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Two Inhibitors Against the 3C-Like Proteases of Swine Coronavirus and Feline Coronavirus

Virologica Sinica 2021年第6期36卷 1421-1430页

作者： Mengxin Zhou yutong han Mengxia Li Gang Ye Guiqing Peng State Key Laboratory of Agricultural Microbiology College of Veterinary MedicineHuazhong Agricultural UniversityWuhan430070China Key Laboratory of Preventive Veterinary Medicine in Hubei Province The Cooperative Innovation Center for Sustainable Pig ProductionWuhan430070China

Coronaviruses(CoVs)are important human and animal pathogens that cause respiratory and gastrointestinal *** epidemic diarrhoea(PED),characterized by severe diarrhoea and vomiting in pigs,is a highly lethal disease caused by porcine epidemic diarrhoea virus(PEDV)and causes substantial losses in the swine industry ***,currently available commercial drugs have not shown great therapeutic *** this study,a fluorescence resonance energy transfer(FRET)-based assay was applied to screen a library containing 1,590 compounds and identified two compounds,3-(aminocarbonyl)-1-phenylpyridinium and 2,3-dichloronaphthoquinone,that target the 3C-like protease(3CL^(pro))of *** compounds are of low molecular weight(MW)and greatly inhibited the activity of this enzyme(IC_(50) values were obtained in this study).Furthermore,these compounds exhibited antiviral capacity against another member of the CoV family,feline infectious peritonitis virus(FIPV).Here,the inhibitory effects of these compounds against CoVs on Vero cells and feline kidney cells were identified(with EC_(50) values)and cell viability assays were *** results of putative molecular docking models indicate that these compounds,labeled compound 1 and compound 2,contact the conserved active sites(Cys144,Glu165,Gln191)of 3CL^(pro) via hydrogen *** findings provide insight into the antiviral activities of compounds 1 and 2 that may facilitate future research on anti-CoV drugs.

关键词： Coronavirus(CoVs) Inhibitor 3C-like Protease Porcine epidemic diarrhoea virus(PEDV) Feline infectious peritonitis virus(FIPV)

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Smart horticulture as an emerging interdisciplinary field combining novel solutions:Past development,current challenges,and future perspectives

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Horticultural Plant Journal 2024年第6期10卷 1257-1273页

作者： Moran Zhang yutong han Dongping Li Shengyong Xu Yuan Huang Key Laboratory of Agricultural Equipment for the Middle and Lower Reaches of the Yangtze River Ministry of AgricultureCollege of EngineeringHuazhong Agricultural UniversityWuhanHubei 430070China National Key Laboratory for Germplasm Innovation&Utilization of Horticultural Crops College of Horticulture and Forestry SciencesHuazhong Agricultural UniversityWuhanHubei 430070China Shenzhen Branch Guangdong Laboratory for Lingnan Modern Agriculture/Genome Analysis Laboratory of the Ministry of AgricultureAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhenGuangdong 518000China Department of Biomedical Engineering Southern University of Science and TechnologyShenzhenGuangdong 518000China Shenzhen Institute of Nutrition and Health Huazhong Agricultural UniversityShenzhenGuangdong 518000China Tibet Lvzhiyuan Modern Agricultural Technology Co. Ltd.ShannanTibet 856000China

Horticultural products such as fruits,vegetables,and tea offer a range of important nutrients such as protein,carbohydrates,vitamins and ***,the present yield and quality do not meet the requirements of the rapid population growth associated with global climate change,the decline in horticultural practitioners,poor automation,and epidemic diseases such as *** this context,smart horticulture is expected to greatly improve the land output rates,resource-use efficiency,and productivity,all of which should facilitate the sustainable development of the horticulture *** technologies,such as artificial intelligence,big data,the Internet of Things,and cloud computing,play an important *** paper reviews past developments and current challenges,offering future perspectives for horticultural chain *** expect that the horticulture industry would benefit from integration with smart *** requires the use of novel solutions to build a new advanced system encompassing smart breeding,smart cultivation,smart transportation,and smart ***,a new development approach combining precise perception,smart operation,and smart control should be instituted in the horticulture *** 30 years,we expect that the industry will embrace mechanical,automatic,and informational production to transform into a smart industry.

关键词： Smart horticulture Horticultural crops Emerging technologies Artificial intelligence Big data The Internet of Things

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Skin appendage-derived stem cells: cell biology and potential for wound repair

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Burns & Trauma 2016年第4期4卷 258-263页

作者： Jiangfan Xie Bin Yao yutong han Sha Huang Xiaobing Fu Key Laboratory of Tissue Repair and Regeneration of PLA and Beijing Key Research Laboratory of Skin InjuryRepair and RegenerationFirst Hospital Affiliated to General Hospital of PLA51 Fu Cheng RoadBeijing 100048People’s Republic of China School of Medicine Nankai UniversityTianjin 300052People’s Republic of China Graduate School of the Second Teaching Hospital of Zhengzhou University Zhengzhou 450000People’s Republic of China Wound Healing and Cell Biology Laboratory Institute of Basic Medical SciencesGeneral Hospital of PLABeijing 100853People’s Republic of China

Stem cells residing in the epidermis and skin appendages are imperative for skin homeostasis and *** stem cells also participate in the repair of the epidermis after injuries,inducing restoration of tissue integrity and function of damaged *** epidermis-derived stem cells,comprehensive knowledge about skin appendage-derived stem cells remains *** this review,we summarize the current knowledge of skin appendage-derived stem cells,including their fundamental characteristics,their preferentially expressed biomarkers,and their potential contribution involved in wound ***,we will also discuss current strategies,future applications,and limitations of these stem cells,attempting to provide some perspectives on optimizing the available therapy in cutaneous repair and regeneration.

关键词： Skin appendages Stem cells Cell biology Wound healing

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Indium-organic framework CPP-3(In)derived Ag/In_(2)O_(3) porous hexagonal tubes for H_(2)S detection at low temperature

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Chinese Chemical Letters 2022年第1期33卷 551-556页

作者： Sihan Li Lili Xie Guifang Luo yutong han Ming Zhou Rawat Jaisutti Zhigang Zhu School of Medical Instrument and Food Engineering University of Shanghai for Science and TechnologyShanghai 200093China Shanghai Normal University Tianhua College Shanghai 201815China School of Environmental and Materials Engineering College of EngineeringShanghai Polytechnic UniversityShanghai 201209China Department of Physics Faculty of Science and TechnologyThammasat UniversityPathumthani 12120Thailand Thammasat Research Unit in Innovative Sensor and Nanoelectronic Devices Thammasat UniversityPathumthani 12120Thailand

There is a great demand for high-performance hydrogen sulfide(H_(2)S)sensors with low operating ***/In_(2)O_(3)hexagonal tubes with different proportions were prepared by the calcination of Ag+-impregnated indium-organic frameworks(CPP-3(In)),and the developed sensors exhibit enhanced gas-sensing performance toward H_(2)*** sensing measurements indicate that the response of Ag/In_(2)O_(3)(2.5 wt%)sensor to 5 ppm H_(2)S has the highest response(119),operated at 70℃.The Ag/In_(2)O_(3)(2.5 wt%)based sensor exhibits short response time(20 s),low detection limit(300 ppb),and good selectivity toward H_(2)S gas,which imply that the CPP-3(In)-derived Ag/In_(2)O_(3)hexagonal tube is a promising candidate to be constructed a low power-consumption H_(2)S sensor.

关键词： Ag/In_(2)O_(3) Indium-organic framework(CPP-3(In)) H_(2)S Gas sensor Low power consumption

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Cytokine storm promoting T cell exhaustion in severe COVID-19 revealed by single cell sequencing data analysis

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Precision Clinical Medicine 2022年第2期5卷 87-99页

作者： Minglei Yang Chenghao Lin Yanni Wang Kang Chen yutong han Haiyue Zhang Weizhong Li Zhongshan School of Medicine Sun Yat-sen UniversityGuangzhou 510080China Center for Precision Medicine Sun Yat-sen UniversityGuangzhou 510080China Key Laboratory of Tropical Disease Control of Ministry of Education Sun Yat-Sen UniversityGuangzhou 510080China

Background:Evidence has suggested that cytokine storms may be associated with T cell exhaustion(TEX)in ***,the interaction mechanism between cytokine storms and TEX remains ***:With the aim of dissecting the molecular relationship of cytokine storms and TEX through single-cell RNA sequencing data analysis,we identified 14 cell types from bronchoalveolar lavage fluid of COVID-19 patients and healthy *** observed a novel subset of severely exhausted CD8 T cells(Exh T_CD8)that co-expressed multiple inhibitory receptors,and two macrophage subclasses that were the main source of cytokine storms in ***:Correlation analysis between cytokine storm level and TEX level suggested that cytokine storms likely promoted TEX in severe ***–cell communication analysis indicated that cytokines(***10,CXCL11,CXCL2,CCL2,and CCL3)released by macrophages acted as ligands and significantly interacted with inhibitory receptors(***3,DPP4,CCR1,CCR2,and CCR5)expressed by Exh T_*** interactions formed the cytokine–receptor axes,which were also verified to be significantly correlated with cytokine storms and TEX in lung squamous cell ***:Cytokine storms may promote TEX through cytokine-receptor axes and be associated with poor prognosis in *** cytokine-receptor axes may reverse *** finding provides novel insights into TEX in COVID-19 and new clues for cytokine-targeted immunotherapy development.

关键词： COVID-19 immune exhaustion cytokine storm single-cell sequencing data analysis T cell immune checkpoint

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A Novel Artificial Neuron-Like Gas Sensor Constructed from CuS Quantum Dots/Bi2S3 Nanosheets

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Nano-Micro Letters 2022年第1期14卷 167-181页

作者： Xinwei Chen Tao Wang Jia Shi Wen Lv yutong han Min Zeng Jianhua Yang Nantao Hu Yanjie Su Hao Wei Zhihua Zhou Zhi Yang Yafei Zhang Key Laboratory of Thin Film and Microfabrication(Ministry of Education) Department of Micro/Nano ElectronicsSchool of Electronic Information and Electrical EngineeringShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China

Real-time rapid detection of toxic gases at room temperature is particularly important for public health and environmental *** sensors based on conventional bulk materials often suffer from their poor surface-sensitive sites,leading to a very low gas adsorption ***,the charge transportation efficiency is usually inhibited by the low defect density of surface-sensitive area than that in the *** this work,a gas sensing structure model based on CuS quantum dots/Bi_(2)S_(3) nanosheets(CuS QDs/Bi_(2)S_(3) NSs)inspired by artificial neuron network is *** analysis by density functional calculation revealed that CuS QDs and Bi_(2)S_(3) NSs can be used as the main adsorption sites and charge transport pathways,***,the high-sensitivity sensing of NO_(2) can be realized by designing the artificial neuron-like *** experimental results showed that the CuS QDs with a size of about 8 nm are highly adsorbable,which can enhance the NO_(2) sensitivity due to the rich sensitive sites and quantum size *** Bi_(2)S_(3) NSs can be used as a charge transfer network channel to achieve efficient charge collection and *** neuron-like sensor that simulates biological smell shows a significantly enhanced response value(3.4),excellent responsiveness(18 s)and recovery rate(338 s),low theoretical detection limit of 78 ppb,and excellent selectivity for NO_(2).Furthermore,the developed wearable device can also realize the visual detection of NO2 through real-time signal changes.

关键词： Artificial neuron-like gas sensor Heterostructure design Nitrogen dioxide detection Wearable device

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Line-scanning microscopy with laterally symmetric imaging using simultaneous cross-line illumination

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Photonics Research 2024年第7期12卷 1513-1521页

作者： DAN SHEN YAFENG LI MENG WANG yutong han BOLIN LU HUI GONG QINGMING LUO JING YUAN Britton Chance Center for Biomedical Photonics and MoE Key Laboratory for Biomedical Photonics Wuhan National Laboratory for OptoelectronicsHuazhong University of Science and TechnologyWuhan 430074China HUST-Suzhou Institute for Brainsmatics JITRI Institute for BrainsmaticsSuzhou 215123China School of Biomedical Engineering Hainan UniversityHaikou 570228China

Using an on-the-fly scanning scheme, line confocal microscopy can obtain complex structures of large biological tissues with high throughput. Yet, it suffers from lateral imaging asymmetry and thus introduces the potential deformations of the observation results. Here, we propose cross-line illumination microscopy (cLIM) that acquires the imaging data of two perpendicular directions simultaneously through the same objective lens in a line scanning and utilizes two-direction deconvolution fusion to achieve lateral symmetric imaging *** fluorescence beads indicates that cLIM reduces lateral resolution asymmetry from 46.1%to 2.5%and improves lateral resolution by 31.0%, compared with traditional line-scanning imaging. Compared with commercial point-confocal microscopy, the cLIM has a 25.84×increase in imaging speed and 1.93×better background-suppressing ability when imaging an 11,306μm×7783μm×100μm mouse kidney slice. We also show the advantages of the cLIM in observing direction-sensitive texture features by imaging a muscular tissue slice. cLIM offers a novel solution to achieve laterally symmetric line-scanning imaging with simple modifications while maintaining high throughput and accuracy for imaging large-scale samples.

关键词： illumination simultaneous scanning

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腐植酸对石油污染土壤特性和生物修复效果的影响

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石油学报（石油加工） 2016年第1期32卷 164-169页

作者：张秀霞韩雨彤张涵丁峥中国石油大学化学工程学院环境与安全工程系山东青岛266580

为研究腐植酸对石油污染土壤生物修复的影响,考察了不同腐植酸含量对石油污染土壤特性以及在低含水条件下对石油污染土壤土著微生物修复效果的影响,探究了腐植酸在干旱少降水地区修复石油污染土壤的可行性。结果表明,土壤腐植酸质量分数... 详细信息

为研究腐植酸对石油污染土壤生物修复的影响,考察了不同腐植酸含量对石油污染土壤特性以及在低含水条件下对石油污染土壤土著微生物修复效果的影响,探究了腐植酸在干旱少降水地区修复石油污染土壤的可行性。结果表明,土壤腐植酸质量分数为100mg/g时有利于调节土壤的C/N质量比,有利于土著微生物对速效磷的利用,土著微生物酶活性比对照土壤样品有显著提高;在低含水率条件下,腐植酸质量分数为100mg/g土壤样品的30d石油烃降解率达到27.7%,而对照土壤样品只有5.9%。

关键词：石油污染土壤腐植酸含量降解率含水率土著微生物酶活性

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固定化微生物对石油污染土壤理化性质的调控作用

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石油学报（石油加工） 2014年第6期30卷 1106-1112页

作者：张秀霞张守娟张涵韩雨彤郭云霞中国石油大学环境与安全工程系山东青岛266580

选取粒径为40目秸秆DG为载体,采用吸附法固定高效石油降解菌SJ-1,制成固定化微生物。调节石油污染土壤样品的C、N、P质量比为100∶10∶1、含水率为18%、pH值为7.2,采用秸秆、游离菌、固定化微生物于室内花盆中进行模拟修复实验,并与土... 详细信息

选取粒径为40目秸秆DG为载体,采用吸附法固定高效石油降解菌SJ-1,制成固定化微生物。调节石油污染土壤样品的C、N、P质量比为100∶10∶1、含水率为18%、pH值为7.2,采用秸秆、游离菌、固定化微生物于室内花盆中进行模拟修复实验,并与土著菌对照,考察35d修复过程中石油烃降解率,土壤pH值,土壤中速效磷、有机质、全氮含量的变化规律,研究固定化微生物对石油污染土壤理化性质的调控作用。结果表明,在采用秸秆、游离菌、固定化微生物和土著菌修复石油污染土壤的4种方法中,采用固定化微生物修复的方法对土壤具有一定的保水性,对土壤pH值有缓冲作用,并可提高土壤营养物质含量,对有机质、全氮和速效磷的利用率高,而且三者下降速率快,从而得到40.8%的最高石油烃降解率。

关键词：固定化微生物石油污染土壤理化性质调控作用

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响应曲面优化固定化微生物修复石油污染土壤

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石油学报（石油加工） 2015年第4期31卷 1028-1034页

作者：张涵韩雨彤张守娟丁铮张秀霞中国石油大学环境与安全工程系山东青岛266580

采用秸秆载体DG吸附高效石油降解菌SJ5-1制备固定化微生物。在花盆中模拟固定化微生物修复石油污染土壤,采用单因素实验考察wC∶wN∶wP(有机质、全氮、速效磷的质量分数的比值)、含水率、接种量对石油烃降解率的影响,再通过Design-Exper... 详细信息

采用秸秆载体DG吸附高效石油降解菌SJ5-1制备固定化微生物。在花盆中模拟固定化微生物修复石油污染土壤,采用单因素实验考察wC∶wN∶wP(有机质、全氮、速效磷的质量分数的比值)、含水率、接种量对石油烃降解率的影响,再通过Design-Expert 8.06响应曲面法设计实验,建立多元二次回归方程预测模型,进一步确定固定化微生物的最佳实验参数组合,并在最佳参数条件下验证模型的准确性。结果表明,预测模型准确;在土壤含油率为4.72%(质量分数)时,固定化微生物修复35d,响应面优化得到固定化微生物最佳降解条件为wC∶wN∶wP=100∶9.79∶1,接种量10.34%、含水率17.8%(质量分数),石油烃降解率为42.4%,高于单因素最优条件时的40.8%;对石油烃降解率影响的显著性从大到小的因素依次是接种量、含水率、wC/wN。

关键词：固定化微生物石油污染土壤响应面优化条件

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