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Estimating the effective reproduction number of COVID-19 from population-wide wastewater data:An application in Kagawa,Japan

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Infectious Disease Modelling 2024年第3期9卷 645-656页

作者： yuta Okada Hiroshi Nishiura Kyoto University School of Public Health Yoshida-KonoeSakyoKyoto606-8601Japan

Although epidemiological surveillance of COVID-19 has been gradually downgraded globally,the transmission of COVID-19 *** is critical to quantify the transmission dynamics of COVID-19 using multiple datasets including wastewater virus concentration ***,we propose a comprehensive method for estimating the effective reproduction number using wastewater *** wastewater virus concentration data,which were collected twice a week,were analyzed using daily COVID-19 incidence data obtained from Takamatsu,Japan between January 2022 and September *** estimated the shedding load distribution(SLD)as a function of time since the date of infection,using a model employing the delay distribution,which is assumed to follow a gamma distribution,multiplied by a scaling *** also examined models that accounted for the temporal smoothness of viral load measurement *** model that smoothed temporal patterns of viral load was the best fit model(WAIC=2795.8),which yielded a mean estimated distribution of SLD of 3.46 days(95%CrI:3.01–3.95 days).Using this SLD,we reconstructed the daily incidence,which enabled computation of the effective reproduction *** the best fit posterior draws of parameters directly,or as a prior distribution for subsequent analyses,we first used a model that assumed temporal smoothness of viral load concentrations in wastewater,as well as infection counts by date of *** the subsequent approach,we examined models that also incorporated weekly reported case counts as a proxy for weekly incidence *** approaches enabled estimations of the epidemic curve as well as the effective reproduction number from twice-weekly wastewater viral load *** weekly case count data reduced the uncertainty of the effective reproduction *** conclude that wastewater data are still a valuable source of information for inferring the transmission dynamics of COVID-19,and that inferential performance is enhanced when tho

关键词： Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) Wastewater-based epidemiology Shedding load distribution'Mathematical model

Epidemiological impact of revoking mask-wearing recommendation on COVID-19 transmission in Tokyo,Japan

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Infectious Disease Modelling 2024年第4期9卷 1289-1300页

作者： Mayu Nagata yuta Okada Hiroshi Nishiura Kyoto University School of Public Health Yoshida-KonoeSakyoKyoto606-8601Japan

Despite the global implementation of COVID-19 mitigation measures,the disease continues to maintain *** mask wearing became one of the key measures for preventing the transmission of COVID-19 early in the pandemic period,many countries have relaxed the mandatory or recommended wearing of *** objective of the present study was to estimate the epidemiological impact of removing the mask-wearing recommendation in *** developed a model to assess the consequences of declining mask-wearing coverage after the government revoked its recommendation in February *** declining mask-wearing coverage was estimated using serial cross-sectional data,and a mathematical model was devised to determine the age-specific incidence of COVID-19 using the observed case count in Tokyo from week of October 3,2022 to October 30,*** explored model-based counterfactual scenarios to measure hypothetical situations in which the mask-wearing coverage decreases or increases relative to the observed *** results show that mask-wearing coverage declined from 97%to 69%by the week of October 30,2023,and that if the mask-wearing recommendation had continued,427 lives could have been saved in *** the mask-wearing coverage had declined to 25%of the observed level,the model suggests there might have been 1587 additional ***,revoking the mask-wearing recommendation had a substantial epidemiological *** future pandemics,our proposed approach could provide a realtime quantification of the effects of relaxing countermeasures.

关键词： COVID-19 Mask wearing recommendation Health policy Counterfactual Mathematical model

MicroRNA-329-3p inhibits the Wnt/β-catenin pathway and proliferation of osteosarcoma cells by targeting transcription factor 7-like 1

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Oncology Research 2024年第3期32卷 463-476页

作者： Hur SUN MASANORI KAWANO TATSUYA IWASAKI ICHRO ITONAGA yuta KUBOTA HROSHI TSUMURA KAZUHRO TANAKA Department of Orthopaedic Surgery Faculty of MedicineOita UniversityOita879-5503Japan

An important factor in the emergence and progre sion of osteosarcoma(OS)is the dysregulated expression of microRNAs(miRNAs).Transcription factor 7-like 1(TCF7LI),a member of the T cell factor/lymphoid enhancer factor(TCF/LEF)transcription factor family,interacts with the Wnt signaling pathway regulator β-catenin and acts as a DNA-specific binding *** study sought to elucidate the impact of the interaction between miR 3293p and TCF7L1 *** growth and apoptosis of OS and analyze the regulatory expression relationship between miRNA and mRNA in osteosarcoma cells using a variety of ***329-3p was significantly downregulated,while TCF7L1 was considerably up-regulated in all examined OS cell ***,a clinical comparison study was performed using the TCGA ***,the regulatory relationship between miR-329-3p and TCF7L1 on the proliferation and apoptosis of OS cells was verified through in vitro and in vivo *** miR 329-3p was transfected into the OS cell line,the expression of TCF7L1 decreased,the proliferation of OS cells was inhibited,the cytoskeleton disintegrated,and the nucleus condensed to fom apoptotic *** expression of proteins that indicate apoptosis increased *** cell cycle was arrested in the G0/G1 phase,and the G1/S transition was *** introduction of miR 3293p also inhibited downstream Cyclin D1 of the Wnt *** experiments indicated that the overexpression of miR-329-3p signi ficanly inhibited the growth of OS xenografts in nude mice,and the expression of TCF7L1 and C-Myc in tumor tssues *** 329-3p was significantly reduced in OS cells and played a suppressive role in tumorigenesis and proliferation by targeting TCF7L1 both in vitro and in *** cell cycle arrest and pathway inhibition were observed upon the regulation of TCF7LI by miR *** these results,it can be inferred that miR.3293p exerts anticancer efects in osteosarcom

关键词： MiR-329-3p TCF7L1 Wnt/β-catenin pathway Osteosarcoma Proliferation

Correction: MicroRNA-329-3p inhibits the Wnt/β-catenin pathway and proliferation of osteosarcoma cells by targeting transcription factor 7-like 1

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Oncology Research 2024年第8期32卷 1369-1370页

作者： HUI SUN MASANORI KAWANO TATSUYA IWASAKI ICHIRO ITONAGA yuta KUBOTA HIROSHI TSUMURA KAZUHIRO TANAKA Department of Orthopaedic Surgery Faculty of MedicineOita UniversityOita879-5503Japan

In the article‘MicroRNA-329-3p inhibits the Wnt/β-catenin pathway and proliferation of osteosarcoma cells by targeting transcription factor 7-like 1’(Oncology Research,2024,Vol.32,No.3,pp.463−***:10.32604/or.2023.044085),there was an error in the compilation of *** have revised Fig.8D to correct this error.A corrected version of Fig.8 is *** correction does not change any results or conclusions of the *** apologize for any inconvenience caused.

关键词： osteosarcoma correction revised

Carotenoid productivity in human intestinal bacteria Eubacterium limosum and Leuconostoc mesenteroides with functional analysis of their carotenoid biosynthesis genes

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Engineering Microbiology 2024年第2期4卷 1-11页

作者： Wataru Matsumoto Miho Takemura Haruka Nanaura yuta Ami Takashi Maoka Kazutoshi Shindo Shin Kurihara Norihiko Misawa Research Institute for Bioresources and Biotechnology Ishikawa Prefectural University1-308SuematsuNonoich-shi 921-8836Japan Department of Science and Technology on Food Safety Kinki University930 NishimitaniKinokawaWakayama 649-6493Japan Research Institute for Production Development Shimogamo-morimotochoSakyo-kuKyoto 606-0805Japan Department of Food and Nutrition Japan Women’s UniversityMejirodaiBunkyo-kuTokyo 112-8681Japan

The human intestinal microbiota that comprise over 1,000 species thrive in dark and anaerobic *** are recognized for the production of diverse low-molecular-weight metabolites crucial to human health and ***,low-molecular-weight pigments known for their antioxidative activity,are delivered to humans through oral ***,it remains unclear whether human intestinal bacteria biosynthesize carotenoids as part of the in-situ *** this study,we investigated carotenoid synthesis genes in vari-ous human gut and probiotic *** a result,novel candidates,the crtM and crtN genes,were identified in the carbon monoxide-utilizing gut anaerobe Eubacterium limosum and the lactic acid bacterium Leuconostoc mesenteroides *** gene candidates were isolated,introduced into Escherichia coli,which synthesized a carotenoid substrate,and cultured *** analysis of the resulting carotenoids re-vealed that the crtM and crtN gene candidates of *** and *** mediate the production of 4,4′-diaponeurosporene through 15-cis-4,4′-*** of the crtE-homologous genes in these bacteria indicated their non-functionality for C40-carotenoid *** and ***,along with the known carotenogenic lactic acid bacterium Lactiplantibacillus plantarum,were observed to produce no carotenoids under strictly anaerobic *** two lactic acid bacteria synthesized detectable levels of 4,4′-diaponeurosporene under semi-aerobic *** findings highlight that the obligate anaerobe ***-sum retains aerobically functional C30-carotenoid biosynthesis genes,potentially with no immediate self-utility,suggesting an evolutionary direction in carotenoid biosynthesis.(229 words)

关键词： C_(30)carotenoid biosynthesis Obligate anaerobe Human gut bacterium Eubacterium limosum Leuconostoc mesenteroides Lactiplantibacillus plantarum

Hand Cooling Enhances the Proprioceptive Drift during Rubber Hand Illusion

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Journal of Behavioral and Brain Science 2024年第7期14卷 210-226页

作者： Masanori Sakamoto yuta Akaike Kazuya Tatsumi Hirotoshi Ifuku Division of Health and Physical Education Graduate School of Education Kumamoto University Kumamoto City Japan Lifelong Sports and Welfare Course Faculty of Education Kumamoto University Kumamoto City Japan

Background: The neural representation of the body is easily altered by integrating multiple sensory signals in the brain. The “Rubber Hand Illusion” (RHI) is one of the most popular experimental paradigms to investigate this phenomenon. During this illusion, ownership of a rubber hand is temporarily induced. It was shown that external and continuous cooling of the palm enhanced the RHI, suggesting an association between altered the autonomic nervous system regulation and altered the sense of ownership of a specific limb. Purpose: To investigate whether artificially cooling the entire hand for a short period affects the magnitude of the illusion. Methods: Participants immersed their entire hand in cool, cold, or warm water for 1 min before the RHI procedure. Results: We found that cooling the entire hand enhanced the proprioceptive drift during the RHI but not the subjective feeling of ownership. In contrast, warming and intense cooling of the entire hand did not affect the RHI strength. Conclusion: Our results suggest that transient and moderate cooling of the entire hand was sufficient in enhancing the illusory disembodiment of one’s own hand.

关键词： Hand Temperature Cooling Rubber Hand Illusion Ownership Proprioceptive Drift

MicroRNA-based targeting of the Rho/ROCK pathway in therapeutic strategies after spinal cord injury

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Neural Regeneration Research 2023年第2期18卷 311-312页

作者： Tetsu kimura yuta Horikoshi Department of Anesthesia and Intensive Care Medicine Akita University Graduate School of MedicineAkitaJapan

Spinal cord injury(SCI)is one of the leading causes of disability and is a devastating condition that requires long-term care,reduces social productivity,and gives an immense emotional burden on patients and their fa *** frequently occurs due to traffic accidents,falls,slips,violence,sports,and medical accidents in today's *** initial mechanical damage triggers a secondary injury cascade that induces more intractable damage(Silva et al.,2014).Secondary injury mechanisms have been postulated,including neuronal apoptosis,inflammation,oxidative stress,and excitotoxicity.

关键词： damage injury emotional

Development of a competitive enzyme-linked immunosorbent assay for therapeutic drug monitoring of afatinib

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Journal of Pharmaceutical Analysis 2019年第1期9卷 49-54页

作者： Rintaro Sogawa Tetsuya Saita yuta Yamamoto Sakiko kimura yutaka Narisawa Shinya kimura Masashi Shin Department of Pharmacy Saga University Hospital Applied Life Science Department Faculty of Biotechnology and Life Science Sojo University Division of Hematology Respiratory Medicine and Oncology Department of Internal Medicine Faculty of Medicine Saga University

Afatinib is an oral tyrosine kinase inhibitor(TKI) approved for treating advanced non-small cell lung cancer. It is necessary to develop a simple quantification method for TKIs in order to facilitate therapeutic drug monitoring(TDM) in clinical settings. This study sought to develop a simple and sensitive competitive enzyme-linked immunosorbent assay(ELISA) to quantify afatinib in plasma for routine pharmacokinetic applications. An anti-afatinib antibody was obtained using(S)-N-4-(3-chloro-4-fluorophenyl)-7-(tetrahydrofuran-3-yloxy)-quinazoline-4,6-diamine(CTQD), which has the same substructure as afatinib, as a hapten. Enzyme labeling of afatinib with horseradish peroxidase was similarly performed using CTQD. A simple competitive ELISA for afatinib was developed based on the principle of direct competition between afatinib and the enzyme marker for the anti-afatinib antibody, which had been immobilized on the plastic surface of a microtiter plate. Plasma afatinib concentrations below the limit of quantification of 30 pg/mL were reproducibly measurable. Also, the values of plasma afatinib levels measured from 20 patients were comparable with those measured by high-performance liquid chromatography, and there was a strong correlation between the values determined by both methods(Y=0.976 X – 0.207, r=0.975). As indicated by its specificity and sensitivity, this newly developed ELISA for afatinib is an important tool for TDM and studies of the pharmacokinetics of afatinib.

关键词： Afatinib Enzyme-linked immunosorbent assay Therapeutic drug monitoring Tyrosine-kinase inhibitor

Novel procedure for hepatic venous outflow block after liver resection:A case report

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World Journal of Clinical Cases 2024年第29期12卷 6320-6326页

作者： Hisanobu Higashi yuta Abe Kodai Abe yutaka Nakano Masayuki Tanaka Shutaro Hori Yasushi Hasegawa Hiroshi Yagi Minoru Kitago Yuko Kitagawa Department of Surgery National Hospital Organization Saitama HospitalWako 351-0102Japan Department of Surgery Keio University School of MedicineTokyo 160-8582Japan

BACKGROUND Postoperative complications like remnant hepatic vein(HV)outflow block and liver torsion can occur after right *** falciform ligament fixation is typically used to prevent liver *** report a novel procedure to manage outflow *** SUMMARY An 80-year-old man developed HV outflow block after remnant right hepatectomy,despite liver fixation and intraoperative HV flow *** had a history of cholangiocellular carcinoma and had undergone posterior segmentectomy and *** falciform ligament fixation was inadequate to maintain liver *** surgery was performed,using an omental flap and mobilized right side colon with ileocecal region to prevent liver dislocation due to intraabdominal *** postoperative course was *** This is the first report providing a novel surgical procedure when the falciform ligament is insufficient for remnant liver fixation.

关键词： Hepatectomy Postoperative complications Budd-Chiari syndrome Hepatic vein outflow block Emergency surgery Case report