Evaluation of nintedanib as a new postoperative antiscarring agent in experimental extraocular muscle surgery

作     者：Gozde Bicaklioglu Dilara Pirhan Yusufhan Yazir Gokhan Duruksu Selenay Furat Rencber Nursen Yuksel 

作者机构：Department of OphthalmologyUniversity of Health Sciences Trabzon Kanuni Training and Research HospitalTrabzon 61250Turkey Department of OphthalmologyKocaeli UniversityFaculty of MedicineKocaeli 41380Turkey Stem Cell and Gene Therapy Research and Application CenterKocaeli UniversityKocaeli 41380Turkey Department of Histology and EmbryologyKocaeli UniversityFaculty of MedicineKocaeli 41380Turkey 

出 版 物：《International Journal of Ophthalmology(English edition)》 (国际眼科杂志（英文版）)

年 卷 期：2022年第15卷第6期

页      面：914-923页

核心收录：

学科分类：1002[医学-临床医学] 100212[医学-眼科学] 10[医学] 

基　　金：Supported by Kocaeli University Scientific Research Projects Unit Fund(No.2019/029) 

主　　题：extraocular muscle surgery fibrosis inflammation nintedanib triamcinolone acetonide 

摘      要：AIM:To investigate the efficacy of nintedanib on reducing postoperative inflammation,fibrosis and adhesion formation following extraocular muscle surgery in rabbits in comparison with triamcinolone acetonide(TA).METHODS:Reinsertion of superior rectus muscle in right eyes of 30 New Zealand white rabbits were *** were randomized to receive one of the following treatments:0.9%normal saline,one of 1-,5-,and 10μmol doses of nintedanib subconjunctivally immediately after surgery and on postoperative day 1,2,3,5,and 7,and TA immediately after *** a control group,unoperated left eyes(n=6)were *** the 28 th day,six eyes from each group were enucleated and histopathologically and immunohistochemically analyzed to assess the postoperative inflammatory changes,fibrosis and *** growth factor beta,matrix metalloproteinase-2 and alpha smooth muscle actin expressions were ***:Conjunctival and scleral inflammation in TA and nintedanib groups were significantly reduced compared to saline(sham)*** vascularity and rectus muscle fibrosis were significantly reduced in 10μmol nintedanib *** groups were the most effective groups in reduction of perimuscular *** three nintedanib groups nor TA group differed statistically from sham group with regard to *** expressions of transforming growth factor beta,alpha smooth muscle actin and matrix metalloproteinase-2 were reduced in nintedanib groups compared to saline ***:Nintedanib appears to attenuate postoperative inflammation and fibrosis after extraocular muscle *** may be a safer and stronger alternative agent in extraocular muscle surgery when compared to *** investigation is needed to prove antiadhesive effect of nintedanib.