Effects of resveratrol and methylprednisolone on biochemical,neurobehavioral and histopathological recovery after experimental spinal cord injury
Effects of resveratrol and methylprednisolone on biochemical,neurobehavioral and histopathological recovery after experimental spinal cord injury作者机构:Department of Neurosurgery Department of Biochemistry Department of Pathology Department of Emergency Medicine Department of BiostatisticsInonu UniversitySchool of Medicine44280 MalatyaTurkey
出 版 物:《Acta Pharmacologica Sinica》 (中国药理学报(英文版))
年 卷 期:2006年第27卷第10期
页 面:1317-1325页
核心收录:
学科分类:1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 1002[医学-临床医学] 100602[医学-中西医结合临床] 10[医学]
主 题:lipid peroxidation resveratrol spinal cord
摘 要:Aim:To investigate the neuroprotective effect of resveratrol in an experimentalspinal cord injury(SCI)model in ***:Male Wistar albino rats weighing200-250 g were randomized into six ***-drop trauma was performedfor *** 1 underwent laminectomy *** 2 underwent laminectomyfollowed by *** 3,4,5,and 6 underwent laminectomy followed by SCIand received resveratrol(100 mg/kg),methylprednisolone(MP)(30 mg/kg),resveratrol(100 mg/kg)plus MP(30 mg/kg),and ethanol(2%),*** were divided into two subgroups for biochemical analysis(killed at 24 h aftersurgery)and for neurobehavioral and histopathological evaluation(killed at 6weeks after surgery).Posttraumatic neurological recovery after surgery was re-corded ***:Groups 3 and 5 revealed significantly lower malon-dialdehyde,nitric oxide,xanthine oxidase,and higher glutathione levels than group4(P0.05).Neurological recovery rates were significantly better in groups 3 and5 than group 4(P0.05).When spinal trauma size ratios were compared,there wasno significant difference between treatment ***:Resveratroltreatment revealed better biochemical recovery in the acute stage of trauma thanMP *** resveratrol and combined treatment revealed betterneurobehavioral recovery than MP treatment;resveratrol,MP,and combined treat-ment modalities improved histopathological recovery at the same level in the finalstage of the *** studies involving different doses of resveratroland different doses combinations with MP could promise better results as eachdrug has a different anti-oxidative mechanism of action.