在一起,聚类效果也更佳。SVM、RF和KNN的预测准确率分别为0.85、0.56、0.79,经过模型验证,PCA+SVM、LDA+RF和LDA+KNN的分类准确率分别为0.97、0.94、0.97。结论设计了一款电子鼻,能够用于检测与识别膀胱癌尿液VOCs标志物气体。

关键词：电子鼻膀胱癌挥发性有机化合物特征工程气体识别

以问题为基础的学习联合在线教学在眼科教学中的应用

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安徽医药 2024年第6期28卷 1259-1263页

作者：张祎冰张冰洁王丹武云龙韩雨彤吉林大学第一医院眼科吉林长春130021

目的探讨以问题为基础的学习(PBL)教学法结合在线教学在眼科学本科教学中的应用效果。方法选取2022年3—6月吉林大学2018级临床医学“5+3”一体化90人为研究对象,采用随机数字表法分为试验组(n=45)和对照组(n=45),试验组采用在线PBL教学... 详细信息

目的探讨以问题为基础的学习(PBL)教学法结合在线教学在眼科学本科教学中的应用效果。方法选取2022年3—6月吉林大学2018级临床医学“5+3”一体化90人为研究对象,采用随机数字表法分为试验组(n=45)和对照组(n=45),试验组采用在线PBL教学,对照组采用传统临床教学模式进行在线授课。在教学结束后对两组学生进行在线随堂测试及问卷调查,比较两组的教学效果和反馈意见。结果两组学生的基础理论考试成绩差异无统计学意义(P>0.05);试验组学生病例分析成绩及总成绩均高于对照组[(40.73±2.67)分比(36.49±3.02)分,(83.78±4.75)分比(78.73±4.57)分],均差异有统计学意义(P<0.05)。与对照组问卷调查结果相比,试验组教学可明显调动学生学习的积极性,提高自学能力、语言表达能力、团队合作能力及分析解决问题能力,学生对在线教学的互动交流与协作效果较为满意,均差异有统计学意义(P<0.05)。结论采用PBL联合在线教学有利于提高学生的学习成绩与综合实践能力,在眼科学本科教学中具有推广价值。

关键词：基于问题的学习眼科教学在线教学教学改革临床教学

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Cytokine storm promoting T cell exhaustion in severe COVID-19 revealed by single cell sequencing data analysis

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Precision Clinical Medicine 2022年第2期5卷 87-99页

作者： Minglei Yang Chenghao Lin Yanni Wang Kang Chen yutong han Haiyue Zhang Weizhong Li Zhongshan School of Medicine Sun Yat-sen UniversityGuangzhou 510080China Center for Precision Medicine Sun Yat-sen UniversityGuangzhou 510080China Key Laboratory of Tropical Disease Control of Ministry of Education Sun Yat-Sen UniversityGuangzhou 510080China

Background:Evidence has suggested that cytokine storms may be associated with T cell exhaustion(TEX)in ***,the interaction mechanism between cytokine storms and TEX remains ***:With the aim of dissecting the molecular relationship of cytokine storms and TEX through single-cell RNA sequencing data analysis,we identified 14 cell types from bronchoalveolar lavage fluid of COVID-19 patients and healthy *** observed a novel subset of severely exhausted CD8 T cells(Exh T_CD8)that co-expressed multiple inhibitory receptors,and two macrophage subclasses that were the main source of cytokine storms in ***:Correlation analysis between cytokine storm level and TEX level suggested that cytokine storms likely promoted TEX in severe ***–cell communication analysis indicated that cytokines(***10,CXCL11,CXCL2,CCL2,and CCL3)released by macrophages acted as ligands and significantly interacted with inhibitory receptors(***3,DPP4,CCR1,CCR2,and CCR5)expressed by Exh T_*** interactions formed the cytokine–receptor axes,which were also verified to be significantly correlated with cytokine storms and TEX in lung squamous cell ***:Cytokine storms may promote TEX through cytokine-receptor axes and be associated with poor prognosis in *** cytokine-receptor axes may reverse *** finding provides novel insights into TEX in COVID-19 and new clues for cytokine-targeted immunotherapy development.

关键词： COVID-19 immune exhaustion cytokine storm single-cell sequencing data analysis T cell immune checkpoint

A Novel Artificial Neuron-Like Gas Sensor Constructed from CuS Quantum Dots/Bi2S3 Nanosheets

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Nano-Micro Letters 2022年第1期14卷 167-181页

作者： Xinwei Chen Tao Wang Jia Shi Wen Lv yutong han Min Zeng Jianhua Yang Nantao Hu Yanjie Su Hao Wei Zhihua Zhou Zhi Yang Yafei Zhang Key Laboratory of Thin Film and Microfabrication(Ministry of Education) Department of Micro/Nano ElectronicsSchool of Electronic Information and Electrical EngineeringShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China

Real-time rapid detection of toxic gases at room temperature is particularly important for public health and environmental *** sensors based on conventional bulk materials often suffer from their poor surface-sensitive sites,leading to a very low gas adsorption ***,the charge transportation efficiency is usually inhibited by the low defect density of surface-sensitive area than that in the *** this work,a gas sensing structure model based on CuS quantum dots/Bi_(2)S_(3) nanosheets(CuS QDs/Bi_(2)S_(3) NSs)inspired by artificial neuron network is *** analysis by density functional calculation revealed that CuS QDs and Bi_(2)S_(3) NSs can be used as the main adsorption sites and charge transport pathways,***,the high-sensitivity sensing of NO_(2) can be realized by designing the artificial neuron-like *** experimental results showed that the CuS QDs with a size of about 8 nm are highly adsorbable,which can enhance the NO_(2) sensitivity due to the rich sensitive sites and quantum size *** Bi_(2)S_(3) NSs can be used as a charge transfer network channel to achieve efficient charge collection and *** neuron-like sensor that simulates biological smell shows a significantly enhanced response value(3.4),excellent responsiveness(18 s)and recovery rate(338 s),low theoretical detection limit of 78 ppb,and excellent selectivity for NO_(2).Furthermore,the developed wearable device can also realize the visual detection of NO2 through real-time signal changes.

关键词： Artificial neuron-like gas sensor Heterostructure design Nitrogen dioxide detection Wearable device

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气力提升系统气液两相流流动特性研究

力学与实践 2024年第3期46卷 548-558页

作者：朱井育杜燕连符孟帝韩雨彤甘羽星沈义俊海南大学机电工程学院海口570100 海南大学信息与通信工程学院海口570100 海南大学化学与工程技术学院海口570100 海南大学海洋科学与工程学院海口570100

以空气-水作为介质,探究气举泵气液两相流的压力和流量特性,并基于压力信号的时域、功率谱密度函数(power spectral density,PSD)和概率密度函数(probability density function,PDF)分析鉴别流型。结果表明:除了进气喷嘴附近外,其他位... 详细信息

以空气-水作为介质,探究气举泵气液两相流的压力和流量特性,并基于压力信号的时域、功率谱密度函数(power spectral density,PSD)和概率密度函数(probability density function,PDF)分析鉴别流型。结果表明:除了进气喷嘴附近外,其他位置的局部平均压力随气体流速的增大逐渐上升达到峰值后减小,峰值随着浸没比的减小而向右移动且上升速度增大;液体流速随着气体流速增大急剧上升达到峰值后几乎保持不变,最大提升效率约为49%,与最大液体流速并不发生在同一个气体流速下;在不同的气流量下,观测到气泡流、帽弹流、弹状流、搅拌流和环状流的出现,不同流型可通过PSD和PDF估计量进行识别;特别是,浸没比越小越有利于形成大气塞。目前,关于气举泵的研究非常有限,本研究结果可为气液固三相流和气液两相流的研究提供数据和技术支撑。

关键词：气举泵气液两相流压力特性流动特性流型识别

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Two Inhibitors Against the 3C-Like Proteases of Swine Coronavirus and Feline Coronavirus

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Virologica Sinica 2021年第6期36卷 1421-1430页

作者： Mengxin Zhou yutong han Mengxia Li Gang Ye Guiqing Peng State Key Laboratory of Agricultural Microbiology College of Veterinary MedicineHuazhong Agricultural UniversityWuhan430070China Key Laboratory of Preventive Veterinary Medicine in Hubei Province The Cooperative Innovation Center for Sustainable Pig ProductionWuhan430070China

Coronaviruses(CoVs)are important human and animal pathogens that cause respiratory and gastrointestinal *** epidemic diarrhoea(PED),characterized by severe diarrhoea and vomiting in pigs,is a highly lethal disease caused by porcine epidemic diarrhoea virus(PEDV)and causes substantial losses in the swine industry ***,currently available commercial drugs have not shown great therapeutic *** this study,a fluorescence resonance energy transfer(FRET)-based assay was applied to screen a library containing 1,590 compounds and identified two compounds,3-(aminocarbonyl)-1-phenylpyridinium and 2,3-dichloronaphthoquinone,that target the 3C-like protease(3CL^(pro))of *** compounds are of low molecular weight(MW)and greatly inhibited the activity of this enzyme(IC_(50) values were obtained in this study).Furthermore,these compounds exhibited antiviral capacity against another member of the CoV family,feline infectious peritonitis virus(FIPV).Here,the inhibitory effects of these compounds against CoVs on Vero cells and feline kidney cells were identified(with EC_(50) values)and cell viability assays were *** results of putative molecular docking models indicate that these compounds,labeled compound 1 and compound 2,contact the conserved active sites(Cys144,Glu165,Gln191)of 3CL^(pro) via hydrogen *** findings provide insight into the antiviral activities of compounds 1 and 2 that may facilitate future research on anti-CoV drugs.

关键词： Coronavirus(CoVs) Inhibitor 3C-like Protease Porcine epidemic diarrhoea virus(PEDV) Feline infectious peritonitis virus(FIPV)

Direct Analysis of Whole Blood by a Disposable Monolithic Column Mass Spectrometry Analysis Kit

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Chinese Journal of Chemistry 2024年第10期42卷 1073-1078页

作者： Wenxin Wang Jin han yutong Zheng Haijie Wang Chengbiao Zhu Yongyi Li Yuqi Feng Zhenwei Wei Xiangyu Wang College of Chemistry and Molecular Science Wuhan UniversityWuhanHubei 430072China School of Public Health Wuhan UniversityWuhanHubei 430072China Schoolof Bioengineering and Health Wuhan Textile UniversityWuhanHubei 430200China

A monolithic column-based mass spectrometry(MS)analysis kit was prepared for whole blood analysis with *** kit is disposable and can be used for purification,storage,transportation and direct analysis of whole *** kit mainly consists of a capillary for quantitative microsampling,a cation exchange monolithic column for purification and storage,and a syringe for loading *** kit is very friendly to various users that one can easily siphon the blood in the kit followed by rapid *** established a quantitative method using the kit with a limit detection as low as 0.33 nmol/L,and achieved more than five orders of magnitude enhancement in sensitivity compared to direct nanoelectrospray ionization MS *** column can avoid analyte exposure to environment,which helps the storage of the sample for laboratory *** relative standard deviation of immediate blood analysis and storage blood analysis within 10 d was less than 10%.This method has been successfully applied to the quantitative analysis of procainamide hydrochloride in 2μL rat *** results indicate that this disposable kit does have the potential to achieve highly sensitive quantitative MS analysis in biological samples,which is expected to become a cost-effective and powerful tool for in vitro diagnostics.

关键词： Clinical Ms Whole blood analysis Porous polymers Matrix isolation Trace analysis

Skin appendage-derived stem cells: cell biology and potential for wound repair

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Burns & Trauma 2016年第4期4卷 258-263页

作者： Jiangfan Xie Bin Yao yutong han Sha Huang Xiaobing Fu Key Laboratory of Tissue Repair and Regeneration of PLA and Beijing Key Research Laboratory of Skin InjuryRepair and RegenerationFirst Hospital Affiliated to General Hospital of PLA51 Fu Cheng RoadBeijing 100048People’s Republic of China School of Medicine Nankai UniversityTianjin 300052People’s Republic of China Graduate School of the Second Teaching Hospital of Zhengzhou University Zhengzhou 450000People’s Republic of China Wound Healing and Cell Biology Laboratory Institute of Basic Medical SciencesGeneral Hospital of PLABeijing 100853People’s Republic of China

Stem cells residing in the epidermis and skin appendages are imperative for skin homeostasis and *** stem cells also participate in the repair of the epidermis after injuries,inducing restoration of tissue integrity and function of damaged *** epidermis-derived stem cells,comprehensive knowledge about skin appendage-derived stem cells remains *** this review,we summarize the current knowledge of skin appendage-derived stem cells,including their fundamental characteristics,their preferentially expressed biomarkers,and their potential contribution involved in wound ***,we will also discuss current strategies,future applications,and limitations of these stem cells,attempting to provide some perspectives on optimizing the available therapy in cutaneous repair and regeneration.

关键词： Skin appendages Stem cells Cell biology Wound healing