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Evaluation of nintedanib as a new postoperative antiscarring agent in experimental extraocular muscle surgery

International Journal of Ophthalmology(English edition) 2022年第6期15卷 914-923页

作者： Gozde Bicaklioglu Dilara Pirhan yusufhan yazir Gokhan Duruksu Selenay Furat Rencber Nursen Yuksel Department of Ophthalmology University of Health Sciences Trabzon Kanuni Training and Research HospitalTrabzon 61250Turkey Department of Ophthalmology Kocaeli UniversityFaculty of MedicineKocaeli 41380Turkey Stem Cell and Gene Therapy Research and Application Center Kocaeli UniversityKocaeli 41380Turkey Department of Histology and Embryology Kocaeli UniversityFaculty of MedicineKocaeli 41380Turkey

AIM:To investigate the efficacy of nintedanib on reducing postoperative inflammation,fibrosis and adhesion formation following extraocular muscle surgery in rabbits in comparison with triamcinolone acetonide(TA).METHODS:Reinsertion of superior rectus muscle in right eyes of 30 New Zealand white rabbits were *** were randomized to receive one of the following treatments:0.9%normal saline,one of 1-,5-,and 10μmol doses of nintedanib subconjunctivally immediately after surgery and on postoperative day 1,2,3,5,and 7,and TA immediately after *** a control group,unoperated left eyes(n=6)were *** the 28 th day,six eyes from each group were enucleated and histopathologically and immunohistochemically analyzed to assess the postoperative inflammatory changes,fibrosis and *** growth factor beta,matrix metalloproteinase-2 and alpha smooth muscle actin expressions were ***:Conjunctival and scleral inflammation in TA and nintedanib groups were significantly reduced compared to saline(sham)*** vascularity and rectus muscle fibrosis were significantly reduced in 10μmol nintedanib *** groups were the most effective groups in reduction of perimuscular *** three nintedanib groups nor TA group differed statistically from sham group with regard to *** expressions of transforming growth factor beta,alpha smooth muscle actin and matrix metalloproteinase-2 were reduced in nintedanib groups compared to saline ***:Nintedanib appears to attenuate postoperative inflammation and fibrosis after extraocular muscle *** may be a safer and stronger alternative agent in extraocular muscle surgery when compared to *** investigation is needed to prove antiadhesive effect of nintedanib.

关键词： extraocular muscle surgery fibrosis inflammation nintedanib triamcinolone acetonide

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