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Effects of resveratrol and methylprednisolone on biochemical,neurobehavioral and histopathological recovery after experimental spinal cord injury

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Acta Pharmacologica Sinica 2006年第10期27卷 1317-1325页

作者： Ozkan ARIES Suleyman CAYLI Eyup ALTINOZ Iclal GURSES Neslihan YUCEL Ayhan KOCAK Saim YOLOGLU yusuf turkoz Department of Neurosurgery Department of Biochemistry Department of Pathology Department of Emergency Medicine Department of Biostatistics Inonu UniversitySchool of Medicine44280 MalatyaTurkey

Aim:To investigate the neuroprotective effect of resveratrol in an experimentalspinal cord injury(SCI)model in ***:Male Wistar albino rats weighing200-250 g were randomized into six ***-drop trauma was performedfor *** 1 underwent laminectomy *** 2 underwent laminectomyfollowed by *** 3,4,5,and 6 underwent laminectomy followed by SCIand received resveratrol(100 mg/kg),methylprednisolone(MP)(30 mg/kg),resveratrol(100 mg/kg)plus MP(30 mg/kg),and ethanol(2%),*** were divided into two subgroups for biochemical analysis(killed at 24 h aftersurgery)and for neurobehavioral and histopathological evaluation(killed at 6weeks after surgery).Posttraumatic neurological recovery after surgery was re-corded ***:Groups 3 and 5 revealed significantly lower malon-dialdehyde,nitric oxide,xanthine oxidase,and higher glutathione levels than group4(P<0.05).Neurological recovery rates were significantly better in groups 3 and5 than group 4(P<0.05).When spinal trauma size ratios were compared,there wasno significant difference between treatment ***:Resveratroltreatment revealed better biochemical recovery in the acute stage of trauma thanMP *** resveratrol and combined treatment revealed betterneurobehavioral recovery than MP treatment;resveratrol,MP,and combined treat-ment modalities improved histopathological recovery at the same level in the finalstage of the *** studies involving different doses of resveratroland different doses combinations with MP could promise better results as eachdrug has a different anti-oxidative mechanism of action.

关键词： lipid peroxidation resveratrol spinal cord

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Cytoprotective effects of amifostine,ascorbic acid and N-acetylcysteine against methotrexate-induced hepatotoxicity in rats

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World Journal of Gastroenterology 2014年第29期20卷 10158-10165页

作者： Sami Akbulut Hulya Elbe Cengiz Eris Zumrut Dogan Gulten Toprak Emrah Otan Erman Erdemli yusuf turkoz Liver Transplant Institute Inonu University Faculty of Medicine Department of Histology and Embriology Inonu University Faculty of Medicine Department of Anatomy Adiyaman University Faculty of Medicine Department of Biochemistry Dicle University Faculty of Medicine Department of Biochemistry Inonu University Faculty of Medicine

AIM: To investigate the potential role of oxidative stress and the possible therapeutic effects of N-acetyl cysteine (NAC), amifostine (AMF) and ascorbic acid (ASC) in methotrexate (MTX)-induced hepatotoxicity.

关键词： Methotrexate Amifostine N-acetyl cysteine Ascorbic acid Hepatotoxicity Oxidative stress

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一项前瞻性随机双盲研究：胸段硬膜外给予新斯的明对腹主动脉手术后肠梗阻的影响

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麻醉与镇痛 2009年第3期5卷 63-68页

作者： Esra Caliskan Ayda turkoz Mesut Sener Nesrin Bozdogan Oner Gulcan Riza turkoz 张瑛(译) Departments of Anesthesiology and Reanimation Baskent University Faculty of Medicine Ankara Turkey Departments of Cardiovascular Surgery Baskent University Faculty of Medicine Ankara Turkey 不详

背景手术后肠梗阻是腹主动脉手术主要的胃肠并发症，可增加患者发病率和死亡率，延长住院时间，增加医疗费用。本项研究中，我们评价了硬膜外给予新斯的明对腹主动脉手术术后肠梗阻的影响。方法选择我院45例行择期腹主动脉手术的患者。... 详细信息

背景手术后肠梗阻是腹主动脉手术主要的胃肠并发症，可增加患者发病率和死亡率，延长住院时间，增加医疗费用。本项研究中，我们评价了硬膜外给予新斯的明对腹主动脉手术术后肠梗阻的影响。方法选择我院45例行择期腹主动脉手术的患者。所有患者均接受相同的全麻联合硬膜外麻醉。全麻诱导前，于T7～T8间隙放置硬膜外导管，给予布比卡因20ml（Q5％）（推注时间〉15分钟）。将患者随机分成两组，术毕和术后8小时分别通过硬膜外导管给予生理盐水稀释的1μg／kg新斯的明5ml（Ⅰ组），或给予生理盐水5ml（Ⅱ组）。在重症监护病房记录手术后出现肠鸣音的时间，同时记录每天肛门排气与排便的时间。结果Ⅰ组患者第1次出现肠鸣音时间和肛门排气时间均明显短于Ⅱ组（分别为11．6±11．2小时vs 22．6±12．8小时；21．8±15．6小时vs 36．6±19．1小时，P〈0．05）。两组第1次排便时间相近（P〉0．05）。Ⅱ组手术后恶心的发生明显高于Ⅰ组（P〈0.05）。两组手术后并发症发生率相近（P〉0.05）。结论胸段硬膜外给予新斯的明能够使腹主动脉手术后肠鸣音恢复更快，手术后肠梗阻时间缩短。

关键词：前瞻性随机双盲研究手术后肠梗阻腹主动脉手术胸段硬膜外新斯的明全麻联合硬膜外麻醉肛门排气时间硬膜外导管

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A Case of Pituitary Hemorrhage Following Cardiopulmonary Bypass Surgery

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Surgical Science 2011年第3期2卷 159-162页

作者： Ozgen Ilgaz Kocyigit Serdar Kabatas Erdinc Civelek Ezgi Tuncay Oguz Omay Tufan Cansever Ayda turkoz 不详

A 68-year-old female patient with previous history of transsphenoidal hypophysectomy operation underwent three-vessel coronary artery bypass graft (CABG) surgery for extensive coronary artery disease. Preoperative neurological examination revealed sequelae visual loss at right temporal visual field. Follow-up Magnetic Resonance Imaging studies showed a residual hypophyseal tumor tissue extending to suprasellar area. No additional pathology was detected in the early postoperative cranial control CT, but aggravation of visual field defect was determined. Coincidently, cranial magnetic resonance imaging (MRI) showed hemorrhage into the tumor tissue. We decided to follow-up the patient who exhibited no additional symptoms and was discharged well on the fifth day due to the signs of resolution of hemorrhage. Follow-up controls of the patient at sixth and twelfth months demonstrated normal hormone levels without any additional clinical complaints. We present preoperative assessment, perioperative anesthesia management, and postoperative clinical follow-up of a patient with a residual hypophyseal tumor.

关键词： Anesthesia Coronary Artery Bypass Graft Surgery Hemorrhage Hypophyseal Tumor

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