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Reactions between olivine and CO2-rich seawater at 300℃:Implications for H2 generation and CO2 sequestration on the early Earth

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Geoscience Frontiers 2017年第2期8卷 387-396页

作者： Hisahiro Ueda yusuke Sawaki Shigenori Maruyama Department of Earth and Planetary Sciences Tokyo Institute of Technology2-12-1 OokayamaMeguro-kuTokyo 152-8551Japan Earth-Life Science Institute Tokyo Institute of Technology2-12-1 OokayamaMeguro-kuTokyo 152-8551Japan

To understand the influence of fluid CO2 on ultramafic rock-hosted seafloor hydrothermal systems on the early Earth,we monitored the reaction between San Carlos olivine and a CO2-rich NaCl fluid at 300 C and 500 *** the experiments,the total carbonic acid concentration（∑XO2） in the fluid decreased from approximately 65 to 9 mmol/*** minerals,magnesite,and subordinate amount of dolomite were formed via the water-rock *** H2 concentration in the fluid reached approximately 39 mmol/kg within 2736 h,which is relatively lower than the concentration generated by the reaction between olivine and a CO2-free NaCl solution at the same *** seen in previous hydrothermal experiments using komatiite,ferrous iron incorporation into Mg-bearing carbonate minerals likely limited iron oxidation in the fluids and the resulting H2 generation during the olivine *** carbonate mineralogy over the temperature range of natural hydrothermal fields,H2 generation is likely suppressed at temperatures below approximately 300℃ due to the formation of the Mg-bearing ***,H_2 concentration in fluid at 300℃ could be still high due to the temperature dependency of magnetite stability in ultramafic ***,the Mg-bearing carbonates may play a key role in the ocean-atmosphere system on the early *** studies suggest that the subduction of carbonated ultramafic rocks may transport surface CO2 species into the deep *** process may have reduced the huge initial amount of CO2 on the surface of the early *** approximate calculations demonstrate that the subduction of the Mg-bearing carbonates formed in komatiite likely played a crucial role as one of the CO2 carriers from the surface to the deep mantle,even in hot subduction zones.

关键词： Olivine CO2-rich condition Early Earth Hydrothermal alteration Serpentinization Experiment

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The evolving role of DNA damage response in overcoming therapeutic resistance in ovarian cancer

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Cancer Drug Resistance 2023年第2期6卷 345-357页

作者： Sara Bouberhan Liron Bar-Peled yusuke Matoba Varvara Mazina Lauren Philp Bo R.eda Division of Hematology/Oncology Department of MedicineMassachusetts General HospitalBostonMA 02114USA Department of Medicine Harvard Medical SchoolBostonMA 02115USA Center for Cancer Research Massachusetts General HospitalBostonMA 02114USA Department of Obstetrics and Gynecology Vincent Center for Reproductive BiologyMassachusetts General HospitalBostonMA 02114USA Obstetrics Gynecologyand Reproductive BiologyHarvard Medical SchoolBostonMA 02115 USA Division of Gynecologic Oncology Department of Obstetrics and GynecologyMassachusetts General HospitalBostonMA 02114USA

Epithelial ovarian cancer(EOC)is treated in the first-line setting with combined platinum and taxane chemotherapy,often followed by a maintenance poly(ADP-ribose)polymerase inhibitor(PARPi).Responses to first-line treatment are *** many patients,however,responses are suboptimal or *** the last several years,multiple new classes of agents targeting DNA damage response(DDR)mechanisms have advanced through clinical *** this review,we explore the preclinical rationale for the use of ATR inhibitors,CHK1 inhibitors,and WEE1 inhibitors,emphasizing their application to chemotherapy-resistant and PARPi-resistant ovarian *** also present an overview of the clinical development of the leading drugs in each of these classes,emphasizing the rationale for monotherapy and combination therapy approaches.

关键词： Ovarian cancer platinum resistance PARPi resistance DDR

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Validation of the Japan Coma Scale for the prediction of mortality in children:analysis of a nationwide trauma database

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World Journal of Pediatric Surgery 2022年第2期5卷 23-28页

作者： Yuki Enomoto yusuke Tsutsumi Asuka Tsuchiya Takahiro Kido Koji Ishigami Masahito Togo Susumu Yasuda Yoshiaki Inoue Department of Emergency and Critical Care Medicine University of TsukubaTsukubaIbarakiJapan Department of Emergency and Critical Care Medicine Mito Medical CenterMitoIbarakiJapan Department of Emergency and Critical Care Medicine Tokai University School of Medicine Graduate School of MedicineIseharaKanagawaJapan Department of Clinical Epidemiology and Health Economics The University of TokyoBunkyo-kuTokyoJapan Department of Pediatrics University of Tsukuba HospitalTsukubaIbarakiJapan

Objective The Japan Coma Scale(JCS)is widely used in clinical practice to evaluate levels of consciousness in *** have been several studies on the usefulness of JCS in ***,its usefulness in evaluating children has not been ***,this study aimed to assess the usefulness of the JCS for the prediction of mortality in *** This is a multicenter cohort study which used data from a national trauma registry(Japan Trauma Data Bank).This study included patients under 16 years of age who were treated between 2004 and *** primary outcome measure was in-hospital *** models were used to examine each item of the Glasgow Coma Scale(GCS)and the *** A included the discrete levels of each *** model B,data regarding age,sex,vital signs on arrival to hospital,the Injury Severity Score,and blunt trauma were added to each *** effectivity of the JCS score was then evaluated using the area under the curve(AUC)for discrimination,a calibration plot,and the Hosmer-Lemeshow test for *** A total of 9045 patients were *** AUCs of the GCS and JCS were 0.929(95%confidence interval(CI)0.904 to 0.954)and 0.930(95%CI 0.906 to 0.954)in model A and 0.975(95%CI 0.963 to 0.987)and 0.974(95%CI 0.963 to 0.985)in model B,*** results of the Hosmer-Lemeshow test were 0.00(p=1.00)and 0.00(p=1.00)in model A and 4.14(p=0.84)and 8.55(p=0.38)in model B for the GCS and JCS,*** We demonstrated that the JCS is as valid as the GCS for predicting *** findings of this study indicate that the JCS is a useful and relevant tool for pediatric trauma care and future research.

关键词： Glasgow prediction nationwide

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Annular Supersonic Swirling Flows with Heterogeneous Condensation

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Journal of Thermal Science 2016年第6期25卷 518-525页

作者： yusuke FUKUSHIMA Shigeru MATSUO Norimasa SHIOMI Toshiaki SETOGUCHI Graduate School of Science & Engineering Saga University Department of Advanced Technology Fusion Saga University Department of Mechanical Engineering Saga University Institute of Ocean Energy Saga University

In recent years,separating and extracting technologies of condensate gas have been developed by combining a swirl flow with non-equilibrium condensation phenomena of condensate gas generated in a supersonic *** technology can reduce the size of the device and does not use ***,there are many unresolved problems for performance of the separation,extraction and operating *** it is necessary to research further in order to improve the performance of the *** the present study,the numerical study was carried out to clarify the effect of the heterogeneous condensation on the characteristics of the swirling flow field in a supersonic annular nozzle,and the differences between homogeneous condensation and heterogeneous condensation in the flow *** the results,it is found that the condensation flow with a swirl affects the position of sonic line,the generating position of condensate and the radial distribution ratio of liquid phase.

关键词：可压缩的流动异构的冷凝作用同类的冷凝作用超声的嘴环形的打漩流动模拟

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Dynamic pressure change in a rotating, laterally oscillating cylindrical container

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Journal of Ocean Engineering and Science 2018年第2期3卷 91-95页

作者： yusuke Saito Tatsuo Sawada Department of Mechanical Engineering Keio University3-14-1 HiyoshiKohoku-kuYokohama 223-8522Japan

We examined wave phenomena pertinent to water in a rotating,laterally oscillating cylindrical *** particular,we measured the time-dependent dynamic water pressure and pressure change by fast Fourier transform *** swirling of water in the container had three frequency components;the frequency responses of each frequency component are reported *** swirling occurs in a rotating cylindrical container,it was found that the wave rotating in the same direction as the rotation of the cylindrical container and the wave rotating in the opposite direction to the cylindrical container exist at the same *** swirling direction was determined by the relationship of these magnitude.

关键词： Sloshing Dynamic pressure Cylindrical container Rotation Oscillation Swirling

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Successful treatment with laparoscopic surgery and sequential multikinase inhibitor therapy for hepatocellular carcinoma:A case report

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World Journal of Gastrointestinal Surgery 2022年第3期14卷 260-267页

作者： Yutaka Endo Motohide Shimazu Tadayuki Sakuragawa yusuke Uchi Motonori Edanami Ken Sunamura Soji Ozawa Naokazu Chiba Shigeyuki Kawachi Department of Surgery Tama Kyuryo HospitalTokyo 1940297Japan Department of Digestive and Transplantation Surgery Tokyo Medical University Hachioji Medical CenterTokyo 1930998Japan

BACKGROUND Hepatocellular carcinoma(HCC)with massive portal vein tumor thrombosis(PVTT)and distant metastasis is considered ***,due to recent developments in systemic chemotherapy,successful cases of conversion therapy for unresectable diseases have been ***,we report a successful multidisciplinary approach for treatment of multi-visceral recurrence with sequential multikinase inhibitor and laparoscopic *** SUMMARY A 63-year-old woman with chronic hepatitis B virus infection was diagnosed with ***,she underwent two rounds of laparoscopic partial hepatectomy,laparoscopic left adrenalectomy,and transcatheter arterial chemoembolization plus sorafenib for *** years after initial hepatectomy,she presented with a 43-mm mass in the spleen and tumor thrombus involving the main portal vein trunk with *** liver function was Child-Pugh B(8),and protein induced by vitamin K absence or antagonist II(PIVKA II)levels were elevated up to 46.291 mAU/*** initial treatment with regorafenib for three months was unsuccessful,the patient was administered *** months post-treatment,there was no contrast enhancement of PVTT or splenic *** was discontinued due to severe ***,splenic metastasis became viable,and PIVKA II ***,hand-assisted laparoscopic splenectomy was *** experienced no clinical recurrence 14 mo after *** Conversion surgery after successful multikinase inhibitor treatment might be considered an effective treatment option for advanced HCC.

关键词： Hepatocellular carcinoma Lenvatinib Portal vein Venous thrombosis Splenic neoplasms Case report

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Active Air Venting of Mold Cavity to Improve Performance of Injection Molded Direct Joining

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Nanomanufacturing and Metrology 2021年第2期4卷 109-117页

作者： Fuminobu Kimura Shotaro Kadoya yusuke Kajihara Institute of Industrial Science The University of Tokyo4-6-1KomabaMeguro-kuTokyoJapan

A surface micro-/nano-structured metal plate can be joined with an injection molded plastic piece in a mold,which has been named injection molded direct joining(IMDJ).The injected plastic melt infiltrates the micro-/nano-structure,e.g.,a porous structure with micro/nano pores,on the metal plate while flowing in the mold cavity where the metal plate is *** solidification of the plastic,the metal and plastic materials are directly joined via the micro-/nano-structured metal *** air is trapped by the plastic melt,it is easily imagined that the air in the mold cavity prevents the melt plastic from contacting the metal surface and infiltrating the micro-/nano-structure,which could result in poorer joining *** avoid the prevention of the air for the better joining performance,the present study proposes a system actively venting the mold cavity during injection *** apply the active venting to IMDJ,venting and sealing systems were newly *** addition,a system measuring air pressure of the mold cavity was *** proposed system was evaluated by a measurement of joining strengths of IMDJ specimens that were produced under various *** the results,it is concluded that the active venting does not necessarily have a positive effect in any cases:the effect depends on the type of surface micro-/nano-structure.

关键词： Metal-plastic direct joining Micro-/nano-structured surface Injection molding Active venting Mold cavity pressure measurement

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Design of Electro-Functional Polymeric Systems with Siloxane Components

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复旦学报（自然科学版） 2005年第5期44卷 635-636页

作者： yusuke Kawakami Japan Advanced Institute of Science and Technology (JAIST) Asahidai 1-1 Nomi Ishikawa 923-1292Japan

Siloxane derivatives have many unique static and dynamic properties like low surface free energy, incompatibility with other component, and bond flexibility. Various functional polymeric systems were designed by takin... 详细信息

关键词：聚合体热稳定性全息术硅氧烷浓缩工艺

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Lymphocyte-to-monocyte ratio is a short-term predictive marker of ulcerative colitis after induction of advanced therapy

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Gastroenterology Report 2022年第1期10卷 370-376页

作者： Natsuki Ishida yusuke Asai Takahiro Miyazu Satoshi Tamura Shinya Tani Mihoko Yamade Moriya Iwaizumi Yasushi Hamaya Satoshi Osawa Takahisa Furuta Ken Sugimoto First Department of Medicine Hamamatsu University School of MedicineHamamatsuShizuokaJapan Department of Endoscopic and Photodynamic Medicine Hamamatsu University School of MedicineHamamatsuShizuokaJapan Department of Laboratory Medicine Hamamatsu University School of MedicineHamamatsuShizuokaJapan Center for Clinical Research Hamamatsu University School of MedicineHamamatsuShizuokaJapan

Advanced therapies for patients with mild-to-severe ulcerative colitis(UC)may result in treatment *** examined whether the lymphocyte-to-monocyte ratio(L/M ratio)could predict the failure of advanced *** retrospective,observational,cohort study included 73 patients who were treated with advanced therapies at the Hamamatsu University School of Medicine(Shizuoka,Japan)between February 2011 and November *** patients were divided into the nonfailure and failure groups,and their leukocyte counts and ratios before induction were *** and multivariate analyses were performed to identify the prognostic *** therapies failed within 3 months in 15(20.5%)*** the L/M ratio was significantly lower in the failure group than in the non-failure group(P=0.004).Receiveroperating characteristic(ROC)curve analysis revealed that an L/M ratio of ≤3.417 was predictive of treatment failure;the area under the curve(AUC)was 0.747(95%CI,0.620–0.874).Kaplan–Meier analysis revealed that the failure-free rate was significantly lower in the group with an L/M ratio of≤3.417 than in the group with an L/M ratio of>3.417(log-rank test P=0.002).Cox proportional hazard regression analysis identified an L/M ratio of≤3.417 as an independent risk factor for failure within 3 months after the induction of advanced ***,ROC analysis of patients who did not receive immunomodulators also revealed that the cut-off L/M ratio was 3.417 and the AUC was 0.796(95%CI,0.666–0.925).In patients receiving advanced therapies for active UC,the L/M ratio can predict treatment failure within 3 months.L/M ratios could facilitate the transition from advanced therapies to subsequent treatments.

关键词： advanced therapy failure lymphocyte-to-monocyte ratio ulcerative colitis

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A simple and novel effective strategy using mechanical treatment to improve the oxygen uptake/release rate of YBaCo_(4)O_(7+δ) for thermochemical cycles

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Journal of Materials Science & Technology 2021年第9期68卷 8-15页

作者： Tingru Chen yusuke Asakura Takuya Hasegawa Teruki Motohashi Shu Yin Institute of Multidisciplinary Research for Advanced Material(IMRAM) Tohoku UniversitySendaiMiyagi980-8577Japan Department of Materials and Life Chemistry Kanagawa UniversityYokohama221-8686Japan

In recent years,oxygen storage materials(OSMs)have been widely used in many *** would be particularly important for researchers to design high-oxygen-uptake/release-rate *** this study,various synthesis processes were used to successfully synthesize YBaCo_(4)O_(7+δ)and comprehensively investigate their potential *** red with traditional solid-state reaction method and co-precipitation method,the results demonstrated that the utilization of mechanical ball milling treatment on co-precipitated precursors could lead to samples with reversible oxygen uptake/release under an oxidative atmosphere at low *** resultant materials exhibited fast oxygen absorption/desorption rate that could uptake/release oxygen directly to the equilibrium state within 9 min and20 min,*** mechanochemically ball-milled sample possessed outstanding oxygen sto rage performance,which could be attributed to their small particle size,the active outer surface of particles,large specific surface area,and relatively low activation ***,the ball-milled sample also exhibited excellent cycling stability during relatively short time *** results also demonstrated that the ball-milled samples could reversibly uptake/release 2.90 wt.%of excess oxygen(while only 0.70 wt.%for solid-state samples)by adjusting the ambient temperature under pure O_(2) atmosphere,which would make them promising candidates in various *** research demonstrated that mechanical treatment could be an effective strategy to tune the properties and oxygen storage capacity(OSC)performances of YBaCo_(4)O_(7+δ).

关键词： Oxygen storage materials Mechanical treatment YBaCo_(4)O_(7) Thermochemical cycles

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