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Petroselinum crispum extract ameliorates scopolamine-induced cognitive dysfunction:role on apoptosis,inflammation and oxidative stress

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Food Science and Human Wellness 2022年第5期11卷 1290-1298页

作者： GökselŞener Gözde Karakadıoglu Dilek Ozbeyli Seren Ede Refiye Yanardag ozlem Sacan Asli Aykac Department of Pharmacology Faculty of PharmacyFenerbahce UniversityIstanbul 34758Turkey Department of Pharmacology Institude of Health SciencesMarmara UniversityIstanbul 34854Turkey Department of Medical Pathology Techniques Vocational School of Health ServicesMarmara UniversityIstanbul 34865Turkey Department of Biochemistry Faculty of EngineeringIstanbul Universityş-CerrahpasaIstanbul 34320Turkey Department of Biophysics Faculty of MedicineNear East UniversityNicosia 99138Cyprus

This study was designed to investigate whether Petroselinum crispum(PC)extract has protective effects on the brain in the scopolamine-induced Alzheimer’s disease(AD)rat *** rats were divided into;control,scopolamine(1 mg/kg,i.p.),galantamine(1.5 mg/kg,i.p.)and PC extract(2 g/kg,p.o.)-treated scopolamine *** day 14,the novel object recognition test(NORT)and Morris water maze test(MWMT)were performed and then the rats were ***-induced cognitive impairments observed in the NORT and MWMT,significantly improved with PC extract and galantamine *** reduced M_(1) receptor expression,Bcl-2/Bax ratio,and glutathione levels in the hippocampus and frontal cortex,while malondialdehyde levels,caspase-3/9 expressions,and acetylcholinesterase(AChE)activity were found to be *** the other hand,PC and galantamine treatments reversed these *** conclusion,PC extract has shown an ameliorative effect on the spatial and recognition memory,M_(1) receptor expression,apoptosis,oxidative stress,and increased AChE ***,it was concluded that PC could prevent AD-like conditions and can be used as a functional ***,since animal models do not completely mimic those of humans,based on the data obtained in this study,the importance of PC on human AD should be demonstrated in future studies.

关键词： Petroselinum crispum Apoptosis Spatial memory Recognition memory Oxidative stress M1 receptor

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A cross-layer fault tolerance management module for wireless sensor networks

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Journal of Zhejiang University-Science C(Computers and Electronics) 2012年第9期13卷 660-673页

作者： ozlem KARACA Radosveta SOKULLU Izmir Vocational School Dokuz Eylul UniversityIzmir 35160Turkey Department of Electrical and Electronics Engineering Ege UniversityIzmir 35100Turkey

It is a well-established fact that wireless sensor networks (WSNs) are very power constraint networks, but besides this, they are inherently more fault-prone than any other type of wireless network and their protocol design is very application specific. Major reasons for the faults are the unpredictable wireless communication channel, battery depletion, as well as fragility and mobility of the nodes. Furthermore, as traditional protocol design methods have proved inadequate, the cross-layer design (CLD) approach, which allows for interactions between different layers, providing more flexible and energy-efficient functionality, has emerged as a viable solution for WSNs. In this study we define a fault tolerance management module suitable to the requirements, limitations, and specifics of WSNs, encompassing methods for fault detection, fault prevention, fault management, and recovery. The suggested solution is in line with the CLD approach, which is an important factor in increasing the network performance. Through simulations the functionality of the network is evaluated, based on packet loss, delay, and energy consumption, and is compared with a similar solution not including fault management. The results achieved support the idea that the introduction of a unified approach to fault management improves the network performance as a whole.

关键词：无线传感器网络管理模块跨层设计容错故障管理协议设计故障检测数据包丢失

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Indoor^(222)Rn Levels and Effective Dose Estimation of Academic Staff in izmir-Turkey

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Biomedical and Environmental Sciences 2014年第4期27卷 259-267页

作者： TURKAN ALKAN ozlem KARADENIZ Department of Medical Physics Institute of Health SciencesDokuz Eyliil University Department of Physics Faculty of SciencesDokuz Eyliil University

Objective To investigate the annual effective doses from indoor radon received by academic staff in the Faculty building. Methods Measurements of indoor radon concentrations were performed in the Arts and Sciences Faculty of Dokuz Eylul University for two surveys of about 1 month duration respectively using the SSNTD （Solid State Nuclear Track Detectors） method with LR115 detectors. Time integrated measurements comprised different locations inside the faculty building： classrooms, toilets, canteen and offices. Homes of academic staff were also tested for radon. Results The aritthmetic mean radon concentration is 161 Bq m-3 with a range between 40 and 335 Bq m-3 in the Faculty. Six offices and three classrooms have a radon concentration above 200 Bq m-3. The results show that the radon concentration in classrooms is generally higher than in offices. Based on the measured indoor radon data, the annual effective doses received by staff in the Faculty were estimated to range from 0.79 to 4.27 mSv, according to UNSCEAR methodology. The annual effective doses received by staff ranged from 0.78 to 4.20 mSv in homes. On average, the Faculty contributed 56% to the annual effective dose. Conclusion Reported values for radon concentrations and corresponding doses are within the ICRP recommended limits for workplaces.

关键词： Indoor radon Solid state nuclear track detectors School Annual effective dose

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Effectiveness of vedolizumab treatment in two different anti-tumor necrosis factor alpha refractory pouchitis: A case report

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World Journal of Clinical Cases 2019年第16期7卷 2316-2321页

作者： ozlem Ozer Cakir Department of Gastroenterology and Hepatology Alanya Alaaddin Keykubat University School of Medicine

BACKGROUND Refractory pouchitis is a common cause of pouch failure,which may require surgical excision of the pouch or permanent *** aimed to show the effect of vedolizumab on treatment of the patient with refractory *** SUMMARY A 32-year-old male with pancolonic ulcerative colitis since the age of 25 with primary failure of infliximab and mesalamine and intolerance of azathioprine,underwent a total proctocolectomy with ileal pouch-anal anastomosis in *** developed chronic diarrhea in 2014,which was watery,30 per day and accompanied with blood and mucus affecting his quality of *** Vedolizumab is safe and effective in the management of anti-tumor necrosis factor alpha refractory pouchitis.

关键词： Anti-tumor necrosis factor alpha Refractory pouchitis Vedolizumab Ulcerative colitis

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Molecular pathways in viral hepatitis-associated liver carcinogenesis: An update

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World Journal of Clinical Cases 2021年第19期9卷 4890-4917页

作者： Gulsum ozlem Elpek Department of Pathology Akdeniz University Medical SchoolAntalya 07070Turkey

Hepatocellular carcinoma(HCC)is the most common type of cancer among primary malignant tumors of the liver and is a consequential cause of cancerrelated deaths *** recent years,uncovering the molecular mechanisms involved in the development and behavior of this tumor has led to the identification of multiple potential treatment *** the vast amount of data on this topic,HCC remains a challenging tumor to treat due to its aggressive behavior and complex molecular ***,the number of studies aiming to elucidate the mechanisms involved in both carcinogenesis and tumor progression in HCC continues to *** this context,the close association of HCC with viral hepatitis has led to numerous studies focusing on the direct or indirect involvement of viruses in the mechanisms contributing to tumor development and *** line with these efforts,this review was undertaken to highlight the current understanding of the molecular mechanisms by which hepatitis B virus(HBV)and hepatitis C virus(HCV)participate in oncogenesis and tumor progression in HCC and summarize new *** evidence indicates that HBV DNA integration promotes genomic instability,resulting in the overexpression of genes related to cancer development,metastasis,and angiogenesis or inactivation of tumor suppressor *** addition,genetic variations in HBV itself,especially preS2 deletions,may play a role in malignant *** dysregulation caused by both viruses might also contribute to tumor formation and metastasis by modifying the methylation of DNA and histones or altering the expression of ***,viral proteins of both HBV and HCV can affect pathways that are important anticancer *** effects of these two viruses on the Hippo-Yap-Taz pathway in HCC development and behavior need to be ***,comprehensive studies are also needed to determine these viruses'interaction with integrins,farnesoid X,and the

关键词： Hepatitis B virus Hepatitis C virus Hepatocellular carcinoma Carcinogenesis Molecular pathways Viral hepatitis

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Orosomucoid in liver diseases

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World Journal of Gastroenterology 2021年第45期27卷 7739-7747页

作者： Gulsum ozlem Elpek Department of Pathology Akdeniz University Medical SchoolAntalya 07070Turkey

In this editorial,the roles of orosomucoid(ORM)in the diagnoses and follow-up assessments of both nonneoplastic diseases and liver tumors are discussed with respect to the publication by Zhu et al presented in the previous issue of World Journal of Gastroenterology(2020;26(8):840-817).ORM,or alpha-1 acid glycoprotein(AGP),is an acute-phase protein that constitutes 1%to 3%of plasma proteins in humans and is mainly synthesized in the *** exists in serum as two variants:ORM1 and *** the variants share 89.6%sequence identity and have similar biological properties,ORM1 constitutes the main component of serum *** interesting feature of ORM is that its biological effects differ according to variations in glycosylation *** variable feature makes ORM an attractive target for diagnosing and monitoring many diseases,including those of the *** findings suggest that a sharp decrease in ORM level is an important marker for HBV-associated acute liver failure(ALF),and ORM1 plays an important role in liver *** viral hepatitis,increases in both ORM and its fucosylated forms and the correlation of these increases with fibrosis progression suggest that this glycoprotein can be used with other markers as a noninvasive method in the follow-up assessment of *** addition,similar findings regarding the level of the asialylated form of ORM,called asialo-AGP(AsAGP),have been reported in a follow-up assessment of fibrosis in chronic liver *** increase in ORM in serum has also been shown to improve hepatocellular carcinoma(HCC)diagnosis performance when combined with other *** addition,determination of the ORM level has been useful in the diagnosis of HCC with AFP concentrations less than 500 ng/*** monitoring patients with AFP-negative HCC,a unique trifucosylated tetra-antennary glycan of ORM may also be used as a new potential *** fact that there are very few studies investigating the expression of this glycopro

关键词： Orosomucoid Alpha-1-acid glycoprotein Viral hepatitis cirrhosis Hepatocellular carcinoma Downregulation

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Tumor budding as a potential prognostic marker in determining the behavior of primary liver cancers

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World Journal of Hepatology 2023年第6期15卷 775-785页

作者： Betul Unal Mennan Yigitcan Celik Elif Ocak Gedik Cumhur Ibrahim Bassorgun Gulsum ozlem Elpek Department of Pathology Akdeniz University Medical SchoolAntalya 07070Turkey

Hepatocellular(HCC)and intrahepatic cholangiocarcinoma(ICC),the most common primary tumors of the liver,are among the most important causes of cancer deaths *** patients with primary liver tumors are frequently diagnosed at an advanced stage and have high mortality,many efforts have been made to identify new markers to determine their behavior and treatment,similar to those in other solid organ ***,morphological assessment of tumor budding(TB)has been revealed as a promising prognostic finding to predict tumor behavior and survival across several different tumor ***,the TB score in colorectal cancer has been revealed as an important parameter in pathology report protocols to determine the course of the *** the liver,despite enormous data showing that many mechanisms involved in TB are associated with tumor behavior in both HCC and ICC,studies focusing on the role of TB in predicting the behavior and prognosis of these tumors have started to be investigated very *** purpose of this review is to present data about TB in primary tumors of the liver,pointing out the potential role of this parameter in determining the course of the disease,and emphasize the need to increase the number of further studies focusing on the evaluation of this parameter with an overview of the mechanisms involved in TB.

关键词： Tumor budding Hepatocellular carcinoma Cholangiocarcinoma Prognosis Liver cancer Epithelial-mesenchymal transition

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The fatty acid compositions of predator Piocoris luridus （Heteroptera： Lygaeidae） and its host Monosteria unicostata （Heteroptera： Tingidae） reared on almond

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Insect Science 2007年第6期14卷 461-466页

作者： ozlem CAKMAK MEHMET BASHAN HALIL BOLU Department of Biology Education Faculty Department of Biology Science and Art Faculty Department of Plant Protection AgricultureFaculty Dicle University 21280 Diyarbakir Turkey

The changes in fatty acid compositions during nutritional interaction among almond Amygdalus communis Linnaeus （Rosales： Rosaceae）（host plant）, lacebug Monosteria unicostata （Mulsant and Rey）（Heteroptera： Tingidae） and its predator Piocoris luridus Fieber （Heteroptera： Lygaeidae） were determined by gas chromatography and gas chromatography-mass spectrometry analyses. The fatty acid profiles of phospholipids and triacylglycerols were substantially different. Unlike the general observations for virtually most terrestrial insects, arachidonic and eicosapentaenoic acids were detected in high proportions of phospholipid fractions in both insects, especially in P. luridus. Also the almond tissues provide very little oleic acid to the herbivore diet, yet both insect species developed high proportions of this component. Our data reveals instances of specific accumulation of fatty acid biosynthesis, elongation/desaturation, and not incorporating selected fatty acids into cellular lipids.

关键词： Arachidonic acid insect fatty acid Monosteria unicostata Piocoris luridus,phospholipids triacylglycerols

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Leucocyte-and platelet-rich fibrin as a rescue therapy for small-to-medium-sized complex wounds of the lower extremities

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Burns & Trauma 2019年第1期7卷 98-106页

作者： Kadri Ozer ozlem Colak Aydin State Hospital PlasticReconstructive and Aesthetic Surgery Clinic09100 AydinTurkey Istanbul Okmeydani Training and Research Hospital PlasticReconstructive and Aesthetic Surgery Clinic34384 IstanbulTurkey

Background:Generally,advanced wound care resources are applied for complex wounds that pose a challenge to the medical and nursing *** this report,the use of leukocyte-and platelet-rich fibrin(L-PRF)is emphasized for complex wounds as an alternative,simple,inexpensive,time-saving process that does not require hospitalization and has a healing potential over that of bare soft tissue,including bone,tendon,and *** aim of this study is to extend the use of L-PRF in small-to-moderate-sized complex wounds of lower extremities in which L-PRF maintains the sensitive structures ***:Between January 2016 and December 2017,17 small-to-moderate-sized complex wounds of lower extremities treated with L-PRF were recruited from the plastic and reconstructive surgery clinic in Aydin State Hospital,*** treatment was administered twice per week in the outpatient *** on the size and extension of the complex wound,two to five blood samples were collected into 8.5 ml dry,glass vacuum tubes with no anticoagulant,and samples were immediately centrifuged at 1630×g for 5 min to obtain *** healing was defined as the day of complete wound ***:The median values of the initial wound size and wound duration were 12 cm^(2)(interquartile range,6 to 23 cm^(2))and 8 months before first admission(interquartile range,4 to 18 months),*** wounds showed significant improvements after L-PRF therapy and full closure after a median of 18months,with an interquartile range of 11 to 34 months of L-PRF *** were recurrences of wounds during the first 6 months after *** adverse events were ***:Our results add to the growing evidence that L-PRF treatments protect and maintain bare soft tissue structures viable,facilitate the formation of granulation tissue and epithelization,and remarkably reduce the need for additional soft tissue surgeries in small-to-medium-sized complex wounds.

关键词： Leukocyte-and platelet-rich fibrin Complex wound Bare bone Bare tendon

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ELECTRORHEOLOGY AND CREEP-RECOVERY BEHAVIOR OF CONDUCTING POLYTHIOPHENE/POLY(OXYMETHYLENE)-BLEND SUSPENSIONS

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Chinese Journal of Polymer Science 2012年第1期30卷 16-25页

作者： ozlem Erol H.Ibrahim Unal Bekir Sari Smart Materials Research Lab Chemistry Department Gazi UniversityAnkaraTurkey

Electrorheological properties and creep-recovery behavior of polythiophene/polyoxymethylene-blend having PT（50%）/POM（50%） composition were *** size,conductivity and dielectric values were measured to be 24.77μm,3.85×10^（-5） S·m^（-1） and 26.75,*** ratio was measured to be 64%at the end of 16 *** effects of dispersed particle volume fraction,external electric field strength,shear rate,frequency and temperature on ER properties and storage modulus of PT/POM-blend/silicone oil（SO） suspensions were *** were observed in the electric field viscosities of the suspensions and thus they were classified as a smart *** thinning non-Newtonian viscoelastic behavior was determined for PT/POM-blend/SO ***,time-dependent deformation was examined by creep-recovery tests and recoverable viscoelastic deformation established.

关键词： Conducting polythiophene/poly(oxymethylene) Blends Electrorheogical fluids Creep-recovery behavior

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